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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Public Health

Future care preparation profiles and self-support ability among rural Chinese older adults: a cross-sectional study

Fangyuan Wang, Xianhong Li, Jiajia Han, Yinghui Guan, Jiaqi Tian, Le Xu, Bing Huang, Jianhui Xie

Background Population aging is accelerating worldwide, and rural older adults may face particular challenges because of limited access to formal care resources. Preparation for future care (PFC) is a multidimensional process involving awareness, avoidance, decision-making, and concrete planning. This study identified latent PFC profiles among rural older adults in China and examined their association with self-support ability. Methods A cross-sectional survey was conducted among 851 older adults from 16 rural villa …

03.09.2026journal-article

Frontiers in Medicine

Clinically silent early proximal seal failure with suspected interval distal endograft displacement after hybrid zone 2 thoracic endovascular aortic repair in severe arch tortuosity: a case report with 1-year follow-up

Fengsheng Yin, Liang Wang, Lingli Tang, Long Yang

Background Durable hybrid zone 2 thoracic endovascular aortic repair depends on adequate healthy sealing length, appropriate oversizing, and close endograft apposition. Severe arch tortuosity can compromise these requirements even when completion angiography is satisfactory. Case presentation A 46-year-old woman with a primary non-post-surgical distal arch and proximal descending thoracic aneurysm underwent left carotid-subclavian bypass, left subclavian artery origin occlusion, and zone 2 thoracic endovascular aor …

03.09.2026journal-article

Frontiers in Lab on a Chip Technologies

Extracellular vesicle-integrated brain organoid-on-a-chip systems for neuroimmune communication and precision therapy in viral encephalitis

Md. M. N. Azim

Viral encephalitis causes substantial neurological morbidity and mortality through the combined effects of direct viral injury, blood–brain barrier (BBB) dysfunction, and dysregulated communication among neural, vascular, and immune cells. Extracellular vesicles (EVs) are increasingly recognized as mediators of this communication because they transfer proteins, lipids, viral constituents, cytokine-related signals, and regulatory RNAs between neurons, astrocytes, microglia, endothelial cells, and peripheral immune c …

03.09.2026journal-article

Frontiers in Digital Health

Artificial intelligence in surgical decision-making across the perioperative continuum: a scoping review

Wasim I. Alghoul, Bassam Awad, Rasha A. Salama, Radwan Aloti, Ayman Agha, Wed B. Al-Shammari, Mohammed M. Ali, Khaled W. Elayyan, Hussain Azimullah, Hesham A. Hamdy, Mohamed Anas Patni, Nihal Wadid

Background The role of artificial intelligence (AI) in supporting clinical decision-making across the perioperative continuum remains incompletely defined. Although the presence of many AI models that perform well in terms of their predictive performance has been established, their role in the actual surgical decision-making process in the real-world in terms of specialties and perioperative phases has not been fully mapped. Objective To map the existing literature on the application of AI in surgical decision-maki …

03.09.2026journal-article

Haematologica

Pediatric-inspired therapy and blinatumomab consolidation improve outcomes in young adults with Philadelphia-like acute lymphoblastic leukemia

Ibrahim Aldoss, Arthur Li, Diana Knobler, Vaibhav Agrawal, Hoda Pourhassan, Paul Koller, Tamer Othman, Monzr M. Al Malki, Amandeep Salhotra, Karamjeet Sandhu, Haris Ali, Ahmed Aribi, Amanda Blackmon, Brian Ball, Idoroenyi Amanam, Salman Otoukesh, Rick Lin, Julio C. Alvarenga Thiebaud, Sunmin Park, Samer Khaled, Jose Tinajero, Dat Ngo, Zhaohui Gu, Lindsey Murphy, Yazeed Samara, Michelle Afkhami, Andrew Artz, Pamela Becker, Ryotaro Nakamura, Anthony Stein, Stephen Forman, Guido Marcucci, Vinod Pullarkat

Philadelphia (Ph)-like acute lymphoblastic leukemia (ALL) is a high-risk subtype of B-cell ALL associated with poor response to induction chemotherapy, suboptimal measurable residual disease (MRD) clearance, and inferior survival outcomes compared to non-Phlike subtypes. We retrospectively analyzed 140 consecutive adult patients with Ph-like ALL treated at our institution. The median age was 33.5 years, and the majority harbored CRLF2 rearrangements (85%). IKZF1plus deletion and JAK mutations were identified in 26% …

03.09.2026journal-article

F1000Research

Sample size determination across study designs in health professions education research: a methodology guide

Waqar M Naqvi, Anusha Divvi, Shivashankar Kengadaran, Aishwarya A Pashine, Maheshkumar Baladaniya, Aditya Patel, Praveen Kumar Kandakurthi, Ramprasad Muthukrishnan

Abstract Background Sample size determination is one of the least reported elements in the methods sections of health professions education (HPE) research. Underpowered studies miss real effects, whereas overpowered studies waste participants and resources. Guidance remains fragmented across statistical textbooks and discipline-specific papers, with no unified reference for HPE researchers. Methods We developed this guide as a structured narrative synthesis. Sources were identified through targeted database searchi …

03.09.2026journal-article

Journal of Intelligent Medicine

Temporal dynamics of visual awareness and target detection revealed by EEG‐based univariate and multivariate analyses

Yichao Huang, Mingliang Liu, Yufeng Ke

Abstract Successful visual processing involves both target detection and visual awareness, but their temporal dynamics remain incompletely understood. Here, we recorded EEG from 17 participants performing a near‐threshold visual task in which targets were defined by a luminance difference between central and peripheral discs. We compared correctly reported target and nontarget trials to examine EEG activity associated with target detection, and seen and unseen target trials to probe activity associated with reporte …

03.09.2026journal-article

The Journal of Clinical Endocrinology & Metabolism

Assessment of testicular function in boys with hematological malignancies: a prospective longitudinal study

Jimena Lopez Dacal, Silvina Prada, Marcela Soria, Cristina Ferraro, Lourdes Correa Brito, Sofía Suco, Sebastián Castro, Maria Gabriela Ropelato, Maria Gabriela Ballerini, Patricia Bedecarrás, Luis Aversa, Ignacio Bergadá, Rodolfo A Rey, Romina P Grinspon

Abstract Context Survival after pediatric hematologic malignancies has improved substantially, increasing concern regarding endocrine sequelae. While gonadotoxic effects on germ cells are characterized in adult survivors, the early impact of cancer and chemotherapy on hypothalamic–pituitary–testicular axis during childhood and adolescence remains insufficiently studied. Design We conducted a prospective longitudinal cohort study including 63 boys and adolescents with acute lymphoblastic leukemia, acute myeloid leuk …

03.09.2026journal-article

Frontiers in Psychology

“Did I look at the blackness, or did I look at the stars?” Meaning making in stories of spirituality, mental health and recovery

Katja Milner, Paul Crawford, Alison Edgley, Mike Slade

This qualitative narrative study explores how adults with lived experience of mental health difficulties draw on spirituality to make meaning and support recovery. Thirty participants were interviewed and asked to share their stories of spirituality, mental health and recovery. A narrative thematic analysis approach was developed to explore the superordinate theme of meaning making which comprised three interrelated themes: (1) Reframing, where spirituality enabled participants to adopt a bigger-picture perspective …

03.09.2026journal-article

Cardiovascular Drugs and Therapy

Profiling Cardiovascular Disease-Associated Changes in the Composition of High-Density Lipoprotein Particles

Tanith Fester, Carmelita Abrahams, Sandrine Lecour

Abstract Cardiovascular disease remains the leading cause of death worldwide, imposing significant morbidity and healthcare costs. While low serum high-density lipoprotein (HDL)-cholesterol levels have traditionally been linked to cardiovascular risk, most pharmacological interventions aimed at raising HDL-cholesterol levels have not consistently improved cardiovascular outcomes. Epidemiologic and genetic studies further suggest that circulating HDL-cholesterol levels may not directly determine cardiovascular risk, …

03.09.2026journal-article

Frontiers in Drug Delivery

Hyaluronidase-enhanced delivery in gene therapy and regenerative medicine for improved vector, cell, and cargo access

Patrick E. Sewell, Christopher Jensen

Efficient delivery of gene therapy vectors and regenerative cargo to the central nervous system (CNS) is limited by the hyaluronic acid (HA)-rich extracellular matrix (ECM). Adeno-associated virus (AAV) particles, mesenchymal stem cells (MSCs), multilineage-differentiating stress-enduring (MUSE) cells, and small extracellular vesicles (sEVs) must traverse the HA-rich ECM of the nasal submucosa, the perineural and perivascular compartments, and brain parenchyma to reach CNS targets. Dense ECM imposes viscosity, ster …

03.09.2026journal-article

Health Affairs Scholar

Implementing a Nicotine Cap to Make America Healthy Again

Dana Mowls Carroll, Dorothy K Hatsukami, Olivia A Wackowski, F Joseph McClernon, Eric Donny, Mitch Zeller

Abstract The U.S. Department of Health and Human Services’ (HHS) "Make America Healthy Again" initiative cannot eradicate the root causes of the nation’s chronic disease epidemic without tackling cigarette smoking, which kills over 480,000 Americans and costs $600 billion annually. This commentary reinvigorates a pivotal 2017 FDA framework by urging the current administration to finalize the proposed rule establishing a maximum nicotine cap in all cigarettes and selected combusted tobacco. Evidence demonstrates tha …

03.09.2026journal-article

Scientific Reports

The impact of patients suicide on the mental health of psychotherapists

Annabelle Siebert, Thomas Schnell, Janina Lehmann, Rüdiger Nübling

Abstract A great number of psychotherapists and psychiatrists experience at least one patient suicide during their career. This study aims to build upon previous research findings concerning the impact of experienced patient suicide on the mental health of practicing and trainee psychotherapists in a German sample. A central aspect involves examining the temporal development of perceived distress and identifying short- and long-term emotional effects of suicide through a mixed methods approach to derive correspondi …

03.09.2026journal-article

BMC Nursing

The impact of social capital on impression management tactics among nurses: a cross-sectional study

Ali Erbaşı, Ömer Faruk Diken, Yaşar Ayşegül Oğuz, İsa Altınışık

Abstract Background Impression management tactics represent important behavioral strategies through which employees navigate social and organizational interactions, including within healthcare settings. However, the relationship between nurses’ social capital and their use of impression management tactics, as well as the potential variation of this relationship across demographic and structural characteristics, remains insufficiently explored. Aim This study aimed to examine the relationship between social capital …

03.09.2026journal-article

Healthcare

Illness Coherence, Exercise Adherence, and Patient-Reported Outcomes in Chronic Spinal Pain: A Moderated Mediation Analysis

Kalliopi Vlastou, Anastasia Beneka, Evangelos Bebetsos, Maria Basta, Charidimos Tzagarakis, Evangelos Karademas, Izolde Bouloukaki, Dimitris Trivizadakis, Panagiotis Simos

Background/Objectives: Illness coherence has been associated with treatment engagement and adherence, but its relationship with exercise adherence and patient-reported outcomes in chronic spinal pain remains unclear. This study examined whether unsupervised exercise adherence mediates the association between baseline illness coherence and patient-reported outcomes and whether this indirect association differs according to the type of intervention received. Methods: A theory-driven secondary analysis was conducted u …

03.09.2026journal-article

Journal of Pharmaceutical Health Care and Sciences

Suspected retention of magnesium oxide tablets during co-administration with recovery K5, a concentrated oral enteral nutrition formula, supported by in vitro disintegration testing

Makoto Ohira, Hirohisa Fujitsuka, Rin Ono, Hikari Terui, Masanori Motegi, Susumu Kurushima, Tatsuru Ota, Toshikazu Kitagawa, Ryosuke Shinkai, Takahiro Amemiya, Takashi Tomita, Kenji Sumiya

Abstract Background Concentrated oral enteral nutrition (EN) formulas are used when adequate energy intake is required despite limited feeding volume, but their compatibility with tablets has not been fully evaluated. We observed computed tomography (CT) findings suggestive of gastrointestinal retention of magnesium oxide (MgO) tablets in an older inpatient receiving concentrated EN and performed an exploratory in vitro disintegration study. Methods Clinical medication, nutrition, and CT data were reviewed retrospe …

03.09.2026journal-article

İnönü University International Journal of Social Sciences (INIJOSS)

An Examination of the New Public Management Approach from the Perspective of Bureaucratic Ethics

Hasan Yılmaz

This study aims to establish a relationship and make a comparison between Max Weber's concept of bureaucracy and bureaucratic ethics and the New Public Management (NPM) approach. Weber's model of bureaucracy, based on rational authority, forms the ethical framework of both institutional structures and management culture as a determinant of modern public management. According to Weber, merit, adherence to rules, hierarchical responsibility, and professional ethics are fundamental norms in the functioning of bureaucr …

03.09.2026journal-article

Pediatric Surgery International

Gastrointestinal symptoms and association to food items in children with hirschsprung disease: a multinational patient-reported outcome study from Latin America and Spain

Carla Scaramella, Lovisa Telborn, Joseph Davidson, Hannah Day, Marta de Andres Crespo, Verónica Busoni, Pablo Lobos, Judith Lindert

Abstract Purpose Children with Hirschsprung disease (HD) frequently experience persistent bowel dysfunction after definitive surgery. Although many families report that diet influences gastrointestinal symptoms, evidence guiding dietary management remains limited. This study evaluated dietary habits, food-related gastrointestinal symptoms, and bowel function in children with HD across Spain and Latin America. Methods A Spanish-language version of the OASIS Nutrition Questionnaire was developed by the multinational …

03.09.2026journal-article

Kybernetes

From landmarks to likes: conceptualizing and measuring the public intangible capital of World Heritage sites

Eva Erjavec, Tjaša Redek, Uroš Godnov

Purpose This study examines whether World Heritage designation acts as public intangible capital that improves tourist destination perceptions. Design/methodology/approach Using 51,000 user-generated reviews from destinations in nine countries, we compare ratings and text sentiment for heritage and non-heritage sites and test for differences by visitor segment using several text-mining approaches, from transformer-based (BERT) sentiment to lexicon averages, aspect-level analysis (architecture, crowding, price) and …

03.09.2026journal-article

Frontiers in Public Health

Governing One Health under climate pressure: policy implementation in Botswana

Thabo Lucas Seleke

Background Climate change is tightening the links between human, animal, and environmental health, especially in settings where systems are already stretched. One Health is now widely recognised in policy circles, but in many cases, it remains more of an intention than something that is consistently practised. Methods This paper draws on a qualitative policy analysis of academic literature, national policy documents, and selected comparative examples from Kenya, Bangladesh, and Germany. The aim was not to be exhaus …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Application of the combined technique of novel transseptal puncture guidewire and steerable sheath in left atrial appendage occlusion: a preliminary feasibility case series

Mei Liang, Wen Jia Wang, Peng Yu Wang, Qing Gu

Objective Transseptal puncture (TSP) is a critical step in left atrial appendage occlusion (LAAO) but presents certain technical challenges. Conventional puncture needles, due to their inherent rigidity, often cause unpredictable needle tip “bouncing” or upward migration at the moment of septal puncture, resulting in a high or suboptimal puncture site, which subsequently compromises the coaxial alignment between the sheath and the left atrial appendage (LAA). This study aims to evaluate the safety and feasibility o …

03.09.2026journal-article

Frontiers in Public Health

Preclinical perspectives on common iron fortificants and their bioavailability in rat models: a systematic review and meta-analysis

Jiejia Zhang, Brian L. Lindshield

Background Numerous preclinical studies on improving iron bioavailability to address iron deficiency anemia have been published; however, no preclinical systematic reviews with pairwise meta-analyses have been conducted. Therefore, it is essential to systematically review, summarize, and evaluate the evidence regarding the effects of iron fortificants in animal studies. Methods The initial articles were identified in four scientific databases (PubMed, Web of Science Core Collection, Scopus, and EBSCO) on 10 January …

03.09.2026journal-article

Frontiers in Medicine

Intrauterine device migration into the bladder with resultant bladder stone formation: a case report

Meilian Chen, Hongmei Xiao, Fei Lai, Yingxue Bai, Yixue Zhou, Xuelian Tan, Limei Wu, Haixia Jiang

Objective To investigate the possible aetiology, clinical characteristics, diagnostic and therapeutic approaches, and prognosis of intrauterine device (IUD) migration into the bladder. Case report A 39-year-old woman presented with recurrent symptoms of urinary urgency and dysuria. Computed tomography scans (CT) revealed that one arm of the IUD had migrated into the bladder, causing bladder stones. The patient underwent transurethral bladder lithotripsy and stone removal, laparoscopic bladder repair, and hysterosco …

03.09.2026journal-article

Frontiers in Public Health

Reframing trauma recovery for public health: introducing the recovery assemblage framework

Victoria Christodoulides, Maike Klein

Psychological trauma represents a major global health challenge, with adverse childhood experiences (ACEs) contributing to long-term difficulties in mental and physical health, relationships, and wellbeing. Despite this, dominant models of trauma recovery are largely grounded in biomedical and individualized paradigms, and prioritize linear pathways focused on symptom reduction and therapeutic outcomes. Such approaches risk locating responsibility for recovery within the individual, overlooking the broader social, …