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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Discover Oncology

Prognostic value of CD8+ TILs and MMR status and their correlation with clinical outcomes in rectal cancer

Baokun Li, Zesong Meng, Feifei Wang, Chaoxi Zhou, Youqiang Liu, Xuhua Hu, Fei Yang

Abstract Objective To explore the associations of CD8⁺ tumor-infiltrating lymphocytes (TILs) and mismatch repair (MMR) status with prognosis in patients with rectal cancer. Methods: Formalin-fixed paraffin-embedded (FFPE) tissue specimens were collected from 414 patients with pathologically confirmed stage I–III rectal cancer. Tissue microarrays (TMAs) with a thickness of 4 μm were constructed. Immunohistochemistry (IHC) using anti-CD8 antibody was performed to detect CD8-positive cell expression. MMR status was ev …

28.08.2026journal-article

JITSS (Journal of Innovation and Trend in Social Sciences)

Management of Knee Pain in Osteoarthritis: A Narrative Review of Current Treatment Options

Tymoteusz Białowąs, Dominika Karolak, Natalia Sara Kuśmierowska, Monika Kuś, Grzegorz Słomkowski, Kacper Cholewiński, Daria Valipur Kolti, Milena Polak, Magdalena Natalia Nowak, Konrad Wiśniewski

Knee osteoarthritis is a common and progressive musculoskeletal condition that contributes substantially to pain, functional limitation, and reduced quality of life, particularly among middle-aged and older adults. The increasing diversity of available treatments highlights the need for an integrated understanding of their roles in clinical management. This narrative review aims to synthesize current therapeutic strategies for knee pain associated with osteoarthritis and examine their position within a stepwise tre …

28.08.2026journal-article

European Spine Journal

The challenge of OF5 vertebral fractures treatment: a modified muscle-preserving surgical technique and case-series presentation with a minimum 2-Year follow-up

Pietro Feltri, Anne Tabard-Fougère, Khalid Al Taha, Andreas Tsoupras, Nicolas Lauper, Dennis E. Dominguez

Abstract Purpose The surgical management of severe osteoporotic vertebral fractures (OF5 type) is complex and lacks a standardized approach. This study aimed: (1) to describe a modified surgical technique designed to offer broad exposure of the spine while preserving the paraspinal musculature; and (2) to present a case series of 15 OF5 patients with a 2-year follow-up. Methods Patients with OF5 were consecutively treated with SpineJack ® system vertebroplasty and navigated posterior fixation performed through a mo …

28.08.2026journal-article

PLOS Pathogens

Epigenetic silencing of innate and adaptive immunity genes underlies the immune evasion cancer hallmark in Theileria-infected B-cells

Marisol Giacomini, Aristeidis Panagiotou, Steve G. Odette, Ariane Honfozo, Jeremy Berthelet, Angelique Amo, Joseph M. Dybas, Julia Orio-Tejada, Katarzyna Kulej, Marie Villares, Benjamin A. Garcia, Magali Hennion, Matthew D. Weitzman, Jonathan B. Weitzman

Cancer hallmarks are characterized by wide-scale changes in gene expression programs. Pioneering studies showed how viral oncogenes target regulatory pathways, but little is known about tumorigenic mechanisms of non-viral pathogens. Theileria annulata is an intracellular parasite (related to apicomplexa parasites causing malaria) which remarkably transforms bovine leukocytes, hijacking host signaling pathways to induce cancer phenotypes, akin to human leukemias. While some host genes contribute to the proliferative …

28.08.2026journal-article

Thoracic Cancer

Decoding Malignant Lung Ground Glass Opacities: A Radiologic–Pathologic Study From Pure to Semi‐Solid Lesions

Alessandro Bonis, Giulia Pagliarini, Vincenzo Verzeletti, Sara Cecchinato, Anna Michielin, Serena Zanardo, Marco De Silvestro, Luigi Lione, Chiara Giraudo, Eleonora Faccioli, Giorgio Cannone, Marco Mammana, Alessandro Rebusso, Giovanni Maria Comacchio, Marco Schiavon, Andrea Dell'Amore

ABSTRACT Purpose Ground‐glass opacities (GGOs) are increasingly detected due to widespread low‐dose CT screening for lung cancer. Among them, malignant GGOs (mGGOs) are a clinical challenge. This study aimed to compare the radiological and anatomopathological characteristics of pure and semi‐solid mGGOs and to identify radiological predictive factors for consolidation. Methods A retrospective study was conducted on patients resected due to mGGOs between 2016 and 2023. Patients were classified based on whether initi …

28.08.2026journal-article

Optics Letters

Polarized photoacoustic imaging for cell division state recognition and tumor assessment

Guobiao Zhou, Hao Gao, Minmin Jiang, Deyuan Gan, Dingwen Liang, Zhongwen Cheng, Qinghui Cao, Zhenhui Zhang

Rapid assessment of tumor proliferation and malignancy is critical for intraoperative margin guidance. However, conventional Hematoxylin and Eosin (H&E)-stained images and fluorescence imaging require extensive sample preparation, limiting real-time applications. Here, we propose a label-free deep ultraviolet polarization photoacoustic imaging technique for identifying mitotic states and assessing tumor aggressiveness through sensitivity to microstructural anisotropy. Following theoretical modeling and system devel …

28.08.2026journal-article

Angewandte Chemie

Neural Engineering Tailored by Molecular Motors With Self‐Reporting for Neuron Activation and Depression Treatment

Pengpeng Lu, Xinjian Guo, Tao Liu, Yang Tian, Limin Zhang

ABSTRACT The discovery of mechanical regulation to neuronal behavior offers a novel perspective for understanding nervous system function and advancing neural engineering. A key challenge lies in achieving precise mechanical control of neurons while simultaneously monitoring their activity in real time. Here, we engineered a novel molecular machine equipped with self‐reporting capability, MM‐VSD1, enabling stable anchoring into the plasma membrane. This integrated molecular tool comprises a light‐driven rotary mole …

28.08.2026journal-article

International Journal of Empirical Economics

Beyond Immediate Effects: Durability under Continued Exposure and Post-Treatment Persistence in Behavioral Environmental Interventions

Jaecheol Lee, Junho Lee

Behavioral environmental interventions are increasingly used as relatively low-cost complements to prices, regulations, and technology-based policies. Their policy value, however, depends not only on their immediate effects but also on how those effects evolve over time. This article reviews long-horizon evidence while distinguishing two empirical objects: durability under continued exposure, or whether effects remain while the relevant intervention continues, and post-treatment persistence, or whether effects surv …

28.08.2026journal-article

ASEAN Journal of Chemical Engineering

Treatment of Swine Biogas Digester Effluent Using Volcanic Ash–Chitosan Composite Ceramic Membranes

Rhonalyn Maulion, Rejie Magnaye, Sicily Tiu, Elisa Gutierrez, Reggie Duenas

Water scarcity is a growing global concern, driven by rapid population growth, industrialization, and agricultural demands. The swine industry, a major contributor to agricultural water consumption, generates large volumes of wastewater that require proper treatment to prevent environmental damage. This study developed a volcanic ash–chitosan composite ceramic membrane (VACCCM) for treating swine biogas digester effluent. The developed VACCCM demonstrated significant reductions in total suspended solids (TSS) from …

28.08.2026journal-article

Journal of Neuro-Oncology

Pathology-validated structural and physiologic habitat imaging for differentiating radiation necrosis from tumor recurrence in brain metastases

Ji Eun Park, Guowen Shao, Shivani Baisiwala, Nakyoung Kim, Amelia Tan, Francesco Sanvito, Andrea Liang, Zexi Wang, Gianluca Nocera, Catalina Raymond, Viên Lam Le, Ho Sung Kim, Noriko Salamon, Whitney B. Pope, Won Kim, Benjamin M. Ellingson, Jingwen Yao

Abstract Purpose Differentiating tumor recurrence from radiation necrosis (RN) after stereotactic radiosurgery (SRS) remains a major diagnostic challenge in brain metastasis. We aimed to validate established MRI-based tumor habitat analysis for distinguishing tumor from RN in an independent cohort with histopathological ground truth. Materials and methods This retrospective study included 104 patients (104 lesions) with pathologically confirmed recurrent metastatic tumors ( n = 68) or RN ( n = 36) who underwent str …

28.08.2026journal-article

Journal of Nanomaterials and Applications

ADVANCED SPINEL FERRITE NANOPARTICLES FOR SUSTAINABLE WASTEWATER TREATMENT: A COMPREHENSIVE REVIEW ON SYNTHESIS, CATION DISTRIBUTION, AND MECHANISM-DRIVEN PERFORMANCE

Vidya Singh

Spinel ferrites have emerged as one of the most versatile multifunctional magnetic oxides owing to their tunable electronic structure, excellent chemical stability, and magnetic separability. Ferrites have attracted increasing attention for environmental remediation owing to their excellent magnetic recoverability, tunable electronic structures, and remarkable catalytic activity because of their high resistance and saturation magnetization. Enhancing ferrite characteristics by different synthesis methods and doping …

28.08.2026journal-article

Al-Turath Journal of Nursing

Awareness of Pre-Graduating Female Students Concerning Early Detection of Breast Cancer at University of Kerbala, Iraq in 2025

Hadeel Rasheed Seger, Taher Mohsin Al-Fahham, Hussein Khleif Kitab

Background: Breast cancer is a major killer in women globally and in developing regions where the early cancer detection facilities are unavailable. Awareness would be a tool to fight this disease through early detection and there by decrease the morbidity and mortality. This study aimed to assess the awareness of pre graduating female students regarding early detection of breast cancer at University of Kerbala in Iraq. Methods: A cross- sectional design was conducted from 27th January 2024 to May 2025 at Kerbala U …

28.08.2026journal-article

Journal of Clinical Medicine

Is Baseline PET/CT-Derived Metabolic Tumor Burden Associated with Treatment Response and Survival in Hodgkin Lymphoma?

Büşra Tuğçe Tonyalı, Mehmet Günhan Tekin, Sefa Bayram, Selin Gül Yaran, Gökhan Burul, Edibe Sevde Eker, Tahir Alper Cinli, Hasan Göze, Burcu Esen Akkaş, Mesut Ayer

Background/Objectives: Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) provide quantitative assessments of metabolically active tumor burden; however, their prognostic value in Hodgkin lymphoma (HL) remains uncertain. This study evaluated the associations of baseline PET/CT-derived MTV and TLG with clinical disease characteristics, treatment response, progression-free survival (PFS), and overall survival (OS) in patients with classical HL. Methods: This retrospective single-center study included 105 …

28.08.2026journal-article

Biomedical Materials

Drug delivery systems modified with cell-penetrating peptide tat and folate reverse multidrug resistance in ovarian and colorectal cancer by endocytosis-mediated efficient uptake and energy production reduction

Junqiao Zhu, Hanhan Zhu, Zhiting Sun, Xinhai Zhu, Yanfang Chen, Min Wang, Yuqin Tang, Yan Zhang, Guichao Liu, Zhigang Zhou, Jianfu Zhao

Abstract Purpose: Multidrug resistance (MDR) remains a severe challenge in the field of cancer treatment.Herein, two types of drug delivery system based on heparin named as H-F-DOX NPs (NPs-1) and H-F-Tat-DOX NPs (NPs-2) are demonstrated for efficiently reversing MDR.Methods:NPs-1 and NPs-2 were developed by nanoprecipitation method to use succinylatedheparin as backbone and decorated with folate-targeting ligand or dual-targeting ligands of folate combined with cell-penetrating peptide Tat to release doxorubicin ( …

28.08.2026journal-article

Journal of Neurological Surgery Part A: Central European Neurosurgery

Mini-Invasive Neurosurgical Treatment of Subdural Empyema: A Two-Patient Case Series

Ejona Rifat Isakaj Lilamani, Aurora Arben Muça, Arben Jonuz Rroji, Artid Agron Lame, Arba Firdus Cecia, Mithat Ismail Demneri, Arsen Haki Seferi, Ridvan Hamid Alimehmeti

Abstract Subdural empyema is a neurosurgical emergency traditionally managed with craniotomy and prolonged intravenous antibiotic therapy. Minimally invasive approaches may represent an alternative in selected cases, particularly when combined with timely diagnosis and targeted antimicrobial treatment. We report two cases of subdural empyema treated with minimally invasive burr-hole evacuation. A 22-year-old man with developmental anomalies and postischemic stroke history presented with intermittent high fever for …

28.08.2026journal-article

European Journal of Haematology

Diagnostic Accuracy of Fluorodeoxyglucose Positron Emission Tomography–Computed Tomography in Differentiating Tumor and Bland Thrombus in Patients With Cancer: A Systematic Review and Meta‐Analysis

Basant Eltaher, Amir Mahmoud, Kavya Balusu, Preetinder Singh Manshahia, Ali Abdelhay, Mouna Reghis, Sara Ng, Amber Afzal, Kristen Sanfilippo, Rushad Patell

ABSTRACT Introduction Differentiating tumor thrombus from bland thrombus can be challenging. This study assessed the diagnostic performance of positron emission tomography–computed tomography (PET/CT) scans in differentiating bland versus tumor thrombi in patients with cancer. Methods We systematically searched for observational studies evaluating the diagnostic accuracy of PET/CT scans in differentiating tumor from bland thrombi in adult cancer patients. We included patients with suspected tumor or bland thrombus …

28.08.2026journal-article

Clinical Medicine and Pharmacology

CHEMORADIATION AND ANTI-PD-1 THERAPY FOR RECTAL CANCER IN A PATIENT WITH MULTIPLE PRIMARY TUMORS: A RARE CLINICAL CASE

M. Bobkov

The article presents a rare clinical case of a 69-year-old patient with three multi-ple primary malignant tumors: cutaneous melanoma (pT4aN2bM0, stage IIIb), synchronous left renal cell carcinoma (cT2N0M0, stage II), and low-ampullary rectal cancer (cT2N0M0, stage I, pMMR/MSS). Treatment with the PD-1 inhibi-tor prolgolimab resulted in complete regression of metastatic melanoma lesions and stabilization of renal cancer. Upon development of rectal cancer, neoadjuvant chemoradiotherapy with capecitabine was initiated …

28.08.2026journal-article

Malignant tumours

Resolution on the results of the expert council on the topic “Diagnosis and treatment of advanced non-small cell lung cancer with BRAF mutation: from the search for molecular targets to therapeutic strategies in real-world clinical practice”

K. K. Laktionov, V. V. Breder, I. A. Demidova, V. V. Karaseva, F. V. Moiseenko, S. V. Orlov, E. V. Reutova, D. L. Stroyakovsky

On January 27, 2026, an Advisory Board was held to discuss issues of molecular genetic diagnosis of the BRAF V600E mutation in patients with advanced non-small cell lung cancer (NSCLC), as well as current treatment options for NSCLC patients with the BRAF V600E mutation. Next generation sequencing (NGS) is the most sensitive and specific method for molecular genetic testing. Its implementation in routine clinical practice will improve the detection rate of BRAF positive NSCLC patients. The accepted standard of care …

28.08.2026journal-article

International Journal of Biology and Life Sciences

Research Progress on TACE Combined with Targeted and Immunotherapy in the Comprehensive Treatment of Massive Hepatocellular Carcinoma

Kewei Fang, Hongwei Lei

Massive hepatocellular carcinoma (HCC) is characterized by large tumor volume, strong invasiveness, high propensity for vascular invasion and intrahepatic dissemination. Consequently, most patients lose the opportunity of radical surgical resection at initial diagnosis. Monotherapy with conventional transarterial chemoembolization (TACE) is associated with low remission rate, high risk of recurrence and metastasis, and poor long-term survival. In recent years, the rapid development of targeted therapy and immunothe …

28.08.2026journal-article

Advanced Materials

A Receptor‐Mediated Endolysosomal Recycling Chimera Enables Catalytic TNF‐α Degradation for Sustained Treatment of Mucosal Inflammation

Wenxue Xie, Yuqing Wu, Xichen Wan, Yuanyuan Chen, Yuanyuan Wu, Xiaowei Huang, Yujian Wen, Yiteng Lu, Yirou Zhang, Bo Gong, Xujiao Zhou, Hang Xing, Jiaxu Hong

ABSTRACT Mucosal inflammatory disorders such as dry eye disease (DED) and inflammatory bowel disease (IBD), driven by TNF‐α‐mediated immune‐epithelial crosstalk, remain therapeutically challenging. Conventional inhibitors often suffer from poor mucosal permeability and transient efficacy with 1:1 binding. Although extracellular protein degradation (eTPD) technologies can eliminate pathogenic proteins, most of them operate stoichiometrically, limiting dosage efficiency and durability. Here, we report a receptor‐medi …

28.08.2026journal-article

Clinical Cancer Research

Neoadjuvant Olaparib and Pembrolizumab Combination Therapy in the Treatment of Patients with HRD-Positive Advanced Ovarian Cancer: A Pilot Study

Kenichi Harano, Takehiro Nakao, Shin Nishio, Takahiro Katsuda, Kazuto Tasaki, Kazuhiro Takehara, Takanori Yokoyama, Hideki Furuya, Kyoko Hongo, Masatoshi Asano, Takashi Ikeno, Masashi Wakabayashi, Akihiro Sato, Hitoshi Saito, Chiaki Mashima, Ryo Kamata, Akihiro Ohashi, Suguru Odajima, Hiroshi Tanabe, Tetsuro Taki, Yasuto Fujimoto, Hirohiko Miyake, Reiko Watanabe, Genichiro Ishii, Toru Mukohara

Abstract Purpose: Preclinical studies suggest that poly (ADP-ribose) polymerase inhibition enhances tumor immunogenicity through stimulation of IFN genes pathway activation, providing rationale for combination with immune checkpoint inhibitors. However, clinical evidence supporting this synergy remains limited. We conducted a neoadjuvant pilot study evaluating olaparib with or without pembrolizumab in homologous recombination deficiency (HRD)–positive advanced ovarian cancer. Patients and Methods: Patients with new …

28.08.2026journal-article

Cancer Medicine

Preoperative RDW –Albumin Ratio as a Prognostic Biomarker in Gastric Cancer Surgery

Xinhang Cao, Weiwei Shang, Dandan Xiao, Wei Wang, Ziyu Wang, Yangbai Sun, Yan Zhang, Mingzhe Ma

ABSTRACT Background The ratio of red blood cell distribution width (RDW) to serum albumin (RAR) combines hematologic and nutritional information from routine blood tests and has shown potential value for prognostication in several diseases. This study aimed to evaluate the prognostic significance of preoperative RAR in patients with gastric cancer undergoing curative gastrectomy and to explore whether RAR could provide additional prognostic information beyond conventional indicators such as TNM stage. Aims This stu …

28.08.2026journal-article

Head & Neck

Head and Neck Lymph Node Metastases From Cancer of Unknown Primary: Outcomes From p16‐Guided Mucosal Radiotherapy

Philippe Harris, Dhiya‐Eddine Mabrouki, Felix‐Phuc Nguyen‐Tan, Edith Filion, Olivier Ballivy, Brian O'Sullivan, Apostolos Christopoulos, Tareck Ayad, Louis Guertin, Eric Bissada, Paul Tabet, Denis Soulières, Antoine Desilets, Alexandre Pellan Cheng, Robert Doucet, Laurent Létourneau‐Guillon, Houda Bahig

ABSTRACT Background The AJCC 8th edition distinguishes p16‐positive oropharyngeal head and neck carcinoma of unknown primary (HNCUP) due to its superior prognosis. However, standardized radiation volume guidelines are lacking. This study evaluates the safety of p16‐guided mucosal volume reduction. Methods A retrospective review of 126 HNCUP patients (2009–2023) was conducted. p16‐negative patients received comprehensive mucosal and laryngeal irradiation; p16‐positive patients received risk‐adapted, reduced‐volume r …

28.08.2026journal-article

JAMA Network Open

Prediction of Treatment Benefit With Internet-Based Cognitive Behavioral Therapy for Depression

Cora Schefft, Heiner Stuke, Selin Demir, Maximilian Preiß, Lukas Pezawas, Jakob Kaminski, Björn Meyer, Steffen Moritz, Thomas Berger, Johanne Schröder, Jan Philipp Klein, Stephan Köhler

Importance Treatment benefit prediction models may help identify which patients will benefit most from internet-based cognitive behavioral therapy (iCBT) for depression; it is unclear whether such models can support useful treatment allocation across programs. Objective To develop a model predicting individual treatment benefit from iCBT for depression across programs and to externally validate it in independent samples. Design, Setting, and Participants This prognostic study used individual participant data from 5 …

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