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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Medicine

Prevalence of financial toxicity and construction of a risk prediction model for lung cancer patients at 6 months after discharge

Ningning Liu, Xiaoyan Wang, Xiaofeng Pan, Caifang Tang, Ximiao Li, Yiting Zhang, Yaru Zhao

Objective To investigate the prevalence of 6-month post-discharge financial toxicity in lung cancer patients, identify its independent predictors, and establish a valid risk prediction model integrating socioeconomic, clinical, and patient-reported outcome variables as baseline predictors, so as to support early financial toxicity screening, targeted financial counseling and standardized nurse-led stratified transitional nursing interventions. Methods A single-center prospective cohort study enrolled 682 hospitaliz …

03.09.2026journal-article

Journal of Patient-Reported Outcomes

Comparing statistically reliable and patient-perceived improvement following hip arthroplasty: Rasch-based and anchor-based approaches

Adam B. Smith, Stuart Mealing, Damian Lewis, Andria Joseph

Abstract Background Interpreting meaningful change in patient-reported outcome measures (PROMs) is essential for assessing hip replacement outcomes. The Oxford Hip Score (OHS) is widely used, yet statistically detectable change may not align with patient-perceived improvement. Objectives To compare Rasch-based classifications of OHS change, following Hobart’s effect size methodology, with anchor-based interpretations derived from patient Global Impression of Change (GIC). Methods OHS data from a large hip replaceme …

03.09.2026journal-article

Frontiers in Medicine

Fractal analysis of peri-implant trabecular bone complexity following transcrestal sinus floor elevation: a retrospective radiographic study

Irfan Ustundag, Sevval Ilkyaz, Numan Dedeoglu, Selman Bolukbasi, Mehmet Sait Simsek, Yunus Çetiner, Bahadir Sancar

Background This retrospective radiographic study aimed to evaluate time- and region-dependent changes in peri-implant trabecular bone structural complexity using fractal dimension analysis after transcrestal sinus floor elevation (TSFE) with 3, 4, or 5 mm sinus membrane elevation. Methods A total of 45 dental implants placed simultaneously with TSFE in 35 patients were categorized into three groups according to sinus membrane elevation height (3 mm, 4 mm, and 5 mm). Fractal dimension analysis was performed using Im …

03.09.2026journal-article

Annals of Surgery

The Impact of Anastomotic Leak After Esophagectomy on Long-term Survival in the Modern Era of Management (ALES Study)

Lorenzo Giorgi, Nadia Guidozzi, Riadh Salem, Wing K. Chou, Stijn Vanstraelen, Helena Gielen, Johnny Moons, Philippe Nafteux, Femke E. Lammes, Jelle P. Ruurda, Richard van Hillegersberg, Alban Todesco, Xavier Benoit D’Journo, Alice Collizzolli, Barbara Ajazi, Simone Giacopuzzi, Maria Bencivenga, Sam Alhayo, Ella Seabourne, Ewen A. Griffiths, Aram Abu Hejleh, Lars M. Schiffmann, Christiane J. Bruns, Giovanni Maria Garbarino, Andrea Pansa, Silvia Basato, Ophélie Bacoeur-Ouzillou, Caroline Gronnier, Sofie P. G. Henckens, Suzanne S. Gisbertz, Rakesh Ahmed, Nithiesh Loganathan, Jessie A. Elliott, Kirsty Cole, Youssef Ibrahim, Chanakya Anand, Philip H. Pucher, Martin Skogar, Jakob Hedberg, Eloise Bonnin

Objective: To determine the impact of severity of esophageal anastomotic leak (AL), standardized by ECCG grading, on long-term survival within a contemporary multicenter cohort. Summary Background data: Historical evidence suggesting AL is associated with increased recurrence and poor survival is limited by heterogeneous definitions and outdated management. This study utilizes the standardized ECCG definition to evaluate the prognostic significance of AL severity under modern perioperative protocols and endoscopic …

03.09.2026journal-article

Petroleum Engineering

ANALYSIS OF THE EFFECTIVENESS OF STEAM TREATMENT DURING CYCLIC STEAM SIMULATED

Yu.E. Mikhailova, D.Yu. Savrey, V.V. Durkin

Cyclic steam simulated (CSS) is the most common technology of thermal impacton the formation of high-viscosity oil. The CSS technology is the injection of steam into a well, followed by the soaking stage (stopping the injection of steam to condense), followed by switching to the operating mode of the producing well. After the production wells are put into operation, production is carried out to a certain level of water cut floating oil or a cost-effective flow rate. The duration of the effect of the CSS can be both …

03.09.2026journal-article

Archives of Orthopaedic and Trauma Surgery

Early surgery of trochanteric femoral fractures in patients on direct oral anticoagulants (DOACs) reduces the length of stay (LOS) and the 1-year mortality rates without increasing the risk for revision surgery: a matched-pair analysis

Valerie Weihs, Roberta Laggner, Michael Humenberger, Andreas Duma, Martin Frossard, Stefan Hajdu

Abstract Background It remains unclear whether early surgical fixation of trochanteric femoral fractures in patients with direct oral anticoagulation (DOAC) therapy has an impact on the long-term outcome. Methods A retrospective cohort study on patients with trochanteric femoral fractures and DOAC therapy between 2016 and 2024 was conducted. Patients were divided into two groups according to their time to surgery and matched with age and ASA score as covariates. The primary outcome of interest was the impact of ear …

03.09.2026journal-article

Viruses

Pediatric Arboviral Infections in Europe: Epidemiology, Clinical Features, Diagnosis and Prevention

Giulia Sturniolo, Silvia Garattini, Denis Doni, Marco Zacchello, Diletta Zanetti, Sofia Galzignato, Andrea Lo Vecchio, Vincenzo Baldo, Daniele Donà

Arboviral infections, including West Nile virus (WNV), dengue virus (DENV), chikungunya virus (CHIKV), Zika virus (ZIKV), and, to a lesser extent, Oropouche virus (OROV), pose a heterogeneous and evolving challenge for pediatric health in Europe. The increasing presence of competent vectors and international travel has resulted in both imported infections and, for selected arboviruses, documented autochthonous transmission events. Although pediatric cases are often underrecognized, children may develop severe manif …

03.09.2026journal-article

Frontiers in Pharmacology

Suspected NIUAA after indobufen in a patient with ibuprofen allergy: a case report suggesting possible cross-reactivity

Long Luo, Jun Li, Ying Yuan, Ling Zhu

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in clinical practice, and hypersensitivity reactions to them are not uncommon. Although ibuprofen and indobufen have different clinical indications, both exert their effects through cyclooxygenase inhibition, suggesting a potential risk of cross-reactivity. This report describes a 52-year-old female patient who experienced pruritus, facial and eyelid edema, tearing, and ocular itching approximately half an hour after two separate exposures to ibuprofe …

03.09.2026journal-article

Clinical Kidney Journal

Hypophosphatemia after CAR-T cell therapy: a prospective study of inflammation, tubular injury and phosphate handling

F Moncho-Francés, R Hernani, MA Solis-Salguero, A Benzaquén, I Juan-García, A Pérez-Martínez, M Micó, JF Navarro-González, JL Piñana, JC Hernández-Boluda, MJ Terol, C Solano, JL Górriz, I Torregrosa

Abstract Background Hypophosphatemia is a frequent electrolyte abnormality after chimeric antigen receptor T-cell (CAR-T) therapy, but the clinical and biological factors associated with phosphate decline remain poorly defined. We prospectively evaluated the incidence, determinants and potential biological associations of hypophosphatemia after CAR-T therapy. Methods We conducted a prospective study including 63 adults with B-cell lymphoma treated with CAR-T therapy between June 2020 and December 2023. Serum phosph …

03.09.2026journal-article

Physics in Medicine & Biology

A real-time image-guided six-degree-of-freedom internal-external correlation framework for motion monitoring on a standard linear accelerator

Alicja Kaczynska, Freeman Jin, Maegan Stewart, John Kipritidis, Jeremy Booth, Nicholas Hardcastle, Paul Keall, Chandrima Sengupta

Abstract Objective. Real-time six-degree-of-freedom (6DoF) tumour motion monitoring is important for accurate stereotactic body radiotherapy (SBRT) of thoracic and abdominal cancer sites, yet existing approaches either require specialised imaging hardware or continuous fluoroscopic imaging. This study presents the development and first experimental implementation of a real-time image-guided 6DoF internal-external correlation (6D-IEC) modelling framework on a standard linear accelerator. Approach. The 6D-IEC framewo …

03.09.2026journal-article

Head and Neck Pathology

Pattern-Anchored Diagnosis of Oral Epithelial Dysplasia: A Position Paper From COST Action INTERCEPTOR Working Group 2

Syed Ali Khurram, Keith D. Hunter, Edward W. Odell, Merva Soluk Tekkeşin, Mark Lingen, Pablo Agustín Vargas, Omar Kujan, Daniela Elena Costea, Paolo Bossi, Pierre Saintigny, Senada Koljenović

Abstract Purpose Oral epithelial dysplasia (OED) is the principal histopathological marker for malignant risk stratification in oral potentially malignant disorders (OPMDs). Current World Health Organisation (WHO) three-tier and other binary grading systems are limited by modest inter-observer reproducibility and suboptimal prognostic discrimination, particularly for architecture-predominant lesions where cytological atypia is inconspicuous. The most clinically consequential failure of current practice is not mis-g …

03.09.2026journal-article

European Journal of Nuclear Medicine and Molecular Imaging

CEA-targeted fluorescence endoscopy for the detection of high-grade dysplasia and early invasive rectal cancer: A proof-of-concept trial

M. I. Warmerdam, T. H. Dijkhuis, D. J. G. Linders, C. M. W. Pesch, A. S. L. P. Crobach, A. Matoshi, K. Basiliya, S. H. van den Berg, F. Cailler, K. C. M. J. Peeters, F. A. Holman, J. S. D. Mieog, A. L. Vahrmeijer, D. E. Hilling, J. J. Boonstra

Abstract Purpose Accurate recognition of high-grade dysplasia (HGD) and early invasive carcinoma (IC) within colorectal polyps is essential for selecting the preferred local resection technique. However, optical endoscopic diagnosis can be challenging, particularly in large and advanced polyps. This study investigates whether carcinoembryonic antigen (CEA)-targeted near-infrared fluorescence (NIRF) imaging can distinguish polyps containing HGD/IC from polyps solely containing low-grade dysplasia (LGD), given prior …

03.09.2026journal-article

Frontiers in Oncology

Risk factors, severity-related factors, and clinical outcomes of immune checkpoint inhibitor-associated pneumonitis in elderly patients with lung cancer

Ying Hu, Shuhua Chen, Yingying Lu, Lingjuan Yang

Objective This study aimed to investigate the clinical characteristics, risk factors, severity-related factors, and clinical outcomes of immune checkpoint inhibitor-associated pneumonitis (CIP) after immune checkpoint inhibitor (ICI) treatment in elderly patients with lung cancer, providing evidence for risk identification and nursing management during ICI therapy. Methods Clinical data from 206 elderly patients with lung cancer who received ICI therapy at the Second Affiliated Hospital of Naval Medical University …

03.09.2026journal-article

Frontiers in Cellular and Infection Microbiology

Multidisciplinary management of severe odontogenic maxillofacial multi-space infection in a patient with HIV–syphilis coinfection and advanced immunosuppression: a case report

Jieying Li, Yuanyong Feng, Xueqiang Guo, Wei Shang, Kai Zhou

Background HIV–syphilis coinfection poses a substantial challenge in the management of severe odontogenic infections, with few reports addressing maxillofacial multi-space infections in this setting. Case presentation A 50-year-old man developed severe left maxillofacial multi-space infection one week after molar extraction, presenting with respiratory distress, trismus, elevated C-reactive protein (235.20 mg/L), computed tomography evidence of gas-forming abscesses, reactive HIV antibody, positive syphilis serolog …

03.09.2026journal-article

Journal of Clinical Medicine

Reference Estimates of Mean Tear Film Lipid Layer Thickness Measured with LipiView® and LipiView II® in Healthy Adults: A Systematic Review and Meta-Analysis

Maria Sobol, Jacek Pniewski

Background/Objectives: Tear film lipid layer thickness (LLT) is an important parameter of ocular surface function and can be objectively measured using LipiView ocular surface interferometry. However, reference LLT estimates in clinically healthy populations remain inconsistent. This systematic review and meta-analysis aimed to estimate pooled reference LLT values and explore potential sources of variability. Methods: A systematic search of PubMed, Scopus, and Web of Science was performed according to PRISMA 2020 g …

03.09.2026journal-article

Indian Journal of Nuclear Medicine

A Resource-Efficient End-to-End Multimodal AI Framework for Automated PET-CT Report Generation and TNM Staging in Breast Cancer

Dibya Prakash, Venkatesh Rangarajan, Manoj Kumar

Objectives: Positron Emission Tomography-Computed Tomography (PET-CT) is integral to breast cancer staging. However, manual interpretation is time-consuming and subject to inter-observer variability. While artificial intelligence has shown promise in lesion detection and standardised uptake value (SUVmax) quantification, existing approaches are fragmented and do not generate complete TNM-aligned structured reports. Consequently, there remains a need for an integrated framework capable of translating PET-CT data int …

03.09.2026journal-article

Frontiers in Surgery

Early outcomes following Duramesh™ implantation for abdominal wall closure: the Croydon experience

Lawrence Nip, Sarah Zhao, Sajid Malik, Reif Hwang, Jessica Quimpo, Eslam Ghazy, Matt Dunstan, Rhys Thomas, Samuel G. Parker

Introduction Mesh suture, or Duramesh™, is gaining traction for abdominal wall closure and ventral hernia repair. However, published data are limited to US case series and institutional registries. Use in UK and European cohorts remains undocumented. This is the first UK series describing indications and outcomes following Duramesh implantation. Methods This is a retrospective case series from a medium-sized tertiary abdominal wall unit in the UK. Institutional implant logs of consecutive patients from 1st Sep 2023 …

03.09.2026journal-article

The Indonesian Journal of International Clinical Legal Education

Legal Education and Child-Responsive Digital Reporting Systems for School Bullying Victims

Anis Widyawati, Diyah Satya Retnani

School bullying remains a significant challenge in educational institutions, affecting children's psychological well-being, academic performance, and access to justice. Despite the existence of legal protection frameworks and anti-bullying policies, many cases remain unreported due to fear of retaliation, limited legal awareness, social stigma, and the absence of child-friendly reporting mechanisms. This study aims to examine the role of legal education as the foundation for developing child-responsive digital repo …

03.09.2026journal-article

Frontiers in Oncology

Factors associated with clinical research participation among Medicare beneficiaries with prostate cancer in the United States

Ryan A. Hankins, Alysha M. McGovern, Abimbola O. Williams, Virgil H. Simons, Sean P. Collins, Deepak Kumar

Introduction Clinical research participation among patients with prostate cancer remains limited, and demographic, clinical, and contextual factors may influence opportunities for participation. Although disparities in prostate cancer diagnosis and treatment are well documented, less is known about the factors associated with clinical research participation in this population. This study examined patient-level and contextual factors associated with clinical research participation among older Medicare beneficiaries …

03.09.2026journal-article

Frontiers in Immunology

The transformative impact of ultra-rapid nanopore sequencing in precision medicine

Sarah Grasedieck, Brendan J. Keating, Stephen Yip, James Lan, Karen R. Sherwood, Paul A. Keown

Nanopore sequencing has emerged as a transformative technology, offering unprecedented speed, ultra-long reads, and portability at a comparatively low cost. These attributes are fundamentally reshaping clinical diagnostics and personalized medicine. This review synthesizes the technological advancements driving nanopore sequencing and elucidates its pivotal applications in time-sensitive areas such as HLA matching in transplantation, infectious disease management, pharmacogenomics, and oncology. Nanopore sequencing …

03.09.2026journal-article

Endodontics Today

Evaluation of post-operative pain following the use of different concentrations of sodium hypochlorite during endodontic treatment: An in vivo study

E.P.M. Pinto, R. A. Pelegrine, A. S. Martin, D.G.P. Rocha, C. P. Stringheta, W. M. Nascimento, A. G. Limoeiro, T.M.C. Coutinho, V. Ronquete, M.A.L.R. Pitzschk, M.F.V. Marceliano-Alves, C.E.S. Bueno

INTRODUCTION. One of the causes of the post-operative pain could be the irrigation solution used during the endodontic treatment. AIM. The aim of this study was to evaluate the pain symptoms after endodontic treatment of teeth with necrotic pulp, using two different concentrations of NaOCl during root canal instrumentation, as well as the necessity of using analgesics. MATERIALS AND METHODS. Fifty single-rooted upper incisors or canines were randomly divided into two groups ( n = 25) according to the concentration …

03.09.2026journal-article

American Journal of Audiology

Clinical Prevalence and Impact of False Air–Bone Gaps in Clinical Audiometry: A Study of 1,000 Ears

Shai Chordekar, Liron Kariv, Nir Fink

Purpose: Accurate hearing loss classification depends on air–bone relationships; however, “false” air–bone gaps (ABGs) in sensorineural hearing loss (SNHL) frequently compromise diagnostic clarity. By shifting the focus from ABG magnitude to clinical prevalence, this study uses the prevalence of clinical ABGs (≥ 15 dB) as a primary metric to quantify diagnostic ambiguity in routine practice and to evaluate the efficacy of bone-conduction (BC) testing at frequencies where frequent false ABGs occur. Method: We retros …

03.09.2026journal-article

Journal of Imaging Informatics in Medicine

Less Is More: Radiologists Prefer Brief Narratives in LLM-Generated Clinical History Summaries

Shawn Lyo, Satvik Tripathi, Ali Tejani, David Vu, Siddhant Dogra, Hamza Alizai, Tessa Cook

Abstract Clinical histories are essential for accurate radiologic interpretation but are often lengthy and time-consuming to review amid increasing radiologist workloads. Large language models (LLMs) offer a potential solution by generating concise, clinically focused summaries from existing documentation; however, the optimal presentation format for radiologists remains unclear. This retrospective reader study evaluated the readability, efficiency, and radiologist preference for a two-stage LLM-based summarization …

03.09.2026journal-article

AlQalam Journal of Medical and Applied Sciences

Clinical Effects and Safety of Deep Dry Needling for Upper Trapezius Myofascial Pain Syndrome: A Prospective Single-Group Study in Tripoli, Libya

Fatima Gazah

Myofascial pain syndrome (MPS) is a common musculoskeletal condition characterised by myofascial trigger points, pain, and functional limitations. Although dry needling is widely used in physiotherapy for myofascial pain, locally derived clinical evidence from Libya remains limited. This study evaluated the short-term clinical effects and safety of deep dry needling in patients with upper trapezius myofascial pain syndrome. A prospective, quasi-experimental, one-group pretest–posttest case series was conducted in t …