Vollständiger Abstract
Worum geht es in dieser Arbeit?
Objective: To determine the impact of severity of esophageal anastomotic leak (AL), standardized by ECCG grading, on long-term survival within a contemporary multicenter cohort. Summary Background data: Historical evidence suggesting AL is associated with increased recurrence and poor survival is limited by heterogeneous definitions and outdated management. This study utilizes the standardized ECCG definition to evaluate the prognostic significance of AL severity under modern perioperative protocols and endoscopic rescue strategies. Methods: An international multicenter cohort across 17 high-volume European centers. Adult patients with esophageal or junctional cancer treated with neoadjuvant CROSS or FLOT, followed by esophagectomy were included (2018–2023). Results: Out of 2905 patients, 425 (14.6%) developed an AL. AL was associated with a nearly two-fold increase in pulmonary complications (46.8% vs. 26.7%; P
Bibliografischer Nachweis
Publikationsdaten
- Autor:innen
- Lorenzo Giorgi, Nadia Guidozzi, Riadh Salem, Wing K. Chou, Stijn Vanstraelen, Helena Gielen, Johnny Moons, Philippe Nafteux, Femke E. Lammes, Jelle P. Ruurda, Richard van Hillegersberg, Alban Todesco, Xavier Benoit D’Journo, Alice Collizzolli, Barbara Ajazi, Simone Giacopuzzi, Maria Bencivenga, Sam Alhayo, Ella Seabourne, Ewen A. Griffiths, Aram Abu Hejleh, Lars M. Schiffmann, Christiane J. Bruns, Giovanni Maria Garbarino, Andrea Pansa, Silvia Basato, Ophélie Bacoeur-Ouzillou, Caroline Gronnier, Sofie P. G. Henckens, Suzanne S. Gisbertz, Rakesh Ahmed, Nithiesh Loganathan, Jessie A. Elliott, Kirsty Cole, Youssef Ibrahim, Chanakya Anand, Philip H. Pucher, Martin Skogar, Jakob Hedberg, Eloise Bonnin
- Quelle
- Annals of Surgery
- Publikation
- 2026-01-01
- Band / Ausgabe
- Nicht angegeben
- Seiten
- Nicht angegeben
- ISSN / ISBN
- 0003-4932, 1528-1140
- Zitationen
- 0 laut Crossref
- Referenzen
- 0 hinterlegt
Zitieren
Zitierfähiger Nachweis
Lorenzo Giorgi, Nadia Guidozzi, Riadh Salem, Wing K. Chou, Stijn Vanstraelen, Helena Gielen, Johnny Moons, Philippe Nafteux, Femke E. Lammes, Jelle P. Ruurda, Richard van Hillegersberg, Alban Todesco, Xavier Benoit D’Journo, Alice Collizzolli, Barbara Ajazi, Simone Giacopuzzi, Maria Bencivenga, Sam Alhayo, Ella Seabourne, Ewen A. Griffiths, Aram Abu Hejleh, Lars M. Schiffmann, Christiane J. Bruns, Giovanni Maria Garbarino, Andrea Pansa, Silvia Basato, Ophélie Bacoeur-Ouzillou, Caroline Gronnier, Sofie P. G. Henckens, Suzanne S. Gisbertz, Rakesh Ahmed, Nithiesh Loganathan, Jessie A. Elliott, Kirsty Cole, Youssef Ibrahim, Chanakya Anand, Philip H. Pucher, Martin Skogar, Jakob Hedberg, Eloise Bonnin (2026). The Impact of Anastomotic Leak After Esophagectomy on Long-term Survival in the Modern Era of Management (ALES Study). Annals of Surgery. https://doi.org/10.1097/sla.0000000000007190