EUVIMEDEuropean Health Evidence
Uhr 10/10Sources Journal Tree
Easy Demo

EUVIMED Themenbrowser · Alter & Demenz · Seite 12

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Physiologia

Changes in Cardiovascular Health and Functional Fitness Following Multicomponent Exercise Training in Community-Dwelling Older Women

Sandra Silva-Santos, Paula Rodrigues, Cidália Freitas, Joana Pinto, Raphael José Perrier-Melo, Manoel J. Rios

Background: Multicomponent exercise promotes healthy aging, but evidence in community-dwelling older women remains limited. This study examined pre–post changes in functional fitness and cardiovascular health following participation in a six-month multicomponent exercise program. Methods: Thirty-five community-dwelling older women (71.39 ± 6.82 years) participated in a quasi-experimental pre–post intervention study. Participants completed supervised multicomponent exercise sessions twice weekly for six months. Anth …

02.09.2026journal-article

Aging Clinical and Experimental Research

Association between the preoperative geriatric nutritional risk index and loss of walking independence 180 days after hip fracture surgery: A retrospective cohort study

Jiachen Ren, Mengyuan Liu, Keyao Yang, Cici Bai, Xu Ma, Zhishang Wang, Guoxin Dong, Yanbin Zhu, Xiuting Li

Abstract Background Malnutrition may impair recovery after hip fracture, but the association between preoperative geriatric nutritional risk index (GNRI) and postoperative walking outcomes remains unclear. We examined the association between GNRI and loss of walking independence (LWI) 180 days after hip fracture surgery. Methods This was a retrospective cohort study of patients aged 65 years and older who sustained a hip fracture and underwent surgery at a tertiary referral hospital between January 2021 and Decembe …

02.09.2026journal-article

npj Dementia

Reimagining biomedical science workflows in the age of large language models

Kaleigh F. Roberts, Srinivas Koutarapu, Justin Melendez, Eric C. Landsness, Justin T. Reese, Donald L. Elbert, Randall J. Bateman

Abstract Large language models (LLMs) are generative artificial intelligence (AI) models that are rapidly reshaping the practice of biomedical science. Their ability to synthesize literature, generate analytical code, and interface with multimodal data offers a new framework for accelerating discovery. Yet their integration into scientific workflows remains irregular, and the field lacks clear guidance for reliable and productive use. We review emerging evidence on researcher adoption, highlight common failure mode …

02.09.2026journal-article

Australian Occupational Therapy Journal

Developing an at‐home dementia rehabilitation intervention: An iterative qualitative codesign study

Clare Stephenson, Sophia Hadjimichael, Kasia Bail, Diane Gibson, Stephen Isbel, Michelle Bennett, Nathan M. D'Cunha

Abstract Introduction There is limited availability of community‐based rehabilitation for people with dementia. This study explored stakeholder perspectives to inform the design of an occupational therapy‐led at‐home dementia rehabilitation programme. Methods Four co‐design workshops were conducted over 6 months with 16 participants, including people with dementia, care partners and health‐care professionals. Transcribed workshop discussions underwent iterative thematic analysis to inform the final intervention com …

02.09.2026journal-article

The Journal of Aging and Social Change

“Outside We May Become Wrinkly but Inside We Are Growing Crumbly”

Liana Winett, Louise Dalingwater

Women’s health in both the United States and the United Kingdom lags that of men in clinical understanding, options, and access. Even some phenomena that exclusively affect women and which represent a near-universal experience, such as menopause, have historically received less attention than their ubiquity might suggest. Given that the governments of both nations have material influence over how health is perceived and addressed, we wished to explore whether and how menopause has been perceived as a national polic …

02.09.2026journal-article

Canadian Geriatrics Journal

Prevalence and Risk of Heart Failure Among Older Adults Experiencing Homelessness: A Systematic Review and Meta-Analysis

Peter M. Hoang, Josephine Ding, Laith Almsari, Jeswende Seedu, Riyad Asgarali, Yu Qing Huang, Charmaine De Castro, Paula Rochon, Maurita Harris, Kristina M. Kokorelias

Background Understanding the prevalence and risk of heart failure (HF) among older adults is crucial for informing the design and implementation of interventions and guiding equitable healthcare delivery. Methods A systematic search was conducted in MEDLINE, Embase, Cochrane Database of Systematic Reviews, CINAHL, and Web of Science from inception to April 2025. We included studies of adults aged 50 years or older experiencing homelessness. Outcomes included HF prevalence, risk of HF, and HF mortality. Screening, e …

02.09.2026journal-article

npj Dementia

Regulators of interferon-responsive microglia uncovered by Genome-wide CRISPRi screening

Amanda McQuade, Vincent Cele Castillo, Venus Hagan, Weiwei Liang, Thomas Ta, Reet Mishra, Olivia Teter, Layla Gomes, Bianca Gonzalez, Noam Teyssier, Kun Leng, Martin Kampmann

Abstract Microglia dynamically support brain health through the induction of specialized activation states in response to injury or disease. Activation of the interferon-responsive microglia (IRM) state has been identified across neurodevelopmental windows, age-related cognitive decline, and neurodegenerative diseases. Functionally, IRM have been linked to synaptic pruning, dead cell removal, and neuroinflammation, making this state critical to brain homeostasis. While the functional importance of this state is bec …

02.09.2026journal-article

Journal of Sleep Research

A Double‐Blind Randomised Controlled Crossover Trial of the Effect of Blue‐Enriched Ambient Light on Sleep in Older Adults With Sleep Disturbance: The CleverLights Study

Teha B. Pun, Craig L. Phillips, Nathaniel S. Marshall, Matthew Rahimi, Rick Wassing, Maria Comas, Angela L. D'Rozario, Camilla M. Hoyos, Delwyn J. Bartlett, Wenye Hu, Sharon L. Naismith, Sean Cain, Svetlana Postnova, Ronald R. Grunstein, Christopher J. Gordon

ABSTRACT Light interventions have been investigated for treating sleep disturbances in older adults; however, findings are mixed. This proof‐of‐concept trial investigated the effect of blue‐enriched ambient light on electroencephalographic (EEG) sleep in older adults with self‐reported poor sleep. Twelve participants (65.6 ± 8.7 years) were randomly exposed to two 72‐h in‐laboratory light conditions separated by 2 weeks. During the day, participants were exposed to either blue‐enriched light (intervention: melanopi …

02.09.2026journal-article

Medicine Advances

Nutritional Treatment After Discharge of Older Patients at Nutritional Risk: A Study Protocol for a Feasibility Study

Martine Kjærsgaard Nielsen, Tina Munk, Anne Marie Beck, Jacob Rosenberg, Jesper Ryg

ABSTRACT Background Malnutrition is prevalent among older hospitalized patients, increasing the risk of complications, extended hospital stays, and reduced quality of life. Upon discharge, a nutritional gap frequently arises, leading to insufficient intake for optimal recovery. Ensuring nutritional treatment in research settings after hospital discharge has demonstrated improvements in readmission rates, muscle strength, quality of life, and nutritional status. This study aims to evaluate the feasibility and effect …

02.09.2026journal-article

Dietetics

Mitochondria-Targeted Nutraceuticals as Metabolic Adjuncts to Physical Rehabilitation in Older Adults with Sarcopenia or Frailty: A Narrative Review

Alessio Turco, Lorenzo Lippi, Francesca Uberti, Alessandro de Sire, Marco Invernizzi

Age-related skeletal muscle wasting, clinically expressed as sarcopenia and frailty, significantly limits the efficacy of physical rehabilitation due to an underlying cellular bioenergetic decline, mitochondrial dysfunction, and chronic inflammaging. This narrative review synthesizes current physiological and clinical evidence evaluating mitochondria- targeted nutraceuticals as targeted metabolic adjuvants to physical exercise in older adults. Comprehensive literature searches were executed across PubMed, Web of Sc …

02.09.2026journal-article

Frontiers in Aging Neuroscience

Knowledge structure and frontier trends of exercise interventions for Parkinson’s disease: a bibliometric and visualized analysis

Jiangxi Yang, Huangyan Li, Shiliang Hu, Yang Xu, Yeting Zhang

Background Parkinson’s disease (PD) is a progressive neurodegenerative disorder with motor and non-motor manifestations. Exercise is increasingly integrated into the management of people with PD, yet the literature spans diverse intervention modalities, outcome domains, and mechanism-related topics. Objective To characterize publication growth, global collaboration, article types, keyword networks, thematic evolution, outcome domains, and emerging research fronts in exercise intervention research for PD. Methods En …

02.09.2026journal-article

Health & Social Work

Middle-Aged and Older Caregivers’ Loneliness and Neighborhood Disorder: The Buffering Role of Social Support

Seungjong Cho

Abstract This study explores the relationship between perceived neighborhood disorder and loneliness among middle-aged and older caregivers. It also examines whether social support buffers the potential negative influence of neighborhood disorder on loneliness. Using data from the 2018 Health and Retirement Study (N = 578), this study estimated relationships using ordinary least squares regression. Loneliness was measured using an 11-item scale. Perceived neighborhood disorder was measured with an eight-item scale …

02.09.2026journal-article

AIDS

Efficacy of dolutegravir or bictegravir-containing therapy in a real-life cohort of people with HIV-1 sub-subtype A6

Miłosz Parczewski, Maurizio Zazzi, Kaja Mielczak, Micha Böhm, Olaf Degen, Rolf Kaiser, Francesca Incardona, Anders Sönnerborg, Maarten A.A. van de Klundert

Objective: The objective of the study was to establish whether HIV-1 sub-subtype A6 (HIV-1A6) is a risk factor for virological failure in people with HIV (PWH) treated with the high genetic barrier integrase strand transfer inhibitors (INSTIs) dolutegravir (DTG) or bictegravir (BIC). Methods: The virological outcome of first-line DTG or BIC-containing antiretroviral therapy (ART) was assessed in 261 people with HIV-1A6 (PWH-1A6) and 1042 people with HIV-1B (PWH-1B) starting treatment between January 2014 and May 20 …

02.09.2026journal-article

AIDS

Sex-modulated associations between cytomegalovirus cell-associated DNA and cognition in people with HIV on ART

Alfonso Cabello-Ubeda, Patricia K. Riggs, Gordon Honerkamp-Smith, Alan Wells, Milenka Meneses, Gemma Caballero, Antoine Chaillon, Donald Franklin, Jennifer Ludicello, Leah H. Rubin, Ronald J. Ellis, Scott L. Letendre, Sara Gianella

Background: People with HIV (PWH) remain at risk for cognitive impairment, despite effective antiretroviral therapy (ART), a phenomenon linked to chronic immune activation and inflammation. Cytomegalovirus (CMV) has been implicated in HIV-associated neurocognitive impairment, but most studies rely on serologic measures that may not capture biologically relevant viral-host interactions. Few studies have examined cell-associated CMV markers or evaluated sex-specific associations with cognition. Methods: We conducted …

02.09.2026journal-article

Biogerontology

Evaluating pharmacological targeting of actin regulatory pathways during aging in C. elegans

Tiffany Wang, Athena Alcala, Daniella Berdan, Veronica Kuo, Gilberto Garcia, Ryo Higuchi-Sanabria, Maxim Averbukh

Abstract Actin is a highly conserved cytoskeletal protein that regulates numerous cellular processes essential for tissue homeostasis and healthy aging. Although genetic studies have established important roles for actin and actin-binding proteins in longevity, pharmacological approaches offer complementary advantages for manipulating conserved cytoskeletal pathways across model systems. Here, we systematically evaluated the effects of small-molecule modulators targeting distinct actin regulatory pathways on lifesp …

02.09.2026journal-article

Canadian Geriatrics Journal

Does Adding Mindfulness to Instability Resistance Training Enhance Dual-Task Mobility and Fall-Related Outcomes in Older Adults with Motoric Cognitive Risk Syndrome? A Randomized Controlled Trial

Gabriel De Amorim Batista, Vinícius Yan Santos Nascimento, Bruno Remígio Cavalcante, Mateus Santos Silva, Higo Faraday Paraíso Leão, Laís Regina De Holanda Santos, Dayane Tays da Silva, Mariana Ferreira de Souza, Ana Carolina Rodarti Pitangui, Rodrigo Cappato De Araújo

Background Older adults with motoric cognitive risk syndrome (MCR) exhibit impairments in dual-task mobility. Non-pharmacological interventions, such as physical exercise and cognitive strategies, have been proposed to mitigate physical and cognitive decline. However, the effectiveness of combining these approaches remains unclear. Objective To evaluate the effects of instability resistance training (IRT) performed with or without mindfulness on mobility under single- and dual-task conditions and fall- related outc …

02.09.2026journal-article

Langmuir

Influence of Deposition Time and Aging on the Wettability, Zeta Potential and Adhesive Properties of Thin Polydopamine Films

Astrid Drechsler, Sascha Putzke, Cordelia A. Zimmerer

Abstract Ultrathin polydopamine (PDA) films have a high potential as bioinspired functional and adhesive coatings. While their preparation has been studied extensively, little attention has been paid yet to their stability and aging under ambient conditions. The study at hand closes this gap by showing that two important macroscopic surface properties, the wettability and zeta potential, change continuously even after the wet-chemical preparation has been finished. PDA films were prepared using a standard procedure …

02.09.2026journal-article

Asia Pacific Journal of Innovation and Entrepreneurship

Harnessing networks for inclusive entrepreneurship: motivation and intentions as drivers of success for people with disabilities

Talha Yousaf, Owais Anwar Golra

Purpose By using social network theory (SNT), this study aims to hypothesize that networks directly and indirectly lead to entrepreneurial success/performance through intention. In particular, it explores how disabled entrepreneurs use these personal and professional networks to achieve success. Design/methodology/approach Through interview-based survey design, 400 people with disabilities (PwDs) were approached, of which 312 agreed to participate in the study. After removing incomplete responses, the final sample …

02.09.2026journal-article

Sports

Associations of Physical Activity with One-Year Functional and Cognitive Trajectories Following High-Speed Resistance Training in Older Adults

Alexandre Duarte Martins, João Paulo Brito, Nuno Batalha, Bruno Gonçalves, Rafael Oliveira, Orlando Fernandes

Background: Engaging in regular physical activity (PA) after completing structured exercise programmes may contribute to sustaining functional and cognitive gains in older adults over the long term. This study investigated whether different levels of PA during the one-year follow-up were associated with the preservation of the physical and cognitive gains achieved after a high-speed resistance training (HSRT) intervention lasting 16 weeks. Methods: Thirty-six community-dwelling older adults who had previously finis …

02.09.2026journal-article

Working with Older People

Reconceptualising complex needs in later life: a multidimensional framework for integrated person-centred care

Leelavathi R, Prasanna P, Somasundaram T, Madhusudhanan R, Surendhranatha Reddy C

Purpose Population ageing has resulted in a growing number of older adults living with multiple long-term conditions, functional limitations, cognitive decline, mental health challenges and social vulnerabilities. These interconnected needs frequently transcend the boundaries of conventional health and social care systems, creating fragmented service experiences and inconsistent care outcomes. This study aims to develop and validate an integrated framework for understanding complex needs in later life by examining …

02.09.2026journal-article

Peer Review

Intermanual transfer of learning in manual dexterity tasks: a study in Portuguese and Brazilian people

Shirley Regina de Almeida Batista, Paula Cristina dos Santos Rodrigues, Maria Olga Fernandes Vasconcelos

This study aims to investigate the expression of intermanual transfer of learning (IMTL) in two manual dexterity tasks (fine and global), by gender, age, direction of hand preference (HP), intensity of HP, and nationality. The task factor was also analyzed. This study evaluated 913 individuals (634 right-handers and 279 left-handers) of both genders, aged between 6 and 95 years, of Portuguese and Brazilian nationality. The HP was verified by the Dutch Handedness Questionnaire (van Strien, 2003). The fine manual dex …

02.09.2026journal-article

Frontiers in Public Health

Bridging the gap in aging systems: health literacy and community health worker workforce innovation to address health-related social needs

Teresa Wagner, Sarah Murphy, Saphina Achi

Introduction Older adults experience complex health and social challenges, including chronic disease, polypharmacy, caregiving demands, social isolation, and unmet health-related social needs (HRSN). Health literacy is a cross-cutting factor influencing the ability to find, understand, communicate about, and navigate health and social services. Community health workers (CHWs) are well positioned to address these intersections, yet integrated workforce training remains limited. Methods This manuscript describes a he …

02.09.2026journal-article

Healthcare

Cumulative Lifestyle Profiles and Osteoporotic Fracture Risk in Older Women: A Nationwide Korean Cohort Study

Dojoon Park, Hae-Seok Koh, Seokwon Jeong, Ju-Yeong Park, Kyungdo Han, Youn-Ho Choi

Background/Objectives: Modifiable lifestyle behaviors may be relevant to osteoporotic fracture risk, but their cumulative association across different levels of skeletal health remains unclear. This study investigated the association between a cumulative lifestyle score and osteoporotic fracture risk according to baseline bone mineral density (BMD) category in older women. Methods: We conducted a nationwide retrospective cohort study using Korean National Health Insurance Service data from 541,770 women aged 66 yea …

02.09.2026journal-article

Journal of the Chinese Medical Association

Decline in dementia patients during the COVID-19 pandemic: A cohort study in Taiwan

Meng-Ju Tsai, Yu-Ruei Lin, Yung-Shuan Lin, Chun-Yu Chen, Jong-Ling Fuh

Background: The cognitive consequences of COVID-19 in patients with dementia remain uncertain. This study examined whether COVID-19 infection was associated with cognitive decline. Methods: From October 2020 to October 2022, COVID-19-naïve patients with dementia were recruited from a hospital-based memory clinic in Taipei. During follow-up, patients who developed COVID-19 were classified as the infected group, while others served as controls. For controls, baseline and follow-up were defined as two consecutive annu …