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Sex-modulated associations between cytomegalovirus cell-associated DNA and cognition in people with HIV on ART

Alfonso Cabello-Ubeda, Patricia K. Riggs, Gordon Honerkamp-Smith, Alan Wells, Milenka Meneses, Gemma Caballero, Antoine Chaillon, Donald Franklin, Jennifer Ludicello, Leah H. Rubin, Ronald J. Ellis, Scott L. Letendre, Sara Gianella

AIDS · 2026

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Background: People with HIV (PWH) remain at risk for cognitive impairment, despite effective antiretroviral therapy (ART), a phenomenon linked to chronic immune activation and inflammation. Cytomegalovirus (CMV) has been implicated in HIV-associated neurocognitive impairment, but most studies rely on serologic measures that may not capture biologically relevant viral-host interactions. Few studies have examined cell-associated CMV markers or evaluated sex-specific associations with cognition. Methods: We conducted a retrospective cross-sectional analysis of 485 PWH on suppressive ART (HIV RNA

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Autor:innen
Alfonso Cabello-Ubeda, Patricia K. Riggs, Gordon Honerkamp-Smith, Alan Wells, Milenka Meneses, Gemma Caballero, Antoine Chaillon, Donald Franklin, Jennifer Ludicello, Leah H. Rubin, Ronald J. Ellis, Scott L. Letendre, Sara Gianella
Quelle
AIDS
Publikation
2026-01-01
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Nicht angegeben
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Nicht angegeben
ISSN / ISBN
0269-9370, 1473-5571
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Alfonso Cabello-Ubeda, Patricia K. Riggs, Gordon Honerkamp-Smith, Alan Wells, Milenka Meneses, Gemma Caballero, Antoine Chaillon, Donald Franklin, Jennifer Ludicello, Leah H. Rubin, Ronald J. Ellis, Scott L. Letendre, Sara Gianella (2026). Sex-modulated associations between cytomegalovirus cell-associated DNA and cognition in people with HIV on ART. AIDS. https://doi.org/10.1097/qad.0000000000004617
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