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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Journal of Comparative Effectiveness Research

US population-level model of clinical impact of lorlatinib treatment on ALK+ metastatic non-small cell lung cancer outcomes

Adam Kasle, Devin Abrahami, David Veenstra, Robert Morlock, Priya Ramachandran, Lindsay Stansfield, Raymond Mak

Aim: Lorlatinib and alectinib are next-generation anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) approved for the treatment of ALK-positive (ALK+) advanced/metastatic non-small cell lung cancer (NSCLC) after demonstrating superior efficacy over crizotinib (first-generation ALK TKI) in the CROWN and ALEX trials, respectively. This analysis estimated the US population-level clinical impact of first-line (1L) lorlatinib versus alectinib treatment for ALK+ advanced/metastatic NSCLC. Materials & meth …

03.09.2026journal-article

كلية القانون- جامعة سومر

<b>الضبط القانوني للاستخدامات المائية للأنهار الدولية في ضوء قواعد القانون الدولي العام</b>

علي يوسف

في ظل تزايد الطلب على الموارد المائية، شكلت النزاعات على الأنهار الدولية تحدياً دولياً وتنامي النزاعات بين الدول المتشاطئة على الأنهار الدولية بسببها، نتيجة عدم وجود ضابط موحد يحكم تنظيم الأنهار الدولية قواعد القانون الدولي العام، ويرجع ذلك لاختلاف الدول في تحديد المفهوم القانوني للأنهار الدولية، وتحليل الأساس القانوني المنظم لاستغلالها، والمبادئ الأساسية الحاكمة لها، وفي مقدمتها مبدأ الانتفاع المنصف والمعقول ومبدأ عدم الإضرار. لذا فإن هذه الدراسة سعت أن تبين الأسس وقواعد القانون الدولي العام على وجه الخصوص الاتفاق …

03.09.2026journal-article

Artefactum - revista de estudos interdisciplinares

THE SUPPORT THAT TRANSCENDS LABOR FORCE: ORGANIZATIONAL PERCEPTION AND SPIRITUALITY AT WORK AMONG EMPLOYEES OF A PUBLIC EDUCATION INSTITUTION IN THE STATE OF RIO GRANDE DO NORTE

Nilton Soares Formiga, Gardênia de Oliveira Galvão, Cleber Medeiros de Lucena, Willian Alber da Silva Farias, Raniere Costa Souza, Ivan do Carmo Lameque

Abstract: Organizational and Positive Psychology emphasizes resources capable of promoting health, well-being, and positive workplace relationships. Among these resources, workplace spirituality stands out as being associated with meaning, purpose, and the quality of professional relationships, while perceived organizational support concerns the recognition of employees’ contributions and the organization’s care for its workforce. This study examined the relationship between perceived organizational support and wor …

03.09.2026journal-article

Migration LAW

A Strong State is the Basis of Public Security

Alik G. Khabibulin, Kamil R. Mursalimov

The article is devoted to the problems of forming a strong state, preserving national statehood, and ensuring public safety. The author argues for a strong state based on an ideology that consolidates the traditional spiritual and moral values of Russian society, uniting the people and defining their creative activities aimed at meeting the public demand.

03.09.2026journal-article

Frontiers in Medicine

Aerosolized antifungal therapy in pulmonary fungal disease: pharmacology, drug delivery and emerging clinical applications

Massimo Caracciolo, Sarah Antonella Caracciolo, Maria Francesca Stagno, Simona Pellicano, Antonino Ripepi, Nadia Pellicano, Clara Scopelliti, Angela Serranò, Antonino Loddo, Stefano La Scala

Pulmonary fungal diseases remain associated with substantial morbidity and mortality, particularly in immunocompromised individuals, transplant recipients, and critically ill patients. Although systemic antifungal therapy remains the cornerstone of treatment, its effectiveness may be limited by suboptimal penetration into selected pulmonary compartments, while systemic toxicity, drug–drug interactions, and prolonged treatment requirements may restrict therapeutic options. Aerosolized antifungal therapy provides a p …

03.09.2026journal-article

Frontiers in Psychiatry

A critical appraisal of integrating family constellation therapy with pharmacological treatment for depression

Wenhao Zhong, Mei Rao, Qian Zhou, Zeying Leng, Bing Zhang, Zhijian Lin

Depression remains a leading cause of disability worldwide, driven by a complex interplay of biological, psychological, and social factors. While pharmacotherapy, particularly selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors, provides essential symptom control, its limitations—including delayed onset, variable response, and side effects—underscore the need for complementary approaches that address systemic and relational roots of the disorder. This narrative review synthesize …

03.09.2026journal-article

Medical Technology and Public Health Journal

An Analysis of Emergency Drills in Enhancing Self-Readiness and Emergency Preparedness Behavior Among Employees at Taman Dolan Tourist Site

Rachmy Rois, Anita Sulistyorini, Dian Puspitaningtyas Laksana

Natural tourism areas are highly vulnerable to disasters, making employees a crucial factor in ensuring visitor safety. One important mitigation strategy is the implementation of emergency drills, also known as emergency response exercises. However, the effectiveness of training in improving employee preparedness remains uncertain. This study aimed to analyzed the effect of emergency drills on self-readiness and emergency preparedness behavior among employees at Taman Dolan Nature Tourism, Batu City. A quantitative …

03.09.2026journal-article

Review of Clinical Pharmacology and Pharmacokinetics

Therapeutic landscape for diabetic macular edema: durable strategies with a focus on aflibercept 8 mg

Martín Roberto Basile-Alvarez, Erick André Escalante-Buendía, Karen A. Palacios-Aguirre, Alejandro Ortega Desio, Omar Yaxmehen Bello-Chavolla

To evaluate current therapies for diabetic macular edema (DME), with emphasis on durability, safety, access, and the evidence supporting aflibercept 8 mg. An expert-selected narrative synthesis of primary clinical trials, pharmacologic studies, regulatory documents, and selected real-world evidence published from January 1, 2000, through August 8, 2026, was performed. Anti-vascular endothelial growth factor therapy remains first-line treatment for most center-involved DME with visual impairment, but observation or …

03.09.2026journal-article

Frontiers in Medicine

From benchmarking to global leadership: Singapore’s health sciences authority’s journey to WHO maturity level 4 and WHO-Listed Authority status for medicines

Dorothy Toh, Adena Lim, Agnes Chan, Alvin Chia, Pei San Ang, Annie Tan, Belinda Foo, Betty Chan, Limei Chong, Qiuyi Choo, Chih Tzer Choong, Christine Ho, Siew Wei Chua, Shin Chet Chuah, Clare Louise Rodrigues, Damian Chuah, Debbie Sun, Diana Koh, Doris Yeo, Esther Tan, Eugene Goh, Evelyn Lee, Flavian Ee, Freddie Foo, Xiao Wei Ge, Cheong Hian Goh, Phey Yen Han, Jalene Poh, Jean Low, Jessica Teo, Joyce Ng, Weng Fai Lai, Hui Keng Lee, Boon Kian Lim, Li Lian Lim, Na Lim, Sharon Lin, Boon Lee Ling, Lisa Tan, Yee Hoo Looi

This article aims to describe Singapore Health Sciences Authority’s (HSA’s) multi-year journey to attaining World Health Organisation (WHO) Maturity Level 4 (ML4) and WHO-Listed Authority (WLA) status for medicines regulatory functions, presenting HSA as a descriptive policy case study on the practical application of the WHO Global Benchmarking Tool (GBT) and WLA frameworks. It outlines the benchmarking and Performance Evaluation (PE) processes, including the scope of assessment, phased reviews, and key milestones …

03.09.2026journal-article

Frontiers in Public Health

The mediating role of psychological capital between work stress and compassion fatigue among clinical nurses: a cross-sectional study

Chengxi Huang, Dengbin Liao, Yunting Luo, Yiran Xu, Haoyang Luo, Lingxiao He

Objective To explore the parallel multiple mediating effects of the sub-dimensions of psychological capital (self-efficacy, hope, resilience, and optimism) between work stress and compassion fatigue among clinical nurses. Methods A cross-sectional study was conducted using convenience sampling. Clinical nurses from a tertiary hospital were recruited. Data were collected using a general demographic questionnaire, the Nurse Work Stress Scale (NWSS), the Psychological Capital Questionnaire-revised (PCQ-R), and the Pro …

03.09.2026journal-article

Frontiers in Psychology

Profiles of sleep hygiene, insomnia, sleep locus of control, and psychological well-being among nursing students: a cluster analysis

Ramya Kundayi Ravi, Daljit Kaur, Shaimaa Hashem Elsalous, Nilda Ensomo Ogsimer, Gifty Thomas, Lakshmi Ramamoorthy, Jaison Jacob, Priya Baby

Introduction Psychological well-being is crucial for nursing students, who often face academic and clinical stressors that disrupt their sleep patterns. Insomnia severity, sleep hygiene, and sleep locus of control are key sleep-related factors that potentially influence mental health. However, the combined effects of these factors on psychological well-being remain underexplored, particularly among Indian nursing students. Methods A cross-sectional analytical study was conducted among 418 nursing students from two …

03.09.2026journal-article

Frontiers in Psychiatry

Motivational climate in school sport and adolescent mental health: a systematic review

Yuan Wei, Guan-Nan Lai, Cheng Ji, Xiao-Ming Yang, Chun-Yuan Tie

Background Motivational climate in school-based physical education and sport represents a potentially modifiable context for adolescent mental health; however, its associations with psychological outcomes have not been systematically synthesised. This review aimed to synthesise evidence on perceived motivational climate and adolescent mental health outcomes in school settings. Methods Databases were searched from the inception to May 2026 following PRISMA guidelines. Inclusion criteria for studies included sampling …

03.09.2026journal-article

Crop Health

Advances in semiochemicals of the sweet potato weevil, Cylas formicarius, and its application in pest management

Shuyan He, Chao Li, Yulin Gao

Abstract The sweet potato weevil (SPW), Cylas formicarius , is one of the most destructive pests of sweet potato, Ipomoea batatas L., across tropical and subtropical regions worldwide. The concealed feeding habits of larvae and the nocturnal activity of adults render conventional chemical-based control largely ineffective. Semiochemical-based management, especially the use of female-produced sex pheromone, has emerged as a promising strategy for integrated pest management (IPM) for this pest insect. This review pro …

03.09.2026journal-article

International Journal of Laboratory Hematology

Clinical and Laboratory Associations of JAK2 V617F Variant Allele Frequency in Patients With JAK2 V617F ‐Positive Erythrocytosis: A Single‐Centre Retrospective Analysis

Tahir Alper Cinli, Çisem Çınar

ABSTRACT Background JAK2 V617F variant allele frequency (VAF) reflects clonal burden in myeloproliferative neoplasms, but the clinical associations of low‐level VAF in patients with erythrocytosis remain uncertain. Objective The objective of this study is to examine associations between diagnostic JAK2 V617F VAF categories and clinical, laboratory, bone marrow and thrombotic outcomes in patients with JAK2 V617F‐positive erythrocytosis. Patients and Methods This single‐centre retrospective cohort included 174 adults …

03.09.2026journal-article

AI & SOCIETY

Beyond the machine: risk, fear, optimism and the foundations of public trust in AI

Steven David Pickering, Martin Ejnar Hansen, Yosuke Sunahara

Abstract What drives public trust in artificial intelligence (AI)? This study examines the individual and institutional foundations of AI trust across two contrasting democracies: Japan and the United Kingdom. Drawing on original survey data ( N = 3235), we test a set of hypotheses derived from trust-transfer perspectives and self-efficacy research, covering institutional trust, AI self-efficacy, technological optimism, perceived societal threat, and job displacement anxiety. The results show that trust in AI is sh …

03.09.2026journal-article

Journal of Palliative Medicine

Palliative Care Services for Patients with Noncancer Diseases in Outpatient Clinics Across Canada: A National Survey Study

Asia Estis-Deaton, Daphna Grossman, Tania Johannsen, Kathleen Milne, Leah Salvage, Michael Bonares

Background: The palliative care needs of patients with noncancer diseases are increasingly recognized, yet the prevalence, models, and delivery of outpatient specialist palliative care for these populations remain understudied. Objective: To describe outpatient palliative care clinics for noncancer diseases across Canada, including clinic prevalence and models of care. Methods: Cross-sectional survey study of practicing Canadian palliative care physicians recruited nationally. Quantitative data were analyzed descri …

03.09.2026journal-article

VIEW

Zn 2+ ‐Driven Self‐Amplifying Nanoplatform Enables Cascade Photothermal–Gene Therapy via Mitochondrial Disruption

Zhi Li, Yuhong Chen, Youfei Zhang, Luzhen Huai, Xingzhou Zhu, Xue Mo, Jiahao Wang, Kui Zeng, Jie Wang

ABSTRACT The therapeutic efficacy of photothermal–gene combination strategies is often limited by intrinsic cellular stress resistance and insufficient intracellular amplification. Here, we report a Zn 2+ ‐activated nanoplatform (DN/Au@ZIF‐8) that enables a self‐amplifying therapeutic cascade through mitochondrial disruption. Upon exposure to the acidic tumor microenvironment, the ZIF‐8 framework undergoes rapid degradation, releasing Zn 2+ ions, gold nanorods, and a structure‐switchable DNA nanocomplex. The libera …

03.09.2026journal-article

BMC Health Services Research

Associations between physical activity in adulthood and utilisation of municipal home and long-term healthcare services in older age: the HUNT study

Aslaug Angelsen, Sigrid Nakrem, Bjørn Heine Strand, Linn Beate Strand

Abstract Background Physical activity is a key component in public health frameworks to maintain functional ability through ageing. In Norway, healthcare services such as home health nursing and long-term institutional stays for older adults account for a significant amount of healthcare expenditures, but little is known about the association between physical activity levels through adulthood and utilisation of these services later in life. To this end, we wanted to explore an association between physical activity …

03.09.2026journal-article

Pathogens

Clinical Characteristics and Antimicrobial Resistance Profiles of Pediatric Enterococcal Infections: A Comparison Between Enterococcus faecium and Enterococcus faecalis

Zixuan Wang, Chenchen Li, Yuanjie Zhou, Xiang Deng, Weichun Huang, Qing Cao

Objective: To compare the clinical characteristics, healthcare exposures, and antimicrobial susceptibility profiles of pediatric Enterococcus faecium and Enterococcus faecalis infections. Methods: This retrospective study included hospitalized children with E. faecium or E. faecalis isolated from sterile specimens between August 2018 and June 2025. Clinical characteristics and antimicrobial susceptibility were compared. Logistic regression identified factors associated with pathogen species, while negative binomial …

03.09.2026journal-article

BMC Urology

Clinical application of systematic prostate biopsy combined with contrast-enhanced ultrasound guided targeted biopsy in patients with PSA gray zone

Yan-Xia Cheng, Sha Hu, Qing-xin He, Xuan Hu, Li-Lan He, Yue Song, Zhi-Kai Lei

Abstract Objective To investigate the clinical value of combining systematic prostate biopsy with contrast-enhanced ultrasound (CEUS)-guided targeted biopsy in patients with serum prostate-specific antigen (PSA) levels in the gray zone. Methods A total of 167 patients in the PSA gray zone treated at Zhejiang Provincial Hospital of Traditional Chinese Medicine from January 2022 to October 2024 were retrospectively analyzed and divided into a systematic biopsy group and a combined biopsy group. Both groups underwent …

03.09.2026journal-article

Electronics

A Hybrid VMD–GWO–BiLSTM–Attention Framework for Accurate State-of-Health Prediction of Lithium-Ion Batteries Under Complex Degradation Dynamics

Chenglin Ding, Hui Liu, Enze Hu, Xuesheng Wang

Accurate State-of-Health (SOH) prediction for lithium-ion batteries is essential for the safe and stable operation of Battery Management Systems (BMSs). However, achieving high-precision estimation remains challenging due to the complex interplay of non-stationary degradation characteristics, observation noise, and bidirectional temporal dependencies. This study proposes a robust hybrid temporal prediction framework integrating Variational Mode Decomposition (VMD), Bidirectional Long Short-Term Memory (BiLSTM) netw …

03.09.2026journal-article

npj Primary Care Respiratory Medicine

Barriers and facilitators to RSV vaccine acceptance among pregnant women and older adults in Hong Kong: a qualitative study guided by the Theoretical Domains Framework

Claire Chenwen Zhong, Man Kin Yim, Zehuan Yang, Vera MW Keung, Chung Yi Lo, Xiaoshu Zhang, Mingtao Chen, Junjie Huang, Martin CS Wong

Abstract Respiratory syncytial virus (RSV) poses a significant health risk to pregnant women, infants, and older adults, yet vaccine uptake remains suboptimal globally. This study aimed to explore the barriers and facilitators influencing RSV vaccine acceptance among pregnant women and older adults in Hong Kong. A qualitative design was employed, involving semi-structured interviews with pregnant women and older adults in Hong Kong. The interview guide was informed by the Theoretical Domains Framework (TDF) to capt …

03.09.2026journal-article

Public International and Private International Law

Digital Financial Assets and Modern Hawala as a Method of Their Practical Application in International Settlements

Vasily P. Afonin, Aleksandr S. Kiselev

The article describes a method developed by the author for the practical application of CFA in international calculations. The name refers to one of the oldest ways of organizing international settlements — hawala. The method is based on the widespread use of offsetting and was actively used in ancient times, in conditions of high transaction risks. In hawala, well-off merchants played an important role, organizing offsets between various entrepreneurs, acting as intermediaries. Modern sanctions risks also lead to …

03.09.2026journal-article

BANKING LAW

PUBLIC-PRIVATE PARTNERSHIPS IN THE SCIENTIFIC AND TECHNOLOGICAL SPHERE OF RUSSIA: AREAS FOR IMPROVING THE FINANCIAL AND LEGAL MODEL

Natalya V. Bondarenko

The article highlights the data indicating the insufficient effectiveness of the interaction between the government and business, as well as the limitations that contribute to this. The article also provides practical examples of existing partnership models in the scientific and technological field. The authors conclude that directly applying the infrastructure model of public-private partnership to scientific and technological projects does not fully take into account their legal and economic specifics.