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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

European Journal of Haematology

Diagnostic Accuracy of Fluorodeoxyglucose Positron Emission Tomography–Computed Tomography in Differentiating Tumor and Bland Thrombus in Patients With Cancer: A Systematic Review and Meta‐Analysis

Basant Eltaher, Amir Mahmoud, Kavya Balusu, Preetinder Singh Manshahia, Ali Abdelhay, Mouna Reghis, Sara Ng, Amber Afzal, Kristen Sanfilippo, Rushad Patell

ABSTRACT Introduction Differentiating tumor thrombus from bland thrombus can be challenging. This study assessed the diagnostic performance of positron emission tomography–computed tomography (PET/CT) scans in differentiating bland versus tumor thrombi in patients with cancer. Methods We systematically searched for observational studies evaluating the diagnostic accuracy of PET/CT scans in differentiating tumor from bland thrombi in adult cancer patients. We included patients with suspected tumor or bland thrombus …

28.08.2026journal-article

Clinical Medicine and Pharmacology

CHEMORADIATION AND ANTI-PD-1 THERAPY FOR RECTAL CANCER IN A PATIENT WITH MULTIPLE PRIMARY TUMORS: A RARE CLINICAL CASE

M. Bobkov

The article presents a rare clinical case of a 69-year-old patient with three multi-ple primary malignant tumors: cutaneous melanoma (pT4aN2bM0, stage IIIb), synchronous left renal cell carcinoma (cT2N0M0, stage II), and low-ampullary rectal cancer (cT2N0M0, stage I, pMMR/MSS). Treatment with the PD-1 inhibi-tor prolgolimab resulted in complete regression of metastatic melanoma lesions and stabilization of renal cancer. Upon development of rectal cancer, neoadjuvant chemoradiotherapy with capecitabine was initiated …

28.08.2026journal-article

Malignant tumours

Resolution on the results of the expert council on the topic “Diagnosis and treatment of advanced non-small cell lung cancer with BRAF mutation: from the search for molecular targets to therapeutic strategies in real-world clinical practice”

K. K. Laktionov, V. V. Breder, I. A. Demidova, V. V. Karaseva, F. V. Moiseenko, S. V. Orlov, E. V. Reutova, D. L. Stroyakovsky

On January 27, 2026, an Advisory Board was held to discuss issues of molecular genetic diagnosis of the BRAF V600E mutation in patients with advanced non-small cell lung cancer (NSCLC), as well as current treatment options for NSCLC patients with the BRAF V600E mutation. Next generation sequencing (NGS) is the most sensitive and specific method for molecular genetic testing. Its implementation in routine clinical practice will improve the detection rate of BRAF positive NSCLC patients. The accepted standard of care …

28.08.2026journal-article

International Journal of Biology and Life Sciences

Research Progress on TACE Combined with Targeted and Immunotherapy in the Comprehensive Treatment of Massive Hepatocellular Carcinoma

Kewei Fang, Hongwei Lei

Massive hepatocellular carcinoma (HCC) is characterized by large tumor volume, strong invasiveness, high propensity for vascular invasion and intrahepatic dissemination. Consequently, most patients lose the opportunity of radical surgical resection at initial diagnosis. Monotherapy with conventional transarterial chemoembolization (TACE) is associated with low remission rate, high risk of recurrence and metastasis, and poor long-term survival. In recent years, the rapid development of targeted therapy and immunothe …

28.08.2026journal-article

Advanced Materials

A Receptor‐Mediated Endolysosomal Recycling Chimera Enables Catalytic TNF‐α Degradation for Sustained Treatment of Mucosal Inflammation

Wenxue Xie, Yuqing Wu, Xichen Wan, Yuanyuan Chen, Yuanyuan Wu, Xiaowei Huang, Yujian Wen, Yiteng Lu, Yirou Zhang, Bo Gong, Xujiao Zhou, Hang Xing, Jiaxu Hong

ABSTRACT Mucosal inflammatory disorders such as dry eye disease (DED) and inflammatory bowel disease (IBD), driven by TNF‐α‐mediated immune‐epithelial crosstalk, remain therapeutically challenging. Conventional inhibitors often suffer from poor mucosal permeability and transient efficacy with 1:1 binding. Although extracellular protein degradation (eTPD) technologies can eliminate pathogenic proteins, most of them operate stoichiometrically, limiting dosage efficiency and durability. Here, we report a receptor‐medi …

28.08.2026journal-article

Clinical Cancer Research

Neoadjuvant Olaparib and Pembrolizumab Combination Therapy in the Treatment of Patients with HRD-Positive Advanced Ovarian Cancer: A Pilot Study

Kenichi Harano, Takehiro Nakao, Shin Nishio, Takahiro Katsuda, Kazuto Tasaki, Kazuhiro Takehara, Takanori Yokoyama, Hideki Furuya, Kyoko Hongo, Masatoshi Asano, Takashi Ikeno, Masashi Wakabayashi, Akihiro Sato, Hitoshi Saito, Chiaki Mashima, Ryo Kamata, Akihiro Ohashi, Suguru Odajima, Hiroshi Tanabe, Tetsuro Taki, Yasuto Fujimoto, Hirohiko Miyake, Reiko Watanabe, Genichiro Ishii, Toru Mukohara

Abstract Purpose: Preclinical studies suggest that poly (ADP-ribose) polymerase inhibition enhances tumor immunogenicity through stimulation of IFN genes pathway activation, providing rationale for combination with immune checkpoint inhibitors. However, clinical evidence supporting this synergy remains limited. We conducted a neoadjuvant pilot study evaluating olaparib with or without pembrolizumab in homologous recombination deficiency (HRD)–positive advanced ovarian cancer. Patients and Methods: Patients with new …

28.08.2026journal-article

Cancer Medicine

Preoperative RDW –Albumin Ratio as a Prognostic Biomarker in Gastric Cancer Surgery

Xinhang Cao, Weiwei Shang, Dandan Xiao, Wei Wang, Ziyu Wang, Yangbai Sun, Yan Zhang, Mingzhe Ma

ABSTRACT Background The ratio of red blood cell distribution width (RDW) to serum albumin (RAR) combines hematologic and nutritional information from routine blood tests and has shown potential value for prognostication in several diseases. This study aimed to evaluate the prognostic significance of preoperative RAR in patients with gastric cancer undergoing curative gastrectomy and to explore whether RAR could provide additional prognostic information beyond conventional indicators such as TNM stage. Aims This stu …

28.08.2026journal-article

Head & Neck

Head and Neck Lymph Node Metastases From Cancer of Unknown Primary: Outcomes From p16‐Guided Mucosal Radiotherapy

Philippe Harris, Dhiya‐Eddine Mabrouki, Felix‐Phuc Nguyen‐Tan, Edith Filion, Olivier Ballivy, Brian O'Sullivan, Apostolos Christopoulos, Tareck Ayad, Louis Guertin, Eric Bissada, Paul Tabet, Denis Soulières, Antoine Desilets, Alexandre Pellan Cheng, Robert Doucet, Laurent Létourneau‐Guillon, Houda Bahig

ABSTRACT Background The AJCC 8th edition distinguishes p16‐positive oropharyngeal head and neck carcinoma of unknown primary (HNCUP) due to its superior prognosis. However, standardized radiation volume guidelines are lacking. This study evaluates the safety of p16‐guided mucosal volume reduction. Methods A retrospective review of 126 HNCUP patients (2009–2023) was conducted. p16‐negative patients received comprehensive mucosal and laryngeal irradiation; p16‐positive patients received risk‐adapted, reduced‐volume r …

28.08.2026journal-article

JAMA Network Open

Prediction of Treatment Benefit With Internet-Based Cognitive Behavioral Therapy for Depression

Cora Schefft, Heiner Stuke, Selin Demir, Maximilian Preiß, Lukas Pezawas, Jakob Kaminski, Björn Meyer, Steffen Moritz, Thomas Berger, Johanne Schröder, Jan Philipp Klein, Stephan Köhler

Importance Treatment benefit prediction models may help identify which patients will benefit most from internet-based cognitive behavioral therapy (iCBT) for depression; it is unclear whether such models can support useful treatment allocation across programs. Objective To develop a model predicting individual treatment benefit from iCBT for depression across programs and to externally validate it in independent samples. Design, Setting, and Participants This prognostic study used individual participant data from 5 …

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28.08.2026journal-article

Eurasian Journal of Medicine and Oncology

Association of tumor localization and treatment stage with anxiety and depression in patients with malignant tumors of the maxillofacial region

Oleksandr Belikov, Oleksandra Roshchuk, Nataliia Belikova, Ruslan Iakymenko, Yaroslav Karavan, Rauf Jafarov, Nataliia Lytovchenko, Liudmyla Belikova, Maksym Bernik, Roman Kostenko

Introduction: Despite advances in psycho-oncology, limited evidence is available regarding changes in the psychoemotional status of patients with malignant tumors of the maxillofacial region across different stages of treatment and rehabilitation, particularly in relation to tumor localization and the severity of functional and aesthetic impairments. Objective: This study aimed to evaluate the dynamics of anxiety and depression in patients with malignant tumors of the maxillofacial region at different stages of tre …

28.08.2026journal-article

The American Surgeon™

Influence of Anatomical Variations due to Horseshoe Kidney on Colorectal Cancer Surgery

Tetsuhiro Urashima, Yasuhiro Ishiyama, Sohei Akuta, Akihito Nakanishi, Yume Minagawa, Hisashi Hayashi, Yusuke Nishi, Takatsugu Fujii, Toshimasa Ishii, Shintaro Ishikawa, Hirofumi Sugita, Chikashi Hiranuma, Yasumitsu Hirano

Background Horseshoe kidney is a rare renal fusion anomaly often associated with vascular and ureteral variations. Previous case reports have described technical considerations during colectomy in patients with horseshoe kidney. However, studies systematically evaluating the impact of anatomical anomalies associated with horseshoe kidney on surgical procedures remain limited. Methods We retrospectively analyzed 13 patients with horseshoe kidney who underwent colectomy for primary colorectal adenocarcinoma at a sing …

28.08.2026journal-article

Pharmaceutics

Tumor Microenvironment-Responsive Polymeric Nanocarriers for the Treatment of Triple-Negative Breast Cancer

Adnan Murad Bhayo, Ying Li, Alaa R. Aboushanab, Junyi Lin, Ashkan Hassankhanirad, Wei Li, Jingjing Sun

Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous subtype lacking effective targeted therapies. Its tumor microenvironment (TME) exhibits distinct features, including acidity, redox imbalance, elevated reactive oxygen species (ROS), and hypoxia, which provide exploitable triggers for targeted drug delivery. Stimuli-responsive polymeric nanocarriers have emerged as promising platforms that enable spatiotemporally controlled and site-specific therapeutic release in response to these endogenous c …

28.08.2026journal-article

Cells

Integration of Spatial Transcriptomics and Mendelian Randomization Identifies Candidate Molecular Regulators of Endometrial Cancer Progression

Jianan Zhao, Xiaonan Liu, Huiyang Zhao, Pingping Zhang, Shenxin Wang, Congying Duan, Yue Liu, Wei Wang, Ping Jiao, Jie Ma

Endometrial cancer (EC) is a common gynecologic malignancy arising from the epithelial cells of the endometrium. The marked cellular heterogeneity of EC and features of its tumor immune microenvironment (TIME) contribute to disease complexity and have been associated with poor prognosis. This study integrates single-cell RNA sequencing, spatial transcriptomics, and Mendelian randomization (MR) to identify candidate genes associated with EC. Single-cell analysis identified MM0 as a putative stemness-associated trans …

28.08.2026journal-article

BMC Neurology

Real-world short-term effectiveness of erenumab after single versus multiple prior preventive treatment failures

Chantal Schmidt, Lukas Becker, Diana Lindner, Christoph Kleinschnitz, Alexander Wolfgang Becker, Dagny Holle, Armin Scheffler

Abstract Background Erenumab, a monoclonal antibody targeting calcitonin gene-related peptide receptor, has been approved in Germany since 2018 for migraine prophylaxis. Initially, reimbursement regulations restricted its use to drug-resistant patients who had failed or were unsuitable for conventional preventive treatments. Over time, initiation after failure of only one prior preventive treatment became possible. As earlier initiation of effective preventive therapy may improve clinical outcomes, we compared the …

28.08.2026journal-article

New Zealand Medical Journal

Aotearoa New Zealand public strongly support investment in cancer treatment and care services: findings from a national survey

Virginia Signal, Ella Iosua, Kate Gregory, Rachael Neumann, Jeannine Stairmand, Jerram Bateman, Andrew Gray, Rana Peniamina, Louise Signal, Bronwen McNoe

aim: Cancer remains a leading cause of morbidity and mortality in Aotearoa New Zealand, with rising incidence, persistent inequities and pressure on diagnosis, treatment and workforce capacity. This study examined public views on government funding, access and delivery of cancer diagnosis, treatment and supportive care services, perceptions of health workforce support and willingness to pay additional tax for healthcare funding. methods: We analysed data from a nationally representative cross-sectional online surve …

28.08.2026journal-article

Frontiers in Immunology

Intratumoral Bacillus regulating colorectal cancer liver metastasis: links to lipid metabolism and APOE+ macrophages

Juhang Chu, Haitao Huang, Yuheng Hu, Qiaoer Wang, Tao Yuan, Shengyu Huang, Jianbo Lin, Chenxiang He, Haoyu Li, Hao Shen, Jun Li

Introduction Colorectal cancer liver metastasis (CRLM) develops in a hepatic niche where tumor cells encounter organ‑specific microbial, metabolic, and immune constraints. The role of intratumoral bacteria in this metastatic ecosystem remains incompletely defined. Methods We analyzed tumor and peritumoral tissues from 20 patients with non‑metastatic colorectal cancer (CRC) and 20 patients with CRLM by 5R 16S rDNA sequencing, untargeted metabolomics, and functional assays. Public datasets were used for single‑cell a …

28.08.2026journal-article

Academia Drug Development and Pharmacotherapy

Micelles in cancer nanomedicine: targeted delivery, imaging, and therapy

Amirhossein Rashnoodi, Zaynab Seraj, Niyoosha Zamani, Bahareh Khalili Najafabad

Despite advancements in oncology, conventional cancer therapies remain limited by poor specificity, systemic toxicity, and suboptimal therapeutic indices. Micellar nanostructures have emerged as a transformative platform to overcome these hurdles, leveraging their amphiphilic nature to encapsulate hydrophobic agents within aqueous biological environments. This review evaluates the current landscape of micelle-based technologies in cancer management, focusing on their integration into medical physics through diagnos …

28.08.2026journal-article

Journal of Testing and Evaluation

Comparative Performance Analysis of AdaBoost-Assisted Deep Learning Models for Lung Cancer Nodule Detection

Ghousia Usman, Usman Ahmad, Huma Tauseef, Muhammad Murad Khan, Ayesha Adnan

ABSTRACT Lung cancer (LC) is among the leading causes of cancer-related deaths, and early identification of pulmonary nodules plays a crucial role in reducing mortality. This work proposes a novel hybrid framework that combines preprocessing, segmentation, feature extraction, and classification for accurate nodule detection from computed tomography scans. Digital imaging and communications in medicine images are first preprocessed using median filtering to remove noise and contrast limited adaptive histogram equali …

28.08.2026journal-article

Journal of Pediatric Hematology/Oncology

Implementation of a Digital Clinical Management Platform in a Tertiary Pediatric Hemato-Oncology Center: Impact on Clinical Outcomes and Patient Safety

Michal Singer, Uri Ilan, Guy Dolinski, Nitsan Halabi, Yuliana Edri, Nisim Rahman, Sigal Sina, Maor Sagi, Sivan Tam, Moshe Ashkenazi

Introduction: Healthcare delivery is increasingly challenged by rising demand, escalating costs, and the need for efficiency. Contributing factors such as the nursing workforce crisis, fragmented and excessive clinical data, outdated IT infrastructures, and the growing complexity of care exacerbate the risk of medical errors, treatment delays, and staff burnout. To address these challenges, we evaluated AMIT, a novel digital platform designed to support nursing practice in pediatric oncology. Methods: AMIT is a web …

28.08.2026journal-article

Cancers

C-Reactive Protein-Based Composite Indices for Predicting Tumor Overgrowth Restenosis After Partially Covered Duodenal Stenting in Gastric Cancer: A Cohort Study

Hyuk Lee, Young Eun Oh, Tae-Se Kim, Yang Won Min, Byung-Hoon Min, Jun Haeng Lee

Background/Objectives: Partially covered duodenal stents rapidly relieve malignant gastric outlet obstruction, but tumor overgrowth restenosis limits durability. We compared six preprocedural inflammatory, nutritional, and immune indices for predicting this outcome in patients with gastric cancer. Methods: We retrospectively analyzed 68 consecutive patients from a prospectively maintained cohort. The primary endpoint was endoscopically or radiologically confirmed tumor overgrowth restenosis. Discrimination was asse …

28.08.2026journal-article

CA: A Cancer Journal for Clinicians

The new (version 9) American Joint Committee on Cancer (AJCC) tumor‐node‐metastasis (TNM) staging protocol for carcinoma of the vulva

Alexander B. Olawaiye, Elliot A. Asare, Ian S. Hagemann, Priya R. Bhosale, Stephanie Gaillard, Brian Rous, Bunja Rungruang, Shitanshu Uppal, Gulisa Turashvili, Kaled M. Alektiar, Jonathan A. Cosin, Uma Krishnamurti, Lee‐may Chen, Keiichi Fujiwara, Matthew A. Powell, Mauricio A. Cuello, David G. Mutch

Abstract The American Joint Committee on Cancer (AJCC) tumor‐node‐metastasis (TNM) staging for all cancer sites has been updated periodically as a published manual for many years. The last update of the manual version, the eighth edition AJCC Cancer Staging Manual , went into use on January 1, 2018. The AJCC has since restructured and updated its processes for curating, analyzing, and publishing updates to the TNM staging system. All AJCC staging‐related data are now housed on its new application programming interf …

28.08.2026journal-article

Journal of Environmental Quality

Pesticide occurrence, transformation, and transport from wastewater treatment plants into stream networks with diverse land uses

Kyra Sigler, Matthew V. Russell, William Ford, Wayne Sanderson, Tiffany L. Messer

Abstract Neonicotinoid insecticides and strobilurin fungicides are detected in many environmental compartments and have been associated with negative environmental and human health implications. Wastewater treatment plants (WWTPs) are often hotspots for introducing such contaminants into the environment. Therefore, the occurrence of strobilurin fungicides, neonicotinoids, and their metabolites at two WWTPs with varying land uses and population sizes was investigated. Polar organic chemical integrative samplers were …

28.08.2026journal-article

Substance Use & Addiction Journal

Evaluation of an Online, Asynchronous Tobacco Treatment Specialist Training: A Mixed-Methods Analysis of Reach, Perceived Trainee Competency, and Training Quality

Tresza D. Hutcheson, Sharon Fitzgerald Wolff, MeLinda Lair, Kimber P. Richter, Babalola Faseru

Background: Although tobacco use disorder is the most prevalent substance use disorder in the United States and remains the world’s leading cause of preventable mortality, health care and social service providers receive little training in how to treat it during their formal education. To enhance access to Tobacco Treatment Specialist (TTS) training, we developed an online, self-paced, asynchronous training paired with a 1-day virtual workshop for skills building and demonstration. Methods: We calculated the reach …

28.08.2026journal-article

ACS Sensors

Reprogramming RNA Degraders as Intracellular Molecule Sensors for Tumor Cell Sensing and Manipulation

Pin-Ru Chen, Ying Han, Pei-Pei Qin, Ying-Yue Xu, Qian Tao, Bang-Ce Ye, Bin-Cheng Yin

Abstract Engineering transgene expression to respond specifically to intracellular cues holds transformative potential for monitoring cell states and modulating cellular functions. Here we introduce TRADER (Target-induced Transgene Activators via Reprogramming of dCas6-barnase Degrader), a versatile and modular platform that enables transgene activation in response to intracellular molecules at the post-transcriptional level. TRADER leverages a proximity-dependent RNA degrader system, in which a catalytically inact …