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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Biomedical Physics & Engineering Express

A deformable lead-attention fusion network for multi-label ECG classification integrating clinical metadata

Enjun Zhou, Xiangyong Kong, Hao Wang, Chenrui Bai

Abstract Cardiovascular diseases remain a major global health burden, making accurate electrocardiogram (ECG) analysis essential for timely diagnosis. While deep learning-based methods have made significant progress in automating ECG classification, they are often limited by the variability of ECG signals, the frequent presence of multiple cardiac abnormalities, and the inadequate integration of diverse clinical data. This study proposes Deformable Lead-Path and Multi-Modal Fusion Network (DLM-Net): a robust deep l …

02.09.2026journal-article

Problems of Gathering Treatment and Transportation of Oil and Oil Products

STUDY OF GROUTING COMPOSITION FOR RESTORING THE TIGHTNESS OF THE PRODUCTION WELL CASING AND ELIMINATING WATER INFLUX

G.S. Dubinsky, V.G. Mukhametshin

This article presents the results of a study of a composite fast-hardening cement slurry based on urea-formaldehyde synthetic resin, designed for effective waterproofing and repair and insulation work. Unlike similar products, this fast-hardening cement slurry effectively cures over a wide temperature range from 20°C to 100°C. The curing time and rate of the analyzed cement slurry are regulated by the hardener concentration and type over a wide time frame, from several tens of minutes to 5-8 hours. The flexural str …

02.09.2026journal-article

JAMA Psychiatry

Serial Ketamine Infusions for Treatment-Resistant Bipolar Depression

Diana K. Orsini, Sara Di Luch, George Tomlinson, Gabrielle F. M. Lovell, Shreya Vasudeva, Nelson B. Rodrigues, Danica E. Johnson, Alastair J. Flint, Cristian-Daniel Llach, Roger S. McIntyre, Rodrigo B. Mansur, Keyvan Karkouti, Amer M. Burhan, Erica Kaczmarek, Noah Chisamore, Anuj Bhatia, Neilesh Soneji, Anahita Joshi, Deep Grewal, Rachel Laframboise, Joshua D. Rosenblat

Importance Antidepressant efficacy of intravenous (IV) ketamine has been demonstrated in major depressive disorder; however, the efficacy and safety of ketamine for bipolar depression remain largely unknown, with limited data available in this specific population. Objective To evaluate the efficacy, safety, and tolerability of adjunctive IV ketamine compared with midazolam for treatment-resistant bipolar I or II depression (TRBD). Design, Setting, and Participants The Ket-BD study (Ketamine for Treatment-Resistant …

02.09.2026journal-article

Clinical Cancer Research

DNMT3B Plays Antagonistic Roles with SMARCB1 and Is a Targetable Vulnerability in Rhabdoid Tumors

Céline Chauvin, Ryszard Wimmer, Ludovica Brunetti, Joanna Cyrta, Ana Boranijasevic, Mamy Andrianteranagna, Julien Masliah-Planchon, Kévin Beccaria, Sandrina Turczynski, Grégory Thomson, Maëva Veyssière, Rachida Bouarich-Bourimi, Zhi-Yan Han, Owen Hoare, Aurore Coulomb, Mylène Bohec, Sylvain Baulande, Gaëlle Pierron, Olivier Delattre, Arnault Tauziède-Espariat, Nicolas Servant, Alexandre Baffet, Franck Bourdeaut

Abstract Purpose: Rhabdoid tumors (RT) are highly aggressive pediatric cancers driven by the biallelic inactivation of the SMARCB1 tumor-suppressor gene, the sole recurrent genetic alteration. SMARCB1 encodes a core subunit of the SWI/SNF chromatin remodeling complex; its loss disrupts epigenetic gene regulation, supporting the classification of RT as prototypical epigenetically driven cancers and highlighting the therapeutic potential of targeting epigenetic modifiers. Notably, previous studies have reported the o …

02.09.2026journal-article

Animals

Clinical Findings, Treatment and Long-Term Outcome in 37 Cats with Non-Associative Immune-Mediated Hemolytic Anemia: A Retrospective Observational Study of Two Treatment Cohorts

Lisa-Maria Kulmer, Pavlos G. Doulidis, Iwan A. Burgener, Nicole Luckschander-Zeller

Background: Non-associative immune-mediated hemolytic anemia (IMHA) is uncommon in cats and carries substantial mortality. Glucocorticoids are first-line treatment, and cyclosporin A (CsA) is frequently added, but data on the clinical course and long-term outcome are limited. We describe clinical findings, treatment, adverse events and outcome in cats with non-associative IMHA. Methods: In this retrospective observational single-center study (October 2014–October 2024), 37 cats diagnosed by the 2019 ACVIM consensus …

02.09.2026journal-article

Asian Journal of Neurosurgery

Polyvinyl Alcohol Nasal Pack as a Rare Cause of Brain Abscess Following Endoscopic Sinus Surgery

Suraj Ethiraj, Ananth P. Abraham, Ranjith K. Moorthy

Abstract Brain abscesses are rare but severe infections that often require surgical intervention and prolonged antibiotic therapy. Development of a brain abscess following endoscopic sinus surgery (ESS) for nasal polyposis is extremely rare. We report the case of a 52-year-old female with a history of multiple endoscopic surgeries for nasal polyposis. She presented with symptoms of headache and fever for 20 days, following revision ESS performed a month earlier. Imaging revealed a right frontal lobe abscess with an …

02.09.2026journal-article

Annals of Plastic Surgery

Final Tongue Size in the Treatment of Macroglossia Associated With Beckwith-Wiedemann Syndrome

Renato da Silva Freitas, Lucas Guimarães Alves, Maitê Mateus, Isabella Correa de Oliveira, Marc Domit Werner Linnenkamp, Isis Juliane Guarezi Nasser, Eduardo Angeli-Freitas

Beckwith-Wiedemann syndrome (BWS) is a rare congenital disorder whose main clinical feature is macroglossia. This frequent manifestation may impair respiratory, feeding, speech, and orofacial developmental functions. When significant functional and/or aesthetic repercussions are evident, surgical excision is the primary management approach, with several techniques described. In this study, we analyzed medical records from 29 patients diagnosed with BWS and macroglossia, and evaluated 26 cases of partial glossectomy …

02.09.2026journal-article

Reproductive Medicine

The Role of Clomiphene Citrate in Gonadotropin Stimulation Protocols in Poor Responders: A Mini-Review of Recent Clinical Evidence

Maria Papadopoulou, Miltiadis Badagionis, Fotios Vlahos, Nikolaos Vlahos, Alexandros Lazaridis, George Mastorakos, Olga Triantafyllidou

Diminished ovarian reserve (DOR) and poor ovarian response (POR) remain among the most challenging conditions in assisted reproductive technology, and no optimal stimulation strategy has been established. Clomiphene citrate (CC), a selective estrogen receptor modulator that augments endogenous gonadotropin secretion and modulates the intraovarian androgenic milieu, has been proposed as an adjuvant to reduce exogenous gonadotropin requirements. This mini-review summarizes clinical evidence published between January …

02.09.2026journal-article

Multidisciplinary Respiratory Medicine

Pilot study comparing the quality of airway seal in an endotracheal tube with a viscoelastic cuff compared to standard endotracheal tubes

Pedro Alejandro Bravo Fernández, Daniel A Cuevas Nieves, Nieves Leon-Gomez, Juan Jose Artazkoz del Toro, Ricardo Martinez-Ruiz

Background: Inadequate endotracheal tube (ETT) cuff sealing permits microaspiration of subglottic secretions, driving ventilator-associated pneumonia and perioperative respiratory complications. Standard cylindrical and tapered cuffs remain susceptible to microchannel formation and leakage. This pilot study evaluated a novel ETT with a 90-mm self-expanding viscoelastic cuff (V-Cuff®) operating at ambient pressure compared to standard and specialty ETTs in vitro. Methods: Five ETTs of each type—standard cylindrical …

02.09.2026journal-article

Ophthalmic Plastic & Reconstructive Surgery

Prospective Analysis of Blink Dynamics and Ocular Surface Changes After Levator Aponeurosis Advancement

Anil Ağaçkesen, Derya Çepni Çakir, Murat Oklar

Purpose: To prospectively evaluate changes in blink dynamics following unilateral ptosis surgery and to assess their relationship with ocular surface parameters. Methods: Sixteen patients (10 female, 6 male; mean age 56.0 ± 13.2 years) undergoing unilateral levator aponeurosis advancement were enrolled. Incomplete blink percentage and blink rate were assessed using slow-motion smartphone videography. Noninvasive tear break-up time, meibomian gland area loss, palpebral fissure height, and margin reflex distance 1 we …

02.09.2026journal-article

Current Oncology

Tumour GDF-15 Expression and Clinical Outcomes in Intermediate-Risk Metastatic Clear-Cell Renal Cell Carcinoma Treated with Second-Line Nivolumab

Orhun Akdogan, Betul Ogut, Osman Sutcuoglu, Melike Urganci, Burcu Ulas Kahya, Ipek Isik Gonul, Hatice Azra Begum Salimoglu, Tuba Ugur Tuzcu, Ozan Yazici, Ahmet Ozet, Nuriye Ozdemir

Background: Immune checkpoint inhibitors have improved outcomes in metastatic clear-cell renal cell carcinoma (mRCC), yet clinically applicable tissue biomarkers remain limited. Growth differentiation factor-15 (GDF-15) promotes tumour immune evasion and has emerged as a potential therapeutic target in immuno-oncology. We evaluated the prognostic significance of tumour GDF-15 expression in patients with intermediate-risk clear-cell mRCC treated with second-line nivolumab. Methods: Forty-six patients with intermedia …

02.09.2026journal-article

Journal of Clinical Medicine

Clinicopathological Significance of SCD Expression in Colon Adenocarcinoma: Association with Histological Grade and Exploratory Assessment in Relation to PCNA

Jerzy Z. Piecuch, Adam Piecuch, Marek Michalski, Magdalena Rynkiewicz, Natalia Matysiak, Magdalena Onyszczuk, Marlena Brzozowa-Zasada

Background/Objectives: Colon adenocarcinoma is a heterogeneous disease, and tumours of similar pathological stage may differ in their metabolic and proliferative characteristics. Stearoyl-CoA desaturase (SCD) is involved in lipid metabolic reprogramming and may reflect aspects of tumour biology. The main goal of this study was to analyse SCD expression and its associations with clinicopathological factors, particularly focusing on histological grade. The relationship between SCD and proliferating cell nuclear antig …

02.09.2026journal-article

Journal of Tropical Health

Secondary Haemophagocytic Lymphohistiocytosis in a Patient with Metaplastic Breast Carcinoma Receiving Anthracycline-Based Chemotherapy: A Case Report

Kogulan Selvanayagam, Sivakumar Jeyalakshmy

Hemophagocytic lymphohistiocytosis is a rare life-threatening hyperinflammatory syndrome characterized by uncontrolled immune activation and cytokine storm. It may occur secondary to malignancy or immunosuppressive therapies. While often associated with hematological malignancy, hemophagocytic lymphohistiocytosis is exceptionally uncommon in solid tumors like breast carcinoma.We report a case of 69-year-old female with T4bN1M0 metaplastic breast carcinoma (T4bN1M0- Tumor locally spread to skin of the breast, two ax …

02.09.2026journal-article

Journal of Travel Medicine

SEVMALrisk: An Externally Validated Clinical Risk Score for Early Risk Stratification of Severe Imported Malaria

Perry J J van Genderen, Michele Fumarola, Robert-Jan Hassing, Foekje Stelma, Jaap J van Hellemond

Abstract Background Early recognition of severe imported malaria is essential because treatment decisions frequently need to be made before reliable parasite density measurements become available. Objective tools to support early risk stratification during this interval are lacking. This study developed and externally validated SEVMALrisk, an explainable clinical risk score derived from a machine-learning prediction model using routinely available admission laboratory parameters. Methods Adult patients with confirm …

02.09.2026journal-article

ASCE MAGAZINE

Barreras y factores asociados al tamizaje y diagnóstico temprano del cáncer cervicouterino en mujeres de zonas rurales: una revisión sistemática

Jessica Andrea Encalada Falconí, Luis Alberto Erosa-De Haro, Jesús Javier Ñaccha Urbano, Milena Mishelle Paredes Sandoval, Nathaly Elvia Sánchez Navarrete

El cáncer cervicouterino, constituye un importante problema de salud pública, aunque dispone de medidas eficaces de prevención, y detección temprana; sin embargo, las mujeres que residen en zonas rurales, enfrentan dificultades que limitan su acceso a los programas de tamizaje, lo que incrementa el riesgo de diagnósticos tardíos, y reduce las posibilidades de tratamiento oportuno. Por ello, el objetivo fue; identificar, analizar y sintetizar, la evidencia disponible sobre las barreras, y los factores asociados al a …

02.09.2026journal-article

Experimental & Molecular Medicine

NatD promotes glioblastoma progression through epigenetic activation of FGFR4 signalling

Chan-Woo Kim, Taek-Yeol Jung, Chanil Kim, EungHan Kim, Heui Og Kim, Jiyeon Chae, Hyelee Kim, Ga-Yeon Ko, You-Jung Yeo, Ji-Young Park, Jaehyuk Pyo, Jeong Taeg Seo, Dokyeong Kim, Junseong Park, Seo Jin Kim, Minji An, Seok-Gu Kang, Jong Bae Park, Chul Hoon Kim, Seung-Hyun Jung, Sug Hyung Lee, Ho-Shik Kim, Hyun-Seok Kim

Abstract N-terminal acetyltransferase D (NatD) acetylates histones H4 and H2A at serine 1 and has been implicated in oncogenesis, yet its role in glioblastoma (GBM) remains unexplored. Here, we show that NatD expression is significantly elevated in GBM at both transcript and protein levels. NatD knockdown markedly suppressed proliferation, colony formation, migration, invasion and tumoursphere formation in GBM cell lines and patient-derived models, indicating a critical role in maintaining cancer stem-like properti …

02.09.2026journal-article

Antibiotics

Antibiotics and the Endocrine System: Mechanisms, Adverse Effects, and Clinical Implications

Łukasz Grabarczyk, Julia Oszytko, Maria Derkaczew, Kamil Sobolewski, Paweł Radkowski

Background/Objectives: Antibiotics are widely used in clinical practice, yet their potential effects on endocrine homeostasis remain insufficiently recognized. This review summarizes endocrine adverse effects associated with selected antibacterial agents, their proposed mechanisms, and clinical relevance. Methods: A narrative literature search was conducted in PubMed/MEDLINE, Scopus, and Web of Science from database inception to 10 August 2026. Clinical, pharmacovigilance, case-based, animal, in vitro, and ex vivo …

02.09.2026journal-article

American Journal of Medical Genetics Part A

The Evaluation of Molecular Genetics and Clinical Manifestations in Patients With LZTR1 ‐Associated Noonan Syndrome: A Retrospective Chart Review and Review of Literature

Hager Jaouadi, Şakir Hicazi, Carolyn R. Raski, Lindsey Aschbacher‐Smith, Ghada Hijazi, Amy E. Roberts, Carlos E. Prada, K. Nicole Weaver

ABSTRACT Pathogenic variants in LZTR1 are an established cause of Noonan syndrome (NS) and uniquely exhibit both autosomal dominant (AD) and autosomal recessive (AR) inheritance. However, the phenotypic spectrum and genotype–phenotype correlations remain incompletely defined. We conducted a multi‐center retrospective chart review of patients diagnosed with LZTR1 ‐NS evaluated at three tertiary care centers. Clinical, molecular, and imaging data were systematically collected. A comprehensive literature review (2015– …

02.09.2026journal-article

World Journal of Traditional Chinese Medicine

Combining Fecal Metabolomics and Gut Microbiome to Investigate the Anti-Depression Mechanism of Kai–Xin–San

Min-Jie Shi, Zong Hou, Zhong Zheng, Jun-Peng Xing, Hong-Shi Bu, Zhi-Qiang Liu, Yan Xu, Shu Liu

Abstract Objective: Kai–Xin–San (KXS) is a traditional Chinese medicine that has been used for thousands of years to treat depression. However, the underlying mechanisms and full range of effects of KXS on depression remain unclear. Materials and Methods: A growing body of evidence suggests that the gut microbiota may interact with the brain and contribute to the development of mental disorders, such as depression and anxiety. Therefore, in this study, we employed a combined microbiomics and metabolomics approach t …

02.09.2026journal-article

The American Journal of Sports Medicine

Quadriceps Tendon Autograft Harvest Technique Affects Both Graft Strength and Cross-sectional Area

Andrew S. Bi, Edouard J. Augustin, Cade C. Smelley, Morgan L. Angotti, Kofi K. Acheampong, Divesh Sachdev, Elizabeth Shewman, Adam B. Yanke

Background: Bone–patellar tendon–bone (BTB) autografts have been considered the gold standard for anterior cruciate ligament reconstruction, although the popularity of quadriceps tendon (QT) autografts is increasing. Hypothesis/Purpose: The purpose of this study was to compare the ultrasound-derived cross-sectional area (CSA) and biomechanical strength of BTB and QT grafts harvested with different techniques. The authors hypothesized that ultrasound CSA measurements would be reliable and that QT grafts would be lar …

02.09.2026journal-article

Applied Biosciences

Pure Mycelium Sheets from Edible Mushrooms for Sustainable Packaging: A Comparative Assessment of Glycerol and ZnONPs Treatment

Sasikan Channgam, Gad Elsayed Mohamed Salem, Thatsanee Luangharn, Supachai Pisuchpen, Thomas Karbowiak, Pornchai Rachtanapun, Wirongrong Tongdeesoontorn

Increasingly, mycelium-based biomaterials are being investigated as sustainable alternatives to conventional packaging materials, but their inherent brittleness limits their practical application. The present study investigated the properties of pure mycelium sheets sourced from Ganoderma sp., Lentinus sp., and Pleurotus sp., employing glycerol plasticization and zinc oxide nanoparticles (ZnONPs). The findings revealed that growth and structural attributes varied according to the species, with Ganoderma and Lentinu …

07.09.2026journal-article

Sexual Medicine

Psychological wellbeing of eunuchs and other individuals with interests in genital altering procedures

Erik Wibowo, Thomas W Johnson, Jamie Agapoff

Abstract Introduction The Eunuch Archive (EA) is an online community where individuals with interests in genital ablation share information, personal experiences, and social support. This study compared psychological wellbeing among individuals with different genital ablation interests and examined patterns and motivations for engaging with the EA. Methods An anonymous online survey was posted on the EA website. Participants were categorized into 4 groups: individuals with genital ablation fantasies without a desir …

02.09.2026journal-article

Measurement Science and Technology

CARENet: a novel interpretable channel attention residual enhanced network for gearbox fault diagnosis under strong noise conditions

Kejia Zhai, Yi Zhang, Yanqiang Yang, Zhiheng Zhang, Yehui Zhao, Qingjiang Li, Guangming Wang

Abstract Gearbox fault diagnosis is crucial for ensuring production safety and improving operational efficiency. However, gearbox fault diagnosis still faces challenges due to strong noise environments. To address these challenges, we propose a novel interpretable channel attention residual enhancement network (CARENet) for robust fault diagnosis under noisy conditions. Vibration signals are first transformed into time-frequency representations using continuous wavelet transform, enhancing the characterization of t …

02.09.2026journal-article

Frontiers in Cardiovascular Medicine

Circulating lipid profiles and atrial fibrillation: from incident risk to post-ablation recurrence

Mi Yan, Jingfeng Zou, Wen Peng

Circulating lipids are widely used in cardiovascular risk assessment, but their relationship with atrial fibrillation (AF) differs from the conventional atherosclerotic framework. Higher triglyceride levels have often been associated with increased AF risk, whereas lower total cholesterol, low-density lipoprotein cholesterol, or remnant cholesterol have paradoxically been linked to greater risk in some populations. These inconsistent findings suggest that lipid measures may reflect stage-specific metabolic and clin …