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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Healthcare

Willingness to Share Smartwatch-Generated Health Data Among a Sample of Adults in Riyadh, Saudi Arabia

Raniah N. Aldekhyyel, Leena M. Shagrani, Shoug M. Albattah, Basmah A. Alghamdi, Adwaa A. Alsalman, Shadin K. Alabbas, Haya E. Alkhlaiwi

Background/Objectives: Wearable devices, such as smartwatches, represent an emerging digital health tool that can enhance patient engagement, support patient-provider communication, and enable more personalized, patient-centered care. Understanding public willingness to share health-generated data with healthcare providers is essential for informing digital health implementation strategies that prioritize patient trust and active participation in the care process. This study aimed to address this gap by assessing t …

03.09.2026journal-article

JAMA Oncology

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

Junjie Li, Tong Liu, Ke-Da Yu, Huawei Yang, Zhen Huang, Yi Zeng, Peng Ji, Xiaoke Hou, Chunping Liu, Yiwen Zhang, Nanlin Li, Zhong Ouyang, Xiaobo Wu, Xiaorong Bai, Yanxiang Guo, Guohui Han, Shien Cui, Zhijun Zhu, Yu Zhang, Xiaobo Hu, Xiaopeng Ma, Peifen Fu, Jinhai Zhu, Yuan Dong, Tao Wu, Hongyan Jia, Fei Xu, Yu Ren, Jianyun Nie, Dai Bing, Qiang Mu, Tao Sun, Jing Luo, Zhenchuan Song, Xiangshun Kong, Hao Zhang, Zhiyong Wu, Zhihong Wang, Dong Song, Haiquan Jia

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-bound docetaxel), have shown promising antitumor activity and an acceptable safety profile in patients with breast cancer. OBJECTIVE To evaluate whether neoadjuvant anbenitamab combined with HB1801 could improve efficacy without increasing …

03.09.2026journal-article

BMC Public Health

Awareness level of cancer risk factors and warning signs among adults in Mansoura District, Egypt

Ahmed M. Eid, Abeer M. Kamal, Asmaa Elsayed, Rahma M. Almetwaly, Basma Kamel, Naira A. Shoman, Aya M. Abdelmohsin, Sara H. Elhendawy, Yasmeen A. State, C. A. collaboration team, Abdallah Gamal, Menna S. Sellow, Nourhan R. Elbatal, Mohamed A. Abdelaziz, Ahmad M. Gewili, Mariam B. Elbialy, Nouran K. Mashaly, Rania S. Omar, Abdelrahman M. Darweesh, Abdelsmad Elhalwaty, Hager S. Elhebeshy, Moustafa Y. Nassar, Hanin Fadl, Ahmed H. Maarouf, Omar M. Eid, Sama Mahmoud Abo Younis, Ashraf Alaziz, Mokhtar M. Elkerdawey, Ahmed Mohamed Zayed, Abdel-Hady El-Gilany

Abstract Background Cancer remains a leading cause of mortality worldwide, with prevention and early detection dependent on the public awareness of its risk factors and warning signs. However, knowledge of cancer-related symptoms and modifiable risk factors remains limited in many populations, particularly in low- and middle-income countries. Limited research exists examining general cancer awareness in Egypt's general population. Objective To assess public knowledge of cancer's early warning signs, risk factors, a …

03.09.2026journal-article

Journal of Intensive Care Medicine

Inferior Vena Cava Filters: Relevant Issues for Hospitalists and Intensivists

Joshua Valbuena, Eric vanSonnenberg, T. Gregory Walker

Inferior Vena Cava (IVC) filters are medical devices that are inserted into the IVC as a form of mechanical prophylaxis against pulmonary emboli (PE). Placement of IVC filters is controversial, as IVC filters can lead to complications, especially when left implanted for longer than the recommended time. In this review, IVC filter complications are divided into several categories: acute, long-term, and those associated with filter removal. Life-threatening complications of IVC filter use also are examined. Key facto …

03.09.2026journal-article

Borneo Nursing Journal (BNJ)

Hubungan Durasi Puasa Terhadap Kejadian Mual Muntah (PONV) Pada Pasien Elektif Post Operasi Dengan Anestesi Umum

Devi Ayu Putri Aryandani, Supono, Kissa Bahari, Tri Nataliswati

Puasa praoperasi merupakan prosedur standar untuk mencegah aspirasi selama anestesi umum. Namun, durasi puasa yang terlalu panjang dapat menimbulkan ketidaknyamanan dan meningkatkan risiko komplikasi pascaoperasi, salah satunya Postoperative Nausea and Vomiting (PONV). Penelitian ini dilakukan untuk mengetahui hubungan antara durasi puasa dengan kejadian PONV pada pasien elektif yang menjalani anestesi umum di RSI Aisyiyah Malang. Penelitian menggunakan desain analitik observasional dengan pendekatan cross-sectiona …

03.09.2026journal-article

Peace Economics, Peace Science and Public Policy

Introducing the Tactics and Resources Dataset: Resources, Sponsors and Escalation of Non-state Actors

Tom Konzack

Abstract To cut through inconsistent findings on non-state violence born of contested concepts and uneven data, I introduce the Tactics and Resources Dataset (TRD): a panel dataset on 649 violent and non-violent political non-state organisations. It focuses on their tactical choices and the types and origins of resources provided to them, alongside political, social, and economic indicators and key historical junctures. TRD offers a robust empirical foundation for studying how various types of resources and externa …

03.09.2026journal-article

Clinical Infectious Diseases

A Multistate Investigation of Serious Adverse Events, including Deaths, following Ceftriaxone Injections, September 2024–August 2025

Rebecca Pierce, Radhika Agarwal, Dumbani Kayira, Maribeth C Lovegrove, Nimalie D Stone, Kelly M Hatfield, Jennifer Lind Lyles, Melissa Morrison, Wes Stubblefield, Sherri L Davidson, Karen Landers, Scott Harris, Rachana Bhattarai, Theresa Dulski, Juliet Stoltey, Lauren Biehle, Josh Hoffner, Argentina Charles, JoAnna Wagner, Haley Beeman, Michael J Curran, Grace Lee, Riley Moore, Jacy Walters, Gargi Patel, Dat Tran, Jenna Sinkevitch, Marco Tori, Christopher Wilson, Simone Godwin, Shehzana Hussaini, Allison G Lafferty, Shaina Bernard, Shannon Ruelle, Catherine O Dasenbrock, Meredith Sheridan, Frank Wackes, Rachna Kapoor, Ramesh Gopalaswamy, Kiran M Perkins

Abstract Background Reports of ceftriaxone serious adverse events (SAEs), including deaths, from multiple jurisdictions during December 2024–January 2025 prompted a nationwide investigation to evaluate product safety, characterize SAEs, and assess for changes in baseline adverse event occurrence via national databases. Methods In February 2025, CDC issued a national call for cases, defined as SAEs involving death or CPR within six hours of ceftriaxone injection, not otherwise explained and occurring in non-ICU sett …

03.09.2026journal-article

Frontiers in Oncology

Clinical trial design for primary brain tumors: a problem-based framework for neuro-oncology practice

Diego Gómez-Puerto, Jesús Yaringaño, Antonio Di Muzio, Oriol Mirallas, María Vieito

Background Primary brain tumor trials may produce an uninterpretable or non-generalizable answer when biological mismatch, inadequate intratumoral exposure, restrictive eligibility, molecular rarity, unstable controls, and disease-specific endpoint ambiguity are addressed separately. The practical problem is not the absence of modern methods, but failure to select and combine them according to the dominant threat to the development decision. Methods We performed a practice-facing narrative synthesis of methodologic …

03.09.2026journal-article

Journal of Patient-Reported Outcomes

Identifying risk of prescription analgesic misuse in chronic pain: screening utility and clinical cut-offs of the Japanese PROMIS Rx Misuse 7a in a low-opioid prescribing environment

Keiko Yamada, Tomohiko Nishigami, Takashi Kimura, Kenta Wakaizumi, Miho Nakanishi, Noriyo Takahashi, Takao Setsu, Takeru Shiroiwa, Kazuhiro Yoshiuchi

Abstract Background Most screening tools for prescription analgesic misuse were developed in high-opioid prescribing contexts. This study evaluated the measurement properties and screening utility of the Japanese version of the PROMIS Prescription Pain Medication Misuse–Short Form 7a (PROMIS Rx Misuse 7a) in a strictly regulated, low-opioid prescribing environment. Methodology A cross-sectional web-based survey was conducted among 500 Japanese adults with chronic pain who were currently prescribed analgesics. The s …

03.09.2026journal-article

Healthcare

A Multi-Indicator Concentration Index for Primary-Care Reimbursement Analytics: Evidence from the Albanian Health-Insurance System

Tomi Thomo, Gjergji Koja, Bujar Elezi

Background: Public payers must regularly decide which prescribers to look at more closely, with records covering thousands of doctors per quarter and review capacity for only a fraction. How that choice is made bears on equitable access to reimbursed medicines as well as on public funds. Methods: We propose a multi-indicator concentration index scoring each prescriber 0–100 as the sum of nine weighted sub-scores, each measuring the doctor’s deviation from their primary-care centre median on one indicator from the p …

03.09.2026journal-article

Culture, Medicine, and Psychiatry

From ‘Sensory’ to ‘Anxiety’: Embodied States, Relational Care, and Ethical Transformation in Parental Care for U.S. Neurodivergent Childhood

Elsa Davidson

Abstract This paper draws on an ethnography of care for social–emotional differences in middle-class North American childhood to explore the relation between care practices employed by parents of neurodivergent, or neuroatypical, children, and emergent ethics of care. Focusing on a single case of asymmetrical care, that between a mother and a neurodivergent child, I draw on video-recorded interviews as well other ethnographic material to highlight how practices of care emphasizing forms of bodily and emotional conn …

03.09.2026journal-article

British Journal of Sports Medicine

Digital therapeutic combining exercise and cognitive–behavioural therapy reduces pain in patients with chronic patellofemoral pain: a multicentre randomised controlled trial

Jae-Young Park, Sanghee Lee, Jong-Min Kim, Sang Hak Lee, Moon Jong Chang, Kyu Sung Chung, Man Soo Kim, Seong Hwan Kim, Dong Jin Ryu, Tae Hyun Park, Chi-Hyun Choi, Chan Yoon, Chong Bum Chang, Jin Goo Kim

Objectives To evaluate whether an 8-week smartphone-based multidisciplinary digital therapeutic (DTx) combining exercise and cognitive–behavioural therapy reduced usual knee pain at 8 weeks compared with education and exercise instruction in chronic patellofemoral pain (PFP). Methods This multicentre, parallel-group randomised controlled trial included 216 participants with chronic PFP, defined as anterior or retropatellar pain lasting at least 3 months with activity-related provocation, recruited from orthopaedic …

03.09.2026journal-article

British Journal of Sports Medicine

Resistance training and depressive symptoms in subcortical vascular cognitive impairment: secondary results of a randomised clinical trial

Ryan S Falck, Cindy K Barha, Ryan G Stein, Sofia Grant, Alexis Bullock, Ken M Madden, Jennifer C Davis, Roger Tam, Teresa Liu-Ambrose

Objectives Cerebral small vessel disease (CSVD) is associated with depressive symptoms. Exercise may reduce depressive symptoms for people with CSVD. We examined the effects of progressive resistance training (PRT) on depressive symptoms among adults with CSVD and mild cognitive impairment (ie, subcortical vascular cognitive impairment (SVCI)). Methods A single-site, 12-month, parallel group, secondary analysis of a randomised controlled trial (ClinicalTrials.gov identifier: NCT02669394 ). Community-dwelling adults …

03.09.2026journal-article

JMIR Research Protocols

Patient-Centered Clinical Decision Support for Recommended Screenings in French Primary Care: Protocol for a Multicenter Mixed Methods Feasibility Study

Pierre-Yves Meunier, Laurent Magaud, Romain Varnier, Emmie Goetz, Melinda Bekaddour, Ludivine Albert, Inès Khati, Ilhem Bensekka, Julie Haesebaert, Denis Maillet, Julien Péron, Laurent Letrilliart

Background Primary care professionals (PCPs) are responsible for identifying eligibility and supporting patient decisions for a wide range of recommended screenings. However, the number of recommendations (42 for adults in France), complex eligibility criteria, limited consultation time, and competing priorities hinder their systematic delivery. Clinical decision support systems (CDSSs) with patient decision aids may help structure prevention-focused consultations and support shared decision-making, but their feasi …

03.09.2026journal-article

كلية القانون- جامعة سومر

الضبط القانوني للاستخدامات المائية للأنهار الدولية في ضوء قواعد القانون الدولي العام

علي يوسف

في ظل تزايد الطلب على الموارد المائية، شكلت النزاعات على الأنهار الدولية تحدياً دولياً وتنامي النزاعات بين الدول المتشاطئة على الأنهار الدولية بسببها، نتيجة عدم وجود ضابط موحد يحكم تنظيم الأنهار الدولية قواعد القانون الدولي العام، ويرجع ذلك لاختلاف الدول في تحديد المفهوم القانوني للأنهار الدولية، وتحليل الأساس القانوني المنظم لاستغلالها، والمبادئ الأساسية الحاكمة لها، وفي مقدمتها مبدأ الانتفاع المنصف والمعقول ومبدأ عدم الإضرار. لذا فإن هذه الدراسة سعت أن تبين الأسس وقواعد القانون الدولي العام على وجه الخصوص الاتفاق …

03.09.2026journal-article

Regional Anesthesia & Pain Medicine

Procedure-specific effects of intravenous lidocaine in adult spine surgery: a systematic review and meta-analysis of randomized controlled trials

Vitor A Felippe, Carlos D A Bersot, Gabriel L Gonzalez, Gustavo R M Wegner, Estevao L C Braga, Carolina C C Silva, Giulia D Matheus, Bruno V M Santiago, Leonardo B Santos, Marcos A Lessa

Background and objectives Perioperative intravenous lidocaine infusion has been proposed as an opioid-sparing analgesic adjunct in spine surgery, but previous meta-analyses pooled heterogeneous procedures and may have obscured procedure-specific treatment effects. We evaluated the analgesic and opioid-sparing effects of perioperative intravenous lidocaine in adult spine surgery and whether efficacy differs by procedure type. Methods We searched PubMed, Embase, Web of Science, and the Cochrane Library from inception …

03.09.2026journal-article

Journal of Comparative Effectiveness Research

US population-level model of clinical impact of lorlatinib treatment on ALK+ metastatic non-small cell lung cancer outcomes

Adam Kasle, Devin Abrahami, David Veenstra, Robert Morlock, Priya Ramachandran, Lindsay Stansfield, Raymond Mak

Aim: Lorlatinib and alectinib are next-generation anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) approved for the treatment of ALK-positive (ALK+) advanced/metastatic non-small cell lung cancer (NSCLC) after demonstrating superior efficacy over crizotinib (first-generation ALK TKI) in the CROWN and ALEX trials, respectively. This analysis estimated the US population-level clinical impact of first-line (1L) lorlatinib versus alectinib treatment for ALK+ advanced/metastatic NSCLC. Materials & meth …

03.09.2026journal-article

BMC Emergency Medicine

Agreement between handheld ultrasonography and computed tomography for abdominal aortic diameter measurement in unselected emergency department patients: a prospective feasibility study

Alihan Elveren, Ferhat Yildiz, Muhammed Fatih Cırıl, Mustafa Akarca, Ebru Ünal Akoğlu, Tuba Ci̇mi̇lli̇ Öztürk, Burcu Azapoğlu Kaymak

Abstract Background Abdominal aortic pathologies (aneurysm, rupture, or dissection) are among the most critical and life threatening diagnoses in patients presenting to the emergency department (ED) with abdominal or back pain. This study aimed to evaluate the agreement between bedside handheld ultrasonography (HHUS) measurements of abdominal aortic diameter performed by ED physicians and the reference standard, contrast enhanced computed tomography (CT), while also assessing inter rater reliability between clinici …

03.09.2026journal-article

Journal of Fish Health

Potential of Local Microalgae from Lembar Bay Waters for Climate Change Mitigation: Insights from Photosynthetic Assimilation Index

Damai Diniariwisan, Alis Mukhlis, Bagus Dwi Hari Setyono, Awan Dermawan, Rizky Regina Kawirian, Sri Hikmah Wulandari

Climate change mitigation requires innovative approaches to reduce atmospheric carbon dioxide (CO₂) through efficient and sustainable carbon fixation. Microalgae are promising biological agents because of their photosynthetic capacity to assimilate inorganic carbon into biomass. This study aimed to assess the potential of local microalgae communities in Lembar Bay waters, West Lombok, as carbon assimilation agents based on the relationship between chlorophyll-a, net primary productivity (NPP), and assimilation inde …

03.09.2026journal-article

Frontiers in Medicine

Case Report: Monoclonal gammopathy associated enteropathy: a potential MGCS related phenotype with response to plasma cell directed therapy

Guo Chen, Li He, Yuan Yuan Chen, Peng Yang, Jing Tan

Background Chronic inflammatory diarrhea with preserved mucosal architecture remains diagnostically challenging when inflammatory bowel disease, autoimmune enteropathy, and infection are excluded. The potential contribution of monoclonal gammopathy in such cases remains poorly defined. Case presentation We report two patients with long-standing, treatment-refractory chronic diarrhea who underwent comprehensive clinical, histopathologic, and hematologic evaluation. Both demonstrated a consistent intestinal pattern c …

03.09.2026journal-article

Frontiers in Oncology

Factors influencing oncologists’ decisions for germline BRCA testing and adjuvant therapy selection in HER2-negative early breast cancer

Qixin Li, M. Janelle Cambron-Mellott, Xiaoqing Xu, Nicole Kashine-Tack, Jennifer F. Hayes, Kathryn Emily Mishkin, Alexandra Gordon, Oliver Will, Lauren A. Howell, Alejandro Noval, Kathleen Beusterien

Introduction With advances in targeted early breast cancer (eBC) treatment, research is needed to understand the factors influencing biomarker testing and respective treatment selection among physicians in routine clinical practice. The purpose of this study was to evaluate factors influencing oncologist decisions for germline BReast Cancer gene (BRCA) mutation (gBRCAm) testing and adjuvant therapy in human epidermal growth factor receptor 2-negative (HER2-) early breast cancer (eBC). Materials and methods US oncol …

03.09.2026journal-article

Frontiers in Medicine

Ultrasound-assisted modified paramedian approach vs. traditional paramedian approach for spinal anesthesia in lower limb surgery: a single-center randomized controlled trial

Wudong Zhuang, Xiaoyuan Li, Jianhua Wang, Ruizhao Lyu, Shan Wang, Rui Liu, Yang Bai

Study objective This randomized controlled trial aimed to determine whether an ultrasound-assisted modified paramedian approach could improve procedural outcomes compared with an ultrasound-assisted traditional paramedian approach for spinal anesthesia in patients undergoing lower limb surgery. Design Prospective, randomized, controlled clinical trial. Setting Operating rooms of Hebei Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine, China. Patients A total of 116 patients aged 18–9 …

03.09.2026journal-article

Frontiers in Surgery

Clinical outcomes of flap reconstruction following lower extremity soft tissue sarcoma resection: a single-center retrospective experience

Xinxin Guo, Jianpeng Li, Jingyu Zhang, Yongcheng Hu

Background Soft tissue sarcomas (STSs) represent a diverse category of tumors with a propensity for the lower limbs. Wide surgical resection is the primary therapeutic approach, often requiring immediate flap reconstruction with or without perioperative adjuvant therapy. This study aims to share our clinical experience and assess the efficacy of customized flap reconstruction designed according to the precise defect area after lower extremity STS resection. Methods This retrospective analysis reviewed 15 cases of l …

03.09.2026journal-article

Frontiers in Public Health

Maternal per- and polyfluoroalkyl substances exposure and the co-occurrence of gestational diabetes mellitus and preeclampsia/eclampsia: a nested case–control study

Nana Li, Lu Li, Ying Deng, Meixian Wang, Yuting Li, Zhen Liu, Hong Kang, Jun Zhu, Ping Yu, Yanping Wang

Objective Few studies have investigated the relationship between maternal exposure to per- and polyfluoroalkyl substances (PFAS) and the co-occurrence of gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy, particularly preeclampsia/eclampsia (PE/E). The present study aimed to explore whether PFAS exposure is associated with the co-occurrence of GDM and PE/E. Methods This study enrolled 333 pregnant women diagnosed with both GDM and PE/E, and 360 healthy controls. First-trimester plasma conc …