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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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22 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
20.08.2026journal-article

Angewandte Chemie

Metal‐Phenolic Networks: Emerging Nanoarchitectures for Cancer Therapy

Kecheng Huang, Ran Meng, Bei Li, Yunlu Dai

ABSTRACT Cancer is a complicated disease driven by multiple etiologies, necessitating urgent, multimodal, and integrated therapeutic strategies. Coined just over a decade ago, metal‐phenolic networks (MPNs) have emerged as broad and powerful platforms, demonstrating great potential in cancer therapy, with broad success achieved in animal models. MPNs are characterized by the network's formation via phenolic ligands and metal ion coordination and serve as versatile drug delivery platforms. Moreover, MPNs not only in …

20.08.2026journal-article

Journal of Pharmaceutical and Sciences

Complementary-Therapy Use, Neuropathic Screening Status, and Quality of Life in Patients with Hypertension or Diabetes: A Pre–Post Observational Study

Aynul Mardhiyah, Dwi Anggraini, Yuni Andriani, Chindiana Khautami

Introduction: Peripheral neuropathy contributes to pain, functional impairment, and reduced quality of life in patients with diabetes mellitus and hypertension. This study evaluated changes in neuropathic screening status and quality of life during the use of complementary therapies alongside standard pharmacotherapy. Methods: This uncontrolled pre-post observational study included 147 patients at RSUD Nurdin Hamzah: 65 with hypertension and 82 with diabetes mellitus. Neuropathic characteristics and quality of life …

20.08.2026journal-article

Biomédica

Fracaso virológico de la terapia antirretroviral en pacientes naïve con HIV: una mirada desde variables farmacológicas

Carlos Alberto Gómez-Mercado, Paulo Andrés Giraldo-Sánchez, Newar Andrés Giraldo-Alzáte, Ana María Hincapié-Zapata, Juliana Madrigal-Cadavid, Jorge Iván Estrada-Acevedo

Introducción. La terapia antirretroviral de gran actividad ha demostrado mejorar la supervivencia a largo plazo de los pacientes con HIV. Sin embargo, una proporción considerable de pacientes presenta fracaso o falla virológica durante el tratamiento.Objetivo. Determinar la relación entre la polimedicación, el cambio de tratamiento, la falta de adhesión y el no reclamar el medicamento, y la falla virológica de los pacientes con HIV que recibieron tratamiento antirretroviral.Materiales y métodos. Se llevó a cabo un …

20.08.2026journal-article

Journal of Rational-Emotive & Cognitive-Behavior Therapy

An Individually Randomized Control Study for Reduction of Stress in Children With Adverse Childhood Experiences (ACEs): Impact of Rational Emotive Family Health Therapy

Clara Odozi Ifelunni, Moses Onyemaechi Ede, Daphney Mawila-Chauke

Abstract Currently, there is an increased prevalence of stress, child abuse, and adverse childhood experiences among children, especially Nigerian school children, which is related to mental health problems. This prevalence has left a significant proportion of school children vulnerable to insecurity and rape. This study evaluates the effect of Rational Emotive Family Health Therapy in reducing stress in children with irrational behaviours stemming from adverse childhood experiences (ACEs). It is a double-blinded a …

20.08.2026journal-article

Clinical Advances in Periodontics

Sequential regenerative therapy using biologic‐based regeneration and connective tissue graft wall technique for a severe infrabony defect: A case report

Wenwen Liu, Yilong Chen, Muhammad Saleh, Hom‐Lay Wang

Abstract Background Regenerative therapy based on the principles of guided tissue regeneration (GTR) is an effective approach for the treatment of periodontal infrabony defects. However, complete resolution for deep and complex defects is not always predictable. The connective tissue graft (CTG) wall technique has recently been proposed to enhance outcomes in such challenging defects. This case report describes a staged regenerative approach combining biologic‐enhanced regenerative procedure and CTG wall technique …

20.08.2026journal-article

Scientific Reports

Rehabilitation workforce perspectives on strategies to improve adherence to physical rehabilitation in patients with delirium post-neurosurgery: a qualitative study

Júlio Belo Fernandes, Diana Vareta, Leonor Monteiro, Cristina Rodrigues, Marlene Monteiro, Ana Gonçalves, Mónica Pinto, Ana Romão, Sónia Fernandes

Abstract Delirium following neurosurgery is a frequent and complex condition associated with cognitive fluctuations, reduced engagement, and poor rehabilitation outcomes. Although early physical rehabilitation is recommended, sustaining adherence in individuals experiencing delirium remains challenging. Current evidence provides limited guidance on how rehabilitation professionals adapt their strategies to maintain participation. This study aims to explore the perspectives of the rehabilitation workforce on strateg …

20.08.2026journal-article

Philology. Theory & Practice

Communicative and pragmatic means of speech modification: hedging and mitigation

Elena Mikhailovna Petrova

Nowadays, holding a successful conversation is one of the most essential skills for every person. The key aspects of successful dialogue are carefully selected communicative strategies, among which are linguistic hedging and mitigation. Although hedging and mitigation are often used as interchangeable phenomena from a functional perspective, these strategies cannot be regarded as identical. This paper aims to substantiate the differentiation of hedging and mitigation as independent communicative-pragmatic strategie …

20.08.2026journal-article

Journal of Human Immunity

Persistent Hypogammaglobulinemia Following Anti-CD20 Therapy in a Patient with 22q11.2 Deletion Syndrome: A Case Report

Ana Drazic, Srdjan Pasic, Maja Stojanovic, Branka Bonaci-Nikolic, Rada Miskovic

Introduction 22q11.2 deletion syndrome (22q11.2 DS) is one of the most common microdeletion syndromes, characterized by congenital anomalies and variable immune dysfunction secondary to thymic hypoplasia. The resulting immune dysregulation frequently predisposes affected individuals to autoimmune manifestations, including immune thrombocytopenia (ITP). Although rituximab is established therapy for refractory ITP, its B cell–depleting mechanism may carry distinct risk in patients whose B cell compartment already dep …

20.08.2026journal-article

JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY

Hematopoietic cell transplantation for myelodysplastic syndromes

Fernando Barroso Barroso, Yhasmine Delles Oliveira Garcia, Karine Sampaio Nunes Barroso, Roberto Luiz da Silva, Lívia Andrade Gurgel, João Paulo de Vasconcelos Leitão, Beatriz Stela Gomes de Souza Pitombeira, Rodolfo Daniel de Almeida Soares, Gustavo Bettarello

For patients with myelodysplastic syndromes (MDS), allogeneic hematopoietic cell transplantation (HCT) is considered the only treatment with curative potential. However, its use is restricted to a selected group of patients, and transplant outcomes are influenced by a complex interaction of disease related characteristics, patient-specific factors, and the HCT procedure. Since the publication of the previous Brazilian consensus, important advances have been made in the classification and risk stratification of MDS. …

20.08.2026journal-article

Frontiers in Medicine

Efficacy and safety comparison of hetrombopag and eltrombopag in children with cancer therapy-induced thrombocytopenia: a single-center retrospective study

Li-Ting Yu, Min Zhang, Jia-Xin Zhang, An-An Zhang, Zhuo Wang, Dan He, Hao-Nan Li, Zhi-Ling Li, Yi-Jin Gao

Objective To compare the efficacy and safety of hetrombopag and eltrombopag in children with cancer therapy-induced thrombocytopenia (CTIT), and to explore the clinical value of eltrombopag for this specific pediatric population given the current lack of dedicated literature. Methods This was a single-center retrospective study. A total of 185 pediatric CTIT patients were enrolled, including 114 cases in the hetrombopag group and 71 cases in the eltrombopag group. Baseline characteristics, platelet (PLT) parameters …

20.08.2026journal-article

Physical Therapy

The Role of Physical Activity in Oral Cancer Recovery:A Systematic Review

Lina Van Lint, Manon Lefever, Yolinne Meert, Lynn Christiaens, Robin Willaert, Kaat Alaerts, Jeroen Van Dessel

Abstract Importance Physical activity (PA) is a cornerstone in cancer rehabilitation, yet evidence in oral cancer remains limited and heterogeneous, despite the significant functional impairments and morbidity associated with treatment. Objective This systematic review synthesizes evidence on PA in people living with or beyond oral cancer (PLWBOC), focusing on its association with recovery-related outcomes across the cancer care continuum. Data Sources A comprehensive systematic search was conducted in 9 databases …

20.08.2026journal-article

JAMA Network Open

Outpatient Parenteral Antimicrobial Therapy Practice Variability Across Veterans Affairs Hospitals

Elizabeth A. Scruggs-Wodkowski, Lauren Gauntlett, Danielle Helminski, Amanda C. Blok, Nicholas Henry, Sara C. Keller, Ronald E. Kendall, Manon Nitta, Allison Ranusch, Milisa Manojlovich, Molly Harrod, Sarah L. Krein

Importance Challenges providing outpatient parenteral antimicrobial therapy (OPAT) can compromise patient safety and care quality, yet little is known about how OPAT is delivered by health care systems across the US. Objective To understand and compare OPAT delivery at US Department of Veterans Affairs Medical Centers (VAMCs). Design, Setting, and Participants This qualitative study using a mixed-methods approach was performed from February 6, 2024, through April 15, 2025. Six midwestern VAMCs were purposively sele …

20.08.2026journal-article

Advanced Healthcare Materials

Dual‐Functional Microreactor Enabling Hydrogen Therapy and Mild Photothermal Therapy for Osteoarthritis Treatment

Zhe Wang, Yuyang Wu, Ze Zhang, Shengyan Yin, Guangbin Wang

ABSTRACT Osteoarthritis (OA) is a prevalent degenerative joint disorder. Current therapeutic approaches have yielded suboptimal clinical outcomes, primarily due to their inability to effectively eliminate reactive oxygen species (ROS), which are the key drivers of inflammatory pathology. Molecular hydrogen (H 2 ) has emerged as a promising therapeutic agent owing to its selective scavenging of cytotoxic ROS, thereby exerting potent anti‐inflammatory effects. In this study, we propose a spatiotemporally controlled, …

20.08.2026journal-article

Science Journal of Clinical Medicine

Potential for Corneal Recovery During Nonstandard Rehabilitation After LASIK

Galina Semak, Volha Remezava, Yuliya Markava, Gleb Krishtopenko

Laser in situ keratomileusis (LASIK) provides predictable refractive outcomes, but clinically silent epithelial basement membrane dystrophy (EBMD) may become apparent during flap creation and lead to epithelial sloughing, delayed epithelial recovery, and postoperative ocular surface instability. This case report describes the management of a 30-year-old man with bilateral moderate myopia and astigmatism who underwent microkeratome-assisted LASIK after a routine preoperative examination showed no corneal epithelial …

20.08.2026journal-article

Advanced Healthcare Materials

Biphasic Co‐Delivery of Curcumin and 5‐FU using 3D‐Printed Dissolving Microneedles for Skin Cancer Therapy

Rutuja N. Meshram, Dimitrios A. Lamprou

ABSTRACT Dissolving microneedle (MN) arrays are a minimally invasive strategy for localized transdermal chemotherapy; however, their translation is limited by drug loading, reproducible dosing, and the difficulty of incorporating chemically distinct drugs into printable matrices. Although MN‐mediated delivery of curcumin and 5‐fluorouracil (5‐FU) has previously been reported using inkjet/coating‐based approaches, those systems deposit drug formulations onto preformed solid MNs and are therefore constrained by surfa …

03.09.2026journal-article

Schizophrenia Bulletin

Cognitive Behavior Therapy for Psychosis in People with Intellectual Disability—A Scoping Review

S R Vogels, A B P Staring, J de Jager

Abstract Background and Hypothesis Cognitive behavior therapy for psychosis (CBTp) is effective in reducing psychiatric symptoms. Most CBTp trials have excluded patients with intellectual disabilities, even though intellectual disabilities are associated with an at least 3 times higher psychosis prevalence. More understanding of evidence-based approaches for this population is needed. The aim of this review was to assess the current state of knowledge about CBTp for people with both intellectual disabilities and ps …

20.08.2026journal-article

Journal of Clinical Medicine

Prenatal mTOR-Inhibitor Therapy for Fetal Cardiac Rhabdomyomas: Indications, Treatment Duration and Perinatal Outcomes

Ioannis Kyvernitakis, Katharina Schramm, Gert Wiegand, Bernd Feyerabend, Ahmet Alexander Baschat

Background: Fetal cardiac rhabdomyomas are strongly associated with tuberous sclerosis complex (TSC). Although many remain asymptomatic and regress spontaneously, large tumors may cause ventricular inflow or outflow obstruction, arrhythmia, impaired ventricular function, pericardial effusion, hydrops fetalis and fetal demise. Transplacental mammalian target of rapamycin (mTOR) inhibition has emerged as a potential rescue therapy. Methods: We performed a narrative review of published reports on prenatal sirolimus or …

20.08.2026journal-article

ACS Applied Materials & Interfaces

Nitroxide Polymer Encapsulating Triptolide for Safe and Effective Small Cell Lung Cancer Therapy by Targeting Energy Metabolism and Pyroptosis

Kuntan Wu, Yixuan Yu, Jiuzhi Xu, Tongxin Zhao, Tingting Hou, Yun Xu, Luyao He, Zhirong Wang, Liansheng Liu, Hai Song, Yu Geng, Qingzhe Wu

Abstract Small cell lung cancer (SCLC) is highly aggressive neuroendocrine tumor with a paucity of effective therapeutic option. Triptolide (TP), a natural diterpenoid triepoxide, exhibits potent antitumor activities, yet its efficacy and underlying mechanisms in SCLC remain largely undefined. Here, we demonstrate that TP effectively inhibits cell viability across all molecular subtypes of SCLC, with greater potency than in nonsmall cell lung cancer. Mechanistically, TP transcriptionally represses hexokinase 1 and …

19.08.2026journal-article

Journal of Back and Musculoskeletal Rehabilitation

Effectiveness of manual therapy on central sensitization in patients with non-specific chronic low back pain: A randomized controlled trial

Serhat Aydoğdu, Naime Uluğ, Zehra Can Karahan, Kamyab Sadeghzadeh, Nagihan Acet

Background Central sensitization (CS), characterized by amplified nociceptive processing within the central nervous system, is considered a key mechanism in chronic nonspecific low back pain (CNLBP). Although manual therapy (MT) is widely used in musculoskeletal rehabilitation, its effectiveness in patients with confirmed CS remains unclear. This study evaluated the effects of MT on CS, pain, disability, and quality of life in individuals with CNLBP. Methods Forty participants with physician-diagnosed CNLBP and CS …

19.08.2026journal-article

Photobiomodulation, Photomedicine, and Laser Surgery

Antimicrobial Photodynamic Therapy Reveals Differential Species Susceptibility and Ecological Shifts in Candida albicans–Pseudomonas aeruginosa Mixed Model

Jiahe Li, Liang Zhou

Background: Candida albicans and Pseudomonas aeruginosa are frequently co-isolated from refractory endodontic infections. Antimicrobial photodynamic therapy (aPDT) is a promising adjunctive disinfection strategy; however, its efficacy against polymicrobial communities containing structurally distinct organisms remains unclear. Objective: To evaluate methylene blue–mediated aPDT at three energy densities (15, 30, and 60 J/cm 2 ) against a dual-species coculture model and to investigate the ecological consequences of …

19.08.2026journal-article

Frontiers in Medicine

Application of Home-based extended care based on cloud follow-up in postoperative rehabilitation of lower extremity arteriosclerosis obliterans

Yuandan Huang, Yanjun Zhang, Yang Xu, Peng Wang

Objective To explore the application effect of Home-based extended care based on cloud follow-up in the postoperative rehabilitation of lower limb arteriosclerosis obliterans and provide a reference for postoperative rehabilitation of lower limb arteriosclerosis obliterans. Methods This study employed a prospective cohort study design. 110 patients with lower extremity arteriosclerosis obliterans who underwent interventional treatment were selected and divided into a control group ( n = 52) and an experimental grou …

19.08.2026journal-article

Canadian Journal of Physiology and Pharmacology

Cardiotropic Adeno-Associated Virus-Based Gene Therapy via Intracoronary Delivery for Nonischemic Heart Failure

Joseph Abraham, Eugene S Chung, Sitaramesh Emani, Ankit Bhatia, Gregory Egnaczyk, Santosh Sanganalmath, Luke Roberts, Timothy D Henry

Heart failure (HF) remains a leading cause of morbidity and mortality with significant residual risk despite major advances in medical therapies. Development of cardiotropic vectors have allowed gene therapy to be revisited to target the molecular roots of (HF) to potentially improve structural cardiac remodeling and cardiac contractility on top of functional improvement offered by current standard of care therapies. In a first-in-human phase 1 trial, a cardiotropic vector gene AB-1002 targets a phosphorylation pat …