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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Urologia Journal

Clinical and epidemiological characteristics of penile cancer in a hospital-based cohort from southwestern Colombia

Nicolás Guerrón Morales, Philippe E. Spiess, Herney Andrés García-Perdomo

Objective: To describe the clinical and epidemiological characteristics of patients diagnosed with penile cancer in a hospital-based cohort from southwestern Colombia. Methods: A retrospective cross-sectional study was conducted using medical records from the Urology Department of a tertiary hospital in Cali, Colombia, between January 2013 and February 2024. Patients with confirmed penile cancer were identified through ICD-10 codes. Sociodemographic, clinical, pathological, and treatment data were extracted and ana …

28.08.2026journal-article

Frontiers in Oncology

ANP32A interacts with LDHA to modulate glycolysis and ferroptosis in hepatocellular carcinoma

Bixia Chi, Zhi Cui, Xinyue Hou, Hongfang Ding, Linjun Li, Rui Ai, Yizhuang Yang, Yue Zhao, Liyan Wang, Juan Wang

Acidic leucine-rich nuclear phosphoprotein 32A(ANP32A) is known to possess multi-functions and has been observed to exhibit different roles across various malignancies. Although the expression of ANP32A has been shown to correlate with metastatic spread and reduced survival in Hepatocellular carcinoma(HCC), the underlying mechanisms have not been fully elucidated. This study utilized univariate Cox regression, differential gene analysis, and WGCNA to identify ANP32A as closely associated with poor HCC prognosis. Ou …

28.08.2026journal-article

ACS ES&T Water

Response Surface Methodology Optimization of Operation Conditions of Dynamic Cloth Media Filtration Used in Primary Wastewater Treatment

Madison De Boer, Tayler J. Zavala, Junho Lee, Leila Sermek, Bhargavi Subramanian, Ganesh Rajagopalan, Ryan W. Holloway, Johan Vanneste, Linda A. Figueroa, Michael B. Heeley, Tzahi Y. Cath, Amanda S. Hering

Abstract Operation of wastewater treatment facilities (WWTF) is essential for human and environmental health but is energy intensive, prompting the need for optimal operation to minimize energy consumption while providing high-quality effluent. Our goal is to identify optimal operational set points for a primary cloth media filtration system under dynamic influent conditions. Machine learning techniques such as reinforcement learning are gaining traction in WWTF, but many facilities lack the automation to adopt the …

28.08.2026journal-article

Esophagus

Robotic repair of an esophago–left main bronchial fistula using a pedicled autologous pericardial patch and latissimus dorsi muscle flap: a novel technique after chemoradiotherapy for cT4b esophageal cancer

Tomoki Makino, Shigeto Nakai, Tomohira Takeoka, Kotaro Yamashita, Kazuya Kuroda, Koji Tanaka, Takashi Kanou, Tateki Kubo, Yasushi Shintani, Shigeru Miyagawa, Hidetoshi Eguchi, Yuichiro Doki

Abstract Once an esophago–airway fistula develops during chemoradiotherapy for cT4b esophageal cancer, further curative treatment is often precluded. We describe a robotic technique for closure of a large esophago–left main bronchial fistula using a pedicled autologous pericardial patch reinforced with a latissimus dorsi muscle flap. A 66-year-old woman with squamous cell carcinoma of the middle to upper thoracic esophagus invading the left main bronchus developed a fistula after definitive chemoradiotherapy. After …

28.08.2026journal-article

Proteomes

Integrative Proteomic Analysis Implicates Inhibition of Intracellular Protein Trafficking in Therapy-Induced Migrastasis in Prostate Cancer

Weining Chen, Saadyeh Rashidi, Henry C.-H. Law, Fangfang Qiao, Johnny W. Zigmond, Katelyn L. O’Neill, Nicholas T. Woods, Chittibabu Guda, Raymond C. Bergan

Background: Dysregulated cell migration leading to metastasis remains the primary cause of cancer-related mortality. It has been challenging to understand how cells regulate migration. We have previously created the first selective inhibitor of cell migration, KBU2046. Here, we use it as a probe to identify regulatory processes. Methods: Metastatic and primary human prostate cancer cells were treated for different times and at different concentrations with KBU2046. Immunofluorescent microscopy examined protein loca …

28.08.2026journal-article

Clinical Cancer Research

Extended Follow-Up of Botensilimab Plus Balstilimab in an Expanded Cohort of Microsatellite-Stable Metastatic Colorectal Cancer Without Active Liver Metastases

Benjamin L. Schlechter, Marwan G. Fakih, Apostolia M. Tsimberidou, Andrea J. Bullock, Agustin Pimentel, Sunil Sharma, Heinz-Josef Lenz, Michael S. Gordon, Ghassan K. Abou-Alfa, Thomas U. Marron, Robert W. Lentz, Wells Messersmith, Ian Chau, Bruno Bockorny, Dhan Chand, Manushak Avagyan, Wei Wu, Benny Johnson, Joseph E. Grossman, Steven J. O'Day, Anthony B. El-Khoueiry, Neil H. Segal

Abstract Purpose: Microsatellite-stable metastatic colorectal cancer (MSS mCRC) has limited treatment options and responds poorly to conventional immunotherapy. We report extended follow-up results from a fully-enrolled, phase 1b cohort evaluating botensilimab (BOT; Fc-enhanced anti–CTLA-4) plus balstilimab (BAL; anti–PD-1) in patients with MSS mCRC and no active liver metastases (NLM). Patients and Methods: Patients received BOT 1 or 2 mg/kg every 6 weeks (Q6W) plus BAL 3 mg/kg Q2W up to 2 years or until progressi …

28.08.2026journal-article

International Journal of Research Publications

From Risk Identification to Real-World Prevention of Preeclampsia: A Scoping Review of Aspirin Prophylaxis, Screening Strategies, Treatment Optimization, and Implementation Gaps

Abdurrahman Fadlilah Amanu

Preeclampsia remains a major cause of maternal and perinatal morbidity, and low-dose aspirin is the most established pharmacological preventive strategy for pregnancies at increased risk. However, preventive benefit depends on more than drug prescription. This scoping review mapped the evidence from risk identification through aspirin optimization and real-world implementation. Scopus was searched using a predefined TITLE-ABS-KEY strategy combining low-dose aspirin, preeclampsia, pregnancy, and prevention terms. Of …

28.08.2026journal-article

Seminars in Interventional Radiology

Thyroid Cancer: What Can We Treat?

Lisa Walker, Fourat Ridouani, Timothy Huber

Abstract Minimally invasive treatment of thyroid cancer is an emerging treatment option for well-selected patients; this is driven by the rising incidence of low-risk disease and increasing emphasis on reducing treatment-related morbidity. Treatment strategies include primary thyroid cancer with either curative or palliative intent or locoregional control of recurrent disease, most commonly metastatic cervical lymph nodes following thyroidectomy. This article will discuss thyroid cancer subtypes, updated guideline- …

28.08.2026journal-article

Medicine

Prevalence and determinants of anxiety and depression among children and adolescents undergoing cancer treatment at a tertiary hospital in a resource-limited setting

Misikir Tesfaye Dirre, Elias Tesfaye, Alemayehu Negash Torba, Bezaye Alemu Tsegaye, Yonas Tesfaye, Mubarek Abera Mengistie, Milki Tufa Feyisa, Puturos Puturos Reta, Tadios Teka Bireda, Tamirat Godebo Woyimo

Childhood cancer significantly impacts the mental health and overall well-being of children and adolescents. Mental health issues, such as depression and anxiety, are common among these children. These conditions can lead to long-term consequences, including poor psychosocial functioning, an increased risk of substance misuse, and chronic mental and physical health problems. This study assesses the prevalence of anxiety and depression, along with associated factors, among children and adolescents undergoing treatme …

28.08.2026journal-article

Annals of Surgical Oncology

Resection Margin Status, Recurrence Pattern, and Salvageability After Resection for Colorectal Liver Metastases

Kizuki Yuza, Odysseas P. Chatzipanagiotou, Andrea Ruzzenente, George A. Poultsides, Kazunari Sasaki, Itaru Endo, Federico Aucejo, Irinel Popescu, Tom Hugh, Nazim Bhimani, Matthew J. Weiss, Jin He, Timothy M. Pawlik

Abstract Background The prognostic significance of margin status after colorectal liver metastases (CRLM) resection remains debated in the era of effective systemic therapy. This study examined the prognostic meaning of microscopically positive (R1) margins, focusing on recurrence pattern and salvageability. Methods Patients undergoing curative-intent resection for CRLM were identified from an international multi-institutional database (2000–2023). Institution-stratified Cox models estimated associations between ma …

28.08.2026journal-article

BMC Musculoskeletal Disorders

What do physiotherapists need to effectively integrate a biopsychosocial approach in treatment of patients with non-specific low back pain? A qualitative analysis

Christopher Riesen, Irina Nast

Abstract Background Musculoskeletal disorders, particularly non-specific low back pain, are significant global health concerns with increasing prevalence and a substantial burden on healthcare systems. Physiotherapists in primary care play a critical role in managing these conditions. Although effective management requires a holistic, patient centered approach, the adoption of such approaches is limited by barriers such as a predominantly biomedical focus in training and communication challenges. While research has …

28.08.2026journal-article

ULAKES JOURNAL OF MEDICINE

DESIGUALDADES ESTRUTURAIS NO CÂNCER OCUPACIONAL BRASILEIRO (2020–2024): PROPOSTAS DE CUIDADO INTEGRAL À LUZ DO MODELO BIOPSICOSSOCIOESPIRITUAL DA ATENÇÃO PRIMÁRIA À SAÚDE

Ailton Gomes da Silva, Bruna Cartapatti Stuchi, Gabrielly Chiesa, Maria Etelvina Pinto-Fochi

Este trabalho analisa os principais agentes carcinogênicos ocupacionais notificados no Sistema deInformação de Agravos de Notificação no Brasil entre 2020 e 2024. A pesquisa busca compreendercomo a exposição a substâncias como amianto, benzeno e radiação ionizante se distribui entre ossetores econômicos e como afeta a saúde de populações trabalhadoras vulneráveis. A abordagemadota os princípios da Atenção Primária à Saúde (APS) com base no modelo biopsicossocioespiritual,além do Método Clínico Centrado na Pessoa e …

28.08.2026journal-article

Archivio Italiano di Urologia e Andrologia

Diagnostic accuracy of MRI and PSMA PET/CT for detection of histologically confirmed lymph node metastasis in prostate cancer: A systematic review

Emeka Ihechi Udeh, Solomon Anyimba, Loius Okolie, Rotimi David, Maureen Udeh

Objective: To compare the diagnostic accuracy of prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) and multiparametric magnetic resonance imaging (mpMRI) for the detection of histologically confirmed pelvic lymph node metastases in patients with intermediate- and high-risk prostate cancer. Methods: A systematic review and meta-analysis were conducted according to PRISMA guidelines. PubMed, Embase, and Cochrane Library databases were searched from January 2011 to March …

28.08.2026journal-article

ASIDE Gastroenterology

Artificial Intelligence-Assisted EUS for Risk Stratification of Pancreatic Cystic Lesions: A Narrative Review of Current Evidence and Future Directions for Predicting High-Grade Dysplasia, Invasive Cancer, and the Need for Surgical Referral

Ahmed Salman

Background: Pancreatic cystic lesions are increasingly detected on cross-sectional imaging, yet accurate risk stratification remains challenging. A clinically important minority, particularly intraductal papillary mucinous neoplasms and mucinous cystic neoplasms, may progress to high-grade dysplasia or invasive carcinoma. EUS plays a central role in cyst evaluation, but interpretation remains operator-dependent, and guideline-based risk categories have imperfect predictive accuracy. Methods: This narrative review w …

28.08.2026journal-article

Journal of Oral Rehabilitation

Cross‐Sectional Survey of Dental Treatment Needs Among Older Adults Receiving Home‐Visit Dental Care for Eating‐Related Problems in Acute, Convalescent and Community‐Based Care Phases

Naoki Todayama, Hiroyuki Suzuki, Chiaki Matsubara, Yasuyuki Iwasa, Yoko Wakasugi, Akira Goda, Shuhei Takeuchi, Yasushi Tamada, Koichiro Matsuo, Haruka Tohara, Junichi Furuya

ABSTRACT Background Oral health in older adults is often compromised by age‐related changes, such as oral frailty and systemic comorbidities. Consequently, older patients requiring home‐visit dental care, mostly due to eating‐related problems, may show stage‐dependent differences in oral conditions and dental care priorities. Objective To clarify care phase‐specific dental care needs among older patients receiving home‐visit dental care. Methods This multicenter cross‐sectional study included 356 older patients who …

28.08.2026journal-article

Journal of Composite Materials

Effect of heat treatment temperature on microstructure and properties of SiC/FeCoNiCrAl high-entropy alloy composite coatings via laser cladding

Diankai Hou, Kai Zhang, Tianqing Ye, Wenlong Wang, Shichen Wang, Huiru Wang, Weijun Liu

To optimize the microstructure and performance of laser-cladded 5 wt.% SiC/FeCoNiCrAl high-entropy alloy (HEA) composite coatings, this study investigated heat treatments at 700°C, 800°C, and 900°C. XRD, SEM, and EDS analyses reveal that post-treatment coatings retain a dual-phase FCC and BCC solid solution structure, accompanied by the precipitation of a Cr 2 Fe 14 C phase. The microstructural evolution exhibited a clear temperature-dependent behavior: static recovery predominated at 700°C, complete recrystallizat …

28.08.2026journal-article

The International Journal of Tuberculosis and Lung Disease

Factors associated with unsuccessful TB treatment outcomes in children and adolescents in Indonesia, 2018–2023

Y.A. Sekarini, F.F. Yani, S. Suyanto, I.W. Gede Artawan Eka Putra, T.T. Pakasi, G.B. Leksono Adhi

BACKGROUNDNon-adherence to TB treatment is associated with substantially increased mortality risk among children, yet determinants of unsuccessful treatment outcomes remain under-recognised. We examined factors associated with unsuccessful TB treatment outcomes among children and adolescents in Indonesia from 2018 to 2023.METHODSWe conducted a retrospective cohort study using the National TB Registry, including 509,290 patients aged 0–19 years with evaluated treatment outcomes. Outcomes were classified as successfu …

28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

Modern approaches to the treatment of NCMT sexually transmitted infections (N. gonorrhoeae, C. trachomatis, M. genitalium, T. vaginalis). Part II. M. Genitalium

E.S. Negasheva, N.V. Frigo, E.A. Popova, M.Yu. Vasil’tsova, A.E. Guschin, N.V. Kitaeva, N.N. Potekaev, I.Yu. Golousenko

An analysis of literature data on modern approaches to the treatment of infection caused by M. Genitalium is presented. As for now, it is not included in the list of reportable infections both in most countries of the world and in the Russian Federation, but, according to various data, it has a fairly high prevalence. The article presents data on the prevalence of this infection in countries around the world, on the antibiotic resistance of M. Genitalium, the rates of which vary and reach 90% in some regions, and r …

28.08.2026journal-article

Biology of Sex Differences

Sex-based analysis of treatment responses in animal models of sepsis: a preclinical systematic review and meta-analysis

Forough Jahandideh, MengQi Zhang, Hannah Laquerre, Partha Patel, Wimonchat Tangamornsuksan, Eva Kuhar, Zoe A. Fisk, Prarthna Karunamurthy, Julianne Morin, Samuel Igweokpala, Rahul Sharma, Nikesh Chander, Breenna Dobson, Mikaela Eng, Eric K. Patterson, Neha Sharma, Risa Shorr, Kimberly B. Tworek, Bassam Almoli, Marc T. Avey, Stephane L. Bourque, Kirsten M. Fiest, Alison Fox-Robichaud, Sean E. Gill, Arnold S. Kristof, Christian Lehmann, Patricia C. Liaw, Asher A. Mendelson, Kimberly F. Macala, Braedon McDonald, Salman Qureshi, Gloria Vazquez-Grande, Juan Zhou, Dean A. Fergusson, Manoj M. Lalu, On behalf of the Canadian Critical Care Translational Biology Group and the Sepsis Canada National Preclinical Sepsis Platform

Abstract Objectives To examine the effect of biological sex on mortality, inflammation, organ dysfunction, and bacterial burden in preclinical sepsis models. Data sources MEDLINE and Embase from January 1, 2011, to May 13, 2025. Study selection We included in vivo animal models of experimentally- induced sepsis with or without intervention that reported sex-stratified data. We excluded non-infectious models and interventions hypothesized to worsen sepsis outcomes. Data extraction We performed full-text screening an …

28.08.2026journal-article

Cancer Research

Mechanosensors Collaborate to Regulate DNA Damage Repair in Hepatocellular Carcinoma

Jiajun Li, Ziyu Ren, Jiamei Yao, Yingying Zhao, Ye Xu, Hongmei Yu, Chuxin Huang, Mimi Wang, Fan Yao, Miao Li, Yaohui Wang, Dongmei Gao, Yan Zhao, Binbin Liu, Zhiming Wang, Yinying Dong, Rongxin Chen, Jiefeng Cui

Abstract Increased matrix stiffness is a biomechanical feature of hepatocellular carcinoma (HCC) that functions as an important promoting factor driving tumor progression. Characterization of the mechanosensors and the underlying downstream mechanisms driving HCC could help identify potential treatment strategies. In this study, we developed a standard procedure for screening and identifying mechanosensors, revealing two HCC mechanosensors, SDC4 and PKD2. These two mechanosensory pathways collaboratively mediated m …

28.08.2026journal-article

BioFactors

Multicohort Construction, Immune Landscape Analysis, and PCOLCE2 Functional Validation of an Inflammation‐Related Prognostic Model in Colorectal Cancer

Minjun Dong, Wentao Xu, Jian Zhang, Guiqing Jia

ABSTRACT Colorectal cancer (CRC) prognosis remains challenging due to tumor heterogeneity and immune evasion driven by aberrant inflammatory signaling, and robust multicohort validated prognostic tools with clear therapeutic implications are still lacking. To address this gap, we integrated five independent CRC cohorts (TCGA, GSE17536, GSE17537, GSE29621, and GSE38832; n = 931) and applied single‐sample gene set enrichment analysis (ssGSEA) across 15 inflammation‐related signaling pathways to construct a prognostic …

28.08.2026journal-article

International Journal of Biology and Life Sciences

Research Progress on Perioperative Thirst Management in Patients Undergoing Gastrointestinal Tumor Surgery

Jie Liu, Mingzhe Li

This article provides an overview of the thirst issue faced by patients undergoing gastrointestinal tumor surgery during the perioperative period and its management strategies. Gastrointestinal tumors are one of the most common types of cancer globally, with surgical resection being the preferred treatment method. Postoperative thirst is a commonly overlooked issue in perioperative management, yet it significantly impacts patient recovery and satisfaction. By optimizing preoperative fluid intake, adopting combined …

28.08.2026journal-article

Supportive Care in Cancer

Catheter-related complications in AML remission induction chemotherapy: a retrospective comparison of PICCs and CICCs

S. Ehrlich, F. Aytan, J. Eufinger, M. Ruzicka, D. Doedens, M. Seidensticker, T. Herold, M. Subklewe, V. Bücklein, M. von Bergwelt-Baildon, K. Spiekermann

Abstract Purpose Central venous catheters (CVCs) are a cornerstone for effective supportive therapy in patients with AML undergoing remission induction chemotherapy. While peripherally inserted central catheters (PICCs) are increasingly used as an alternative to centrally inserted central catheters (CICCs), real world data on their implications on AML and supportive therapy remain limited. This study aimed to compare infectious and non-infectious complications of PICCs vs. CICCs in this population. Methods We condu …

28.08.2026journal-article

EJSMT

Fenton Oxidation for Organic Wastewater Treatment

Falah Kareem Hadi Al-Kaabi

Among advanced oxidation processes, Fenton’s reagent has gained attention for its ability to achieve high levels of purification at room temperature and atmospheric pressure, while utilizing non-harmful and easy-to-handle chemicals. Its efficiency and simplicity make it a promising solution in water treatment applications. In this study, an effort was made to degrade organic pollutants in laboratory wastewater using homogeneous Fenton system. The experiments were conducted under batch conditions. Key parameters suc …