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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Pharmacology

Exposure–response relationship of sintilimab in advanced gastric cancer: insights from time-dependent pharmacokinetics and biomarker integration for precision immunotherapy

Jingyi Zhou, Jingzhi Wang, Lin Liu

Background Immune checkpoint inhibitors (ICIs), particularly programmed cell death protein-1 (PD-1) antibodies, exhibit substantial interpatient variability in both efficacy and immune-related adverse events (irAEs). Conventional exposure-response (E-R) paradigms are often insufficient to capture these dynamics, limiting their utility for individualized immunotherapy. Objective To critically re-evaluate the E-R relationship of Sintilimab in advanced gastric cancer (AGC) by integrating pharmacokinetics (PK), host- a …

03.09.2026journal-article

Healthcare

The Correlation of Psychological Symptoms, Quality of Life and Resilience in Patients with Recurrent Non-Melanoma Skin Cancer

Goran Šimić, Tomislav Sušac, Josip Lesko, Ana Dugandžić Šimić, Vedran Markotić, Dragan Babić

Recurrent non-melanoma skin cancer (NMSC) may be accompanied by cosmetic, functional, and emotional consequences. Aims: To examine associations among psychological symptoms, quality of life, resilience, and religiosity and to compare psychological outcomes between patients treated once and patients with recurrent facial NMSC. Methods: This cross-sectional study included 160 patients after surgery for facial NMSC (63 treated once and 97 with recurrent disease). Data were collected with a sociodemographic questionnai …

03.09.2026journal-article

Acta Neurochirurgica

Risk stratification and treatment outcomes after surgical treatment of 0unruptured intracranial aneurysms: a single-center retrospective review

Jessica Y Jung, Alex Kostynskyy, Ronit Agid, Pascal Mosimann, Timo Krings, Hugo Andrade Barazarte, Michael Tymianski, Ivan Radovanovic

Abstract Purpose Management of unruptured intracranial aneurysms (UIAs) requires weighing rupture risk against treatment risk. As endovascular techniques have evolved, microsurgical intervention has become increasingly concentrated at high-volume centers and reserved for complex cases, potentially representing a higher-risk endeavor than reflected in earlier series. A contemporary evaluation of patient and aneurysm-related features associated with surgical risk and postoperative outcomes is needed. Methods We condu …

03.09.2026journal-article

Frontiers in Oncology

Lattice SFRT in a geriatric patient with an initially inoperable leg bulky sarcoma: case report and literature review

Francesco Di Siervi, Bruno Curcio, Renato Cuocolo, Silvio Maffei, Carolina Mainardi, Immacolata A.M. Pilotti, Davide Di Gennaro

Background Management of inoperable bulky soft tissue sarcomas mostly in geriatric patients presents a significant clinical challenge due to high and hypoxia-induced radioresistance, proximity to dose-limiting Organs at Risk (OARs), and the need to minimize systemic toxicity. Spatially Fractionated Radiation Therapy (SFRT), specifically 3D Lattice Radiation Therapy (LRT), offers a novel approach to safely escalate dose within the tumor volume. Case presentation 85-year-old female presenting a massive (20.7 x 9.8 cm …

03.09.2026journal-article

Cancer Research

CDState Resolves Malignant Cell Heterogeneity from Bulk Tumor RNA Sequencing Data

Agnieszka Kraft, Josephine Yates, Florian Barkmann, Valentina Boeva

Abstract Intratumor transcriptional heterogeneity (ITTH), defined as the coexistence of diverse cell states within a single tumor, complicates cancer treatment and contributes to variable therapeutic responses. Although single-cell RNA sequencing (scRNA-seq) can resolve this complexity, its cost and technical demands limit large-scale use. Bulk RNA-seq provides a scalable alternative but requires computational methods to deconvolve bulk transcriptomes into distinct cell states. Existing supervised approaches rely o …

03.09.2026journal-article

BMC Anesthesiology

Comparative influence of opioid-free versus opioid-containing anesthetic techniques upon Th1/Th2 balance during laparoscopic colorectal cancer procedures: a randomized controlled trial

Li Hong, Yunyan Wang, Zhi Cheng, Hengfei Luan, Zhibin Zhao

Abstract Background Surgical resection is central to colorectal cancer management, but surgery and anesthesia can induce perioperative immunosuppression. Opioids, a mainstay of perioperative analgesia, may impair cellular immunity, including disruption of Th1/Th2 immune equilibrium. This randomized controlled trial evaluated whether opioid-free anesthesia (OFA) better preserves perioperative immune function than opioid-based anesthesia. Methods Sixty patients scheduled for elective laparoscopic colorectal cancer re …

03.09.2026journal-article

Frontiers in Surgery

Case Report: Management of tibial fracture nonunion: a case study of treatment failure and lessons learned

Chaoshuai Wang, Chen Wang

Concept of “mechanical–biological balance” is fundamental to successful fracture healing; disruption of either component can lead to healing failure. Fractures of the middle and distal tibia are commonly encountered in clinical practice, particularly when associated with comminution. Managing fracture nonunion requires a comprehensive assessment of infection status, skeletal alignment, bone defect, implant stability, and host biological characteristics. This case report aims to explore the etiological factors of ti …

03.09.2026journal-article

Neuroradiology

Mapping without tasks: resting-state fMRI for motor and language localization in neuro-oncology

Esmat Mahmoud, Taha A.E. Ashraf, Nada K. Abdelsattar, Ayman Nada

Abstract Purpose Presurgical functional mapping is essential for maximizing tumor resection while preserving motor and language function. While task-based fMRI (tb-fMRI) is the current non-invasive standard, its utility is substantially limited in patients with aphasia, paresis, or cognitive impairment who cannot comply with active paradigms. Resting-state fMRI (rs-fMRI) offers a task-free alternative, yet its spatial fidelity and clinical validity compared to task-based methods remain under rigorous evaluation. Me …

03.09.2026journal-article

Smart Molecules

AI‐enabled engineering of hesperidin/ursodeoxycholic acid nanomedicine for synergistic treatment of drug‐induced liver injury

Kai Xiao, Meng Fan, Haoyu Zheng, Boyuan Gu, Shaowen Wang, Ziping Wu, Shiming Zhang, Xin Zhao, Wensheng Zhang, Quanxin Ning, Sigen A, Chao Yang, Huayi Sun, Ren Mo, Dan Shao

Abstract Drug‐induced liver injury (DILI) is a complex and intractable disease because existing anti‐oxidate therapies in clinic fail to modulate multiple pathological pathways concurrently. Here, we present a direction‐aware framework that integrates disease‐network analysis, AI‐guided molecular screening, and self‐assembled nanomedicine design for precise protection of DILI. Time‐resolved transcriptomic profiling of DILI identifies two complementary repair axes: the suppression of cytokine‐cytokine receptor signa …

03.09.2026journal-article

Journal of the Endocrine Society

Recombinant Human Thyrotropin Reducing Insulin Resistance in Patients with Differentiated Thyroid Cancer

Yu-Hsuan Li, Junyi Wu, I-Te Lee

Abstract Context Postsurgical radioactive iodine (RAI) therapy is indicated for adults with differentiated thyroid cancer (DTC) who are at an intermediate-to-high risk of recurrence. Thyrotropin (TSH) stimulation to facilitate RAI uptake can be achieved by injection of recombinant human TSH (rhTSH) or thyroid hormone withdrawal (THW). Objective This study aimed to compare the effects of rhTSH administration and THW programs on insulin resistance. Methods This prospective observational study included 47 patients who …

03.09.2026journal-article

Frontiers in Oncology

An investigational prognostic framework for stage IVB cervical cancer based on metastatic patterns: a population-based study with exploratory external evaluation

Bingbiao Lin, Xuehan Huang, Hongxin Huang, Keyan Xie, Jianzhou Chen, Chuangzhen Chen, Yizhou Zhan

Background Current staging system classifies all patients with metastatic cervical cancer as stage IVB, without accounting for prognostic heterogeneity. This study aimed to develop an exploratory metastatic pattern-based framework for prognostic stratification within stage IVB cervical cancer. Methods Patients with de novo stage IVB cervical cancer were identified from the Surveillance, Epidemiology, and End Results database and the Cancer Hospital of Shantou University Medical College. Random survival forest and C …

03.09.2026journal-article

Frontiers in Oncology

Early postoperative morbidity and short-term outcomes after cytoreductive surgery and HIPEC for peritoneal surface malignancies: initial single-center experience from Palestine

Marwan Abufara, Qais M. Alnjoom, Amanda Siniora, Elias Yacoub, Tareq Jarrar, Ibraheem AbuAlrub

Background Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is an established treatment option for selected patients with peritoneal surface malignancies. However, data from newly introduced programs in resource-constrained settings are limited. We report our initial experience in Palestine, a single center, in evaluating the feasibility, perioperative safety and short-term oncologic outcomes of CRS-HIPEC. Methods We conducted a retrospective descriptive study of all consecutive pa …

03.09.2026journal-article

Frontiers in Oncology

Integrating artificial intelligence across the cancer drug discovery pipeline using a design-test-refine workflow

Jinming Bai, Jessica Sarah Faure, Tawfeeq Ahmed Khalfe, Rongqin Huang, Carly Ann Burmeister, Annick van Niekerk, Sharon Prince

Artificial intelligence-driven drug design (AIDD) is increasingly transforming cancer drug discovery, but its applications are often considered as individual computational tasks rather than interconnected stages of the drug discovery pipeline. This mini-review addresses this gap by firstly identifying the following four interconnected stages of anticancer drug development (1) target identification and biomarker-guided prioritization (2), structure-based and generative molecular design (3), perturbational mechanism- …

03.09.2026journal-article

Frontiers in Pharmacology

Targeting pancreatic cancer with natural compounds: molecular mechanisms, preclinical evidence, clinical perspectives, and limitations

Alberto Orta, Miguel Angel Hidalgo-Leon, Carlos Lacalle-Gonzalez, Miriam M. Rodriguez de Lope, Lara Sanz-Criado, Jesus Garcia-Foncillas, Javier Martinez-Useros

Pancreatic cancer remains one of the most aggressive and lethal malignancies, with poor survival outcomes and limited therapeutic options. Surgical resection is currently the only potentially curative treatment; however, fewer than 20% of patients are eligible for this at diagnosis due to the stage of the advanced disease. Despite substantial progress in understanding the molecular pathogenesis of pancreatic cancer, effective targeted therapies remain scarce, and current systemic treatments provide only modest clin …

03.09.2026journal-article

Cancers

Amplification-Driven S100A11 Overexpression in Hepatocellular Carcinoma Is Associated with Metabolic Reprogramming, ECM Remodelling, and Immune Evasion: A Pan-Cancer Genomic Study

Stuart Lutimba, Eiman Aleem

Background: S100A11, a calcium-binding S100 family protein, is increasingly implicated in carcinogenesis, yet its molecular regulation and clinical relevance across cancers remain unclear. Hepatocellular carcinoma (HCC) carries a dismal prognosis, in part due to a lack of reliable biomarkers for risk stratification of established disease. Methods: We conducted a pan-cancer analysis of S100A11 genomic alterations across 31 studies (10,767 samples) obtained from TCGA, encompassing copy number alterations, somatic mut …

03.09.2026journal-article

Dasinya Journal for Engineering and Informatics

Adaptive-Preprocessing-Enhanced YOLOX-L For Breast Cancer Mass Detection in Contrast-Enhanced Spectral Mammography

Ahmed Alaa Hani Alkurdi, Amira B. Sallow

Breast cancer detection using contrast-enhanced spectral mammography (CESM) is still a challenging task, especially when lesions are subtle, low in contrast, or located within dense breast tissue. In this paper, an automated breast mass localization pipeline was developed using the YOLOX-L object detection framework. The proposed pipeline applies a piecewise adaptive contrast enhancement method before the detection stage. This method depends on dynamic thresholding to improve the visibility of lesion regions while …

03.09.2026journal-article

Frontiers in Oncology

Case Report: Neuroretinitis following combination checkpoint inhibition therapy with nivolumab and ipilimumab for stage IIIC melanoma

Nuha S. Arefin, Jared Moon, Aaron B. Roller, Moe H. Aung

Purpose Neuroretinitis is a very rare but recognized immune-related adverse event (irAE) of immune checkpoint inhibitor (ICI) therapy. We present a case of likely ICI-associated neuroretinitis following combination nivolumab and ipilimumab treatment for stage IIIC cutaneous melanoma. Observations Our patient is a 48-year-old woman with stage IIIC melanoma who developed acute left eye vision loss approximately three months after initiating nivolumab and ipilimumab, near the end of a corticosteroid taper for a concur …

02.09.2026journal-article

Extracellular Vesicles and Circulating Nucleic Acids

Proteomic profiling of high purity extracellular vesicle subtypes from megakaryoblastic leukemia cells provides insights into myeloproliferative neoplasm biology

Xiaogang Zhang, Sarita Sehra, Cynthia Timmers, Tony Chadderton, Matthew Stubbs, Xiaowei Xu

Aim: Extracellular vesicles (EVs) are emerging as important mediators in myeloproliferative neoplasms (MPNs), but the characteristics of distinct EV subtypes remain unclear. This study aimed to characterize the molecular heterogeneity of MEG-01-derived large EVs (lEVs) and small EVs (sEVs). Methods: lEVs and sEVs were isolated from MEG-01 cell culture medium by differential centrifugation followed by density gradient ultracentrifugation. EVs were characterized by transmission electron microscopy, nanoparticle track …

02.09.2026journal-article

Receptors

Differential Regulation of Soluble and Membrane 4-1BB and OX-40 Within the Peripheral Compartment of Cervical Cancer

Jose Manuel Rojas-Diaz, Fernando Galvan-Ledezma, Ksenia Klimov-Kravtchenko, Nadia Tatiana Garcia-Barrientos, Ana Delia Orozco-Jacobo, Alan Delgadillo-Gutierrez, Blanca Estela Bastidas-Ramirez, Jesse Haramati, Susana del Toro-Arreola

Background: Members of the tumor necrosis factor receptor superfamily (TNFRSF), including 4-1BB (CD137) and OX-40 (CD134), play central roles in regulating cytotoxic lymphocyte activation and anti-tumor immunity. In addition to their membrane-bound forms, soluble receptor isoforms may modulate signaling by influencing ligand availability and receptor engagement. However, the peripheral regulation of soluble and membrane 4-1BB and OX-40 in cervical cancer remains incompletely defined. Methods: Plasma concentrations …

02.09.2026journal-article

Cancer Epidemiology, Biomarkers & Prevention

Implementing a Risk-Stratified National Breast Screening Programme in the United Kingdom: A Model-Based Cost-effectiveness Analysis

Stuart J. Wright, Joe Hilton, Gabriel Rogers, Ewan Gray, Anna Donten, Lorna McWilliams, D. Gareth R. Evans, David P. French, Katherine Payne

Abstract Background: Risk-stratified breast screening, in which women are offered different screening intervals based on their breast cancer risk, has been proposed as a way to improve the benefits of screening in the United Kingdom National Breast Screening Programme (UK-NBSP). The aim of this study was to explore the cost-effectiveness of potential risk-stratified breast screening strategies in the UK-NBSP. Methods: An existing validated discrete event simulation model (MANC-RISK-SCREEN) was used to evaluate the …

02.09.2026journal-article

Clinical and Translational Oncology

Clinical outcomes of stereotactic body radiotherapy in oligometastatic disease: a national real-world cohort study

Macarena Teja, Fernando López Campos, Álvaro Pinto, Israel J. Thuissard, María González, David Esteban, Abrahams Ocanto, Castalia Fernández, Daniela Gonsalves, Lisselott Torres, María Isabel Garrido, Escarlata López, Jaume Fernández, Loubna Aakki, Antonio Ristori, José Begara, Sigfredo Elias Romero Zoghbi, Jon Andreescu, Ana Belén Bezares, María Mateos, Miguel Ángel Berenguer, Daniel Rivas, Elisabet González del Portillo, Cristina Andreu, Esther Holgado, Shankar Siva, Constantinos Zamboglou, Felipe Couñago

Abstract Purpose We conducted the first multicentre Spanish real-world study assessing the efficacy and safety of stereotactic body radiotherapy (SBRT) in oligometastatic patients treated in routine clinical practice. Methods This retrospective, multicentre observational study included oligometastatic patients with primary solid tumours treated with SBRT between 2020 and 2024 across 12 Spanish radiotherapy centres. The primary endpoint was 1-year progression-free survival (PFS). The secondary endpoints included ove …

02.09.2026journal-article

Applied Immunohistochemistry & Molecular Morphology

Profiling NFκB and VEGF Expression in Mouse Embryonic Stem Cells, Lung Cancer Cells, and Fibroblasts

Berrin Ozdil, Eda Acikgoz, Gulperi Oktem, Kubilay Dogan Kilic, Huseyin Aktug

Cancer is one of the leading causes of morbidity and mortality worldwide, with lung cancer ranked among the most lethal malignancies. A key hallmark of cancer progression is neovascularization, primarily mediated by vascular endothelial growth factor (VEGF), which stimulates vasculogenesis and angiogenesis. In parallel, the transcription factor nuclear factor of kappa B (NFκB) plays a critical role in inflammation, immune regulation, and tumor development by modifying numerous signaling pathways. In this study, we …

02.09.2026journal-article

Journal of Chemical Technology and Metallurgy

EFFECT OF ULTRASONIC TREATMENT AND CALCINATION TEMPERATURE OF RICE HUSK ASH ON THE CHARACTERISTICS OF SILICA-CHITOSAN COMPOSITES

Ani Purwanti, Fajar Yulianto Prabowo

This study investigates the effect of calcination temperature and ultrasonic treatment during the extraction of silica from rice husk ash and its implications for the characteristics of silica-chitosan composites. Rice husk ash was calcined at temperatures of 500, 600, and 700°C, followed by extraction using 2M NaOH solution with and without ultrasonic treatment. The extracted silica was subsequently combined with chitosan to form silica-chitosan composites. Characterization was carried out using X-ray fluorescence …