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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Risk factors for Cefepime Resistance in Bacteria Causing Gram-negative Bloodstream Infections in a Children’s Cancer Center

Alexander Pruett, Jose Ferrolino, Ronald Dallas, Yilun Sun, Elisabeth Adderson

Abstract Background Strategies that seek to provide timely and effective therapy for febrile neutropenia (FN) in children with cancer or hematopoietic cell therapy (HCT) are threatened by increasing rates of antimicrobial resistance (AR). At our institution clinically stable patients with FN are treated with cefepime but this carbapenem-sparing strategy results in delays in the time to effective antimicrobial therapy and poorer clinical outcomes in patients with Gram-negative bloodstream infection (GNBSI) caused by …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

A Continental Perspective on Managing Antibiotics: Lessons Derived from Children's Cancer Units in Africa

Kauke Zimbwe, Alphonce Marrealle, Agness Chitedze, Reham Khedr, Stijn Verhulst, Bruno Raphael, Jaques van Heerden

Abstract Background Antimicrobial stewardship (AMS) in paediatric cancer services optimises antibiotic use to reduce the development of antibiotic resistance. Yet, very little has been published about AMS in African childhood cancer services. This study assessed AMS implementation, identified facilities offering paediatric cancer and AMS services, and gauged staff willingness in Africa to engage in educational programs for immunocompromised children. Methods A web-based, cross-sectional survey was conducted from Se …

29.08.2026journal-article

Cancers

Immunohistochemical and Transcriptomic Assessment of Cytochrome 2J2 in Prostate and Renal Cancer

Yousef M. Al-saraireh, Fatemah OFO Alshammari, Awad Dmour, Ahmed. A. Al-abadleh, Mohannad Ja’Awin, Marwan Herzallah, Fadi Sawaqed, Anas O. Satari, Sameeh A. Al-sarayreh, Sa’ed M. Al-dalain, Aiman Al-Qtaitat, Jehad M. Al Shuneigat, Abulmaaty M. Elsayed, Mohammad Salem Hareedy

Background: Cytochrome P450 2J2 (CYP2J2) has been implicated in tumor biology, but its expression pattern and clinical significance in prostate and renal cancers remain poorly characterized. Methods: Commercially available tissue microarrays containing 208 renal and 121 prostate tissue specimens were used for immunohistochemical (IHC) characterization of CYP2J2 protein expression. We performed transcriptomic analysis and examined correlations with clinicopathological features and survival using the OncoDB 2.0 platf …

29.08.2026journal-article

Biomedicines

BUB1 and CDK4/6 Dual Inhibition Increases Radiation Sensitivity in Glioblastoma, Lung Cancer, and Triple-Negative Breast Cancer

Shivani Thoidingjam, Sushmitha Sriramulu, Asya Haider Muratoglu, Rhea Hede-Sakhardande, Sunita Ghosh, Anthony J. Davis, Stephen L. Brown, Farzan Siddiqui, Benjamin Movsas, Corey Speers, Shyam Nyati

Background: Solid tumors including glioblastoma (GBM), lung cancer (LC), and triple-negative breast cancer (TNBC) exhibit marked radioresistance driven by dysregulated cell-cycle control and genomic instability. Although CDK4/6 inhibitors suppress tumor proliferation, their radiosensitizing capacity is limited by persistent DNA repair. BUB1, a mitotic checkpoint kinase overexpressed in aggressive cancers, has emerged as a regulator of DNA damage signaling. We tested whether co-targeting BUB1 and CDK4/6 enhances rad …

29.08.2026journal-article

Medical Oncology

Risk-adapted first-line therapy selection in advanced EGFR-mutant NSCLC: a practical clinical algorithm integrating tumor biology and patient factors

Ashish Sharma, Joecelyn Kirani Tan, Harendra Kumar, Hareesha Rishab Bharadwaj

Abstract Advanced EGFR -mutant non-small cell lung cancer (NSCLC), specifically tumors harboring classical activating mutations (exon 19 deletions and L858R substitutions, which are the exclusive focus of this review), is no longer a single-treatment landscape. The MARIPOSA and FLAURA2 phase 3 trials have established that combination regimens of amivantamab plus lazertinib and osimertinib plus platinum-pemetrexed, respectively, extend both progression-free and overall survival compared with osimertinib monotherapy. …

29.08.2026journal-article

Medical Oncology

FAK regulates leptin-induced angiogenesis and vasculogenic mimicry in breast cancer

Ana K. Herrera-Vargas, Ricardo Jaime-Cruz, Alejandra Rodríguez-Leviz, Miguel A. Mendoza-Catalán, Monserrat Olea-Flores, Laura Villavicencio-Guzmán, Marcela Salazar-García, Carlos C. Patiño-Morales, Napoleón Navarro-Tito

Abstract Leptin, an adipokine primarily secreted by adipose tissue, has been implicated in tumor progression by regulating angiogenesis. Leptin also plays a key role in tumor vascularization by promoting vasculogenic mimicry (VM). During tumor progression, leptin activates several signaling pathways, including the focal adhesion kinase (FAK) pathway. This study aimed to determine whether leptin promotes and regulates angiogenesis and VM through the FAK pathway. We used the chick chorioallantoic membrane (CAM) as a …

29.08.2026journal-article

Journal of Cancer Education

Digital Divide Among U.S. Adults with and without Cancer: Prevalence and Associated Factors

Yupawadee Kantabanlang, Shushun Ren, Misun Hwang, Rumei Yang, Abdul-Ghaniyu Alidu, Yun Jiang

Abstract Digital technologies have transformed healthcare, yet disparities persist, particularly among older adults and individuals with cancer. The digital divide encompasses not only access but also challenges in electronic communication and cognitive engagement, affecting health equity. This study examined the prevalence of three digital divide dimensions (Access, E-communication, and Cognitive Gaps) among U.S.adults with and without cancer and assessed their associations with sociodemographic factors, clinical …

29.08.2026journal-article

Journal of Medical Ultrasonics

Does the addition of contrast-enhanced ultrasonography to B-mode ultrasonography improve diagnostic accuracy for breast cancer? A systematic review and meta-analysis

Shotaro Inoue, Kazuaki Nakashima, Kazutaka Nakashima, Tomonari Kunihisa, Koichi Hirokaga, Kaori Tane, Yoshihito Goto, Takeo Nakayama

Abstract Purpose This study aimed to determine whether the addition of contrast-enhanced ultrasonography (CEUS) to B-mode ultrasonography improves diagnostic accuracy in differentiating benign from malignant breast lesions. Methods A comprehensive literature search was performed using PubMed (MEDLINE), Ichushi, and the Cochrane Library up to July 2025. Eligible studies assessed the diagnostic performance of CEUS for suspected breast cancer, with histopathology as the reference standard. Pooled sensitivity, specific …

29.08.2026journal-article

Turkish Journal of Cerebrovascular Diseases

Evaluation of inflammatory parameters in patients with acute distal middle cerebral artery occlusion treated with intravenous thrombolytic treatment

Recep Dönmez, Oruç Şahin

Objective: The aim of this study was to evaluate the association of various inflammatory parameters with early neurologic damage and three-month functional outcomes in patients with acute distal middle cerebral artery (MCA) occlusion who received intravenous thrombolytic treatment (IV tPA). Materials and Methods: This retrospective exploratory study included 75 patients who underwent IV tPA for distal MCA infarction and had complete clinical and laboratory data. Inflammatory indices were calculated from blood param …

29.08.2026journal-article

Information

Refined Graph-Guided Fusion Network for Explainable Multimodal Lung Cancer Classification Using CT Imaging and Semantic Features

Adiba Jafar, Raheela Asif, Syed Muslim Jameel

Classifying benign and malignant lung nodules from computed tomography (CT) images remains difficult because lung nodules can be hard to classify, and unimodal models cannot capture complementary diagnostic information. Despite the success of deep learning, existing methods rely only on image information and miss semantic information that can be obtained from an expert radiologist’s knowledge. Hence, the authors propose a new multimodal lung nodule classification model in this study, named the Graph-Guided Fusion N …

29.08.2026journal-article

Güncel Hemşirelik Araştırmaları Dergisi

Analysis of Scientific Publications on the Use of Artificial Intelligence in Childhood Cancer: A Descriptive Study

Bahar Aksoy, Şule Şenol, Süleyman Bilgin, Ali Coşkun Çoşar

Aim: This study aimed to analyze the scientific literature on the use of artificial intelligence (AI) in childhood cancers through a bibliometric approach, combining descriptive analyses with analytical synthesis to identify publication trends, leading countries, journals, institutions, and major research themes.Methods: A bibliometric analysis was conducted using publications retrieved from the Web of Science Core Collection database between 2003 and 2025. A total of 1.091 publications were included in the analysi …

29.08.2026journal-article

Journal of Pharmaceutical Health Care and Sciences

Association of telephone follow-up–based prescription proposals initiated by community pharmacists with oncology-related professional certification on quality of life of cancer patients receiving outpatient chemotherapy: a single-center observational study

Toshiki Nakamura, Kazunori Tamegai, Takeshi Sakamoto, Michinori Sakai, Masahiko Kimura, Takeshi Hirayama

Abstract Background The association of prescription proposal after telephone follow up (TFU) initiated by health insurance-covered pharmacy-based pharmacists (hereinafter “community pharmacists”) having oncology-related professional certification with patients’ quality of life (QOL) has not been elucidated. This study investigated changes in QOL before and after prescription proposals following TFUs in cancer patients receiving outpatient chemotherapy. Methods Cancer patients undergoing outpatient chemotherapy, who …

29.08.2026journal-article

African Journal of Pharmacy and Alternative Medicine

Efficacy of Senna occidentalis Leaf Extracts in the Treatment of Bacterial Gastroenteritis

Esther GEORGE NYADZUA, Onyango EVANDER OCHIENG, Lunani KEITH WAKASIAKA, Uhuru FAITH BERYL, Kariuki JOSHUA, Rop MOSES KIPLIMO, Titus SUGE, Michael WALEKHWA

Bacterial gastroenteritis remains a significant global health challenge due to the rising issue of antibiotic resistance and the high cost of conventional drugs, especially in low-resource settings. Addressing this gap, this study evaluated the efficacy of Senna occidentalis leaf extracts in treating bacterial gastroenteritis through an in vitro laboratory-based experimental design. Before the commencement of the study, an Ethical clearance certificate and a permit to conduct the study were sought from Kabarak Univ …

29.08.2026journal-article

BMC Cancer

Continued high mortality following diagnosis of HIV-associated Kaposi sarcoma in East Africa in the “Treat All” antiretroviral therapy era ― 2021-2024

Helen Byakwaga, Aggrey Semeere, Megan Wenger, Esther Freeman, Miriam Laker-Oketta, Elyne Rotich, Beatrice P. Mushi, Matthew Ssemakadde, Hilda Muwando, Bronia Mwine, Racheal Ayanga, Celestine Lagat, Sigrid Collier, Zainab Illonga, Robert Lukande, Philippa Kadama-Makanga, Pendo Ibrahim, Linda Chemutai, Toby Maurer, Charles Kasozi, Winnie Muyindike, Elia Mmbaga, David V. Glidden, Samson Kiprono, Kara Wools-Kaloustian, Andrew Kambugu, Jeffrey Martin

Abstract Background Stage at time of diagnosis and survival after diagnosis are critical parameters regarding control of any cancer in any geographical setting. In earlier research focusing on the initial years of the “Treat All” era (2016–2019), we found that HIV-associated Kaposi sarcoma (KS) in East Africa continued to be diagnosed at advanced stage of disease and conferred high mortality. Given the potential for broader implementation of “Treat All” as well as the announcement of National Comprehensive Cancer N …

29.08.2026journal-article

BMC Cancer

NU7441 reveals DNA-PK and BRD4 convergence as a therapeutic vulnerability in ovarian cancer

Julie A. Disharoon, Brandon C. Johnson, Elizabeth A. Ampolini, Natasha L. Curry, Abigail F. Quesnelle, Joe R. Delaney, David T. Long

Abstract BRD4 and DNA-PK play critical roles in regulating DNA repair, genome integrity, and cellular growth and proliferation, highlighting their potential as targets for cancer therapy. BRD4 is upregulated in multiple cancers, including ovarian cancer, where its expression increases during tumor development and correlates with poorer overall and progression-free survival. In this study, we provide evidence that NU7441, traditionally classified as a selective DNA-PK inhibitor, also functions as a BRD4 inhibitor by …

29.08.2026journal-article

BMC Complementary Medicine and Therapies

Chinese herbal medicine (Yiqi Huayu Jiedu Decoction) combined with chemotherapy for preventing postoperative recurrence and metastasis in elderly gastric cancer patients: protocol for a multicenter, double-blind, randomized, placebo-controlled trial

Peipei Yang, Jian Wang, Xiaoyu Wu, Ju Yang, Yan Sun, Xiaowei Wei, Jun Wu, Zhengxiang Han, Yanzhi Bi, Zhenguo Zhao, Ran Yang, Mengzhu Yang, Peng Shu

Abstract Introduction Gastric cancer (GC) has a generally unfavorable prognosis. Elderly patients often tolerate dual-drug chemotherapy poorly, experience limited benefits from monotherapy, and face high rates of postoperative recurrence and metastasis. To address this unmet clinical need, this study evaluates the efficacy and safety of Yiqi Huayu Jiedu Decoction (YHJD) combined with chemotherapy in preventing recurrence and metastasis in elderly patients with stage II/III GC after surgery. Method This is a multice …

29.08.2026journal-article

Journal of Interpersonal Violence

A Voluntary Prison-Hospital Treatment Program for Individuals Convicted of Sexual Offenses: A Prospective Evaluation Study

Patrick Lussier, Guillaume Masson, Guy Giguère, Maude Payant

In 2008, the provincial government approved a project for the implementation of a specialized treatment program (PETRAAS) in a prison setting in Quebec, Canada, for individuals convicted of sexual offenses. Dubbed a “prison-hospital,” the program was launched 2 years later as a joint initiative by the Ministry of Health and the Ministry of Public Safety to address the lack of a treatment program in provincial detention facilities for individuals serving short custodial sentences. Since 2010, PETRAAS offers a volunt …

29.08.2026journal-article

Genes

Transcriptional Heterogeneity Underlying Cancer Cell Migration Converges on Shared Regulatory Programs

Ismael Ortiz, Paul V. Taufalele, Victor L. Dunagan, Samantha S. Hodge, Jing Wang, Qi Liu, Cynthia A. Reinhart-King

Background/Objectives: Cancer cell migration is a hallmark of cancer and is associated with metastasis. While large-scale functional screens have identified regulators of migration, less is known about how intrinsic transcriptional heterogeneity drives highly migratory phenotypes within individual cancer models or whether these transcriptional changes are conserved across different models of varying tissues of origin. This study aims to define shared and cell line-specific transcriptional programs associated with c …

29.08.2026journal-article

Materials

Influence of Temperature on FLD and CLD Damping Treatment

Piotr Łabuński, Lucjan Witek, Paweł Obal

The damping capabilities of viscoelastic materials depend heavily on the operating temperature. Since these materials are used for passive vibration damping, it is necessary to determine the damping properties of selected materials across a range of temperatures. This paper presents the results of an experimental investigation into the effect of temperature on the damping performance of viscoelastic materials applied to aluminium cantilever beams using free-layer damping (FLD) and constrained-layer damping (CLD) te …

29.08.2026journal-article

Vaccines

From Universal Aspiration to Precision Immunization: A Hypothesis Framework for Antigen-Defined, HLA-Restricted Cancer Vaccines

Sarfaraz K. Niazi

Cancer vaccination addresses four distinct problems: preventing oncogenic infection, intercepting premalignant clones, clearing molecular residual disease, and treating established cancer. This hypothesis framework proposes seven sequential gates for antigen-defined, HLA-restricted T-cell vaccines: tumor specificity, natural peptide–HLA presentation, population coverage, persistence under immune selection, selective T-cell recognition, manufacturability, and randomized clinical benefit. The proposed architecture co …

29.08.2026journal-article

BMC Cancer

Establishing non-inferiority of rituximab plus lenalidomide in the treatment of advanced previously untreated follicular lymphoma

Jemma Perks, Alex Allen, Caroline Farmer, Sophie Robinson, G. J. Melendez-Torres

Abstract Background and purpose The current standard of care for first-line treatment for people with advanced (stage 3 or 4) follicular lymphoma (FL) is chemotherapy plus rituximab. Rituximab plus lenalidomide is an oral treatment which has been shown to be an effective alternative treatment. In order to support a license extension application for lenalidomide in this indication, NHS England considered the re-analysis of the RELEVANCE trial to determine whether the treatments can be shown to be statistically and c …

29.08.2026journal-article

Journal of Food Science

Dietary‐Derived Corchorus olitorius L. Extract Suppresses KRAS‐Mutant Pancreatic Cancer by Activating Ferritinophagy‐Dependent Ferroptosis

Chiao‐Yun Tseng, Hui‐Hsuan Lin, Charng‐Cherng Chyau, Pei‐Rong Yu, Yu‐Hsuan Liang, Yueching Wong, Jing‐Hsien Chen

ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by frequent activating mutations in the Kirsten rat sarcoma viral oncogene homologue (KRAS) and limited therapeutic options. Corchorus olitorius L., a traditional edible plant widely consumed in Asia, possesses documented anti‐inflammatory properties; however, its anticancer potential remains unclear. This study investigated whether Corchorus olitorius L. leaf extract (COE) induces ferroptosis in KRAS‐mutant pancreatic …

29.08.2026journal-article

Discover Computing

High-performance next-generation screening technology system using teaching–learning-based optimization for cancer detection

Alok Kumar Shukla, Shubhra Dwivedi, Sunil Kumar Singh, Neeraj Kumar Sharma

Abstract Early and accurate detection of breast cancer remains challenging due to high-dimensional clinical data, feature redundancy, and limitations of existing diagnostic decision systems. To address these issues, this study proposes a hybrid feature selection and classification framework that improves prediction performance while reducing overfitting. The method combines a filter-based ReliefF algorithm with a wrapper-based Teaching–Learning-Based Optimisation (TLBO), referred to as Re-wTLBO, to identify a compa …

29.08.2026journal-article

Advanced Science

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Lei Wang, Xiaoyan Li, Yiran Liang, Yifei Wang, Yuhan Jin, Jianing Wang, Dan Luo, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Wenjing Zhao, Bing Chen, Lijuan Wang, Qifeng Yang

ABSTRACT Triple‐negative breast cancer (TNBC) is characterized by high metastatic tendency and poor prognosis, largely driven by dynamic crosstalk between cancer cells and the tumor microenvironment (TME). Cancer‐associated fibroblasts (CAFs) are a major component of the TME, yet their functional contributions to TNBC progression remain incompletely understood. In this study, we isolated exosomes from patient‐derived CAFs and normal fibroblasts (NFs), and profiled their circRNA content using RNA sequencing. circFAD …