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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Journal of Clinical Psychopharmacology

The Randomization Effect in a Double-Blind Placebo-Controlled Depression Study

Steven D. Targum, Paulette Ceesay, Christopher Lines, Michael E. Thase, Gerard Sanacora, Aristide Merola

Background: Double-blind, placebo-controlled trials are often affected by higher-than-anticipated placebo responses that may contribute to study failure. It is common to observe symptomatic improvement immediately after randomization regardless of treatment allocation. Methods: This post hoc analysis examined the early randomization effect in a recent 4-week double-blind, placebo-controlled study that examined a novel presynaptic mGluR2 inhibitor, MK-1942, in a daily or twice-weekly dosing strategy versus placebo a …

02.09.2026journal-article

Journal of Clinical Medicine

International Imaging Practices for Sacroiliac Joint MRI Acquisition Protocols in Patients with Juvenile Spondylarthritis

Arthur B. Meyers, Mirkamal Tolend, Walter P. Maksymowych, Rawan Hafiz, Tarimobo M. Otobo, Jacob L. Jaremko, Robert G. W. Lambert, Nele Herregods, Marion A. J. van Rossum, Jennifer Stimec, Simone Appenzeller, Shirley Tse, Philip G. Conaghan, Lennart Jans, John A. Carrino, Eva Kirkhus, Joke Dehoorne, Pamela F. Weiss, Andrea S. Doria

Background/Objective: International recommendations exist for MRI evaluation of sacroiliac joints (SIJs) in adult spondylarthritis (SpA) and other joints in juvenile (J)SpA. However, consensus recommendations for MRI acquisition protocols for SIJs in JSpA are lacking. Our survey gathered information on current imaging practices on SIJ MRI and expert opinions about imaging protocols. Methods: A survey was sent to an international group of pediatric radiologists and rheumatologists. Participants were asked about prac …

02.09.2026journal-article

ACS Nano Medicine

CompELS vs SELEX: Comparative Aptamer Discovery Integrating Rational Libraries and Enzymatic Elution

Steven Ochoa, Valeria Tohver Milam

Abstract Aptamers are oligonucleotides that fold into structures with target-binding activity comparable to antibodies, yet their discovery remains laborious and inconsistent. Traditional Systematic Evolution of Ligands by Exponential Enrichment (SELEX) screening often relies on randomized sequence libraries, repeated amplification, and harsh elution methods, each of which introduces bias and limits reproducibility. An alternative aptamer screening platform called Competition-Enhanced Ligand Selection (CompELS) emp …

02.09.2026journal-article

Clinical Spine Surgery

Biportal Endoscopic Cervical Laminectomy for Cervical Myelopathy

Jueun Kim, Maximillian Y. Lee, Daniel K. Park

Study Design: Retrospective review. Objective: To analyze the clinical and radiologic outcomes of biportal endoscopic cervical laminectomy (BECL) for cervical myelopathy. Summary of Background: Cervical myelopathy is a progressive disease caused by spinal cord compression that significantly impacts quality of life. While open posterior surgeries have been utilized, they carry risks such as postoperative instability, kyphosis, and muscle damage. BECL has emerged as a minimally invasive technique designed to minimize …

02.09.2026journal-article

Psicologia e Saúde em debate

PLANTÃO PSICOLÓGICO NO CONTEXTO HOSPITALAR: Um ensaio sobre riscos psicossociais e a interface entre clínica e gestão

Jurema Barros Dantas

Objetiva-se analisar o plantão psicológico no contexto hospitalar como dispositivo clínico-institucional capaz de contribuir para a identificação, compreensão e enfrentamento dos riscos psicossociais relacionados ao trabalho, à luz das diretrizes estabelecidas pela Norma Regulamentadora nº 1 (NR-1). Trata-se de um ensaio teórico de caráter reflexivo e crítico, fundamentado nos referenciais da fenomenologia, da clínica ampliada, da saúde coletiva, da saúde do trabalhador e da psicodinâmica do trabalho. A discussão f …

02.09.2026journal-article

Clinical Cancer Research

Phase I Trial of IL13Rα2-Targeted CAR T-cell Therapy for Recurrent Malignant Glioma: Clinical Results and Pharmacokinetics

Kiwan Kim, Seong-Won Song, Yeongha Jeon, Soyoung Choi, Jiyoun Choi, Sungmin Jun, Ju-Hwang Park, Song-Jae Lee, Nayoung Han, Yun-Sik Dho, Sang-Hoon Shin, Heon Yoo, Kyu-Chang Wang, Ho-Shin Gwak

Abstract Purpose: This single-center, open-label, phase I trial evaluated the safety and tolerability of chimeric antigen receptor (CAR) T cells targeting interleukin 13 receptor α2 (IL13Rα2) in patients with malignant gliomas. Patients and Methods: Adults with World Health Organization grade 3 to 4 gliomas, recurrent after standard treatment and expressing IL13Rα2 (confirmed by immunohistochemistry), received a single intravenous infusion of autologous CAR T cells. Primary objectives were to measure the maximum to …

02.09.2026journal-article

Weather and Forecasting

Winter Precipitation Type Diagnosis and Uncertainty Quantification with a Physically Consistent Machine Learning Method

Charlie Becker, David John Gagne II, Julie Demuth, John S. Schreck, Jacob Radford, Gabrielle Gantos, Eliot Kim, Dhamma Kimpara, Sophia Reiner, Justin Willson, Christopher D. Wirz

Abstract Accurately forecasting winter precipitation type and its transitions is critical for high-impact decision making. However, existing methods struggle in thermodynamically ambiguous regimes, and most do not quantify forecast uncertainty from a single model run. We developed an evidential neural network that predicts calibrated probabilities for four winter precipitation types (rain, snow, freezing rain, and ice pellets) along with epistemic uncertainty estimates at the computational cost of a standard neural …

02.09.2026journal-article

Journal of Intensive Care Medicine

Comparison of Midline Venous Catheters Versus Peripherally Inserted Central Catheters for Intravenous Therapy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Kumail Mustafa Ali, Hafsa Ahmed, Syeda Fatima Mustafa Zaidi, Talha Khalid, Ahmed Hasan, Urooba Mughal, Ibrahim Zulfiqar Ali, Farida Khan Kakar, Muhammad Hamza, Samina FNU, Rohin Kumar, Suraksha Rani, Tayyaba Uzair, Ahmed Mustafa Rashid

Background Midline venous catheters (MVCs) have been encouraged as alternatives to peripherally inserted central catheters (PICCs) for intermediate to long-term intravenous therapy. However, randomized controlled trials (RCTs) have reported contradictory findings regarding their comparative safety and resilience. We aim to compare MVCs and PICCs in patients receiving intravenous therapy. Methods PubMed/MEDLINE, Embase, Scopus, and the Cochrane Central databases were searched from inception through March 2025. RCTs …

02.09.2026journal-article

Medicine and Pharmacy Reports

The clinical effects of an intravenous perioperative lidocaine infusion during hepatectomy: a pilot study

Sergiu Sargarovschi, Andreea Abouritei, Ioana Rucsanda, Dan Valean, Raluca M. Hategan, Daniela Ionescu

Background. Intravenous (i.v.) lidocaine exhibits multimodal analgesic, anti-inflammatory, and anticancer properties. However, concerns regarding systemic toxicity and impaired hepatic drug clearance during liver resection necessitate caution in perioperative dosing protocols. This study aimed to evaluate the clinical recovery parameters and systemic inflammatory markers following continuous perioperative i.v. lidocaine infusion in patients undergoing elective hepatectomy for hepatocellular carcinoma (HCC). Methods …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Hidden Burden of Cystic Echinococcosis in Arequipa, Peru: An Unrecognized Population at Risk

Ricardo Castillo-Neyra, Wilfredo Victor Gutiérrez Zarate, María Paula Requena-Herrera, Lizzie Ortiz-Cam, Guillermo Porras, Jesus Marcelo Manturano Lopez, Jose Fernando Macedo Milla, Jorge L. Cañari-Casaño, Javier A. Bustos

ABSTRACT. Peru carries the highest burden of cystic echinococcosis (CE) in South America, yet major geographic gaps persist in understanding the distribution and intensity of the disease. The Arequipa region in southern Peru has historically been considered nonendemic, with no previous systematic clinical characterization of CE, despite increasing reports. Clinical records of 129 of 177 CE surgical cases treated between December 2011 and November 2013 at a government-funded CE surgical unit at a major referral hosp …

02.09.2026journal-article

IECCMEXICO

Optimizing Elective Surgical Access: Integrated Strategies for Waiting-List Prioritization, Efficiency, Equity, and Clinical Outcomes

Valeria Hidalgo Figueroa, Susana María López Rojas, Keren Abigail Saynes Jarquin, Ana Carla Naranjo González, Pedro Aníbal Bailón de la O, Jaime Héctor Cisneros Sandoval, Blas David Santana Perez, Martín Ham San Martín

Surgical waiting lists represent a major challenge for healthcare systems because prolonged delays can affect not only service efficiency but also patient function, quality of life, equity of access, and clinical outcomes. This study analyzed the principal strategies used to manage elective surgical waiting lists, with emphasis on patient prioritization, referral management, cancellation prevention, perioperative efficiency, and dynamic reassessment. A structured review of the literature was conducted using evidenc …

02.09.2026journal-article

Problems of Gathering Treatment and Transportation of Oil and Oil Products

DEVICES FOR CLEANING WATER SURFACES FROM OIL POLLUTION

V.D. Katin, A.N. Lutsenko, M.A. Potetyurin

The problem of environmental pollution from oil and its byproducts has become particularly acute in recent decades. Despite technological advances and stricter safety measures, the transportation and storage of these substances remain high-risk. Regular accidents cause serious damage not only to the economy but, more importantly, to the fragile natural balance. When oil spills into water, the consequences are always dire: fish and microorganisms die, birds lose their ability to fly, natural oxygen exchange is disru …

02.09.2026journal-article

Medical Care

Trade-Offs Between Patient Experience and Health Care Access

Michelle S. Wong, W. Neil Steers, Kimberly E. Lind, Donna L. Washington

Background: Racial and ethnic disparities in patient-reported experiences exist in the Veterans Health Administration (VA) and in VA-paid health care from non-VA providers (“community care”), but how these disparities compare is unknown. Objectives: We compared racial and ethnic disparities in patient-reported experiences between VA primary care and community care, and calculated differences in VA versus community care by patient race and ethnicity. Methods: Using cross-sectional data from the 2020 to 2023 VA Surve …

02.09.2026journal-article

Orthopaedic Surgery

Global Alignment and Proportion ( GAP ) Score in Predicting Mechanical Complications After Long‐Segment Fixation for Chinese Geriatric Patients With Adult Degenerative Scoliosis: A Mid‐Term Comparative Study

Xiangyao Sun, Jiang Huang, Yuqi Liu, Siyuan Sun, Li Cao, Juyong Wang, Shibao Lu

ABSTRACT Objectives The predictive value of the global alignment and proportion (GAP) score in the Chinese geriatric population, which has unique demographic and degenerative characteristics, has not been validated. Given the high incidence of mechanical complications in this specific cohort, a dedicated mid‐term evaluation is essential to guide surgical planning. To address this gap, this study aimed to analyze the accuracy and characteristics of the GAP assessment system in predicting mechanical complications fol …

02.09.2026journal-article

UAEU Law Journal

ضوابط استخدام تقنية النانو في المجال الطبي: دراسة تأصيلية

حبيبة يوسف جاما علي, محمد سليمان النور

تقوم الدراسة حول بيان مفهوم تقنية النانو وتطبيقاتها الطبية المعاصرة، وما تنطوي عليه هذه التقنية من مصالح ومفاسد، كما تهدفُ إلى توظيف النظر الاجتهادي في المسألة بالاستهداء بالأدلة العامة، والمقاصد الشرعية، والقواعد الفقهيّة تمهيدًا لبيان الحكم الشرعي في المسألة.وقد اتبعتُ في هذا البحث المنهج الاستقرائي بتتبع المادة العلمية من مظانها، والمنهج الوصفي لوصف المسألة وفق ما قرره أهل الخبرة والاختصاص، واستعنت بالمنهج التحليلي لتحليل الأدلة والنصوص والنظر في المقاصد الشرعية والقواعد الفقهية؛ لاستنباط الحكم الشرعي للمسألة، و …

02.09.2026journal-article

Annals of Surgery

Safety and Performance of the Colovac Anastomosis Protection Device. A Pooled Analysis of Prospective Studies Compared With Diverting Loop Ileostomy (SAFE-2025)

Patricia Sylla, Katherine Lam, Niels Komen, Jean-Jacques Tuech, Antonio Spinelli, Joseph Martz, Rebecca Rhee, Jorge Marcet, Guy Bernard Cadière, Philippe Rouanet, Aleksei Karachun, Quentin Denost, Narkhodzha Sametdinov, Andre D’Hoore, Sang Lee, Jérémie H. Lefèvre

Objective: To compare the safety and effectiveness of the Colovac Anastomosis Protection Device with standard diverting ostomy (DO) following low anterior resection (LAR) for rectal cancer. Summary Background Data: DO is standard of care (SOC) following LAR for rectal cancer but is associated with substantial morbidity. Colovac Device is designed to divert the fecal stream away from the anastomosis intraluminally. Methods: Three prospective multicenter Colovac trials were pooled and compared with a prospective coho …

02.09.2026journal-article

Pure and Applied Chemistry

Development of functional materials for the microplastics removal and treatment in surface water

Fio Febrian, Henny Purwaningsih, Mohammad Khotib

Abstract Microplastics (MPs) are persistent emerging contaminants increasingly detected in aquatic environments and pose potential risks to ecosystems and human health. Conventional single-stage removal technologies may be limited by their treatment efficiency and operational costs. This study aimed to develop a sustainable integrated approach for MP removal by combining aluminum chlorohydrate (ACH) coagulation, polyacrylamide (PAM) flocculation, and column adsorption using phosphoric acid (H 3 PO 4 )-activated bio …

02.09.2026journal-article

Journal of Clinical Medicine

Beyond Binary ICU Admission: Duration-Sensitive Evaluation and Patient-Level Reclassification of Textbook Outcome After Colorectal Cancer Surgery

Adem Ozcan, Gizem Gunes, Ali Bal, Abdulkadir Unsal

Background/Objectives: Textbook outcome (TO) is an all-or-none composite in which a common, practice-sensitive component may exert disproportionate influence on patient classification. We evaluated the classification impact of binary postoperative intensive care unit (ICU) admission and the additional information retained by actual ICU duration after colorectal cancer surgery. Methods: This retrospective single-center cohort included 241 patients undergoing colorectal cancer resection between 2020 and 2026. Compreh …

02.09.2026journal-article

Bioinformatics

Identifying expanding TCR clonotypes with a longitudinal Bayesian mixture model and their associations with cancer patient prognosis, metastasis-directed therapy, and VJ gene enrichment

David Swanson, Alexander Sherry, Cara Haymaker, Alexandre Reuben, Chad Tang

Abstract Motivation Examination of T cell receptor (TCR) clonality has become a way of understanding immunologic response to cancer and its interventions in recent years. An aspect of these analyses is determining which receptors expand or contract statistically significantly as a function of an exogenous perturbation such as therapeutic intervention. Results We characterize the commonly used Fisher’s exact test approach for such analyses and propose an alternative formulation that does not necessitate pairwise, wi …

02.09.2026journal-article

Pain Medicine

Does the National Resident Matching Program Rank List Predict Accreditation College of Graduate Medical Education Trainee Performance Among Multispecialty Pain Medicine Fellows? A Multicenter Study

Steven P Cohen, Oludare O Olatoye, Peter Schumaker, Dalia Elmofty, Heejung Choi, Bhavana Yalamuru, Lynn R Kohan

Abstract Background Training programs seek to match fellows who will perform well during training. The National Resident Matching Program (NRMP) allows programs to choose the most capable trainees, with higher ranked applicants expected to perform better. Pain medicine is one of the most popular non-internal medicine fellowships in the U.S., and multiple specialty pathways for entry make selecting candidates challenging. Objective The aim of this study is to correlate fellow rank order and match number with academi …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Prevalence of Parasitic Diseases among Internally Displaced Persons, Ethiopia, 2024

Yohannes Shimelis Masresha, Gizachew Tadesse Wassie, Carolyn Strobel, Francisco Averhoff, Gavin Cloherty, Steven S. Yoon

ABSTRACT. Parasitic diseases remain a major public health concern globally, particularly among vulnerable populations such as internally displaced persons (IDPs), i.e., people who relocate within their own countries due to conflict, natural disasters, or other crises. We assessed the prevalence and associated factors of schistosomiasis, geohelminthiasis, and anemia among IDPs in Ethiopia. We conducted a cross-sectional survey during March and April 2024 among IDPs in camps located in Debre Birhan, Ethiopia. Stool s …

02.09.2026journal-article

LUMEN ET VIRTUS

MANEJO DA SÍNDROME DE ABSTINÊNCIA ALCOÓLICA GRAVE: ESTRATÉGIAS ATUAIS PARA PREVENÇÃO DE CONVULSÕES E DELIRIUM TREMENS

Laysa Cordeiro Cavalcanti Nunes, Nathália Déo Gasparotto, Matheus Pereira Do Vale, Bruna Bastos Bezerra, Luisa Bastos Bezerra, Gabriella Lara Silva Santos, Heder Albuquerque Azevedo Rocha, Antonio Jose Angulo Mora, Ágata Raposo De Medeiros, Isadora Casagrande Amalcaburio, Maria Eduarda dos Santos Pinto, Amanda Andressa de Souza Carvalho, Eberson da Silva Rodrigues Do Nascimento, Wanuelly Andreza Silva Melo, Vitória Ferreira Alves, Gianluca Homero Rebelo De Souza, Gustavo Fleury Gomes Ferreira, Maria Fernanda Mendes De Andrade, Lucca Corcini Biscaino, Bruna Letícia Olinda Vieira Moreira, Lyvia Rodrigues Parreira Braga, Debora Dias Figueiredo Veloso, Márcio José de Carvalho Lima, Emerson Renê de Souza Cordeiro, Adriel Dias Marinho Da Silva

A síndrome de abstinência alcoólica grave constitui uma emergência clínica potencialmente fatal, sobretudo pela ocorrência de convulsões e delirium tremens. Este estudo teve como objetivo analisar as evidências atuais sobre estratégias de prevenção e manejo dessas complicações em adultos. Realizou-se uma revisão integrativa da literatura, de abordagem qualitativa e caráter clínico-prático, com busca nas bases PubMed/MEDLINE, Scopus, SciELO e ScienceDirect, contemplando estudos publicados entre 2016 e agosto de 2026 …

02.09.2026journal-article

Journal of Clinical Medicine

Considerations in Using Artificial Intelligence to Simulate Orthodontic Treatment for Implant-Prosthetic Purposes

Amelia Smaranda Roșianu, Sanda Mihaela Popescu, Daniel Adrian Târtea, Stelian Mihai Sever Petrescu, Răzvan Mercuț, Marina Olimpia Amărăscu, Mihaela Ionescu, Ionuț Cristian Reşceanu, Alin Gabriel Ionescu

Background/Objectives: Orthodontic treatment planning software with artificial intelligence has been introduced into practice in recent years. They allow the simulation of the results of orthodontic treatment in several scenarios. The aim of the study was to compare the results of a simulated preimplantation orthodontic treatment plan in cases of oral rehabilitation between two software, with three different setups and their evaluation by an orthodontist. Methods: The in silico study included 10 cases of digital mo …

02.09.2026journal-article

Journal of Wound Care

Risk factors for pressure ulcer development among adults undergoing surgery: a systematic review

Sadie Badrie, Pinar Avsar, Sherly George, Shijimol Kurian, Zena Moore, Hannah Wilson

Objective: To examine risk factors for pressure ulcer (PU) development among adults undergoing surgery. Method: A total of five electronic databases were searched from inception to March 2024. Study selection, data extraction and quality appraisal were performed by two independent reviewers, using the Crowe Critical Appraisal Tool (CCAT v1.4; Michael Crowe, James Cook University, Australia), with scores ≥75% indicating high methodological quality. Results were categorised and reported as preoperative, intraoperativ …