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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Clinical Cancer Research

EZH2 Inhibition and Myeloid Risk: A Feature of On-Target Biology

Joshi J. Alumkal, Leigh Ellis

Abstract In March 2026, Ipsen voluntarily withdrew the enhancer of zeste homolog 2 (EZH2) inhibitor tazemetostat (Tazverik) from all markets and indications following results from the confirmatory phase Ib/III SYMPHONY-1 trial demonstrating hematologic second primary malignancies (SPM) in 5.7% of treated patients, compared with none in the control arm. The most frequently reported SPMs were myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Although this finding may be interpreted as an idiosyncratic …

28.08.2026journal-article

Journal of Plant Protection Research

Seed treatment strategies combining Bacillus amyloliquefaciens and insecticides for management of the emerging soil pest Scutigerella immaculata in soybean

Adilson Moraes Santos, João Batista Coelho Sobrinho, Yamile Salvatierra Nuñez, Luciana Barboza Silva, Matheus Henrique dos Santos Oliveira, Allison Samara Zabala Ramos, Lucas Adjuto Ulhoa, Jardel Lopes Pereira, Luiz Leonardo Ferreira, Alexandre Igor Azevedo Pereira

Scutigerella immaculata (Symphyla: Scutigerellidae) causes increasing problems in soybean-producing areas of Brazil, particularly in MATOPIBAPA, one of the country’s most recent agricultural frontiers. This study evaluated soybean seed treatments for the control of S. immaculata, using Bacillus amyloliquefaciens applied alone or combined with chemical insecticides, and assessed pest sampling methods and soybean responses to these treatments. Soybean seeds were treated on the day of planting in the municipality of A …

28.08.2026journal-article

Frontiers in Oncology

Risk factors for postoperative intensive care unit admission after minimally invasive esophagectomy following neoadjuvant chemoimmunotherapy in patients with esophageal squamous cell carcinoma: a retrospective cohort study

Zhen Chen, Zhi-jing Liu, Qiu-xia Liu, Peng-fei Chen, Yu-cai Jiang

Introduction Patients with esophageal squamous cell carcinoma (ESCC) who undergo minimally invasive esophagectomy (MIE) after neoadjuvant chemoimmunotherapy (nCIT) and subsequently require postoperative intensive care unit (ICU) admission may experience a greater economic burden and poorer clinical outcomes. This study aimed to identify perioperative factors independently associated with postoperative ICU admission in patients with ESCC treated with nCIT followed by MIE. Methods We conducted a retrospective cohort …

28.08.2026journal-article

Frontiers in Oncology

Acquired TPM3::NTRK1 fusion as a novel off-target resistance mechanism to selpercatinib in RET-positive lung adenocarcinoma: a case report

Ritwika Choudhury, Mansi Sharma, Abhinav Dewan, Sabeena K. Choudhary, Priyanka Venkatraman, Vivek Subbiah, Ullas Batra

Acquired resistance remains a major challenge in RET fusion-positive non-small cell lung cancer treated with selective RET inhibitors. NTRK fusions represent a rare off-target resistance mechanism in this setting, with limited clinical data to guide management. We report the first case of an acquired TPM3::NTRK1 fusion as a resistance mechanism to selpercatinib in KIF5B::RET-positive lung adenocarcinoma. A male in his late 40s, a non-smoker, underwent surgical resection for NSCLC after incidental detection of a pul …

28.08.2026journal-article

MedComm

SPR‐UPLC‐QTOF/MS‐GNPS‐Guided Discovery of Hypermonol J as a Novel Tumor Necrosis Factor‐Binding Small‐Molecule Lead for Inflammatory Storm Intervention

Yongqi Li, Weiguang Sun, Xingpiao Jin, Lanqin Li, Xiaotian Zhang, Pingping Fan, Yahui Huang, Chaohu Xiong, Jinsheng Wang, Jiangchun Wei, Yonghui Zhang, Zhengxi Hu

ABSTRACT This study developed an integrated strategy combining surface plasmon resonance (SPR) for real‐time biomolecular interaction analysis, ultra‐performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry (UPLC‐QTOF/MS) for compound profiling, and Global Natural Products Social Molecular Networking (GNPS)‐based molecular networking for structural annotation in complex herbal systems. Using this platform, we identified hypermonol J (HPJ), a polycyclic polyprenylated acylphlorogluc …

30.08.2026journal-article

Česká gynekologie

Treatment of stress urinary incontinence using a single incision sling, quality of fixation of implants into the obturator complex and its influence by infiltration anesthesia

Petr Kolek, Tereza Duchoňová

This article reviews current surgical options for treatment of stress urinary incontinence (SUI), focusing on Single Incision Sling (SIS) systems and the effect of infiltration anesthesia on implant fixation within the obturator complex. By analyzing the current literature, this study highlights the advantages of minimally invasive approaches – such as reduced surgical burden, shorter recovery time, and lower economic costs – while identifying their limitations in long-term efficacy. Anatomical and technical factor …

28.08.2026journal-article

World Journal of Gastroenterology

Non-exonuclease domain POLE mutations and their biological significance in colorectal cancer

Ilektra Kyrochristou, Gerasimia D Kyrochristou, Georgios D Lianos

Recent advances in colorectal cancer (CRC) genomics have expanded the understanding of molecular alterations beyond the traditional mismatch repair/microsatellite instability framework. While exonuclease domain mutations (EDMs) in DNA polymerase epsilon (POLE ) are established drivers of ultra-mutated, immunogenic tumors with favorable responses to immune checkpoint inhibition, growing evidence suggests that non-EDMs may also carry biological and clinical significance. Emerging data indicate that non-EDM POLE varia …

28.08.2026journal-article

Frontiers in Oncology

IFI44L modulates chemoradiotherapy sensitivity and CD8+ T cell infiltration in colorectal cancer

Linlin Zheng, Mengjie Li, Ruoqing Yan, Wen Tan

Objective Chemoradiotherapy (CRT) represents a cornerstone treatment for colorectal cancer (CRC), yet heterogeneous responses to CRT in treatment response remain a major clinical challenge. Increasing evidence suggests that the tumor immune microenvironment (TME) especially intratumoral CD8 + T cells plays an important role in determining CRT efficacy; however, the molecular mechanisms linking tumor-derived factors to immune-mediated treatment sensitivity remain poorly understood. Here, we aimed to identify and cha …

28.08.2026journal-article

Science, Engineering and Technology

A Lightweight Explainable AI Framework for Early Brain Tumor Detection Using EEG Functional Connectivity

Haider TH. Salim AlRikabi, Mohand Lokman Al Dabag, Razan Abdulhammed, Hussain Ali Mutar, Ibtihal Razaq Niama ALRubeei, Shaima Miqdad Mohamed Najeeb

Early identification of brain tumors is an important technique for timely clinical assessment, but magnetic resonance imaging (MRI) and computed tomography (CT) remain the primary modalities for anatomical confirmation and tumor localization. Electroencephalography (EEG) provides a non-invasive and comparatively accessible complementary modality that can capture functional alterations in neural activity. This study presents Graph EEG Net-Lite, a lightweight and explainable graph neural network for auxiliary brain t …

28.08.2026journal-article

Medicina

Clinical Outcomes of COVID-19 Convalescent Plasma According to Treatment Timing and ELISA Antibody Levels: A Real-World Retrospective Cohort Study

Özlem Bayraktar Saral, Ayla Yavuz, Şenol Ardıç, Tuncay Yazıcı, Serap Özer Yaman

Background and Objectives: Convalescent plasma (CP) was widely used during the early phase of the COVID-19 pandemic; however, evidence regarding its clinical benefit has remained inconsistent. This study evaluated the associations of CP administration timing and the ELISA antibody level of the transfused unit with clinical outcomes among patients with COVID-19. Materials and Methods: This retrospective real-world cohort study included 272 adults with RT-PCR-confirmed COVID-19 who received a single CP unit at the Un …

28.08.2026journal-article

Frontiers in Immunology

CEA-targeted CAR-NK cells derived from embryonic stem cells exhibit potent anti-tumor activity against colorectal cancer

Gaohua Li, Lingping Zhao, Jingzhi Shen, Haiyang Wang, Jinru He, Yiming Liu, Ruge Zang, Tiantian Cui, Quan Zeng, Junnian Zhou, Wen Yue, Yanan Wang, Jiafei Xi

Background Carcinoembryonic antigen (CEA) is overexpressed in most colorectal cancers (CRC) and serves as a promising immunotherapeutic target. However, current immune cell therapies against CRC show limited clinical efficacy, and the lack of renewable, standardized cell sources hampers broader application. The present study aimed to establish a scalable source of CEA-targeted natural killer (NK) cells from engineered human embryonic stem cells (hESCs). Methods hESCs were genetically engineered to express a CEA‑spe …

28.08.2026journal-article

Farmatsevtychnyi zhurnal

Marketing research of medicinal products used for the treatment of primary cicatricial alopecia

N. P. Darzuli, N. M. Maksymovych, О. М. Zaliska

Primary cicatricial alopecias belong to a group of chronic inflammatory diseases of the hair follicles that lead to their irreversible destruction and the formation of scar tissue. The complexity of diagnosis, limited therapeutic options, and the lack of unified approaches to treatment necessitate an assessment of the current range of medicinal products available for the pharmacotherapy of this pathology. The aim of the study was to investigate the structure and range of medicinal products on the domestic pharmaceu …

28.08.2026journal-article

Nurse Educator

Clinical Severity and the Mental Health Treatment Gap Among Nursing Students: Findings From the Healthy Minds Study

Lisa M. Black Thomas

Background: Nursing students report high rates of psychological distress, but how their use of mental health treatment varies with symptom severity is unclear. Purpose: To describe mental health symptom prevalence and treatment use among nursing students and examine the association between clinical severity and help-seeking. Methods: Secondary analysis of 2024 to 2025 Healthy Minds Study data from nursing students (N = 5817). Depression and anxiety were measured with the PHQ-9 and GAD-7; suicidality and past-year t …

28.08.2026journal-article

Applied Sciences

Mining and Metallurgical Waste Valorization for Water Treatment: A Review

Vladimir Efremov, Gaukhar Smagulova, Aigerim Imash, Kaster Kamunur, Lyazzat Mussapyrova, Aisulu Batkal, Ryskul Azhigulova, Aisulu Zhussupova, Anton Kononov

Mining and metallurgical wastes contain reactive Fe-, Al-, Ca-, Mg-, and Mn-bearing phases. These phases can be used for water treatment. Their performance depends on mineral accessibility, processing history, and water chemistry rather than waste identity alone. This review compares tailings, slags, red mud, and leaching residues for inorganic and organic contaminant removal, focusing on mechanisms, modification intensity, and validation. Cations are removed by ion exchange, surface complexation, and precipitation …

28.08.2026journal-article

Swiss Medical Weekly

Management of chronic non-cancer pain in Swiss nursing homes: an observational mixed-methods study

Florent Macé, Marion Yerli, Damien Cateau, Tosca Bizzozzero, Isabelle Levasseur, Anne Niquille

STUDY AIMS: The management of chronic non-cancer pain in nursing home residents represents a major challenge, given the complexity and fragility of this population. The aim of this study was to evaluate professional practice in this management in nursing homes of the French-speaking part of Switzerland. METHODS: Our observational study was based on a panel of 124 nursing homes in the Vaud canton. Two convergent parallel approaches were carried out to collect data: an online questionnaire for nurses and referring ph …

28.08.2026journal-article

AlQalam Journal of Medical and Applied Sciences

Knowledge, Attitude and Practice of Breast Self-Examination and Breast Cancer Risk Factors among Female Medical Students at the University of Benghazi

Asma Salem, Yatreb Alkhbulli, Mohammed Albahloul, Fatma Ziuo, Hamzah Shaeroun, Bissane Aboudaya

Breast cancer (BC) is the most common malignancy among women globally and a leading cause of cancer-related mortality in Libya, where late-stage diagnosis remains prevalent. Breast self-examination (BSE) is a low-cost, accessible screening tool particularly valuable in resource-limited settings. This study assessed the knowledge, attitudes, and practices (KAP) of BSE, as well as awareness of BC symptoms, risk factors, and protective factors among female medical students at the University of Benghazi. A descriptive …

28.08.2026journal-article

Genes

Genome-Wide Analysis of Alternative Splicing Identifies a Prognostic Signature in ER-Positive Breast Cancer

Ahmed M. Basudan, Yazeed Alshuweishi, Hamood AlSudais, Mohammad A. Alfhili

Background/Objectives: Alternative splicing (AS) contributes substantially to transcriptomic diversity and has emerged as an important regulator of cancer progression. However, the genome-wide characterization of AS events specific to estrogen receptor (ER)-positive breast cancer remains limited. This study aims to comprehensively profile AS in ER-positive breast cancer and identify a prognostic AS signature associated with patient outcome. Methods: Clinical and splicing data (Percent Spliced In values) were obtain …

28.08.2026journal-article

Cells

Cellular Recovery and Therapeutic Rechallenge After Cancer Therapy-Induced Kidney Injury: Mechanistic Insights and Clinical Implications

Yosuke Dotsu, Kazumasa Akagi, Noritaka Honda, Midori Matsuo, Hirokazu Taniguchi, Shinnosuke Takemoto, Tomoya Nishino, Hiroshi Mukae

Cancer therapy-related acute kidney injury has become an increasingly common challenge as modern treatments prolong survival and increase exposure to potentially nephrotoxic therapies. Decisions regarding therapeutic rechallenge have relied on normalizing serum creatinine and recovering estimated glomerular filtration rate, despite growing evidence that biochemical recovery does not necessarily indicate restoration of kidney integrity or resilience. In this review, we propose biological kidney recovery as a concept …

28.08.2026journal-article

Trends in Immunotherapy

Optimized Spiking Neural Network-Based Myeloid Cell Reprogramming Framework Targeting TAMs, MDSCs, and Dendritic Cells for Precision Oncology Immunotherapy

Veeramani Thangavel, Kavitha Raghuraman, Bharatha Babu Kannan, Bandarupalli Mouleswararao, Gopalakrishnan Selvarasu, Elangovan Muniyandy

Cancer immunotherapy has been a successful therapeutic approach by improving the ability of the immune system to recognise and destroy tumour cells. However, the accurate prediction of patient-specific immunotherapy responses still remains a major challenge because of the heterogeneous tumour microenvironment (TME), in which complex interactions among Tumour-Associated Macrophages (TAMs), Myeloid-Derived Suppressor Cells (MDSCs), Dendritic Cells (DCs), cytokines, and immune checkpoint molecules exhibit highly nonli …

28.08.2026journal-article

International Journal of Medical Science and Dental Health

Trimester-Specific Dynamics of Haematological, Coagulation, Biochemical And Angiogenic Biomarkers In Pregnancies At Risk Of Early-Onset Preeclampsia: A Prospective Comparative Study Of Early Diagnosis And Complex Treatment

Sharipova Shakhnoza Ulugbekovna, Tuksanova Dilbar Ismatovna

Background. Preeclampsia (PE) is driven by systemic endothelial dysfunction and an angiogenic imbalance. We characterised the trimester dynamics of haematological, coagulation, biochemical and angiogenic biomarkers and assessed the impact of early diagnosis and complex treatment. Materials and Methods. In this prospective comparative study, 102 pregnant women were allocated to a control group (physiological pregnancy, n=30), an early-diagnosed and treated group (n=32) and an untreated group (n=40). Complete blood c …

28.08.2026journal-article

World Journal of Gastroenterology

Pristimerin attenuates spasmolytic polypeptide-expressing metaplasia via p57 ( Cdkn1c )-mediated glycolytic reprogramming: A metabolic avenue for gastric cancer prevention

Jun-Hao Han, Kong-Rui Lu, Min Zhang, Guo-Hua Gong

Gastric cancer is a malignancy with high mortality globally, and spasmolytic polypeptide-expressing metaplasia (SPEM), a critical precancerous lesion in gastric carcinogenesis, represents a crucial target for early intervention to halt malignant progression. Pristimerin is a natural triterpenoid compound that primarily induces apoptosis and cell cycle arrest, and inhibits tumor cell migration and invasion by suppressing signaling pathways, such as nuclear factor kappa-B, phosphatidylinositol 3-kinase/protein kinase …

28.08.2026journal-article

eLife

Understanding pain in women with polyendocrine metabolic ovarian syndrome: health risks and treatment effectiveness

Tess Cherlin, Stephanie Mohammed, Samantha Strydesky, Sasha Ottey, Katherine Sherif, Shefali Setia Verma

Background: Polycystic ovary syndrome (PCOS), recently renamed as polyendocrine metabolic ovarian syndrome (PMOS), is a prevalent endocrine disorder in women, often accompanied by various symptoms, including significant pain, such as dysmenorrhea, abdominal, and pelvic pain, which remains underexplored. Methods: This retrospective study examines electronic health records (EHR) data to assess the prevalence of pain in women with PMOS. Conducted in January 2026, using data from 120 Health Care Organizations within th …

28.08.2026journal-article

Malignant tumours

Treatment tactics for colon cancer complicated by acute obstruction: comparison of short-term outcomes in right-sided and left-sided tumors

S. N. Shchaeva, L. I. Volynets, N. S. Kryukov

Objectives. To evaluate of short-term outcomes of emergency surgeries for right-sided and left-sided colon cancer complicated by acute obstruction, to determine the independent predictors of postoperative complications. Material. A cohort retrospective study was performed, including 250 patients: group 1‑patients who underwent emergency operations for cancer of the right colon complicated by acute obstruction, n = 73 (29,2 %); group 2‑patients who underwent emergency surgeries for cancer of the left colon complicat …

28.08.2026journal-article

Science Advances

Tracking breast cancer progression using Methylscape

Zhen Zhang, Emtiaz Ahmed, Nicolas Constantin, Jennifer Lu, Stephanie Portelli, David B. Ascher, Darren Korbie, Alain Wuethrich, Abu Ali Ibn Sina, Matt Trau

Cancer progression is driven by epigenetic reprogramming, where promoter hypermethylation of tumour-suppressor genes and global hypomethylation reshape gene regulation and cellular phenotypes, promoting oncogenesis and disease advancement. We previously introduced the Methylscape, a cancer-specific DNA methylation landscape characterized by clustered promoter hypermethylation and gene body hypomethylation that enhances DNA’s physical affinity for gold surfaces. Here, we demonstrate that Methylscape can be leveraged …