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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
21.08.2026journal-article

Experimental Oncology

STUDY OF PREDICTIVE VALUE OF RAD51 EXPRESSION FOR THE EFFECTIVENESS OF PLATINUM-BASED THERAPY OF HIGH-GRADE SEROUS OVARIAN CARCINOMA

P. Gordiichuk, M. Doronina, O. Ponomarova, M. Gordiichuk, D. Shapochka, D. Melnyk, A. Tereshchenko

Background. The search for novel markers of predictive significance is an important issue in the management of ovarian cancer (OC) patients. Recently, the expression of the RAD51 protein, involved in homologous DNA repair has been shown to be predictive of platinum chemotherapy response in OC patients. Aim. To establish the relationship between the level of RAD51 protein expression in patients with high-grade serous ovarian carcinoma (SOC) after neoadjuvant platinum chemotherapy and the frequency of recurrence, dis …

21.08.2026journal-article

BMC Health Services Research

Adherence and clinical outcomes among patients with sickle cell disease receiving prophylactic therapy in Bamenda, Cameroon: a cross-sectional study

Leslie Tasha Mbapah, Dinayen Dieudonne Yusinyu, Geh Martin Meh, Midrelle Syntyche Tsague, Sandra Tabe Etaka, Mandeng Edgar Ma Liwa, Orock Clinton Achale, Che Desmond Shu, Ndzi Courage Mbing-Kuni, Djike Puepi Yolande Fokam

Abstract Background Long-term prophylactic therapy is central to sickle cell disease (SCD) care, but evidence on medication adherence and patient-reported outcomes in Cameroon remains limited. We assessed SCD medication adherence and compared clinical outcomes before and during clinic-based prophylactic therapy. Methods A cross-sectional study was conducted at St Maria Soledad Catholic Hospital in Bamenda, Cameroon, from August to October 2024. Participants with SCD who had received hydroxyurea and folic acid, with …

21.08.2026journal-article

Frontiers in Endocrinology

Correlation between the reduction of IL-6 and TNF-α with muscle mass restoration in hyperthyroid patients post-radioactive iodine therapy

Yuqian Ren, Cuijuan Zheng, Meng Wang, Yanzhi Wang

Objective To investigate whether dynamic resolution of IL-6 and TNF-α after radioactive iodine (RAI) therapy is a key determinant of muscle recovery in Graves’ disease and to evaluate their potential as longitudinal biomarkers. Methods A prospective cohort of 157 patients with Graves’ disease was enrolled. Skeletal muscle index (SMI) was assessed by dual-energy X-ray absorptiometry (DXA), and serum IL-6 and TNF-α were measured by enzyme-linked immunosorbent assay (ELISA). Patients were re-evaluated 6 months after 1 …

21.08.2026journal-article

Jurnal Ners

Pengaruh Cognitive Behavioral Therapy (CBT) Terhadap Tingkat Kepatuhan Aktivitas Fisik dan Tekanan Darah Pada Lansia Hipertensi di Panti Werdha Pangesti Lawang

Fatun Fadianti, Abdul Qodir, Rahmaniah Ramadhani

Hipertensi pada lanjut usia tidak hanya berkaitan dengan perubahan fisiologis, tetapi juga dengan kemampuan mempertahankan perilaku hidup sehat. Aktivitas fisik yang rendah dapat menjadi salah satu hambatan dalam pengelolaan hipertensi, sementara hambatan kognitif seperti kekhawatiran dan keyakinan yang kurang tepat dapat membuat lansia semakin pasif. Penelitian ini bertujuan menganalisis pengaruh Cognitive Behavioral Therapy (CBT) terhadap tingkat kepatuhan aktivitas fisik dan tekanan darah pada lansia hipertensi …

21.08.2026journal-article

Media of Health Research

Complementary and Integrated Nutritional Interventions in Midwifery Care for Adolescent Reproductive and Respiratory Health in Urban Communities: A Systematic Literature Review

Titin Martini, Hikmah Hikmah, Eka Mardiana Afrilia

Urban adolescents and women of reproductive age continue to experience interconnected nutritional, reproductive, and respiratory health challenges, particularly in low- and middle-income countries. This systematic review aimed to synthesize recent evidence on complementary and integrated nutritional interventions within midwifery care to improve reproductive and respiratory health outcomes among urban adolescents. Following PRISMA 2020 guidelines, we conducted a systematic search in Scopus and supplemented it with …

21.08.2026journal-article

International Journal of Molecular Sciences

Iron Oxide Nanozyme for Magnetothermal Activation of ER-TRPV1 Enables Efficient Intravesical Therapy of Bladder Cancer

Galong Li, Dongyan Li, Bin Lan, Yuanyuan Cheng, Hongxia Liang, Wenli Zhang, Xiaopan Xu, Hongbing Lu

Drug-mediated intravesical therapy is a widely used treatment approach for bladder cancer (BCa), which is limited by poor tumor accumulation and the toxicity of drugs. Herein, a facile approach utilizing magnetic hyperthermia therapy (MHT) for BCa treatment is reported through intravesical instillation of tumor-targeting iron oxide nanoparticles (IONPs), which are coated with anti-FGFR3 antibodies for specific binding to FGFR3 overexpressed on BCa cells. The antibody coating significantly enhanced targeting ability …

21.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

Exploring the challenges that public transportation drivers face in Lebanon

Mahmoud Salam, Gladys Honein-AbouHaidar, Sawsan Abdulrahim

Background Public transportation drivers face numerous challenges, especially in countries experiencing economic crises. It is essential to gain a comprehensive understanding of these real-world issues. Objectives To explore the public transportation system in Lebanon and to identify the challenges faced by its drivers. Methods Following a convergent-parallel approach, interviews were held with stakeholders who provided insights into the transportation system and its regulatory policies. 63 taxi / bus drivers were …

21.08.2026journal-article

NeuroRehabilitation

Beyond Conventional Therapy in Parkinson's Disease Patients: The Impact of Visual Feedback Training on Balance and Trunk Control – A Prospective Cohort Study

Alessandro de Sire, Andrea Demeco, Andrea Parente, Andrea Racinelli, Angela Russo, Chiara Conte, Gianpaolo Ronconi, Marco Invernizzi, Nicola Marotta, Antonio Ammendolia

Background Postural instability and impaired balance are major contributors to disability and fall risk in individuals with Parkinson's disease (PD). Technology-assisted rehabilitation based on visual biofeedback may enhance the effects of conventional physiotherapy. This study aimed to evaluate the effects of a visual feedback training program combined with conventional physiotherapy on balance, mobility, and functional independence in patients with PD. Methods In this prospective cohort study, 21 patients with PD …

21.08.2026journal-article

Physiotherapy Research International

Alterations in Spatiotemporal Parameters in Patients With Lower‐Limb Amputation: A Systematic Review With Meta‐Analysis

Luis Augusto Mendes Fontes, Guilherme Auler Brodt, Adna Thalita do Nascimento Silva, Isabela Regina de Lima Andrade, Livia Barboza de Andrade

ABSTRACT Objectives To evaluate differences in spatiotemporal gait parameters in individuals with transfemoral (TFA) and transtibial amputation (TTA) compared with physically able individuals. Methods This systematic review with meta‐analysis was conducted according to the MOOSE guidelines. Cross‐sectional studies or clinical trials that assessed spatiotemporal gait parameters in adults with unilateral TFA or TTA were included. Searches were performed in Medline (via PubMed), CINAHL, Scopus, LILACS, Cochrane Librar …

21.08.2026journal-article

Computational Intelligence

Dual‐Path Higher‐Order Information Interaction With Time‐Frequency Attention and Multi‐Scale Feature Extraction Based Nested U‐Net for Speech Enhancement

Shaik AreefaBegam, Sunny Dayal Vanambathina

ABSTRACT Speech enhancement plays a crucial role in enhancing the perceptual quality and intelligibility of speech signals that are degraded by noise. Conventional U‐Net‐based architectures effectively capture local spectral patterns but exhibit limited long‐range dependency modeling and may propagate residual noise through skip connections. Transformer‐based approaches enhance global context modeling but often incur high computational cost and insufficient preservation of fine‐grained spectral cues, limiting real‐ …

21.08.2026journal-article

CNS & Neurological Disorders - Drug Targets

Combining Lycopene, Quercetin, and Poloxamer 188 Therapy Reduces Learning and Memory Deficits in the 3-nitropropionic Acid-induced Rat Model of Huntington's Disease

Arti A. Bhimanwar, Swati P. Barangule, Hemlata M. Nimje, Suchita P. Dhamane, Virendra S. Gomase

Introduction: The current study was carried out to assess the pharmacological action of combine effect of Poloxamer 188, Lycopene, and Quercetin on memory and energy deficit in Huntington’s disease-like signs induced by 3 Nitropropionic acid in Wistar rats. Methods: After one week of acclimatization all animals were randomly assigned in six groups, (n = 6), as normal control, Huntington’s disease control, Lycopene treated (25 mg/kg po), Quercetin treated (50 mg/kg po), combinations with and without Poloxamer 188 (8 …

21.08.2026journal-article

Journal of modern medicine

INFLUENCE OF INDIVIDUALIZED EARLY REHABILITATION ON INFLAMMATION, ENDOTHELIAL DYSFUNCTION, AND PULMONARY HEMODYNAMIC PARAMETERS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE

A.Kh Abdullaev, J.O. Matkomilov

This study evaluated the effect of an early comprehensive rehabilitation program—comprising physical ther­apy (exercise therapy), a herbal preparation, and magnetotherapy in addition to standard treatment and standard rehabilitation—on inflammation, endothelial dysfunction, and pulmonary hemodynamics in 127 patients with chronic obstructive pulmonary disease (COPD). The results demonstrated that in the main group, the levels of TNF-α de­creased significantly by 43.91–51.58%, VEGF by 49.50–50.46%, and Endothelin-1 b …

21.08.2026journal-article

Medicine

Evaluating the efficacy and safety of macrolide therapy in primary ciliary dyskinesia

Masoumeh Ghasempour Alamdari, Paniz Pourpashang, Simin Khayatzadeh Kakhki, Malihe Sadat Rahimi Azghadi, Niloufar Ghanbari, Parisa Ashournia, Arezoo Akhlaghi, Ghazal Shariatpanahi

Background: Primary ciliary dyskinesia (PCD) is a rare genetic disorder characterized by impaired ciliary function, defective mucociliary clearance, recurrent respiratory infections, and progressive respiratory morbidity. Macrolides, particularly azithromycin, have antibacterial, anti-inflammatory, and immunomodulatory properties and may therefore provide therapeutic benefit in PCD. This systematic review evaluated the efficacy and safety of macrolide therapy in patients with PCD. Methods: This systematic review wa …

21.08.2026journal-article

International Journal of Research Publication and Reviews

Integrating Infection Prevention and Occupational Therapy to Improve Rehabilitation Outcomes Among Medically Vulnerable Patients

Bridget Asamoah

Healthcare-associated infections remain a major threat to patient safety, recovery, and continuity of care, particularly among medically vulnerable populations whose underlying conditions, reduced immunity, prolonged hospitalization, or functional limitations increase susceptibility to infection. Rehabilitation services must therefore balance intensive therapeutic participation with measures that minimize exposure, transmission, and preventable complications. This paper examines the integration of infection prevent …

21.08.2026journal-article

American Journal of Physical Medicine & Rehabilitation

Efficacy of Transcranial Direct Current Stimulation in Acute Ischemic Stroke

Qianqian Yao, Xiantong Gao, Quanye Ding, Zhuokun Li

Objective: To evaluate the efficacy and safety of transcranial direct current stimulation (tDCS) initiated strictly within the acute ischemic stroke. Design: A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted via PubMed, Embase, and Cochrane Library. Outcomes included neurological deficit, upper limb and lower limb motor function, and functional independence. Data were synthesized using random-effects models to calculate weighted mean differences (WMD) and standardized mean d …

21.08.2026journal-article

Frontiers in Psychiatry

Efficacy of structured psychoeducational group therapy grounded in Yalom’s interpersonal principles for parents of adolescents with depression

Tongtong Wang, Qiyong Li, Tao Ding, Songying Fang, Menglan Zu, Yanli Zhao, Lin Ma

Objective To explore the efficacy of structured psychoeducational group therapy grounded in Yalom’s interpersonal therapeutic principles on parental anxiety, depressive symptoms, and family cohesion and adaptability among parents of adolescents with depression, and to provide clinical evidence for parent-focused family psychological support for adolescents with depression. Methods A total of 90 parents (45 couples) of adolescents aged 12–18 with depression were recruited from the outpatient department of a psychiat …

21.08.2026journal-article

Scientific Reports

Interpretable rehabilitation-oriented motion anomaly detection using wearable sensor data

Kumar Dorthi, Kiran Kumar Mamidi, Ravi Kanth Kotha, Neelima Bayyapu

Abstract Accurate detection of motion anomalies during physical rehabilitation is important for patient safety and recovery monitoring. Traditional assessment methods rely on visual observation. This often leads to subjective and inconsistent evaluations. To address this limitation, we propose a Support Vector-Guided Decomposition (SVGD) framework for semi-supervised rehabilitation-oriented motion anomaly detection using wearable sensor data. The framework integrates low-rank and sparse matrix decomposition with ma …

21.08.2026journal-article

Healthcare

Social Determinants of Healthcare Access: Horizontal Inequity in Rehabilitation Utilization and the Limits of Care in Mediating the Income–Depression Gradient in Türkiye

Derya Azim, Muhammed Emre Güvey, Sevde Betül Kara, Sümeyra Gündem, Ecenur Aydemir, Salim Yılmaz

Background/Objectives: Structural inequalities in access to healthcare persist even within systems that have achieved near-universal coverage, reflecting the enduring influence of social determinants of health on service utilization. This study examines horizontal inequity in rehabilitation and specialist care in Türkiye and investigates whether access inequality mediates the well-documented income–depression gradient. Methods: Analyzing the nationally representative 2022 Türkiye Health Survey (adults aged ≥15; N = …

21.08.2026journal-article

Acıbadem Üniversitesi Sağlık Bilimleri Dergisi

The Predictive Role of Specific Audiometric Frequencies in Speech-in-Noise Perception: A Machine Learning Approach

Özgenur Gavgalı

Purpose: Speech comprehension performance in noisy environments is a complex process that cannot be fully predicted by standard audiometric assessments. The aim of this study is to use machine learning (ML) algorithms to predict individuals’ difficulties in understanding speech in noise based on clinical data.Methods: The study utilized retrospective clinical data obtained from the Oldenburg Hearing Health Record (OHHR) dataset. Machine learning algorithms were trained to classify speech-in-noise performance based …

21.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

An investigation of the relationships between psychosocial status, quality of life, occupational balance, and sleep quality among motorcycle couriers

Medine Nur Özata Değerli, Samet Sevinç, Onur Altuntaş

Background Motorcycle couriers are an essential workforce within the delivery sector and are exposed to substantial physical and psychosocial demands due to their working conditions. Objective This study aimed to assess psychosocial distress, quality of life, occupational balance, and sleep quality among motorcycle couriers, and to examine both the relationships and the independent contributions of these factors to quality of life domains. Methods This cross-sectional study included 75 male motorcycle couriers. Par …

21.08.2026journal-article

Bioconjugate Chemistry

Development of a Homogeneous Trastuzumab-Triptolide Conjugate for Targeted Therapy of HER2-Overexpressing Ovarian Cancer

Idowu E. Fadayomi, Maria Jangan, Dilna Varghese, Elisabete Pires, James McCullagh, Alan Richardson, Adrian Murray Brunt, Wen-Wu Li

Abstract Ovarian cancer remains a lethal malignancy due to chemoresistance and toxicity, which limits the dose of chemotherapy that can be used, necessitating the development of more targeted therapies such as antibody-drug conjugates (ADCs). However, conventional ADCs suffer from heterogeneity. This study aimed to develop a stable, homogeneous ADC by utilizing a bifunctional dibromomaleimide (DBM) linker to cross-link antibody cysteine residues via disulfide-bridging. A DBM linker was synthesized from 3,4-dibromof …

21.08.2026journal-article

Journal of Clinical Medicine

Course of Testosterone Levels and Potential Biochemical Biomarkers of Androgenization with a Conservative Protocol of Androgen Hormone Therapy in Transgender Males

Guillermo Velasco de Cos, María Teresa García Unzueta, Ana Moyano Martínez, Pedro Muñoz Cacho, Aurelia Villar Bonet, Armando Raul Guerra Ruiz, Bernardo A. Lavin-Gómez, Maialen Ormazabal Monterrubio, Luis Alberto Vázquez

Objectives: This study aimed to evaluate the hormonal, hematologic, and biochemical outcomes of a conservative protocol for androgen therapy for transgender males. Methods: This was an observational, prospective, and comparative study conducted in the gender identity clinic of a tertiary university hospital. Testosterone therapy consisted of testosterone cypionate administered intramuscularly every month at an initial dosage of 25 mg/month, which was increased to 50 mg/month at month 3, 100 mg/month at month 6, and …

21.08.2026journal-article

Cancer Gene Therapy

Investigating the role of costimulatory domains in enhancing CAR-T cell persistence in TNBC

Hany E. Marei, Giacomo Pozzoli, Carlo Cenciarelli

Abstract This work summarizes how costimulatory domains can mediate the persistence, function, and therapeutic potential of CAR-T cells in triple-negative breast cancer (TNBC), a highly aggressive malignancy with limited treatment options and an immunosuppressive tumor microenvironment. Although CAR-T cell therapy has produced remarkable results in hematologic malignancies, its translation to TNBC remains limited by poor T cell persistence, metabolic dysfunction, and rapid exhaustion. Current evidence identifies ca …

21.08.2026journal-article

Jurnal Ners

Efektivitas Cognitive Behavior Therapy (CBT) Berbasis Telenursing dalam Mengatasi Perilaku Self-Harm Pada Mahasiswa di Cirebon

Judika Rubi Marta Sirait, Ni Made Dian, Khrisna Wisnusakti, Nenden Lesmanawati, Fifi Siti Fauziah Yani

Perilaku self-harm merupakan masalah kesehatan mental yang signifikan di kalangan mahasiswa, dengan prevalensi yang terus meningkat. Intervensi Cognitive Behavior Therapy (CBT) berbasis telenursing menjadi alternatif untuk mengatasi perilaku self-harm. Penelitian ini bertujuan untuk mengetahui efektivitas penerapan CBT berbasis telenursing dalam mengatasi perilaku self-harm pada mahasiswa keperawatan di Cirebon. Penelitian menggunakan desain quasi experimental dengan pendekatan one group pretest-posttest design. Po …