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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Medicine

Case Report: Extremely elevated ascitic fluid amylase as a diagnostic clue for peritoneal mucormycosis caused by Rhizopus microsporus following exertional heatstroke

Guanghui Chen, Haibo Lei, Guyi Wang, Yanyan Zhou

Background Mucormycosis is a rapidly progressive, life-threatening fungal infection that typically affects immunocompromised hosts. Disseminated peritoneal mucormycosis is extremely rare and often diagnosed late. Heatstroke is an under-recognized predisposing condition. Case presentation A 54-year-old male brickworker developed peritoneal mucormycosis caused by Rhizopus microsporus following exertional heatstroke. On day 11 after heatstroke, he developed massive ascites. Ascitic fluid amylase was markedly elevated …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Evolution of electrocardiographic manifestations mimicking acute coronary syndrome secondary to hypoparathyroidism: a case report

Gerile Zhang, Riletu Ge, Jing Gao, Yuzhen Zhou

Objective To promptly identify electrocardiographic (ECG) manifestations, including deep T-wave inversions and QT-interval prolongation, secondary to hypoparathyroidism and to improve its diagnostic accuracy and therapeutic management. Methods We conducted a comprehensive analysis of the integrated treatment for a patient presenting with chest pain and evolving ECG changes secondary to hypoparathyroidism, supplemented by a review of the relevant literature. Results In this case, a patient diagnosed with hypoparathy …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

PVN-centered multi-omics and single-cell analyses suggest shared inflammatory and immune features in acute myocardial infarction-associated ventricular arrhythmia and atrial fibrillation

Wenlong Wang, Wenbo Zhao, Yuran Chen, Xin Wang, Chunrui Ji, Jingmei Sun, Yu Bai, Yuhang Yang, Xiufen Qu

Objective Acute myocardial infarction (AMI) increases the risk of arrhythmias, particularly ventricular arrhythmias (VA), and atrial fibrillation (AF) is also common after AMI. The paraventricular nucleus (PVN) is a key regulator of sympathetic outflow. This study used a PVN-centered strategy to investigate molecular changes after AMI, prioritize candidate molecules associated with VA, and assess whether related inflammatory and immune features are also present in AF cohorts. Methods An AMI model was established in …

03.09.2026journal-article

Frontiers in Medicine

Direct visualization-guided endoscopic management of complex colonic diverticular disease: a proof-of-concept case series

Tianjie Han, Junshan Li

Background Complex colonic diverticular disease, including diverticular bleeding, inflammatory diverticular disease, presents substantial therapeutic challenges for conventional colonoscopy because of limited intradiverticular visualization, difficult access, and restricted maneuverability. Failure to precisely localize the culprit lesion or inflammatory nidus may lead to recurrent symptoms, delayed treatment, or surgical intervention. The EyeMax direct visualization system, originally designed for pancreatobiliary …

03.09.2026journal-article

Trials

Optimizing patient recruitment in community pharmacies using implementation science principles: a Study Within A Trial (SWAT)

Kirstin Messner, Alexa Rosenthaler, Manuel Leuenberger, Meret Berger, Lena Walz, Isabelle Arnet, Samuel Allemann

Abstract Background Decentralized trial approaches involving community pharmacies have gained increasing attention. However, recruitment in community pharmacies faces complex conditions and tailored strategies are necessary. Applying implementation science principles is a promising but underrepresented approach to facilitate recruitment processes. On the example of adherence-enhancing services, we aimed to investigate influencing factors to trial recruitment in the community pharmacy setting and to identify impleme …

03.09.2026journal-article

International Journal of STD & AIDS

Anti–IL-17 therapy in people living with HIV who have cutaneous psoriasis: A four-patient case series

Melike Merve Güçlü, Fatma Aslı Hapa, Fatma Elif Yıldırım

Aim To describe the clinical, immunological, virological and safety outcomes observed during anti–IL-17 therapy in patients living with HIV who had cutaneous psoriasis. Method Four patients living with HIV who had cutaneous psoriasis and were treated with anti–IL-17 agents were included in this case series. Psoriasis Area Severity Index (PASI) scores, CD4 cell counts, HIV RNA levels, treatment duration and adverse events were obtained from medical records. Results Three patients received secukinumab and one receive …

03.09.2026journal-article

Frontiers in Biomaterials Science

Machine learning-enabled formulation development of implantable drug delivery systems for precision medicine: from ocular and cochlear implants to personalized therapeutics

Rohini Ganvenwaer, Shaktiprasad Pradhan, Kranti Jadhav, Kuldeep Vinchurkar, Rohit Ramesh Doke

In order to provide regulated, targeted, and prolonged therapeutic delivery while reducing systemic side effects, implantable drug delivery systems (IDDSs) have become a potential substrate. By enabling data-driven prediction of material properties, drug release kinetics, biocompatibility, and patient-specific treatment responses, recent developments in machine learning (ML) are revolutionizing the formulation and refinement of these systems. ML algorithms combine clinical, biological, and physicochemical facts to …

03.09.2026journal-article

Digital Diagnostics

Differential Diagnosis of Lipomas and Liposarcomas of the Soft Tissues of the Extremities: A Multicenter Study Using Machine Learning Based on Clinical, Semiotic, and Radiomic Features Extracted from Non-Contrast Magnetic Resonance Imaging.

Aleksandr Urazov, Svetlana P. Aksenova, Nikolay V. Nudnov, N V Kharchenko, Nikolay I. Sergeev, Vladimir A. Solodkiy, Andrey D. Kaprin

IntroductionThe differential preoperative diagnosis of lipomas and liposarcomas of the soft tissues remains challenging due to their significant similarity on MR images, which can lead to delays in treatment. Unlike benign lipomas, liposarcomas are characterized by frequent recurrence and metastasis. The use of radiomics methods can automate the analysis of medical images and identify diagnostic features unavailable to traditional visual analysis, potentially accelerating the interpretation of results, reducing dia …

03.09.2026journal-article

Neurosurgical Review

Penetrating dural venous sinus injury: a scoping review of clinical presentation, operative management, and prognosis

Yaxel Levin-Carrion, Jayant Bhasin, Taylor Campbell, Ebrahim Faizullabhoy, Kevin Titkov, Carlos Coronado-Guzman, Arman Sawnhey, Sraavya Anne, Daniela A. Perez-Chadid, Drew Thibault, Alejandro Pando, Nemanja Novakovic, Hai Sun

Abstract Penetrating injury to the dural venous sinuses (DVS) commonly occurs at the superior sagittal sinus (SSS), transverse sinus (TS), and torcular confluence. While rare, DVS penetrating injuries carry high risk of intracranial hemorrhage, air embolism, and venous infarction. The current literature pertaining to penetrating DVS injury consists primarily of isolated case reports and small series. This scoping review consolidates published cases to characterize mechanisms, management strategies, and clinical out …

03.09.2026journal-article

BMC Complementary Medicine and Therapies

Frequency, patterns of use, and perceptions about natural remedies among adults in the United Arab Emirates regarding COVID-19

Razan Ibrahim Faris Yousef, Eman Mohamad El Khatib, Hashim Almishhadany, Amna Ibrahim Zaidan, Jennat Alamara, Mohammed Rahim Hossain, Hiba Jawdat Barqawi, Saryia Adra, Eman Abu Gharbieh

Abstract Introduction The global coronavirus disease (COVID-19) pandemic drove significant interest in alternative options for disease prevention and treatment. Among these alternatives, natural remedies (NRs) gained considerable attention. This study aims to explore the frequency, usage patterns and perceptions regarding NRs for the prevention and treatment of COVID-19 among adults in the United Arab Emirates (UAE). Methods A cross-sectional study was conducted between February and March 2021 using a self-administ …

03.09.2026journal-article

Frontiers in Oncology

Clinical and genomic characterization of KRAS G13X non-small cell lung carcinoma

Benjamin J. Staum, Rachaita Lakra, Aditya Ravindra, Sarah L Mott, Deqin Ma, William Zeitler, Margaret Byrne, Nirmal Choradia, Abdul Rafeh Naqash, Raid Aljumaily, Muhammad Furqan

Background KRAS mutations (KRAS m )represent the most common oncogenic drivers in non–small cell lung cancer (NSCLC). However, molecular features and clinical implications of the less common, codon 13 mutations ( KRAS G13X) remain poorly characterized. We conducted a retrospective study to characterize KRAS G13X-positive NSCLC. Methods We reviewed patients’ charts with KRAS m NSCLC treated at University of Iowa Health Care. Based on intent of therapy, patients were assigned to curative-intent (CI) or palliative-int …

03.09.2026journal-article

General Thoracic and Cardiovascular Surgery

Minimally invasive cardiac surgeries in 2023–annual report of the Japanese association for minimally invasive cardiac surgery

Tomoki Shimokawa, Hiraku Kumamaru, Noboru Motomura, Naoko Kinukawa, Hiroyuki Nishi, Hiroyuki Nakajima, Hiroyuki Kamiya, Kazuma Okamoto, Soh Hosoba, Yoshikatsu Saiki, Takashi Miura, Minoru Tabata, Akira Shiose, Taichi Sakaguchi

Abstract Objective To establish updated nationwide perioperative benchmarks for minimally invasive cardiac surgery (MICS) in Japan by presenting the 2023 annual report and summarizing procedural trends from 2021 to 2023. Methods Data on mitral valve (MV) surgery, aortic valve replacement (AVR), coronary artery bypass grafting (CABG), atrial septal defect (ASD) closure, and cardiac tumor resection performed via MICS in 2023 were extracted from the Japan Cardiovascular Surgery Database. Perioperative outcomes, includ …

03.09.2026journal-article

Multidisciplinary Respiratory Medicine

Peri-procedural code status discussions before bronchoscopy: a cross-sectional survey of German and Swiss pulmonologists

Flavio Gössi, Armon Arpagaus, Benjamin Bissmann, Samuel Kaspar Zumbrunn, Thierry Girard, Jürgen Hetzel, Kathleen Jahn, Katrin E Hostettler, Sabina Hunziker

Introduction: In-hospital cardiac arrest is associated with poor outcomes, yet peri-procedural code status discussions before bronchoscopy may be inconsistent, particularly in patients with elevated procedural risk. Methods: We conducted an anonymous online survey of a convenience sample of hospital-based pulmonologists in Germany and Switzerland between April and July 2025. The survey assessed routine practices and attitudes regarding peri-procedural code status discussions, risk stratification, and management of …

03.09.2026journal-article

BJGP Open

A primary care intervention to expedite cancer diagnosis: protocol for the ThinkCancer! phase III trial

Daniel Walker, Stefanie Disbeschl, Kausthuba Raman, Annie Hendry, Clio Evans, Benjamin Cotterell, Nic Nikolic, Richard Evans, Nia Goulden, Rachel Evans, Bethany Fern Anthony, Victory Ezeofor, Isobel McFadzean, Nefyn Howard Williams, Katherine Brain, Julia Hiscock, Andrew Carson-Stevens, Rhiannon Edwards, Janice Rose, Elfyn Jones, Richard Neal, Clare Wilkinson

Background Five-year cancer survival rates in the United Kingdom (UK) compare poorly with other high-income countries and a comparatively late stage of cancer diagnosis is a key driver. Primary care referrals led to 58.6% of cancer diagnoses in the UK in 2020, making general practice the ideal setting for targeted interventions focusing on improving early cancer diagnosis. ThinkCancer! is an innovative, team-based, theoretically-driven, complex behavioural and educational intervention aimed at reducing primary care …

03.09.2026journal-article

Frontiers in Medicine

Diagnostic performance of ultrasonographic medial gastrocnemius muscle thickness for sarcopenia in patients on maintenance hemodialysis

Meilin Yan, Wei An, Leting Zhou, Weiwei Shan, Xiran Zhang, Aiyan Du, Zhijian Zhang, Liang Wang

Objective The study aimed to evaluate the performance of ultrasonographic medial gastrocnemius muscle thickness (MGMT) and pennation angle (MGMPA) in diagnosing sarcopenia among patients on maintenance hemodialysis (MHD). Methods The MGMT and MGMPA were measured ultrasonographically. Baseline characteristics were compared between the sarcopenia and non-sarcopenia groups. Correlations between ultrasound parameters and sarcopenia indicators were evaluated. The diagnostic performance of the ultrasound parameters was a …

03.09.2026journal-article

Frontiers in Oncology

Treatment and outcomes of hepatoblastoma in a tertiary care pediatric institution: a single-center experience

Aleksandar Sretenović, Srđa Janković, Nada Krstovski, Polina Pavićević, Jelena Lazić, Goran Milošević, Marija Ćazić, Jelena Krcunović, Branislav Jovanović, Tijana Radović, Đorđe Pavlović, Dubravka Milutinović, Jelena Pejanović Jovanović, Ivana Dašić, Sofija Cvejić, Jovana Svorcan Pavlović, Predrag Rodić

Introduction Hepatoblastoma is the most prevalent pediatric malignant liver neoplasm, and despite substantial advances in multimodal treatment, outcome data from Southeast European pediatric centers remain limited. The aim of this study was to evaluate the clinical characteristics, treatment approaches, surgical management, and outcomes of children treated for hepatoblastoma at a tertiary pediatric institution over a 17-year period. Methods This retrospective single-center cohort study included 24 pediatric patient …

03.09.2026journal-article

Frontiers in Medicine

A Bayesian network-based predictive model for gout onset risk: associations with traditional Chinese medicine constitution in hyperuricemic populations

Xiaobing Tian, Junlong Chen, Qianqiong Chen, Runxia Teng

Objective To develop a Bayesian network model for predicting gout onset risk in hyperuricemic individuals based on TCM body constitutions, quantify their influence, and provide evidence for early warning and TCM intervention. Method A total of 826 hyperuricemia (HUA) patients were enrolled in this prospective cohort study. All participants underwent standardized TCM constitution identification per “Classification and Identification of Constitution in Traditional Chinese Medicine.” Clinical variables including gende …

03.09.2026journal-article

Frontiers in Surgery

Electrophysiological stimulation is associated with improved lower-extremity venous hemodynamics and postoperative recovery following laparoscopic nephrectomy

Yuwen He, Li'e Lin, Ningning Tian, Jiamei Chen, Yanping Wang, Sijing Huang, Yongnan Li, Li Lan, Yun Xie, Zihao Feng, Peiwei Wang, Yingwen Zhu, Xiaoping Huang

Background Venous thromboembolism (VTE) is a common and potentially serious complication following laparoscopic nephrectomy. Conventional preventive measures are limited by bleeding risk and poor compliance. Electrophysiological stimulation therapy has emerged as a non-invasive approach to improve venous circulation, but its perioperative efficacy remains unclear. Methods This prospective, non-randomized controlled study included 108 patients undergoing laparoscopic nephrectomy. Patients were allocated to a control …

03.09.2026journal-article

Frontiers in Psychiatry

Clinical characteristics and neuropsychiatric profiles of young-onset dementia: a retrospective cross-sectional study at a tertiary care center in Northern Thailand

Sirivipa Jekpoo, Kittithatch Booncharoen, Supisara Prompila, Tinakon Wongpakaran, Huali Wang, Nahathai Wongpakaran

Background Data on young-onset dementia (YOD) in Thailand remain limited. We aimed to describe clinical presentation, general cognitive performance, neuropsychiatric symptoms, neuroimaging features, and selected laboratory findings across YOD subtypes in a tertiary-care cohort in Northern Thailand. Methods We conducted a retrospective cross-sectional study of 295 individuals with YOD (symptom onset < 65 years) treated at Chiang Mai University Hospital (2010–2025). Data extracted included demographics, presenting …

03.09.2026journal-article

Frontiers in Artificial Intelligence

Multi-resolution perceiver-based residual attention for explainable fault diagnosis in power transmission systems

Shantanu Dinesh Wani, S. Abinaya, S. Abirami, R. Priyadarshini

Fault diagnosis in power transmission systems requires the simultaneous identification of fault type and location from high-dimensional, multichannel, and temporally evolving measurements. Conventional deep learning approaches may struggle to jointly capture localized transient patterns, global temporal dependencies, and spatially distributed fault signatures while providing interpretable diagnostic information. To address these challenges, a Multi-Resolution Perceiver-Based Residual Attention (MRP-RA) framework is …

03.09.2026journal-article

Experimental & Molecular Medicine

The inhibition of lactate/Gpr81 signalling driven by moderate-intensity continuous training protects against osteoarthritis

Peng Sun, Yilan Guo, Aochuan Xue, Jingting Ni, Yichen Ren, Yan Sun, Xingyu Qian, Xiaoliu Li, Yu You, Ying Zhao, Lijun Tang, Shimin Zhu, Yuqiang Li, Liang He

Abstract Osteoarthritis (OA) is among the most prevalent chronic diseases worldwide. However, currently employed pharmacological therapies for OA are associated with various reported side effects. Exercise therapy represents a potentially safer and more effective strategy for OA treatment, although its underlying mechanism remains unclear. Here, we demonstrate that compared with high-intensity continuous training, moderate-intensity continuous training (MICT) has greater therapeutic potential for OA. Notably, these …

03.09.2026journal-article

Frontiers in Oncology

Sequencing immunotherapy in locally advanced head and neck squamous cell carcinoma: a narrative clinical-translational review

Ruey-Long Hong

Background Immune checkpoint inhibitors have entered curative-intent treatment of locally advanced head and neck squamous cell carcinoma, but randomized trials have shown divergent results across definitive, perioperative, and postoperative settings. Methods We reviewed pivotal randomized phase II–III trials and key translational studies to examine how treatment sequence relative to radiation and surgery, together with anatomic context, influences efficacy. Results Concurrent immunotherapy with definitive chemoradi …

03.09.2026journal-article

Current Pediatrics

Demographic Window of Opportunities: Clinical and Economic Justification of HPV Vaccination Inclusion in NIS in 2027

Leyla S. Namazova-Baranova, Marina V. Fedoseenko

Human papillomavirus (HPV) infection is highly contagious and is the most common sexually transmitted infection. It causes irreversible damage to human reproductive health, leading to benign and malignant neoplasms in anogenital and other areas. Cervical cancer continues to have the leading position in mortality among young women of reproductive age. The key tool in combating HPV infection is primary prevention, vaccination; furthermore, the implementation of the Global Strategy for HPV vaccination will prevent up …