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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
21.08.2026journal-article

Drug Delivery Letters

PLGA-Based Polymeric Nanoparticles for Voglibose Delivery in Antidiabetic Therapy

Parimita Kalita, Rajesh Jesudasan, kalyani pathak, Jon Jyoti Sahariah

Introduction: Diabetes mellitus is a chronic metabolic disorder requiring innovative therapeutic approaches. Voglibose, an effective α-glucosidase inhibitor, has limitations, including low solubility and a short duration of action when taken as a tablet. Polymeric nanoparticles, particularly PLGA (Poly-lactic-co-glycolic acid), offer promising platforms for sustained drug release and improved bioavailability. This study aimed to develop and evaluate PLGA-based nanoparticles for delivering voglibose, enhancing its t …

21.08.2026journal-article

Reviews in Cardiovascular Medicine

Lipid Metabolism as a Therapeutic Target in Arrhythmogenic Cardiomyopathy: Emerging Therapeutic Implications of Lipid-Lowering Therapy

Nicolò Pasini, Federico Barocelli, Alberto Bettella, Alessia Ristagno, Mattia Santoro, Eleonora Canu, Antonio Crocamo, Filippo Luca Gurgoglione, Laura Torlai Triglia, Francesca Russo, Angela Guidorossi, Nicola Gaibazzi, Maria Francesca Notarangelo, Gian Luca Gonzi, Giampaolo Niccoli

Arrhythmogenic cardiomyopathy (ACM) is a hereditary myocardial disorder characterized by progressive replacement of ventricular myocardium with fibro-fatty tissue, leading to life-threatening ventricular arrhythmias and heart failure. Historically, management has focused on arrhythmia suppression and prevention of sudden cardiac death (SCD). However, recent advances in understanding disease mechanisms have redefined ACM as a structural–metabolic cardiomyopathy. Central to this evolving paradigm is the “adipogenic s …

21.08.2026journal-article

Power and Education

Defending the university against bad-faith policy interventions: Equality, diversity and inclusion, free speech, and institutional power

Sean Walton, Syra Shakir

Recently, there has been a resurgence of claims that equality, diversity, and inclusion (EDI) initiatives threaten freedom of speech in UK higher education. Using the Alumni for Free Speech (AFFS) report (2025) as an example of this, we argue that the opposition between free speech and EDI is a politically manufactured false binary that obscures how power, voice, and harm are unevenly distributed within universities. Drawing on Critical Race Theory, decolonial scholarship, Black Radical Politics, and critical polic …

21.08.2026journal-article

Journal of Health and Allied Sciences NU

Effect of Music Therapy on Physiological Parameters Among Patients on Mechanical Ventilation

Varsha Evare, Nutan Podar

Objectives Patients on mechanical ventilation in intensive care units often experience physiological instability. Music therapy is considered a supportive non-pharmacological intervention. The present study aimed to assess the effect of Carnatic music therapy (Raga Ananda Bhairavi) on physiological parameters in patients receiving mechanical ventilation. Material and Methods The study employed a single-group quasi-experimental pre-test and post-test design. The study involved 50 adult ventilated patients who were s …

21.08.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

CONTRIBUIÇÕES DA TERAPIA COGNITIVO-COMPORTAMENTAL PARA A SAÚDE MENTAL DA POPULAÇÃO LGBT: UMA REVISÃO INTEGRATIVA DA LITERATURA

Joel Leal Pinto de Souza Moura, Paula Oliveira Silva, Silvia Helena Modenesi Pucci

Estudos descrevem que a população LGBT apresenta maior vulnerabilidade a transtornos mentais e sofrimento psicológico em comparação à população heterossexual e cisgênero, associada à exposição a estressores sociais crônicos, como preconceito, discriminação e exclusão. Nesse contexto, a Terapia Cognitivo-Comportamental é amplamente reconhecida como uma abordagem baseada em evidências para o manejo de condições em saúde mental. Objetivo: Analisar as contribuições de intervenções fundamentadas na TCC para a saúde ment …

21.08.2026journal-article

Medicine

Complete remission of Helicobacter pylori-negative gastric MALT lymphoma following eradication therapy

Hui Chen, Jingtong Tang, Lin Mo, Xi Wang, Guobin He

Rationale: Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is typically associated with Helicobacter pylori infection; however, approximately 10% of cases are H pylori -negative. Management guidelines differ between the European Society for Medical Oncology (ESMO) and the National Comprehensive Cancer Network (NCCN) regarding first-line treatment for these patients. Here, we report a case of H pylori -negative gastric MALT lymphoma that achieved complete remission following standard eradication therapy. P …

21.08.2026journal-article

Medicine

Robot-assisted rehabilitation therapy for adhesive capsulitis

Seung Min Ryu, Jeong Hee Park, Woosung Choi, Joonhyoung Hong, Hui Ben, Hangsik Shin, In-Ho Jeon

Background: Adhesive capsulitis, commonly known as frozen shoulder, presents with pain and restricted movement. Treatments include physical therapy focusing on stretching exercises, intra-articular corticosteroid injections, and surgical intervention if conservative management fails. The efficacy of robot-assisted rehabilitation therapy (RART) for adhesive capsulitis remains unexplored, necessitating clinical application and analysis. Methods: A prospective, randomized controlled trial was conducted involving patie …

21.08.2026journal-article

Archives of Health Science and Research

Executive Functions in Children with Speech Sound Disorders: A Qualitative Content Analysis of Studies Conducted in Türkiye

Nurdan CANKUVVET, Gizem Nur GÖR

Objective: Speech sound disorder (SSD) is common developmental communication disorders increasingly viewed as embedded within broader cognitive processes. Executive functions (EF) support speech production, phonological representation, and self-regulation; however, their multidimensional nature is not consistently reflected in SSD research. This study aimed to systematically examine how EF have been conceptualized, operationalized, and reported in studies of children with SSD conducted in Türkiye. Methods: A qualit …

21.08.2026journal-article

The Ukrainian Journal of Clinical Surgery

Neoadjuvant Hormone Therapy for Hormone-Receptor-Positive, HER2-Negative Breast Cancer: Experience of the Transcarpathian Anticancer Center

F. M. Pavuk, K. Ye. Rumyantsev, S. M. Chobei, M. F. Rishko

Objective. To summarize the experience of using neoadjuvant hormone therapy for hormone-receptor-positive, HER2-negative breast cancer in the real-world clinical practice of the Transcarpathian Cancer Center and to evaluate its impact on the frequency of breast-conserving surgery, long-term oncological outcomes, and patients’ quality of life.Materials and Methods. This retrospective study included 1,612 patients with hormone-receptor-positive, HER2-negative breast cancer who received treatment between 2010 and 2024 …

21.08.2026journal-article

INTERNATIONAL JOURNAL OF MULTIDISCIPLINARY RESEARCH AND ANALYSIS

Occupational Stress, Coping, and Work Motivation among Members of the Criminal Justice System: A Conceptual Paper

Shirleen Martins, Dr. Shahnaz Sheibani, Dr. Bilal Ahmad Lone

Members of the Criminal Justice System operate within high-stakes, ethically demanding, and emotionally taxing environments that may significantly influence their occupational stress, coping strategies, and work motivation. Drawing upon Person–Environment Fit theory, Coping Theory, and Herzberg’s Two-Factor Theory, this conceptual paper proposes an integrative framework explaining the interrelationships among occupational stress, coping, and work motivation in Criminal Justice System professionals. Ten hypotheses a …

21.08.2026journal-article

Journal of Marital and Family Therapy

Relational Therapy in Post‐Incarceration Reentry: A Scoping Review

Eman Tadros, Thita Lamsam, Chandni Anandha Krishnan

ABSTRACT An estimated 600,000 individuals returning home after incarceration each year face significant challenges that constrain their reentry and reintegration into society. A scoping review was conducted on how relational therapy is discussed in the literature on post‐incarceration. Utilizing the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis, 19 out of 304 articles met the inclusion criteria for full review. Our findings highlight the limited empirical evidence on relational therapy interven …

21.08.2026journal-article

Journal of Occupational & Environmental Medicine

Mortality Patterns Among Utah Firefighters, 2001–2024: A Proportionate Mortality Study

Yanling Shi, Devinne Hart, Nicole Bissonette, Kyle Lunt, Xiaoming Sheng

Objective: Firefighters face exposures linked to chronic disease and suicide. This study evaluated cause-specific mortality among Utah firefighters versus other occupations. Methods: Utah death certificates (2001–2024) were analyzed using 2018 Census codes and NCHS causes. We estimated adjusted proportionate mortality odds ratios (aORs) for cancer, heart disease, diabetes, and suicide. Results: Analysis included 734 firefighter deaths and 366,952 others. After adjusting for demographics and tobacco use, firefighter …

21.08.2026journal-article

Neurosurgical Review

Intrathecal immune checkpoint inhibitors as adjunctive therapy for leptomeningeal disease: A case series and systematic review

Manav Daftari, Christian K. Ramsoomair, Anurag Aka, Vratko Himic, Anna Hudson, Manuela Aramburu Berckemeyer, Morgan Johnson, Victor M. Lu, Jay Chandar, Vaidya Govindrajan, Jose Lutzky, Michael E. Ivan, Ricardo J. Komotar, Ruham Nasany, Ashish H. Shah

Abstract Immune checkpoint inhibitors (ICIs) are promising for leptomeningeal disease (LMD), but systemic delivery is limited by poor cerebrospinal fluid penetration and treatment-related toxicity. This study evaluates the safety and efficacy of adjunctive intrathecal (IT) ICI therapy compared with systemic ICI alone. We report two institutional cases of melanoma-associated LMD treated with IT ICI alongside systemic therapy. Following PRISMA guidelines, PubMed, Embase, and Scopus were systematically reviewed, ident …

21.08.2026journal-article

EAS Journal of Orthopaedic and Physiotherapy

Functional Outcome of Open Latarjet Procedure for Recurrent Anterior Shoulder Instability with Hill-Sachs Lesion Following Sports Injury

Mohammad Lockman, Md. Zahir-Ul Islam, Mobinul Hoque, Muhammad Ariful Islam, Muhammad Rafiqul Islam, Suraiya Siddika, G.M. Jahangir Hossain

Background: The anatomical and biomechanical factors render shoulder joint the most unstable and frequently dislocated joint. Anterior instability is common and glenoidal bony defect result in recurrence. Effective surgical treatment is crucial to restore the normal functioning shoulder and return to the preinjury state The aims of this study were to assess the functional outcome of recurrent anterior shoulder instability with Hill-Sachs lesion following Latarjet procedure by ROWE score and report complications if …

21.08.2026journal-article

Current Stem Cell Research & Therapy

Conditioned Medium from IFNγ-Pretreated Human Gingival Mesenchymal Stromal Cells Enhances the Immunomodulatory Effects on Neutrophils

Alexia Almaraz-Arreortua, William de Jesús Ríos-Ríos, Sorely Adelina Sosa-Luis, María de los Ángeles Romero-Tlalolini, Sergio Roberto Aguilar-Ruiz, Honorio Torres-Aguilar

Introduction/ Objective: Neutrophils are crucial for an effective innate immune response. However, overactivation is associated with chronic inflammation, as in systemic lupus erythematosus (SLE). Gingival mesenchymal stromal cells (GMSCs) are used as anti-inflammatory therapies because they possess strong immunomodulatory properties, primarily acting through paracrine mechanisms. GMSCs exhibit immunoplasticity in response to their microenvironment and adjust their secretion profile. This study aimed to investigate …

21.08.2026journal-article

Frontiers in Cell and Developmental Biology

The role of molecular profiling for castration-resistant prostate cancer treatment and therapy development

Timothy J. Mann, Therese M. Becker, Tara L. Roberts, Paul de Souza, John G. Lock

Early-stage prostate cancer (PCa) is overwhelmingly driven by aberrant androgen receptor (AR) signalling. Accordingly, standard-of-care treatments include androgen deprivation therapy (ADT) and AR pathway inhibitors (ARPIs), with disease detection and therapy-response monitoring relying on blood-borne PSA, a product of AR transcriptional programs. Crucially, resistance to these therapies is inevitable but heterogeneous in nature; potentially driven by a diverse array of alternate signalling pathways and differentia …

21.08.2026journal-article

Neurology International

Rehabilitation Outcomes in Patients Who Regained Consciousness

Elena Aidinoff, Almothana Khatib, Anna Oksamitni, Ilana Gelernter, Lilach Front, Amiram Catz, Sharon Shaklai, Marina Motin, Corinne Serfaty, Deborah Rubin-Asher

Background/Objectives: Patients with prolonged disorder of consciousness (PDOC) who regained consciousness in intensive care for consciousness rehabilitation (ICCR) were referred to further brain rehabilitation (FBR). The current retrospective cohort study evaluated the functional and cognitive outcomes of FBR. Methods: We assessed outcomes in 258 PDOC patients during FBR and used multivariate regression analyses to examine the influence of demographic and clinical characteristics on outcomes. Results: During FBR, …

21.08.2026journal-article

Journal of Advances in Dental Practice and Research

Exercise-induced temporomandibular disorder in a young boxer managed successfully with physiotherapy: A detailed case report

Mehar Singh Malhi, Rajvir Singh

Temporomandibular joint disorder (TMD) comprises a group of musculoskeletal conditions affecting the temporomandibular joint (TMJ), masticatory muscles, and associated structures. Parafunctional habits such as clenching are well-recognized etiological factors; however, clenching associated with intense physical activity is often underreported. This case report describes a 21-year-old male boxer who presented with restricted mouth opening and jaw pain following repeated forceful clenching during weightlifting. Clini …

21.08.2026journal-article

International Journal of Web Information Systems

Explainable hate speech detection with multi-class rationale learning and multi-task learning

Yuta Honjo, Jianwei Zhang, Wei Zhang, Lin Li

Purpose High-performance hate speech detection models achieve high accuracy; however, their complex architectures make it difficult to interpret the basis of their predictions. Although methods focusing on explainability have been proposed, their effectiveness remains limited. This study aims to develop a hate speech detection model with improved explainability. Design/methodology/approach This study proposes an enhanced two-stage learning model for hate speech detection, consisting of rationale learning in the fir …

21.08.2026journal-article

Journal of Medicinal Chemistry

A Subcellular Keap1-Nrf2 Disruption Strategy for Atopic Dermatitis Therapy

Zixi Zhang, Jia Wu, Jingqi Liu, Daniel Shiu-Hin Chan, Chun-Yuen Wong, Jing Wang, Chung-Hang Leung, Wanhe Wang

Abstract Nuclear factor erythroid 2-related factor 2 (Nrf2) is a promising target for atopic dermatitis due to its role in skin barrier repair, yet effective modulators of Nrf2 are lacking. Here, we report an itaconate-iridium(III) complex conjugation strategy for the disruption of the Keap1-Nrf2 protein–protein interaction (PPI) for treating atopic dermatitis. The conjugate (1) specifically engages cytoplasmic Keap1 to restore Nrf2 activity, thus upregulating anti-inflammatory genes HO-1 and NQO1 while suppressing …

21.08.2026journal-article

African Journal of Health Nursing and Midwifery

Exploring the Contextual Factors Influencing the Implementation and Effectiveness of Community Health Worker–Led Malaria Community Case Management in Kailahun District, Sierra Leone

M. A., Koroma, L. S., Babawo, S., Mayhew, M. K., Rogers, B. E., Koroma, A. T., Bockarie, E. E., Babawo

Background. CHW-led malaria community case management (CCMm) extends services to rural, hard-to-reach communities in Kailahun District, Sierra Leone, where the malaria burden is heaviest; yet the same standardised intervention produces different outcomes across chiefdoms. This paper asks how contextual conditions enable or block the mechanisms through which CHWs produce outcomes. Methods. A qualitative realist evaluation using the Context–Mechanism–Outcome framework drew on six key informant interviews, three CHW c …

21.08.2026journal-article

Inflammatory Bowel Diseases

GLP-1 receptor agonist therapy is associated with increased symptomatic remission in ulcerative colitis: a matched cohort study

Budoor Alqinai, Swapna Gayam, Jennifer Hadam-Veverka

Abstract Background Ulcerative colitis (UC) remains associated with significant morbidity despite therapeutic advances. The impact of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) on UC disease activity is not well defined. Methods We performed a retrospective cohort study using electronic health records from a single tertiary academic health system (2022-2024). Adults with UC initiating liraglutide or semaglutide for metabolic indications and maintained on therapy ≥ 12 weeks were included. A 1:1 matched co …

21.08.2026journal-article

Journal of Neuro-Oncology

Five-year changes in health-related quality of life after proton therapy in a primarily meningioma cohort: a prospective study

Per Fessé, Linda Åkeflo, Karin Ahlberg, Emelie Blomqvist, Per Fransson, Ingrid Kristensen, Kristin Kunni, Ulrica Langegård, Emma Ohlsson-Nevo, Katarina Sjövall

Abstract Purpose Long-term patient-reported outcomes after Proton beam therapy (PBT) remain insufficiently described for patients with benign intracranial and seller-region tumors. The aim of this study was to evaluate health-related quality of life (HRQoL) and brain tumor–specific symptoms over five years after PBT in a primarily meningioma cohort. Methods In this prospective cohort study, adults treated with PBT completed the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 and QLQ-BN20 …

21.08.2026journal-article

The Canadian Journal of Psychiatry

Comparing Health System Costs for Recipients of Minimally Guided Internet-Based Cognitive Behavioural Therapy (iCBT) and Therapist-Guided CBT in Routine Care: A Cohort Study Using Ontario's Linked Health-Administrative Data: Comparaison des coûts pour le système de santé entre les personnes suivant une thérapie cognitivo-comportementale par Internet (TCCI) avec des orientations minimales et les personnes suivant une TCC menée par un ou une thérapeute en soins courants : étude de cohorte utilisant les données administratives de santé liées en Ontario

Evgenia Gatov, Claire De Oliveira, Gillian Strudwick, David Wiljer, Onil Bhattacharyya, Paul Kurdyak

Objective Internet-based Cognitive Behavioural Therapy (iCBT) is a scalable alternative to therapist-guided CBT, requiring fewer therapist resources. We compared health system costs in individuals receiving minimally guided iCBT (self-directed online modules with asynchronous therapist support) to those receiving therapist-guided CBT (scheduled, one-on-one sessions) in Ontario, Canada (January 2020–August 2021). Methods This retrospective cohort study leveraged linked health-administrative data to estimate person-c …