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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

BMJ Case Reports

Suspected menopause nutraceutical-induced eosinophilic ascites: a rare clinical presentation

Gemma Vicens-Novell, Alejandro Alonso-Galera, Rosa Muñoz-Cano, Joaquín Sáez-Peñataro

A middle-aged woman presented with a 2-month history of ascites without associated symptoms. She reported taking no regular medication, except for a menopause supplement for the preceding 4 months. Initial blood investigation revealed marked peripheral eosinophilia (49%) but was otherwise unremarkable. Analysis of the ascitic fluid demonstrated a predominance of eosinophils (90%) with no evidence of malignancy. Abdominal ultrasonography identified liver lesions; however, malignancy was excluded by CT. Gastroscopy f …

01.09.2026journal-article

Frontiers in Immunology

Intrathecal IgG synthesis as a biomarker for CNS involvement in anti-GQ1b antibody syndrome: a case report and hypothesis-generating treatment framework

Han Zhou, Xiuming Guo

Anti-GQ1b antibody syndromes span a clinical continuum from peripheral Guillain-Barré syndrome (GBS) to central Bickerstaff brainstem encephalitis (BBE), but reliable biomarkers of central nervous system (CNS) involvement that could guide treatment intensity are lacking. We report a 37-year-old woman with a relapsing GBS–Miller Fisher syndrome (MFS)–BBE overlap phenotype. In the first episode (March 2024), plasma exchange, intravenous methylprednisolone and IVIG were administered after anti-GD1a IgG was detected. A …

01.09.2026journal-article

Journal of Otorhinolaryngology, Hearing and Balance Medicine

Hybrid Respiratory Epithelial Adenomatoid Hamartoma and Seromucinous Hamartoma Clinically Mimicking Bilateral Nasal Polyposis: A Case Report

Raquel Muñoz-Andrés, Carlos Carazo-Casas, Mayte Herrera, Alfonso Santamaría-Gadea, Mónica Garcia-Cosio Piqueras, Kadir Jesús Quintero-Gil

Background: Respiratory epithelial adenomatoid hamartoma (REAH) and seromucinous hamartoma (SH) are uncommon benign epithelial lesions of the sinonasal tract. Their clinical and endoscopic appearance may overlap with inflammatory nasal polyps, and a definitive diagnosis usually requires histopathologic examination. Case presentation: A 37-year-old man presented with several years of nasal obstruction, hyposmia, and facial pressure over the paranasal sinus regions. He had no history of asthma or previous sinonasal s …

01.09.2026journal-article

Canadian Pharmacists Journal / Revue des Pharmaciens du Canada

Description of pharmaceutical interventions and clinical impacts of a new electronic tool used to identify and manage medication of vulnerable hospitalized elderly patients

Joëlle Flamand-Villeneuve, Julie Boisvert, Pascale Blais-Lecours, Cassandra Denis, Catherine Denis, Julie Méthot

Abstract Background: Older adults are at high risk of medication-related problems due to polypharmacy and potentially inappropriate medications (PIMs) use. A computerized tool was developed at Institut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval (IUCPQ-UL) to identify older patients who may benefit from pharmacist-led interventions. Methods: This prospective longitudinal descriptive study described the number and types of geriatric pharmacological problems detected by the electronic to …

01.09.2026journal-article

Medicine & Science in Sports & Exercise

Comparison of Different Exercise Modalities on Neuronal Plasticity and Spatial Memory

Tavor Ben-Zeev, Chagai Levi, Nicholas A. Ratamess, Henriette van Praag, Jay R. Hoffman

Purpose: The relationship between exercise and brain function has been studied extensively; however, whether different exercise modalities promote hippocampal neurogenesis and cognitive function through shared or distinct biological pathways remains unclear. This study examined the effects of endurance training (ET), resistance training (RT), and high-intensity interval training (HIIT) on hippocampal neurogenesis, spatial memory, and neurotrophic factors. Methods: Forty 3-month-old male C57BL/6J mice were randomize …

01.09.2026journal-article

JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY

Impact of a Pharmacist‐Led Antimicrobial Stewardship Program on Empiric Prescribing Appropriateness in the Emergency Department: A Retrospective Cohort Study

Ali A. Althubyani, Benito Fernandez Lopez, Lily G. Fechtmeyer, Daria K. Szczepanek, Melissa A. Catalano, Kyle Brown, Dana J. Holger

ABSTRACT Background Inappropriate antimicrobial use in emergency departments (EDs) contributes significantly to antimicrobial resistance (AMR). Pharmacist‐led antimicrobial stewardship programs (ASPs) can potentially optimize antimicrobial prescribing and improve patient outcomes; however, their specific impact in the ED setting warrants further evaluation. Methods This retrospective cohort study evaluated adult patients receiving empiric antimicrobial therapy in the ED of a large, tertiary‐care, community teaching …

01.09.2026journal-article

ACG Case Reports Journal

The Tissue Systems Pathology Test Enabled Detection of Missed Prevalent High-Grade Dysplasia in a Presumed Clinically Low-Risk Patient With Nondysplastic Barrett's Esophagus

Breanna Dobberpuhl, Falak Hamo, Salih Samo

Clinical guidelines recommend the use of histopathology and segment length to risk stratify patients with Barrett's esophagus (BE), the only known precursor of esophageal adenocarcinoma (EAC). However, these clinicopathologic factors have limited ability to accurately identify patients with nondysplastic BE (NDBE) who may be at high risk of progression. The tissue systems pathology-9 (TSP-9) test (TissueCypher) is clinically validated to predict the risk of progression of BE to high-grade dysplasia (HGD) or EAC wit …

01.09.2026journal-article

Welding Journal

Examining Stress Modification in Dissimilar and Similar Metal Welds through Ultrasonic Impact Treatment

American Welding Society, HAMID EISAZADEH, JEFFREY R. BUNN, ANDREW PAYZANT, PARIS CORNWELL, DARYUSH K. AIDUN

Residual stress (RS) from welding poses major challenges, especially in dissimilar joints such as 1018 steel and 304 stainless steel, where thermal expansion mismatches intensify tensile stress. Conventional post-weld heat treatments, although effective for homogeneous materials, often require substantial energy, specialized equipment, and extensive processing time, making them less practical for dissimilar metal weld applications. This study explores an alternative, energy-efficient method — ultrasonic impact trea …

01.09.2026journal-article

Tributaries journal for Studies and Researches In sports sciences

أثر برنامج علاجي في تحسين وظائف الركبة وجودة الحياة لدى المصابات بهشاشة العظام

امال محمد إبراهيم بابكر, عاتقة الأمين, رحمة إبراهيم

تهدف هذه الدراسة إلى التعرف على أثر برنامج علاجي حركي لمدة ثمانية أسابيع في تحسين وظائف مفصل الركبة وجودة الحياة لدى النساء المصابات بهشاشة مفصل الركبة (Osteoporosis). استخدمت الدراسة المنهج شبه التجريبي بتطبيق القياس القبلي والبعدي على عينة مكوّنة من (30–40) سيدة تتراوح أعمارهن بين (45–65) عامًا، والمشخّصات بهشاشة مفصل الركبة من الدرجة الأولى أو الثانية. اشتمل البرنامج العلاجي على تمارين للمرونة، وتمارين تقوية العضلات، وتمارين التوازن، إضافة إلى تمارين وظيفية موجهة للمفصل، بواقع ثلاث جلسات أسبوعيًا. أظهرت النتائج …

01.09.2026journal-article

Arab Media Renewal Journal

معالجة الأزمات الإنسانية في الصحافة الرقمية المصرية والأمريكية: دراسة تحليلية مقارنة

شروق حسنين قاسم

استهدفت الدراسة رصد وتحليل معالجة الصحافة الرقمية الأمريكية والمصرية للأزمات الإنسانية، بالتطبيق على موقعَي «اليوم السابع» المصري، و»USA Today» الأمريكي، وذلك في إطار نظرية المسؤولية الاجتماعية، ونظرية المشاركة الديمقراطية. وقد اعتمدت الدراسة على استخدام منهج المسح، وأسلوب المقارنة المنهجية، بالاعتماد على استمارة تحليل المضمون لجمع بيانات الدراسة، التي شملت (603) موضوعًا صحفيًا إنسانيًا تم نشرها خلال فترتين زمنيتين مختلفتين، هما (يناير-أبريل 2017) و(يناير-أبريل 2022) بموقعي الدراسة.وأظهرت النتائج تقاربًا في الحجم ا …

01.09.2026journal-article

Clinical Kidney Journal

Twelve-month real-world outcomes of sparsentan in a multicentre Spanish IgA nephropathy cohort

Clara García-Carro, Antolina Rodríguez-Moreno, Lucía Cordero, María Vanessa Pérez-Gómez, Helena Marco Rusiñol, Enrique Pasache, Alejandro Morales, Rocío Zamora, Diego Parra, Juan Villa, Elena Guillén-Olmos, Verónica Coll-Brito, Álvaro Álvarez, Juliana Bordignon, Carola Arcal, Olga Gracia, Patricia Delgado, María José Soler, Ana I Sánchez-Fructuoso

Abstract Background Sparsentan has demonstrated significant antiproteinuric effects in randomized trials of IgA nephropathy (IgAN). However, real-world evidence remains scarce and is largely limited to short-term follow-up. Data on the durability of the antiproteinuric response in routine clinical practice are still lacking. Methods This multicenter retrospective study included patients with biopsy-proven IgAN treated with sparsentan in routine clinical practice across Spanish centers. Patients were eligible if the …

01.09.2026journal-article

Orthodontics & Craniofacial Research

Clinical Outcomes Associated With Integrated Orthodontic Management of Tipped Teeth: A Retrospective Cohort Analysis of Functional Recovery, Occlusal Stability, Complications, and Retreatment

Lei He, Rujuan Gong

ABSTRACT Background Tipped teeth are frequently managed by orthodontic uprighting, retention, and subsequent tooth‐preserving or restorative care, but real‐world pathways are heterogeneous. Evidence comparing coordinated treatment pathways with less standardised management remains limited, and observational comparisons require careful interpretation. Methods We retrospectively analysed 204 adult patients with at least one tipped tooth requiring clinical management at a single tertiary dental centre from January 202 …

01.09.2026journal-article

ASM Case Reports

Co-detection of measles virus vaccine strain and seasonal coronavirus in an immunocompromised patient with pneumonia

C. Anderson, R. Odrobina, L. T. Murugan, B. T. Bradley

ABSTRACT Background Measles vaccination is recommended for hematopoietic stem cell transplant (HSCT) recipients ≥24 months post-transplant in the absence of graft-versus-host disease and immunosuppressive therapy. Administration of live vaccines during immunosuppression may result in iatrogenic injury. Case Summary We describe a 76-year-old patient with stage 3 multiple myeloma who had undergone autologous HSCT and received multiple therapies, including chimeric antigen receptor T-cell therapy and recent daratumuma …

01.09.2026journal-article

Frontiers in Surgery

Endoscopic diagnosis and treatment of colon cancer: current evidence and future directions

Huimei Gong, Hongyu Li, Zhiwen Zheng, Hanbin Zhu, Yanni Zhang

Colorectal cancer remains a major cause of cancer morbidity and mortality, while screening and advances in endoscopic imaging have increased detection of lesions that may be amenable to organ-preserving treatment. Accurate assessment of morphology, optical pattern, and invasion depth is central to selecting among endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), endoscopic full-thickness resection (EFTR), and surgery. This structured narrative review synthesizes contemporary evidence and m …

01.09.2026journal-article

Clinical Spine Surgery

Radiologic Outcomes Following All-Pedicle Screw Selective Thoracic Fusion in Adolescent Idiopathic Scoliosis Patients With Lenke Type 1 and 2 Curves

Shun Herng Tan, Chris Yin Wei Chan, Chee Kidd Chiu, Mohd Shahnaz Hassan, Mun Keong Kwan

Study design: Retrospective study. Objective: To evaluate the long-term clinical and radiologic outcomes of adolescent idiopathic scoliosis (AIS) patients with Lenke 1B, 1C, 2B, and 2C curves treated with selective thoracic fusion (STF) using an all-pedicle screw construct. Summary of Background Data: STF has been reported in the literature to achieve better perioperative outcomes, including shorter operative duration, reduced blood loss, and lower operative risks. However, complications such as coronal decompensat …

01.09.2026journal-article

Nature Medicine

Isthmin-2 is a first-trimester predictor of preeclampsia and fetal growth restriction

Ruoyu Miao, Sungsam Gong, Ulla Sovio, Irving L. M. H. Aye, Giulia Avellino, Jacqueline Guettler, Stephanie N. Rogers, Emma Cook, Ana Toribio, Lina Bergman, Susanne Lager, Anna-Karin Wikström, IMPACT Consortium, Ylva Carlsson, Stefan R. Hansson, Peter Lindgren, Anders Larsson, Peter Conner, Alice Zancanaro, Marius Kublickas, Anna Sandström, Paul D. W. Kirk, D. Stephen Charnock-Jones, Gordon C. S. Smith

Abstract Preeclampsia and fetal growth restriction (FGR) are major causes of global morbidity and mortality. Both conditions are associated with impaired invasion of the uterus by extravillous trophoblast (EVT). We performed proteomics in maternal serum obtained at ~12 weeks of gestational age in a prospective pregnancy cohort (Pregnancy Outcome Prediction Study). Here we show that low maternal serum isthmin-2 (ISM2) was the strongest protein signal (out of 2,904) in the first trimester of pregnancy for preeclampsi …

01.09.2026journal-article

American Journal of Physiology-Lung Cellular and Molecular Physiology

Mechanical and chemical power and mortality in acute respiratory distress syndrome: an exploratory analysis of six patient cohorts

Thijs A. Lilien, Lieuwe D. J. Bos, Lukas Martin Mueller-Wirtz, Pien Swart, Siebe G. Blok, Luciano Cesar Pontes Azevedo, Giacomo Bellani, Michela Botta, Elisa Estenssoro, Eddy Fan, Juliana Carvalho Ferreira, Hendrik Helmerhorst, John G. Laffey, Ignacio Martin-Loeches, Ana Motos, Tai Pham, Óscar Peñuelas, Antonio Pesenti, Ary Serpa Neto, Emanuele Rezoagli, Antoni Torres, Anissa M. Tsonas, Frederique Paulus, Marcus J. Schultz, David M. P. van Meenen, Reinout A. Bem, for the ERICC-, LUNG SAFE-, PRoVENT-COVID-, EPICCoV-, CIBERESUCICOVID-, and SATI-COVID-19-Investigators

This observational study of a combined cohort of patients with acute respiratory distress syndrome assessed the association of the novel concept of chemical power, a surrogate marker of oxygen exposure intensity, with mortality and its relative weight in this association when compared with mechanical power. Chemical power and mechanical power were independently associated with mortality. An interaction between these powers was not observed. Future experimental studies should aim to validate and optimize this novel …

01.09.2026journal-article

Annals of Clinical and Analytical Medicine

Primary pediatric cardiac tumors: a single-center experience from a high-volume pediatric cardiac center

Halise Zeynep Genç, Erkut Öztürk

Aim Cardiac tumors in children are rare and often asymptomatic. Nevertheless, in a subset of pediatric patients, they may lead to serious clinical conditions such as arrhythmia, outflow tract obstruction, or even death. This study aimed to evaluate the clinical characteristics, surgical management, and outcomes of pediatric patients diagnosed with cardiac tumors in a single high-volume pediatric cardiac center. Methods This retrospective study included all pediatric patients who underwent surgery for cardiac tumors …

01.09.2026journal-article

Journal of the European Society of Surgery

Clinicopathological Spectrum and Long-Term Outcomes of Appendiceal Neoplasms: A Bicentric Cohort Study

Haris Sulejmani, Blagica, Filip Vasilevski, Andrej Nikolovski

Background: Appendiceal neoplasms are rare and biologically heterogeneous, with diverse clinical presentations, pathological features, and treatment requirements. Their rarity has limited detailed real-world outcome data, particularly from smaller health-care systems. Methods: We conducted a retrospective bicentric cohort study of patients with histologically confirmed appendiceal neoplasms treated at two tertiary surgical centres in Skopje, North Macedonia, between January 2016 and May 2026. Patients with appendic …

01.09.2026journal-article

Eurasian Clinical and Analytical Medicine

Clinical outcomes and replant survival after microsurgical replantation following traumatic single-digit amputation

Mehmet Melih Asoglu, Volkan Kizilkaya, Ali Levent, Emre Mücahit Kartal

Aim Traumatic single-digit amputations may appear limited in extent, yet they can seriously impair hand function and quality of life. Factors determining survival of the replanted digit and functional recovery remain debated. We aimed to report our replantation outcomes and identify factors associated with replant survival. Methods Sixty patients who underwent microsurgical replantation for single-finger amputation between January 2020 and January 2025 were reviewed retrospectively. Patients were grouped according …

02.09.2026journal-article

Therapeutic Advances in Infectious Disease

Doravirine and islatravir for HIV-1 treatment: A systematic review and meta-analysis with GRADE assessment

Muhammad Tayyab Azam, Muhammad Hussain Azam, Muhammad Arif Khan, Muhammad Hassan Azam, Zain Ul Abideen Shahid, Shahzad Ashraf, Syeda Momina Umer, Rabeea Arshad, Hasibullah Aminpoor, Hammad Javaid

Background Two-drug antiretroviral regimens are increasingly explored to simplify HIV-1 treatment while maintaining durable viral suppression. Doravirine combined with Islatravir (DOR/ISL) represents a novel non-integrase strand transfer inhibitor (non-INSTI) regimen. However, comprehensive synthesized evidence remains limited. Objectives To systematically evaluate the efficacy and safety of fixed-dose Doravirine (100 mg) plus Islatravir (0.25 or 0.75 mg) for HIV-1 treatment in adults. Design Systematic Review and …

01.09.2026journal-article

ASEAN Journal of Rehabilitation Medicine

Cross-Cultural Adaptation and Psychometric Properties of the Thai Version of the Short-Form Urinary Quality of Life Questionnaire (SF-Qualiveen) in Individuals with Neurogenic Lower Urinary Tract Dysfunction Following Spinal Cord Injury

Pasinee Theerapap, Chayaporn Chotiyarnwong, Thanitta Thanakiatpinyo

Objectives: To develop the Thai version of the short form of the Urinary Quality of Life Questionnaire (SF-Qualiveen) and evaluate its validity and reliability in patients with neurogenic lower urinary tract dysfunction following spinal cord injury Study design: Cross-cultural adaptation and psychometric validation study Setting: Department of Rehabilitation Medicine, Faculty of Med-cine Siriraj Hospital, Mahidol University, Thailand, a tertiary care university hospital Participants: Patients with spinal cord injur …

01.09.2026journal-article

National Journal of Community Medicine

Quality of Life and Its Determinants among Patients on Vitamin K Antagonist Therapy in India: A Baseline Cross- Sectional Analysis

Janet Prameela Dsouza, Jyothi Chakrabarty, Padmakumar Ramachandran, Baby S Nayak, Elsa Sanatombi Devi, Vasudeva Guddattu, Judith Angelitta Noronha Noronha

Background: Vitamin K Antagonist (VKA) therapy has been extensively recommended for years to prevent thromboembolic disorders. The continued use of this treatment emphasizes its clinical importance across healthcare settings, particularly in resource-limited countries such as India. Chronic use of this therapy can impact patients’ QOL owing to treatment-related burden. Given that limited data are available related to the QOL of patients on VKA therapy at tertiary referral hospitals in the region, this study was und …

03.09.2026journal-article

Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders

Associated Determinants of Sexual Dysfunctions in Non-Specific Low Back Pain Patients in Cameroon: A Cross-Sectional Study

Womsi Tatuegan Ruslaine, Wankeu-Nya Modeste, Mekoulou Ndongo Jerson, Djeumeni Néely Ornéla, Watcho Pierre, Massoma Dieudonné Lembè

Background: Non-specific low back pain (NSLBP) is a significant factor involved in the onset of sexual dysfunctions (SDs). However, studies demonstrating the correlation between these 2 conditions are rare. This study aimed to determine the prevalence and factors associated to SDs in patients suffering from NSLBP in Cameroon. Method: A cross-sectional study was conducted among patients suffering from NSLBP in the 3 main town (Yaoundé, Douala and Bafoussam) of Cameroon. Clinical characteristics and sexual activity o …