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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Reproductive Health

The “puberty deadline”: cultural constructions of maturity, anticipated shame, and child marriage as a perceived risk-mitigation strategy in rural Niger

Jean Christophe Fotso, Aichatou Hamadou, Ferdinard Ngong, Paul Bukuluki

Introduction In rural Niger, child marriage remains highly prevalent, often functioning as a mechanism of risk mitigation. This qualitative study explores the cultural and bio-social drivers of child marriage, focusing on the intersection of physical maturation, anticipatory shame, and economic vulnerability. Methods The study drew on 53 in-depth interviews, six body mapping focus group discussions (FGDs), and 9 social norms mapping FGDs with adolescents, parents, and community leaders (n = 165) in the Maradi regio …

03.09.2026journal-article

Frontiers in Medicine

The role of Advanced Practice Providers in improving primary care capacity: practice perspectives on challenges and opportunities

Marie Shoen, Ben Webel, Jacqueline Britz, Hailee Hoffman, Jennifer Gilbert, Alex H. Krist, E. Marshall Brooks

Background In Virginia and across the United States, primary care workforce shortages limit access to care and exacerbate adverse health outcomes. We conducted a statewide survey of primary care practices in 2022 and found that 42% of practices reported losing a physician or Advanced Practice Provider (APP), including Nurse Practitioners (NPs) and Physician Assistants (PAs), in the past year. Adding APPs to primary care teams is one strategy practices are using to mitigate the shrinking availability of primary care …

03.09.2026journal-article

Frontiers in Public Health

Associations of work-related extended availability with overweight and obesity among Chinese workers

Huiying Wang, Xin Li

Objective Work-related extended availability (WREA) has become an increasingly salient feature of the contemporary labor market and may be associated with workers' health outcomes. Nevertheless, the associations of WREA with overweight and obesity remain insufficiently explored. This study aimed to examine the associations of WREA with overweight and obesity among Chinese workers. Methods Using data from the 2020 and 2022 waves of the China Family Panel Studies, we constructed an analytical sample of 16,969 observa …

03.09.2026journal-article

Frontiers in Ecology and Evolution

Spatiotemporal evolution and associated factors of coupling coordination between socio-economic development and ecological health: county-level evidence from the Central Yunnan Urban Agglomeration, China

Ying Li, Lede Niu, Anlin Li, Yan Zhou

Understanding how socio-economic development aligns with ecological health is essential for the sustainable governance of mountainous urban agglomerations. This study investigates 49 county-level units in the Central Yunnan Urban Agglomeration, China, from 2010 to 2023. Socio-economic development and ecological health were evaluated using a pooled entropy-weighted TOPSIS framework. A baseline coupling coordination degree (CCD-B) and a reconstructed non-overlapping measure (CCD-R) were developed to reduce mechanical …

03.09.2026journal-article

Physics in Medicine & Biology

Rapid whole-brain susceptibility source separation using sub-minute three-dimensional multiple overlapping-echo detachment acquisition

Longkun Chen, Qinqin Yang, Shiwei Huang, Nuowei Ge, Zejun Wu, Jianjun Zhou, Jianfeng Bao, Lijun Bao, Yuanhao Cheng, Jianfa Chen, Shuhui Cai, Zhong Chen, Liuhong Zhu, Congbo Cai

Abstract Objective. Magnetic susceptibility source separation provides profound insights into tissue pathophysiology by disentangling the underlying paramagnetic and diamagnetic sources within the human brain. However, the highly time-consuming nature of existing acquisition techniques creates a critical need for rapid and reliable separation methodologies to facilitate routine clinical applications. Approach. A highly accelerated framework for whole-brain magnetic susceptibility source separation was proposed by u …

03.09.2026journal-article

Frontiers in Neurology

Efgartigimod-alfa therapy in acetylcholine receptor antibody myasthenia gravis: Romanian experience

Nicolae Grecu, Oana Antonia Mihalache, Eugenia Irene Davidescu, Rodica Bălașa, Mihaela Simu, Vitalie Văcăraș, Ileana-Maria Vodă, Andreea-Ioana Mușuroi, Andra Mădălina Ene, Diana Mihaela Petrescu, Cristina Elena Mitu, Lorena Furnică, Amalia Cornea, Romana Homorodean, Crisanda Vîlciu, Cristina Tiu

Background Efgartigimod alfa, the first neonatal Fc receptor inhibitor approved for the treatment of acetylcholine receptor antibody (AChR)-positive generalized myasthenia gravis (MG), has demonstrated efficacy in randomized controlled trials. However, real-world data, particularly from Eastern Europe, remain limited. Methods This prospective, multicenter study enrolled AChR-positive generalized MG patients treated with efgartigimod across six Romanian university hospitals between March 2024 and September 2025. Out …

03.09.2026journal-article

Open Research Europe

A survey on Open Science perceptions and experiences among One Health researchers in South Asia

Naheeda Hamza, Rosemarie De La Cruz Bernabe, Alina Coman, Uma Kulkarni

Background Open Science aims at improving the quality of research, transparency, and data sharing through open-access platforms, data sharing, inclusion of citizen scientists, making research results accessible to both professionals and citizens. As science becomes increasingly data-driven, responsible open science practices enable collaboration, reduce barriers in multisectoral teams, and support integrative approaches such as One Health. In response to the rise of zoonotic diseases globally, many countries have a …

03.09.2026journal-article

Communications Medicine

KV7 channel activation inhibits human and murine myometrium contractility and delays delivery in a mouse model of preterm birth

Yosef T. Mansour, Hiten D. Mistry, Evonne C. Chin-Smith, Mariola K. Zaleska, Deanna C. Sekulich, Jennifer L. Herington, Jeff Reese, Rima Patel, Philip I. Aaronson, Donna M. Slater, Sarah K. England, Iain A. Greenwood, Mark R. Johnson, Paul D. Taylor, Rachel M. Tribe

Abstract Background Spontaneous preterm birth, defined as delivery before 37 weeks of gestation, remains a global cause of neonatal illness and death, yet treatments for preterm labor remain limited. We hypothesized that K V 7 channels in the uterus (myometrium), could be a therapeutic target for preventing or treating preterm labor. The aim was to characterize K V 7 channel subtypes in human myometrium present after labor onset, and to use a preterm birth mouse model to provide proof-of-principal evidence that act …

03.09.2026journal-article

Eastern Mediterranean Health Journal

Experiences of mothers and female community health workers accessing and implementing the Marwo Caafimaad programme in Somalia

Ayan Mohamed, Kathleen West, James Pfeiffer, Ahmed Ali, Farah Mohamed, Mohamed Ali, Abdirizak Hersi, Abdirisak Artan, Isse Jama, Salma Osman

Background: Somalia has one of the highest maternal mortality ratios globally, with low antenatal care coverage and low skilled birth attendance. In Puntland, Somalia, the Marwo Caafimaad programme trains female community health workers to provide reproductive health education, basic care and referrals. Aim: To assess the experiences of mothers and female community health workers accessing and implementing the Marwo Caafimaad programme in Puntland, Somalia. Methods: In 2022, we conducted focus group discussions wit …

03.09.2026journal-article

Paediatrics & Child Health

Providing care through a different lens: how paediatricians use complexity and systems theory in practice

Linda Peritz, Harold (Hal) Siden, Lorelei Lingard, Laura Nimmon

Abstract Objectives This study aimed to gather examples of how paediatricians use complex adaptive systems theory and complexity in their practice. Methods Semistructured interviews were conducted, using a descriptive exploratory approach. Participants Paediatricians practising in British Columbia participated in the study. Results Participants told rich stories about their care of children with complex illness and how they interacted with other care providers. Aspects of their stories aligned with elements of syst …

03.09.2026journal-article

Frontiers in Public Health

Activity-function transitions and interpretable machine learning for predicting incident depressive symptoms among ACE-exposed middle-aged and older adults: a multi-cohort study

Zhenhao Lin, Yuwen Shangguan, Young-Je Sim, Dahua Chen, Xiang Wang

Background Ad--verse childhood experiences (ACEs) are associated with increased risk of depressive symptoms in later life. This study aimed to develop and externally validate an interpretable machine-learning model for predicting incident depressive symptoms among ACE-exposed middle-aged and older adults. Methods Data were obtained from the English Longitudinal Study of Aging (ELSA) and the Health and Retirement Study (HRS). Participants with baseline depressive symptoms were excluded. ELSA was used for model devel …

03.09.2026journal-article

JAMA Ophthalmology

Patient With Bilateral Corneal Opacities

John Placide, Daniel J. Lee, Afshan A. Nanji

A 31-year-old woman from Guam with no known medical history was referred by an ophthalmologist to a US cornea clinic for bilateral progressive blurred vision and corneal opacities. What would you do next?

03.09.2026journal-article

Experimental & Molecular Medicine

Pleura organoid transplantation facilitates visceral pleural repair through CD133+ progenitor cell-mediated regeneration

Biao Deng, Pengli Huang, Qu Wang, Ye He, Liuping Gong, Chunyuan Chen, Yanxia Wu, Zhenghao Lu, Zhu Liang

Abstract Persistent pulmonary air leakage following thoracic surgery remains a major clinical challenge. Here we establish murine and human pleura organoids as a novel regenerative therapy. Morphological and functional analyses confirm that these organoids retain mesothelial markers and secretory activity critical for pleural homeostasis. Xenotransplantation beneath the renal capsule of immunodeficient mice generates pleura-like structures with a mesothelial monolayer and collagen-elastin networks. In vitro wound h …

03.09.2026journal-article

Pathogens

Tuberculous Meningitis in Pediatric Patients: Diagnosis, Clinical Course, and Outcomes in the Modern Era

Irina Vasilyeva, Nadezhda Klevno, Aleksey Kazakov, Aziza Pakhlavonova, Alena Prikhodko, Ekaterina Sokolskaya, Elizaveta Zakharova, Ksenia Rudakova, Alexandr Chuishchev, Inga Enilenis, Ivan Martel

Tuberculous meningitis (TBM) is a critically severe form of extrapulmonary tuberculosis in pediatric patients, presenting a significant diagnostic challenge during the early stages of clinical manifestation. Delayed recognition of meningeal tuberculous inflammation leads to the involvement of the brain parenchyma (encephalitis) and may result in irreversible neurological sequelae. Objective: To evaluate the clinical features, the spectrum of complications, and the acute outcomes of tuberculous meningitis in pediatr …

03.09.2026journal-article

Journal of Translational Medicine

Tau phosphorylation in Alzheimer’s disease: emerging mechanisms, network interactions, and therapeutic implications

Xue Li, Leihan Zhang, Lijun Zhao, Lang Qin, Qingyu Bai, Chao Zeng, Zhenbo Gao, Junjun Ni, Guihua Zeng, Aleena Saidova, Hong Qing, Hui Li

Abstract While amyloid-β (Aβ) has historically dominated the research landscape of Alzheimer’s disease (AD), the limited clinical success of Aβ-centric therapies has redirected focus toward tau pathology, which correlates more robustly with cognitive deterioration and synaptic dysfunction. Transcending the traditional linear pathological model, this review reframes tau phosphorylation as a dynamic hub within a multi-scale regulatory network. We first synthesize recent breakthroughs in molecular mechanisms, detailin …

03.09.2026journal-article

Signal Transduction and Targeted Therapy

CDK12/13 inhibition overcomes platinum resistance by impairing RNA metabolism

Ilenia Pellarin, Valentina Rossi, Riccardo Giuseppe Margiotta, Javad Karimbayli, Alessio Polacchini, Ashwani Bahl, Milena Nicoloso, Maura Sonego, Sara D’Andrea, Laura Sala, Simone Canesi, Andrea Favero, Anna Nespolo, Danilo Licastro, Michele Bartoletti, Fabio Puglisi, Antonino Ditto, Vincenzo Canzonieri, Monica Schiappacassi, Iain McNeish, Guido Sanguinetti, Barbara Belletti, Gustavo Baldassarre

Abstract Epithelial ovarian cancer (EOC) is a highly lethal disease characterized by a high rate of platinum (PT)-resistant recurrence. Dysregulation of transcriptional and alternative splicing (AS) has been suggested as a possible mechanism of PT resistance involving transcriptional cyclin-dependent kinases (CDKs). We report that pharmacological CDK12/CDK13 inhibition (CDK12i) synergistically enhances PT-induced cytotoxicity in a large number of PT-sensitive and PT-resistant EOC models. CDK12i effectively delayed …

03.09.2026journal-article

El-Mal: Jurnal Kajian Ekonomi & Bisnis Islam

Employee Performance is Assessed in Terms of Work-Life Balance, Work-Family Conflict, Mental Health, and The Generation Gap

Dias Ratih Rahmandini, Istiatin Istiatin, Suhendro Suhendro

The purpose of this study is to analyze the influence of work-life balance, work-family conflict, mental health, and the generation gap on employee performance at the Klaten Pratama Tax Office. This study uses a quantitative approach with a survey method. The study population was all Klaten Pratama Tax Office employees with a sample of 88 respondents. Data collection techniques were carried out through questionnaires, while data analysis used multiple linear regression with the help of the Statistical Product and S …

03.09.2026journal-article

Frontiers in Medicine

Case Report: A case of cutaneous collagenous vasculopathy

Chenjian Tang, Liping Chen, Jiangxiu Yu, Mei Zhu

We report a case of a 62-year-old woman presenting with a 6-year history of purpuric patches and macules on the lower extremities, initially misdiagnosed as allergic purpura and treated with prednisone. Skin biopsy revealed dilated dermal vessels with perivascular collagen deposition, positive for collagen IV and diastase–periodic acid–Schiff (D-PAS) staining, consistent with cutaneous collagenous vasculopathy (CCV). Treatment included hydroxychloroquine, vitamin C, doxepin, and topical mucopolysaccharide polysulfa …

03.09.2026journal-article

Frontiers in Oral Health

Bio-waste-derived hydroxyapatite from fish bone, bovine bone, and bovine teeth for enamel remineralization

Chawan Karim Jabar, Hadi M. Ismail

Objectives To investigate whether calcined fish bone, bovine bone, and bovine teeth can be converted into bioactive hydroxyapatite powders, and whether these materials can function as slurries and promote the remineralization of enamel. The novelty of this study is the production of hydroxyapatite from biowaste-derived bovine bone and bovine teeth powders, and its use as remineralizing agents for demineralized enamel for the first time. Methods Eighty-four human premolar enamel specimens were allocated into seven g …

03.09.2026journal-article

Frontiers in Medicine

EchoSAM2: enhancing anatomical consistency in few-shot cardiac ultrasound segmentation via sequence-wise memory and registration

Chunmin Li, Ziyu Zhou, Lijuan Guo, Qiulian Wang, Xiaoji Bai, Wenhao Wang

Introduction Few-shot segmentation in echocardiography is highly valuable for rapid clinical assessment, yet remains challenging because expert annotations are scarce, cardiac morphology varies across patients, and ultrasound videos exhibit complex temporal motion. Although the Segment Anything family provides strong generic priors, its direct deployment on echocardiographic videos often suffers from unstable frame-wise predictions and limited adaptation under low-label conditions. Methods We propose EchoSAM2, a fe …

03.09.2026journal-article

Frontiers in Medicine

Differential risk signals of cutaneous adverse drug reactions among β-lactam antibiotics: ceftriaxone shows increased signals for SJS/TEN in clinical and real-world cohorts

Leonard von Grundherr, Henrike Alexandra Faesser, Andreas Recke, Ralf J. Ludwig, Katharina Boch, Philip Curman

Background Cutaneous adverse drug reactions (CADRs) are triggered by numerous antibiotic drugs. Most drug reactions are in the spectrum of a maculopapular eruption (MPE) with a self-limiting disease course. In contrast, severe cutaneous adverse reactions (SCARs), including Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), are rare but may follow a life-threatening course. In this study, we investigated the key drug-related triggers of CADRs in a retrospective single-center cohort and, based on these fi …

03.09.2026journal-article

British Journal of General Practice

Primary care quality and secondary healthcare utilisation in patients with multimorbidity: a retrospective cohort study

Qian Gao, Benedict WJ Hayhoe, Meryem Cicek, Geva Greenfield, Michaela Otis, Gesthimani Misirli, Ana Luisa Neves, Azeem Majeed, Paul Aylin, Alex Bottle

Background High-quality primary care can improve multimorbidity management but little evidence is available to understand its impact on secondary care use over time. Aim To assess the concurrent and lagged associations between quality of primary care and planned and unplanned secondary care use, examining the modifying role of frailty. Design and Setting A retrospective cohort study included 468,172 patients with multimorbidity in England from the Discover research platform (April 2022-March 2024). Method We used p …

03.09.2026journal-article

Culture, Medicine, and Psychiatry

…And Breathe! Wellness, the Nation, and Holistic Reproductive Practitioners in India

Adhvik Shetty

Abstract Garbh Sanskar (GS) is an Indian holistic reproductive programme that claims roots in ancient Ayurvedic and yogic traditions while drawing upon contemporary wellness practices and international health policy. GS centres offer breathwork, guided meditation, and counselling to expectant and hopeful couples. This article draws upon interviews with GS practitioners across nine Indian cities to examine how these practitioners use wellness discourses to articulate strategies of individual and national improvement …

03.09.2026journal-article

Veterinary Clinical Pathology

Two Cases of Feline Hepatosplenic Cytotoxic T‐Cell Lymphoma With Hemophagocytosis

Hiroki Yamazaki, Yuki Kimura, Seio Onoyama, Hideo Akiyoshi

ABSTRACT This report describes the clinical courses of two cats with hepatosplenic cytotoxic T‐cell lymphoma (TCL) with tumor‐cell hemophagocytosis (THP). Both cats presented with pancytopenia and marked splenomegaly with a honeycomb pattern on ultrasonography. Cytology of splenic aspirates revealed large atypical lymphocytes with phagocytosis of erythrocytes and leukocytes. Immunohistochemical analysis revealed positive staining for CD3 and granzyme B. Bone marrow analysis revealed preserved trilineage hematopoies …