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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
21.08.2026journal-article

Advanced Functional Materials

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang

ABSTRACT Extracellular vesicles (EVs) from immune cells represent a novel drug delivery system with inherent anti‐tumor properties. To remodel the immunosuppressive tumor microenvironment and mediate multimodal therapy, we produced neutrophil nanovesicles at high yield and loaded them with drug (doxorubicin, DOX), near‐infrared region II fluorescent dye (FD1080), and PD‐1 inhibitor (TFA) through a simple extrusion method and further modified them with DSPE‐PEG2000‐cRGD to enhance their tumor‐targeting ability. The …

21.08.2026journal-article

Journal of Clinical Medicine

More than Rehabilitation: The Role of Contextual Factors in Pain Perception and Recovery: What the Physiotherapy Literature Reports—A Narrative Review with a Systematic Search Strategy

Giulia Leonardi, Francesco Bonanno, Angelo Alito, Francesca Cucinotta, Clara Lombardo, Antonio Di Dio, Francesca Sposito, Carmen Cucinotta, Alfio Garofalo, Simona Portaro

Background: Pain is a multidimensional experience shaped not only by nociceptive input but also by cognitive, emotional, and social processes. In musculoskeletal (MSK) rehabilitation, outcome variability among patients with similar clinical presentations suggests that determinants beyond tissue pathology may influence pain perception and recovery. Contextual factors (CFs)—communication, therapeutic relationship, patient expectations, and environmental cues—are increasingly recognized yet remain inconsistently integ …

21.08.2026journal-article

Frontiers in Medicine

Pharmacist-led medication therapy management improving medication adherence in a patient with type 2 diabetes: case report

Hong Jiang, Jing Liu, Yin Ying, Mingwan Zhang, Lu Zhao

Background Poor medication adherence is a major challenge in healthcare for patients with type 2 diabetes mellitus (T2DM), particularly those with long disease duration, multiple comorbidities, and complex therapeutic regimens. This case report describes the application of pharmacist-led MTM (medication therapy management) in a patient with T2DM presenting complex therapeutic regimens and poor adherence. Patients and methods A 76-year-old female with a 30-year history of T2DM complicated by diabetic peripheral neur …

21.08.2026journal-article

Renal Replacement Therapy

The NF-κB/miR-378c/IRG1 axis drives tubular injury in septic AKI by suppressing immunometabolic protection

Lu Zhou, Xiang Zhou, Hongmei Deng, Miaoyuan Zhang, Zheng Li

Abstract Background Septic acute kidney injury (AKI) is a life-threatening complication with high morbidity and mortality. Despite decades of research, therapeutic options remain limited to supportive care, underscoring the urgent need to decipher the molecular drivers that govern septic AKI. Methods We used a murine LPS-induced septic AKI model and cultured BUMPT cells. miR-378c expression was assessed by qPCR and fluorescence in situ hybridization. Gain- and loss-of-function studies were performed using miR-378c …

21.08.2026journal-article

Frontiers in Drug Delivery

Harnessing liposomal delivery to boost polyphenols’ potential in chronic wound therapy

Lisa Myrseth Hemmingsen, Marte Kristensen, Cecilie Thanh Loan Dang, Mari Salamonsen, Elizabeth G. Aarag Fredheim, Nataša Škalko-Basnet

Introduction Chronic wounds pose a significant clinical challenge due to impaired healing, persistent inflammation, and susceptibility to infection, often by antimicrobial-resistant bacteria. Therefore, active compounds should ideally act both as antimicrobials with limited potential for resistance development and offer other beneficial wound-healing properties. Polyphenols, such as chlorogenic acid (CGA) and quercetin (QCT), exhibit those properties, but are limited by poor stability or low bioavailability. Method …

21.08.2026journal-article

Future Health

Yoga therapy for mental resilience in technology professionals: From mechanisms to practice

Santosh Kumar Sahu, Ajit Kumar Pradhan, Prasanta Kumar Sahoo, Mohammad Zaki Ahmad

The technology sector involves sustained cognitive load, high-performance demands, prolonged screen exposure, and sedentary patterns, all of which contribute to stress, anxiety, and burnout, impairing well-being and productivity. Yoga therapy (YT), a multimodal mind-body practice that combines breath regulation, mindful movement, and meditative attention, offers a promising strategy for enhancing mental resilience in such contexts. Evidence indicates that YT may modulate stress physiology by improving heart rate va …

21.08.2026journal-article

The Oncologist

IUC26672-88 Treatment beyond progression in primary refractory mRCC during 1L systemic therapy (Meet-Uro 33)

D Aspden, D Bimbatti, A Dalla Volta, G Roviello, R Iacovelli, G Bozza, M G Vitale, E Fantinel, A Guida, F M Deppieri, C Nasso, S Scagliarini, E Cocorocchio, B Maiorano, C Caserta, A Cavo, F Paolieri, F La Russa, L Fratino, S E Rebuzzi

Abstract Background The optimal management of metastatic renal cell carcinoma (mRCC) patients (pts) experiencing progressive disease (PD) at the 1st radiological assessment during 1st line therapy (primary refractory pts) remains undefined. While treatment beyond progression (TBP) may be appropriate for selected pts with clinical benefit, evidence on pts selection and survival outcomes in this setting is limited. Methods Meet-Uro 33 is an ongoing Italian multicenter retrospective/prospective observational study of …

21.08.2026journal-article

Behavioral Sciences

A Non-Controlled Study of Cognitive Behavior Therapy for Panic Disorder in Veterans

Daniel F. Gros, Jeffrey M. Pavlacic

Panic disorder is a highly prevalent and impairing diagnosis in veterans. Despite consistent efficacy findings in community samples, few studies have investigated evidence-based psychotherapies in veterans with panic disorder, limiting the understanding of their utility and deployment in Veterans Affairs (VA) settings. The present study preliminarily investigated cognitive behavioral therapy (CBT) for panic disorder via a non-controlled design in a treatment-seeking veteran sample with panic disorder at the VA. Of …

21.08.2026journal-article

eJournal Kedokteran Indonesia

Rehabilitation in Juvenile Myasthenia Gravis: Strategies and Challenges in Enhancing Pediatric Patient Quality of Life

zulfahmidah zulfahmidah, Nila Mayasari

Juvenile Myasthenia Gravis (JMG) is a rare autoimmune disorder characterized by impaired neuromuscular transmission, resulting in fatigable weakness and significant functional limitations in pediatric patients. Despite growing recognition of rehabilitation's importance in JMG management, there remains a critical need to synthesize current evidence and establish standardized approaches. This comprehensive review examines the pathophysiology of JMG, focusing on autoantibody-mediated disruption of acetylcholine recept …

21.08.2026journal-article

Genes

4-Phenylbutyrate Plus Wildtype GAT-1 Augmentation: A Dual Therapy to Rescue SLC6A1 Variant-Associated Developmental and Epileptic Encephalopathy

Aiden James Delahanty, Kaitlin James, Emma Grace Carter, Ziang Debbie Song, Juexin Wang, Melissa Bassette, Jing-Qiong Kang

Background: Pathogenic variants in SLC6A1, which encodes the γ-aminobutyric acid (GABA) transporter GAT-1, cause developmental and epileptic encephalopathies (DEEs) through reduced GABA uptake, impaired transporter trafficking, and functional haploinsufficiency. 4-phenylbutyrate (PBA) is a clinically available small molecule with chemical-chaperone and histone-deacetylase-inhibitor activities that can rescue misfolded GABAergic proteins, but variant-level rescue data are needed to guide precision treatment. Methods …

21.08.2026journal-article

Journal of Artificial Organs

Clinical differences between destination therapy and bridge-to-transplant left ventricular assist device implantation: a 17-year single-center experience in Japan

Koichi Inoue, Daisuke Yoshioka, Yusuke Misumi, Ai Kawamura, Shin Yajima, Takuji Kawamura, Shunsuke Saito, Takashi Yamauchi, Shigeru Miyagawa

Abstract The use of left ventricular assist device (LVAD) implantation for destination therapy (DT) has been recently increased worldwide. In 2021, DT was also approved in Japan. Here, we report a single-institution experience of LVAD implantation for DT. This retrospective observational study was conducted at Osaka University Medical Hospital in Japan. Forty patients who underwent LVAD implantation for DT were included. The primary endpoint was on-device survival, and the secondary endpoint was the incidence of LV …

21.08.2026journal-article

Environmental Science & Technology

Nontarget Analysis of the Volatile and Semivolatile Chemical Profile of Wildland Firefighter Gear: Insight into Occupational Exposure and Health Implications

Patrica-Ivy Agorsor, Husam Kafeenah, Margaret D. Taiwo, Robin Verble, Michael O. Eze

Abstract Prescribed fire releases a complex mixture of volatile and semivolatile organic compounds to the environment. Firefighters are directly exposed to these hazardous mixtures through occupational activities. This study investigated the volatile and semivolatile chemical contamination profile of firefighter protective gear and the effectiveness of laundering as a decontamination strategy. Our results revealed that firefighter gear accumulated a broad spectrum of combustion-derived contaminants, predominantly c …

21.08.2026journal-article

European Heart Journal: Acute Cardiovascular Care

Injectable antiplatelet therapies in acute coronary syndromes: Current status and Emerging Therapies. A position paper of the Task Force of Antithrombotic therapy of the ACVC

Uwe Zeymer, Sogol Koolaji, Diego Araiza-Garaygordobil, Peter Clemmensen, Mario Gramegna, Konstantin A Krychtiuk, Christoph B Olivier, Andrea Rubboli, Benedikt Schrage, Christophe Vandenbriele, Kurt Huber, Diana A Gorog

Abstract Injectable antiplatelet agents can provide immediate and effective platelet inhibition in patients with acute coronary syndromes (ACS). These agents are able to overcome many of the limitations of oral antiplatelet agents, and maybe of particular benefit in patients with ST-elevation myocardial infarction (STEMI), especially those presenting with cardiogenic shock or rescuscitated cardiac arrest. In these patients, factors such as vomiting, altered physiology, sedation, mechanical ventilation or therapeuti …

21.08.2026journal-article

International Journal of Molecular Sciences

Single-Exposure Prophylactic Transcranial Nano-Pulsed Laser Therapy Promotes Functional Resilience Following Mild Blast-Induced Neurotrauma

Nikita Gupta, Katherine N. Sheffield, Mohammadhossein Khanmirzaei, Auston C. Grant, Jutatip Guptarak, Ian J. Bolding, Kathia M. Johnson, Rinat O. Esenaliev, Donald S. Prough, Maria-Adelaide Micci

Blast-induced traumatic brain injury is a prevalent and underreported condition, particularly among military service members, for whom effective prophylactic interventions are lacking. Nano-pulsed laser therapy (NPLT) is a non-invasive neuromodulatory approach that delivers short pulses of near-infrared light to generate optoacoustic effects within cerebral tissue and has previously demonstrated therapeutic benefit following TBI. In this study, we evaluated whether a single pre-exposure application of NPLT could co …

21.08.2026journal-article

Reviews in Cardiovascular Medicine

Functional Heterogeneity of Immune Cell Subpopulations in Atherosclerosis: From Basic Mechanisms to Precision Therapy

Ming Li, Ce Bian, Bo Li

Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of death worldwide. Accumulating evidence has established ASCVD as a lipid-driven chronic inflammatory disease in which the functional heterogeneity of immune cell subsets plays a pivotal role in plaque development and stability. This review systematically summarizes the dynamic immune microenvironment in atherosclerosis, moving beyond static cell categorization to explicitly link immune heterogeneity to the major stages of disease progression: …

21.08.2026journal-article

Tạp chí Y học Quân sự

ĐÁNH GIÁ THỰC TRẠNG Ô NHIỄM HƠI TNT TRONG MÔI TRƯỜNG LAO ĐỘNG VÀ NHIỄM TNT NGHỀ NGHIỆP TẠI MỘT SỐ KHO QUÂN KHÍ NĂM 2025

Đào Thị Lê Dung, Hoàng Thị Lan Anh, Phạm Quyết Chiến, Nguyễn Văn Đông, Ngô Quang Hải, Nguyễn Kiên Cường

Mục tiêu: Mô tả thực trạng ô nhiễm hơi TNT trong môi trường lao động, nhiễm TNT nghề nghiệp ở người lao động và xác định nhóm công việc có nguy cơ phơi nhiễm cao tại một số kho quân khí, năm 2025. Đối tượng và phương pháp: Nghiên cứu mô tả cắt ngang 711 người lao động và 418 mẫu môi trường lao động tại 16 đơn vị kho quân khí, từ tháng 9-12/2025. Đánh giá kết quả theo QCVN 03:2019/BYT và Quy trình kĩ thuật thường quy của Viện Sức khỏe nghề nghiệp và Môi trường. Kết quả: Tỉ lệ mẫu TNT trong không khí tại nơi làm việc …

21.08.2026journal-article

ACS Materials Letters

Biomaterial-Assisted Strategies to Improve Islet Encapsulation and Transplantation for Type 1 Diabetes Therapy

Haofei Li, Peihua Long, Wenxuan Qin, Xingyu Chen, Chuanlong Liao, Haoting Shi, Yang Liu, Lu Gao

Abstract Islet transplantation is a promising therapy for type 1 diabetes mellitus (T1DM), but its clinical application is limited by host immune rejection and insufficient mass transfer. Biomaterial-assisted strategies hold the potential to address these challenges by providing an immune-isolated microenvironment and facilitating nutrient and oxygen supplementation. Therefore, this review outlines the primary bottlenecks in islet transplantation and then discusses current biomaterial engineering approaches to over …

21.08.2026journal-article

Frontiers in Immunology

YBX1 as an adaptive RNA hub in cancer: linking state-dependent RNA regulation to tumor immunity, metabolic reprogramming, and therapy resistance

Zhang XiaoTian, Wang YiTong, Feng Chongchong

Y-box binding protein 1 (YBX1) has been implicated across an unusually broad range of malignancies and processes: immune remodeling, epithelial plasticity, metabolic rewiring, epitranscriptomic reading, and resistance to chemotherapy, targeted agents, and checkpoint blockade. A linear one-gene/one-pathway oncogene model does not readily accommodate this breadth. We argue that the apparent diffuseness reflects a context-dependent regulatory node rather than experimental noise, and develop the hypothesis that YBX1 ac …

21.08.2026journal-article

The Oncologist

IUC26698-96 Durvalumab + BCG therapy in BCG-naïve, high-risk NMIBC: efficacy and safety analyses from POTOMAC

S Hussain, N Shore, H Nishiyama, J Palou Redorta, M Krawczynski, A Seyitkuliev, F Guerrero-Ramos, M Kato, T Powles, M De Santis

Abstract Background Durvalumab (D) plus BCG induction (I) + maintenance (M) vs BCG (I+M) demonstrated statistically significant, clinically meaningful improvement in disease-free survival (DFS) in patients with BCG-naïve, high-risk non-muscle-invasive bladder cancer (NMIBC; POTOMAC, NCT03528694). We report in-depth efficacy and safety analyses for D+BCG (I+M) vs BCG (I+M). Methods Patients were randomized 1:1:1 D+BCG (I+M), D+BCG (I), or BCG (I+M). For D+BCG (I+M) vs BCG (I+M), we report time to cystectomy (TTC; se …

21.08.2026journal-article

Neuro-Oncology Advances

Combination of EZH2 and MEK inhibitors as an Effective Therapy for Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheath Tumors

Sogo Oki, Yukitomo Ishi, Shigeru Yamaguchi, Manabu Natsumeda, Christine A Pratilas, Michiyuki Hakozaki, Hideki Tanizawa, Zen-ichi Tanei, Miki Fujimura

Abstract Background Neurofibromatosis type 1 (NF1)–associated malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas with poor outcomes and limited therapeutic options. Although mitogen-activated protein kinase kinase (MEK) inhibitors are active in benign plexiform neurofibromas, their efficacy in MPNST treatment is modest. Enhancer of zeste homolog 2 (EZH2) inhibitors are preclinically efficacious in MPNST treatment, but their mechanisms of action remain unclear. We evaluated the therapeutic pot …

21.08.2026journal-article

Applied Sciences

Manual Diaphragm Therapy and Masseter Muscle Activity in Healthy Young Women: An Exploratory Randomized Study of sEMG, Mandibular Motor Function, and Perceived Stress

Joanna Golec, Monika Nowak, Joanna Balicka-Bom, Sara Gamrot, Iwona Sulowska-Daszyk, Monika Michalik, Jędrzej Golec, Aneta Wieczorek

This exploratory randomized study examined whether manual diaphragm therapy is associated with masseter muscle activity, mandibular motor function, and perceived stress in healthy women. Forty-two asymptomatic women aged 20–30 years were randomized to an intervention group (n = 20), receiving six sessions over two weeks, or a no-intervention control group (n = 22). Before and after the intervention period, bilateral masseter surface electromyography (sEMG) was recorded at rest and during standardized mandibular mot …

21.08.2026journal-article

Applied Sciences

Rehabilitation of Shoulder Disorders: An ICF-Oriented Lexical Network Analysis of the Literature

Daniele Coraci, Gianluca Regazzo, Gianpaolo Ronconi, Gabriele Santilli, Cristina Razzano, Lucrezia Tognolo, Stefano Masiero

(1) Background: The continuous growth of rehabilitation literature makes evidence synthesis increasingly challenging. Lexical network analysis may provide quantitative information on the organization of scientific knowledge. This study aimed to characterize the shoulder rehabilitation literature through an International Classification of Functioning, Disability and Health (ICF)-oriented lexical network approach. (2) Methods: PubMed was searched for papers on shoulder rehabilitation published from 2016 to 2025. ICF- …

21.08.2026journal-article

Healthcare

Thematic Structure of Clinical Rehabilitation Research in the Early Post-Pandemic Period: An LDA-Based Analysis of Publications from 2022 to 2025

Alina Alshevskaya, Ivan Khutornoy, Natalia Sivitskaya, Marat Fatkhullin, Elena Aksenova

Background/Objective: Recent advances in scientometric topic modeling have enhanced the capacity to rapidly assess evolving research priorities. This study aimed to characterize the thematic reorganization of clinical rehabilitation research during the early post-pandemic period and to compare how an Latent Dirichlet Allocation (LDA)-derived topic structure, SciVal, and OpenAlex represent this interdisciplinary research domain. Methods: Titles of 55,711 publications on clinical rehabilitation (2022–2025) were analy …

21.08.2026journal-article

Current Drug Therapy

Culture and Identification Techniques of Rat Bone Marrow Mesenchymal Stem Cells

Wanying Li, Tongze Cai, Ding Wang, Caiyue Lin, Simin Wen, Liangna Huang, Yanqi Zhang, Jinghui Zheng

Introduction: Although current stem cell research is considerably advanced, systematic studies on rat Bone Marrow Mesenchymal Stem Cells (BMSCs) remain limited. Novice researchers often encounter difficulties in cell extraction, culture, and identification. Methods: Tibias and femurs were obtained from 4-week-old Sprague-Dawley rats, and bone marrow was extracted through centrifugation. Cell morphology was monitored from P0 to P5. Flow cytometry was performed to detect surface antigen (CD29, CD44, CD90, CD11b, CD34 …