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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
22.08.2026journal-article

Journal of Clinical Medicine

The Safety of Pre-Filter Heparin for Circuit Clotting Prevention in Continuous Renal Replacement Therapy: A Retrospective Evaluation

Thomas Diaz, Traci Grucz, Stephanie Davis, John Lindsley, Kathryn E. Dane, Hailey Burns, Samir Gautam, Gianna Iantosca

Background: Circuit clotting is a common complication of continuous renal replacement therapy (CRRT). Pre-filter unfractionated heparin (UFH) is widely used to maintain circuit patency, but real-world data describing its safety and efficacy are limited. Methods: This retrospective, single-health-system study evaluated critically ill adults receiving pre-filter UFH for CRRT clotting prevention between 2021 and 2025. The primary outcome was clinically relevant major bleeding, adapted from International Society on Thr …

22.08.2026journal-article

Small

Efficient Colon Cancer Immunogene Therapy by Hydrogel Ball Loaded With Two Types of Cell Membrane‐Coated Nanoparticles

Jingmei Li, Jin Zhang, Xiayu Chen, Shan Wu, Jieping Wu, Xizi Fu, Yan Gao, Lixia Guo, Xingmei Duan, Ke Men

ABSTRACT Biomimetic technology has high potential for enhancing cancer immunogene therapy. Cell membrane‐coated nanoparticles (CMNPs) obtain extra targeting, recognition, and signaling transduction functions. However, a single kind of CMNPs is limited when facing complicated tumor immunogene therapy. Here reported the collaboration of two types of CMNPs using a double‐layered spherical scaffold. This scaffold was prepared by stacking photosensitive hydrogels with two concentrations. After implantation, the two laye …

22.08.2026journal-article

Indonesian Journal of Global Health Research

Navigating Therapy for Hyperthyroidism in Lactation: A Case Report and Review of Antithyroid Drug Safety

Maya Safira, Naufal Gusti

Graves’ disease is the leading cause of hyperthyroidism in women of reproductive age and may relapse in the postpartum period, when immune reactivation and the desire to continue breastfeeding complicate antithyroid drug selection. This case report aims to describe the therapeutic decision making process in a breastfeeding mother with Graves’ hyperthyroidism and to provide practical insights that help bridge the gap between guideline recommendations and day to day clinical practice in navigating treatment options d …

22.08.2026journal-article

Klinik Psikoloji Dergisi

The effects of a child-parent relationship therapy based psycho-education program on children and parents in single-parent families

Gülçin Güler Öztekin, Başaran Gençdoğan

Single-parent families, one of the common family structures in society, experience some challenges as well as advantages. One way to deal with these challenges is to strengthen the child-parent relationship. The aim of this study was to reduce problematic behaviors in single-parent children and increase parental empathy and acceptance levels of their parents by implementing a psycho-education program based on Child-Parent Relationship Therapy. The study employed a pre-test-post-test control group experimental desig …

22.08.2026journal-article

Diseases of the Esophagus

P1.101. Treatment Selection and Real-World Outcomes of First-Line ICI-Based Therapy for Unresectable or Recurrent Esophageal Cancer in a Regional Hospital

Tomonari Suetsugu, Narutoshi Nagao, Kazuo Yamamoto, Shinya Ohno, Shunya Kiriyama, Kakeru Tawada, Yoshinori Iwata, Chihiro Tanaka, Masahiko Kawai

Abstract Topic Esophageal Cancer: Management of Metastatic Cancer Background Based on pivotal clinical trials, immune checkpoint inhibitors (ICIs) have demonstrated efficacy in patients with unresectable advanced or recurrent esophageal cancer and are now incorporated as standard treatment in the Japanese clinical practice guidelines. Although expanded therapeutic options are expected to improve survival outcomes, real-world data remain limited. Our institution is a regional hospital where a large proportion of pat …

22.08.2026journal-article

Diseases of the Esophagus

PD01.07. Surgery Timing After Neoadjuvant Therapy for Esophageal Carcinoma: A Meta-Analysis of 7,544 Patients

Jianfeng Zhou, Pinhao Fang, Yong Yuan, Zewen Wang

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background In treating locally advanced esophageal carcinoma, neoadjuvant therapy followed by surgery represents a key approach. However, the timing of surgery following neoadjuvant therapy in esophageal carcinoma remains controversial. Methods We conducted a systematic search of PubMed, EMBASE, Web of Science, and Cochrane Library for studies published up to August 1, 2024. Studies that compared delayed versus early surgery for locally advanced …

22.08.2026journal-article

Pharmaceuticals

Neurofilament Light Chain (NfL) in Neurodegenerative Diseases: Biological and Clinical Significance, Multi-Omics Integration, and AI-Driven Biomarker Modeling for Precision Therapy

Nawaf Alshammari, Reyaz Hassan, Mitesh Patel, Mohd Adnan

Neurodegenerative diseases represent a major cause of disability and death, but early diagnosis, prognosis, and therapeutic monitoring are challenging due to biological heterogeneity and the absence of disease-specific biomarkers. Neurofilament light chain (NfL) is a highly sensitive fluid biomarker of neuroaxonal injury with well-established clinical utility in selected neurological disorders, especially in disease monitoring and prognostic evaluation. However, since NfL is not disease-specific, the interpretation …

22.08.2026journal-article

Techniques in Coloproctology

Salvage surgery after total neoadjuvant therapy and watch-and-wait in rectal cancer: a systematic review and proposed minimum outcome set

J. R. Burke, I. Samuel, R. Clifford, P. Sutton, C. Arthur, A. G. Renehan

Abstract Background Salvage surgery for local regrowth following watch-and-wait (W&W) after total neoadjuvant therapy (TNT) is perceived to be technically more difficult than immediate surgery after treatment. However, surgical difficulty lacks standardised definition and reporting. This methodological review proposes a structured minimum outcome set (MOS) to distinguish intra-operative technical complexity from surgery-related morbidity and evaluates current reporting against this framework. Methods A predefined f …

22.08.2026journal-article

Diseases of the Esophagus

P1.055. Combination of CAR-T Cell Therapy With Immune Checkpoint Inhibition Enhances Anti-Tumor Efficacy in Esophageal Squamous Cell Carcinoma

Ning Zhao

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Chimeric antigen receptor (CAR)-T cell therapy has limited efficacy in solid tumors like esophageal squamous cell carcinoma (ESCC). This study investigates whether combining CAR-T cells with an anti-PD-1 antibody can overcome immunosuppression and improve therapeutic outcomes by remodeling the tumor microenvironment (TME). Methods We constructed second-generation CAR-T cells targeting mesothelin, an antigen overexpressed in ESCC. Using …

22.08.2026journal-article

JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY

Prenatal molecular diagnosis and allogeneic hematopoietic stem cell transplantation in an infant with RAG2 deficiency

Maria Laura Herrera Andino, Milagros López Orozco, María Victoria Suen, Carlos Hernán Hollmann, Lucía Spossito, Arjan Lankester, María Emilia Mas, Ana Lisa Basquiera

RAG2 deficiency is a cause of severe combined immunodeficiency (SCID), characterized by a defect in the development of T and B lymphocytes that predisposes patients to life-threatening infections during the first months of life. We present the case of an infant with a prenatal molecular diagnosis of SCID secondary to RAG2 deficiency who underwent allogeneic hematopoietic stem cell transplantation (HSCT) using a human leukocyte antigen-identical sibling donor at 3 months old. The subsequent clinical course was favor …

22.08.2026journal-article

Cells

Cardiovascular Toxicity in Cancer Therapy: Potential Mechanisms of Ferroptosis and Treatment Strategies

Jiani Dai, Yufei Wang, Chunna Jin, Liuguang Song, Yao Xie, Liangliang Jia, Meixiang Xiang

Advances in anticancer therapies have substantially improved cancer survival but have also highlighted the growing challenge of cancer therapy-related cardiac dysfunction. Ferroptosis, an iron-dependent form of regulated cell death characterized by iron dysregulation, lipid peroxidation, and impaired antioxidant defense, has emerged as a promising strategy for eliminating therapy-resistant tumors. However, the lack of tissue specificity in ferroptosis regulation raises concerns regarding its potential contribution …

22.08.2026journal-article

International Journal of Computer Trends and Technology

A Distilbert Case-Based Deep Learning Model for Part-of-Speech Tagging for Under-Resourced Kenyan Language: A Case of Dholuo

Maureen Otieno, Lilian Wanzare, Calvins Otieno

One of the basic Natural Language Processing (NLP) tasks is Part-of-Speech (POS) tagging, which helps in various applications like sentiment analysis and information retrieval. However, creating accurate POS taggers for low-resource African languages continues to be difficult due to the scarcity of linguistic resources that are annotated. Its contribution is a deep learning method for POS tagging of Dholuo, a less-resourced Western Nilotic language, spoken by about four million people in Kenya and Tanzania. The sug …

22.08.2026journal-article

International Journal of Innovative Science and Research Technology

Occupational Health and Safety of Employees in Wood Processing Industries in Cameroon

Ateba François René, Oum René, Ngongo Isidore Seraphins

Workers safety in Africa faces significant challenges, marked by the high number of workplace accidents, inadequate support from employers, a general shortage of personal protective equipment across all industries, insufficient controls, and unequal legal frameworks across countries. This article provides some answers both to help reverse the trend of occupational accidents and to raise awareness among decision-makers in African countries.

22.08.2026journal-article

Journal of Medicine and Health Research

Electronic Waste Exposure and Public Health Risks among Informal Recycling Workers: A Critical Narrative Review of Occupational Mixtures, Health Effects and Prevention

Hameedat Titilade Sanusi, Ogunyemi Joel, George-Oloja Nkechinyere, Elona Erezi

Electronic waste recycling sustains livelihoods and recovers valuable materials, yet informal processing can transfer a substantial fraction of the environmental and occupational costs of the digital economy to workers with limited access to engineering controls, occupational health services and social protection. This critical narrative review evaluates the evidence linking informal electronic waste work with hazardous exposures and adverse health outcomes, with emphasis on worker-specific studies rather than comm …

22.08.2026journal-article

Journal of Endovascular Therapy

Concurrent Peripheral Arterial Disease Predicts Re-Intervention Following Abdominal Aortic Aneurysm Repair: A Single-Centre Propensity Matched Retrospective Study

Navanith Murali, Angela Lee, Lukschana Senathirajah, Eman Otify, Jing Zhou, Tariq Ali, Philip Stather

Purpose: Abdominal aortic aneurysm (AAA) and peripheral arterial disease (PAD) share common risk factors and may co-exist in patients undergoing AAA repair. The impact of concomitant PAD on clinical outcomes post AAA repair remains unclear. This study aims to evaluate whether concurrent PAD is associated with adverse clinical outcomes following AAA repair. Materials and Methods: This was a single-centre retrospective propensity matched analysis involving patients undergoing infrarenal AAA repair at a single UK cent …

22.08.2026journal-article

Journal of Web Engineering

Immersive Web Virtual Environment for Language Learning: Multimodal Interaction and Error Correction Based on Speech, Gesture and Eye Tracking

Shuwen Yu

In order to solve the problems of existing Web language learning tools, such as single interaction dimension, lagging error correction feedback and insufficient attention perception, this paper designs and verifies a multimodal immersive Web virtual environment optimization scheme which integrates voice, gesture and eye tracking. The core breakthroughs are as follows: (1) a dual-mechanism adaptive fusion algorithm of “attention weight+dynamic threshold” is proposed, which solves the problem of error correction fail …

22.08.2026journal-article

Lasers in Medical Science

Photobiomodulation therapy and postoperative recovery after abdominoplasty: a non-randomized pilot study

Carmen Lucia Kretiska Araujo, Graziele Silveira Fardin, Ana Paula Bernardi, Joane Severo Ribeiro, Ricardo Vitiello Schramm, Isadora Frois Ourique, Maria Luiza Santos, Betina Vescovi, Tássio Fernando Crusius, Flávia Marafon, Denis Valente, Níveo Steffen, Patricia Viana da Rosa, Alessandra Peres

Abstract Photobiomodulation (PBM) has been proposed as a non-invasive therapeutic strategy to support wound healing and modulate oxidative and inflammatory responses. However, clinical data evaluating its effects in the postoperative period of abdominoplasty remain limited. This non-randomized clinical trial included 31 female patients undergoing abdominoplasty, divided into two groups: PBM intervention ( n = 15) and control ( n = 16). Salivary samples were collected at three time points: preoperative (T0), 48 h po …

22.08.2026journal-article

ShodhKosh: Journal of Visual and Performing Arts

EFFECTIVENESS OF TRAUMA-INFORMED ART THERAPY IN REDUCING PTSD SYMPTOMS AMONG WOMEN SURVIVORS OF DOMESTIC VIOLENCE IN ERNAKULAM, KERALA

Tanya Filbert

Domestic violence is associated with substantial psychological consequences, including post-traumatic stress disorder (PTSD), anxiety, depression, impaired self-esteem and difficulties in interpersonal functioning. Although psychological, legal and social-support services are available to survivors, access to sustained and culturally responsive trauma-focused interventions remains a concern. The present study examines the potential effectiveness of an eight-week trauma-informed art-therapy intervention among women …

22.08.2026journal-article

Renal Replacement Therapy

Antioxidant assessment of vitamin E-coated hemodialysis membranes: mechanistic context and implications for novelty

Francesco Galli

Abstract Vitamin E-coated polysulfone (VE-PS) dialysis membranes were developed to enhance both antioxidant performance and biocompatibility of conventional dialyzers and have been investigated for more than three decades both in experimental models and clinical studies. Tange et al. recently reported that VE-PS membranes retain greater antioxidant capacity than conventional polysulfone following exposure to Fenton’s reagent and proposed their assay as a new standardized in vitro method. Although the experimental a …

22.08.2026journal-article

Diseases of the Esophagus

P1.145. The pCR Paradox: Unmasking Systemic Failure in Esophageal Cancer Following Neoadjuvant CROSS Therapy

Manish Jethani, Ganesh Jadhav, Rajesh Mistry, Imran Shaikh, Pranav Chadha

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background While neoadjuvant chemoradiotherapy (nCTRT) followed by esophagectomy has established itself as the global standard for locally advanced esophageal cancer - predominant squamous histology, the "Achilles' heel" remains disease recurrence. Although achieving a pathological complete response (pCR) suggests a favourable prognosis, it does not guarantee a cure. We aimed to characterize the specific timing and patter …

21.08.2026journal-article

Advanced Functional Materials

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang

ABSTRACT Extracellular vesicles (EVs) from immune cells represent a novel drug delivery system with inherent anti‐tumor properties. To remodel the immunosuppressive tumor microenvironment and mediate multimodal therapy, we produced neutrophil nanovesicles at high yield and loaded them with drug (doxorubicin, DOX), near‐infrared region II fluorescent dye (FD1080), and PD‐1 inhibitor (TFA) through a simple extrusion method and further modified them with DSPE‐PEG2000‐cRGD to enhance their tumor‐targeting ability. The …

21.08.2026journal-article

Journal of Clinical Medicine

More than Rehabilitation: The Role of Contextual Factors in Pain Perception and Recovery: What the Physiotherapy Literature Reports—A Narrative Review with a Systematic Search Strategy

Giulia Leonardi, Francesco Bonanno, Angelo Alito, Francesca Cucinotta, Clara Lombardo, Antonio Di Dio, Francesca Sposito, Carmen Cucinotta, Alfio Garofalo, Simona Portaro

Background: Pain is a multidimensional experience shaped not only by nociceptive input but also by cognitive, emotional, and social processes. In musculoskeletal (MSK) rehabilitation, outcome variability among patients with similar clinical presentations suggests that determinants beyond tissue pathology may influence pain perception and recovery. Contextual factors (CFs)—communication, therapeutic relationship, patient expectations, and environmental cues—are increasingly recognized yet remain inconsistently integ …

21.08.2026journal-article

Frontiers in Medicine

Pharmacist-led medication therapy management improving medication adherence in a patient with type 2 diabetes: case report

Hong Jiang, Jing Liu, Yin Ying, Mingwan Zhang, Lu Zhao

Background Poor medication adherence is a major challenge in healthcare for patients with type 2 diabetes mellitus (T2DM), particularly those with long disease duration, multiple comorbidities, and complex therapeutic regimens. This case report describes the application of pharmacist-led MTM (medication therapy management) in a patient with T2DM presenting complex therapeutic regimens and poor adherence. Patients and methods A 76-year-old female with a 30-year history of T2DM complicated by diabetic peripheral neur …

21.08.2026journal-article

Renal Replacement Therapy

The NF-κB/miR-378c/IRG1 axis drives tubular injury in septic AKI by suppressing immunometabolic protection

Lu Zhou, Xiang Zhou, Hongmei Deng, Miaoyuan Zhang, Zheng Li

Abstract Background Septic acute kidney injury (AKI) is a life-threatening complication with high morbidity and mortality. Despite decades of research, therapeutic options remain limited to supportive care, underscoring the urgent need to decipher the molecular drivers that govern septic AKI. Methods We used a murine LPS-induced septic AKI model and cultured BUMPT cells. miR-378c expression was assessed by qPCR and fluorescence in situ hybridization. Gain- and loss-of-function studies were performed using miR-378c …