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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
22.08.2026journal-article

Journal of Applied Physiology

Cardiometabolic Benefits and Risks for Transgender Youth with the Initiation of Gender-Affirming Hormone Therapy: a case series

Nina S. Stachenfeld, Cheryl A. Leone, Stuart A. Weinzimer

Background. Interventions for transgender youth include puberty suppression and gender affirming hormone therapy (GAHT). Studies have begun to show changes in cardiometabolic outcomes in adolescent transgender males (TGM) and females (TGF). We hypothesized that in TGM and TGF youth, GAHT would increase total cholesterol (TC), LDL cholesterol (LDL-C), insulin resistance (IR) and adiposity, while decreasing HDL cholesterol (HDL-C) and endothelium-dependent vasodilation. Methods. We measured IR (oral glucose tolerance …

22.08.2026journal-article

Diseases of the Esophagus

P1.079. Real-World Adoption of Adjuvant Immunotherapy Following Trimodality Therapy for Esophageal Cancer: A National Cancer Database Analysis

Zamaan Hooda, Ana McCracken, Antonio Luna, Mara Antonoff, Arlene Correa, Jenny Li, Steven Lin, Reza Mehran, David Rice, Stephen Swisher, Ara Vaporciyan, Garrett Walsh, Wayne Hofstetter, Ravi Rajaram, Kyle Mitchell

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Following CheckMate 577 (CM577, 2021), adjuvant nivolumab was approved for patients with esophageal cancer (EC) and residual disease following trimodality therapy. As perioperative paradigms continue to evolve, early adoption patterns may inform implementation of future multimodality strategies. We evaluated adoption trends and factors associated with receipt of guideline-concordant adjuvant immunotherapy. Methods The National Cancer D …

22.08.2026journal-article

Diseases of the Esophagus

P1.058. Angiotensin System Inhibitors and Outcomes After Neoadjuvant Therapy for Locally Advanced ESCC

Feng Su, Subinuer Maimaiti, Xu Huang, Jun Yin, Yaxing Shen

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Renin angiotensin system signaling has been implicated in tumor growth, angiogenesis, immune modulation, and responses to cytotoxic and radiation-based therapies, yet clinical effects appear heterogeneous across tumor histologies and treatment contexts.Angiotensin system inhibitors (ASIs) are widely used for cardiovascular indications and represent a plausible, readily implementable adjunct if associated with improved oncologic outcome …

22.08.2026journal-article

Journal of Functional Biomaterials

Glucose-Responsive Nanomedicine in Diabetes Therapy: Emerging Advances and Clinical Prospects

Adnan Alsaei, Ayah Binrajab, Shahd Alsaei, Fatema Rahimi, Ahmad Zarwi, Helen N. Zarwi, Renad Alansari, G. Roshan Deen

Diabetes mellitus continues to impose a substantial global health burden, underscoring the need for therapeutic systems capable of achieving precise, adaptive, and patient-friendly glycemic control. Conventional diabetes treatments, including repeated insulin injections and oral hypoglycemic agents, are often constrained by non-physiological drug release, poor adherence, systemic side effects, and the persistent risk of hypoglycemia. In this context, glucose-responsive nanomedicine has emerged as a promising platfo …

22.08.2026journal-article

South African Journal of Communication Disorders

Clinical characteristics and outcomes of referrals for speech and language delay to the Speech Therapy and Audiology department at a district hospital in Gauteng, South Africa

Lucie B.L. Graca, Renate Strehlau, Jacqueline K. Bezuidenhout

Background: Speech and language skills are essential for effective communication. Speech and language delays may have far-reaching consequences on a child’s development; their early identification and intervention are paramount to a child reaching their full potential. Objectives: To describe the referral process, clinical characteristics, risk factors and outcomes of paediatric referrals to a Speech Therapy and Audiology (STA) department at a district-level hospital in Gauteng, South Africa. Method: A retrospectiv …

22.08.2026journal-article

Diseases of the Esophagus

P1.052. Photodynamic Therapy (PDT) in the Treatment of Gastroesophageal Reflux Disease (GERD) Complicated by Metaplasia of the Esophageal Mucosa in Children

Sofya Sosnova, Dmitry Khaspekov, Dmitry Morozov, Arthur Sar

Abstract Topic Benign Disease: Pediatric Esophageal Disorders Background GERD is common among children. Conservative treatment methods and surgical interventions for GERD complicated by esophageal mucosal metaplasia, do not always lead to reversal of the metaplasia or a reduction in the risk of esophageal adenocarcinoma. In some cases, PDT is used after antireflux surgery to target the metaplastic mucosa. Methods Five patients with a diagnosis of esophageal mucosal metaplasia were treated in the Thoracic Surgery De …

22.08.2026journal-article

Respiratory Care

Year in Review: Cystic Fibrosis Modulator Therapy—Efficacy, Access, and Evolution

Dawn Selhorst, Elena Stekolchik

The introduction of cystic fibrosis transmembrane conductance regulator (CFTR) modulators has transformed the therapeutic landscape of cystic fibrosis. CFTR modulators target specific functional defects in the CFTR protein, improving its folding, trafficking, gating, or conductance depending on mutation class. As CFTR modulators become the standard of care, emerging data highlight not only their transformative benefits but also knowledge gaps regarding long-term outcomes, variability in therapeutic response, effect …

22.08.2026journal-article

Diseases of the Esophagus

P1.078. Long-Term Follow-Up of Tislelizumab Combined With Chemotherapy or Radiotherapy as Neoadjuvant Therapy for Resectable Esophageal Squamous Cell Carcinoma (TINES)

Yong Zhang, Shaomin Che, Nanzheng Chen, Xinju Li, Tuotuo Gong, Junke Fu, Chenao Yu, Tianren Wang, Runjia Liang, Haozhen Xu, Aoran Liu, JiangTao You, Xiaohai Cui, AL-AMEERWAILHUSSEIN AHMED

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Esophageal squamous cell carcinoma (ESCC) is a prevalent and aggressive malignancy with limited treatment options. Neoadjuvant therapy has shown promise in improving surgical outcomes and overall survival. This study focuses on long-term follow-up results of tislelizumab combined with chemotherapy or radiotherapy as neoadjuvant treatment for resectable ESCC. Methods Patients with resectable ESCC (T2-4aNanyM0) were randomized into two a …

22.08.2026journal-article

Diseases of the Esophagus

PD04.01. Multimodal Treatment Strategies Incorporating Conversion Therapy for Thoracic Esophageal Cancer With Adjacent Organ Invasion

Kohei Kanamori, Rie Nakashima, Kohei Tajima, Mika Ogimi, Yamato Ninomiya, Yoshiaki Shoji, Akihito Kazuno, Miho Yamamoto, Takayuki Nishi, Kazuo Koyanagi

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Management of thoracic esophageal cancer with suspected adjacent organ invasion remains challenging because of diagnostic uncertainty and limited curative options. Recent advances in induction chemotherapy, including DCF and immune checkpoint inhibitors, have enabled downstaging and subsequent conversion to curative-intent treatment in selected patients. Methods We retrospectively reviewed 57 patients with locally advanced, initial …

22.08.2026journal-article

International Urogynecology Journal

Stem Cell Therapy for Stress Urinary Incontinence: Why Has Clinical Success Remained Limited?

Rodrigo A. Castro

Abstract Introduction and Hypothesis Stem cell therapy for stress urinary incontinence (SUI) has been pursued for more than a decade, supported by a compelling regenerative rationale and reassuring early-phase safety data. Yet clinical efficacy has remained modest, complete continence uncommon, and durability uncertain. Method In this Clinical Opinion, we argue that translation has stalled for reasons that are both biological and conceptual: heterogeneous cell products and manufacturing variability undermine reprod …

22.08.2026journal-article

International Journal of Molecular Sciences

Protease-Activated Receptor-2 as a Proteolytic Rheostat in Colorectal and Pancreatic Cancer: From Mechanism to Biomarker-Guided Therapy

Hodasadat Tabatabaei Yeganeh, Malak Sellat, Zayd Anis, Reine Chiri, Rajashree Patnaik, Shloka Gambhir, Yajnavalka Banerjee

Protease-activated receptor-2 (PAR-2; encoded by F2RL1) is emerging as a context-dependent driver of gastrointestinal cancer. Activated by irreversible N-terminal cleavage, its signalling output is not fixed but is calibrated by the identity and source of the activating protease, the receptor cleavage state, cellular context and biased coupling to G-protein αq (Gαq), G-protein α12/13 (Gα12/13) and β-arrestin. PAR-2 is best understood not as a simple inflammatory receptor but as a proteolytic rheostat that converts …

22.08.2026journal-article

Journal of Advances in Education and Philosophy

Leveraging Animated Cartoons as a Pedagogical Tool to Enhance Speech Proficiency in Children Aged 4–8

Sikolia Doreen, Ruth N. Otunga, David Kessio

This study investigated the influence of cartoon viewing on English language proficiency among children aged 4 to 8 years in Nairobi City County. Recognizing the importance of English as the official language and medium of instruction in Kenyan educational institutions, this research addressed the challenges of English language acquisition in a culturally and linguistically diverse environment. Using an experimental research design, the study evaluated the impact of cartoon viewership on speech proficiency, focusin …

22.08.2026journal-article

Diseases of the Esophagus

P1.038. Minimising the Systemic Effects of an Oesophageal Leak Following High Risk Myotomy Repair Using Prophylactic Endoluminal Vacuum Therapy (EVT) – Time for a Change?

Unaiza Waheed, Alexander Ribbits, Vijayendran Sujendran, Ayesha Noorani, Andrew Hindmarsh

Abstract Topic Benign Disease: Iatrogenic Esophageal Disease, Perforation and Postsurgical Complications Case Submission An 80 year old frail lady (ASA 2, BMI 22) was referred with progressive dysphagia, regurgitation, and unintentional weight loss. Endoscopy demonstrated a dilated oesophagus and tight lower oesophageal sphincter without mucosal lesions. Computed Tomography confirmed a patulous lower oesophagus with no malignancy. Barium swallow showed a dilated, aperistaltic oesophagus with severe tertiary contrac …

22.08.2026journal-article

Diseases of the Esophagus

S24.0.1. Integrating Anti-CTLA4 Salvage With Locoregional Therapy After Anti-PD-1 in Liver-Dominant Metastatic ESCC

Chien-Huai Chuang, Huai-Cheng Huang, Jhe-Cyuan Guo, Chih-Hung Hsu

Abstract Submission Category Esophageal Cancer: Management of Metastatic Cancer Case Submission The 70-year-old man was diagnosed with squamous cell carcinoma of the mid-esophagus and underwent endoscopic submucosal dissection (ESD) in November 2022. Pathology demonstrated pT1b disease with negative margins but lymphovascular invasion (LVI) present. Given the adverse pathologic feature, he underwent additional lymph node dissection, which confirmed pN0 disease. He was followed with surveillance until September 2024 …

22.08.2026journal-article

Diseases of the Esophagus

PD02.03. Proximal Resection Margin and Survival in Esophageal Adenocarcinoma Surgery Following Neoadjuvant Therapy

Laser Arif Bazancir, Andreas Weise Mucha, Thomas Baastrup Piper, Trygve Ulvund Solstad, Gustav Holm Schæbel, Mette Kjoelhede Nedergaard, Rajendra Singh Garbyal, Michael Patrick Achiam

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Achieving an adequate proximal resection margin is considered essential for oncologic control in esophageal adenocarcinoma. However, the prognostic significance of margin length following neoadjuvant therapy remains uncertain, particularly in patients who don't complete adjuvant chemotherapy. This study evaluates the clinical impact of proximal margin distance and adherence to national guidelines. Methods This retrospective single- …

22.08.2026journal-article

Advanced Functional Materials

Membrane Protein‐Instructed Peptide Self‐Assembly for Cancer Therapy

Jiaying Zhang, Yanyan Zhou, Ruo‐Chen Guo, Junyan Du, Wenjun Zhan, Gaolin Liang

ABSTRACT Abnormal membrane proteins often play a crucial role in the development and progression of cancer, making them ideal targets for cancer treatment. However, traditional membrane protein inhibitor‐based therapies only benefit a small part of patients and suffer from notorious drug resistance due to their occupation‐driven pharmacology. Recently, membrane protein‐instructed peptide self‐assembly has emerged as a powerful tool in precision cancer treatment. Due to its unique merits such as high tumor targeting …

22.08.2026journal-article

Diseases of the Esophagus

PD01.02. Renin–Angiotensin System Blockade During Neoadjuvant Therapy is Associated With Enhanced Tumor Regression and Survival in Esophageal Squamous Cell Carcinoma

Maohui Chen, Yizhou Huang, Zhenyuan Yang, Taidui Zeng, Chun Chen, Bin Zheng

Abstract Topic Esophageal Cancer: Other Background Beyond blood pressure regulation, the renin–angiotensin system (RAS) has been implicated in tumor angiogenesis, stromal remodeling, and immune modulation. Pharmacologic blockade of this pathway through angiotensin-converting enzyme inhibitors or angiotensin receptor blockers has demonstrated potential antineoplastic properties in several malignancies. Whether exposure to these agents during neoadjuvant treatment influences pathological response or long-term outcome …

22.08.2026journal-article

Diseases of the Esophagus

P1.081. The Effect of Pre-Rehabilitation During Neoadjuvant Chemotherapy in Esophageal Cancer

Ryoma Haneda, Eisuke Booka, Takahiro Kuroda, Shuhei Yasumoto, Keita Misu, Yuki Sakai, Kenichi Sekimori, Shunta Nakamura, Wataru Soneda, Tomohiro Murakami, Tomohiro Matsumoto, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Hiroya Takeuchi

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background The standard treatment for resectable advanced esophageal squamous cell carcinoma is neoadjuvant chemotherapy (NAC) followed by surgery. Rehabilitation is recommended during NAC; however several adverse events often hinder its completion. This study examined the impact of rehabilitation completion rates during NAC on postoperative complications. Methods We retrospectively analyzed 111 patients who had esophagectomy after NAC for thorac …

22.08.2026journal-article

Diseases of the Esophagus

P1.059. Calcium-Channel Blocker Use and Survival After Neoadjuvant Therapy for Locally Advanced ESCC

Feng Su, Subinuer Maimaiti, Xu Huang, Jun Yin, Yaxing Shen

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Calcium-channel blockers (CCBs) are commonly prescribed for cardiovascular disease. Beyond hemodynamic effects, experimental studies suggest that CCBs may modulate tumor biology through interference with apoptosis and alterations in proliferative signaling, however, clinical evidence remains inconsistent and may depend on tumor histology and treatment modality.Whether CCB exposure influences outcomes in esophageal squamous cell carcino …

22.08.2026journal-article

Indonesian Journal of Global Health Research

The Effectiveness of Binaural Beats Music Therapy in Reducing Anxiety Levels in Pre Urological Surgery Patients

Zahra Khoirunnisa, Sugiharto Sugiharto

Preoperative anxiety is a psychological response often experienced by patients before undergoing surgical intervention and can lead to increased physiological responses such as heart rate, blood pressure, and stress hormones. This condition can disrupt patient stability and slow recovery. Therefore, an effective, safe intervention that minimizes side effects is needed to reduce this anxiety. One non-pharmacological intervention is binaural beats music therapy, which stimulates alpha and theta brain waves to increas …

22.08.2026journal-article

Current Gene Therapy

Efficacy and Safety of Immune Checkpoint Inhibitors for Recurrent or Metastatic Cervical Cancer: A Systematic Review and Meta-Analysis

Yuanyuan Li, Songyi Wang, Yirui Mai, Zhixi You, Yu Wang, Jiake Wang, Ye Lei

Background: Cervical cancer is a major global health challenge and requires the exploration of novel treatment strategies. Immune checkpoint inhibitors, particularly those targeting Programmed Death 1 (PD-1) and Programmed Death-Ligand 1 (PD-L1), have emerged as promising therapeutic agents in oncology. This study aimed to evaluate the efficacy and safety of these inhibitors in the treatment of cervical cancer. Methods: A comprehensive literature search was conducted across PubMed, Embase, Web of Science, Scopus, t …

22.08.2026journal-article

Diseases of the Esophagus

P1.045. Management of a Large Esophagojejunostomy Defect After Laparoscopic Total Gastrectomy Using Endoscopic Vacuum Therapy and Adjunctive Stenting

Jeong Ju NOH, Ji Yeon Park, Ki Bum Park, Hyun Wook Shin, Oh Kyoung Kwon

Abstract Topic Benign Disease: Other Background Esophagojejunostomy (EJ) leakage after total gastrectomy remains a life-threatening complication. While endoscopic vacuum therapy (EVT) has emerged as an effective treatment option, management of large anastomotic disruption and subsequent stenosis remains challenging. We report a case successfully managed with repeated EVT and subsequent stent placement. Methods An 80-year-old woman with antral gastric cancer underwent planned totally laparoscopic distal gastrectomy. …

22.08.2026journal-article

Journal of Clinical Medicine

The Safety of Pre-Filter Heparin for Circuit Clotting Prevention in Continuous Renal Replacement Therapy: A Retrospective Evaluation

Thomas Diaz, Traci Grucz, Stephanie Davis, John Lindsley, Kathryn E. Dane, Hailey Burns, Samir Gautam, Gianna Iantosca

Background: Circuit clotting is a common complication of continuous renal replacement therapy (CRRT). Pre-filter unfractionated heparin (UFH) is widely used to maintain circuit patency, but real-world data describing its safety and efficacy are limited. Methods: This retrospective, single-health-system study evaluated critically ill adults receiving pre-filter UFH for CRRT clotting prevention between 2021 and 2025. The primary outcome was clinically relevant major bleeding, adapted from International Society on Thr …

22.08.2026journal-article

Small

Efficient Colon Cancer Immunogene Therapy by Hydrogel Ball Loaded With Two Types of Cell Membrane‐Coated Nanoparticles

Jingmei Li, Jin Zhang, Xiayu Chen, Shan Wu, Jieping Wu, Xizi Fu, Yan Gao, Lixia Guo, Xingmei Duan, Ke Men

ABSTRACT Biomimetic technology has high potential for enhancing cancer immunogene therapy. Cell membrane‐coated nanoparticles (CMNPs) obtain extra targeting, recognition, and signaling transduction functions. However, a single kind of CMNPs is limited when facing complicated tumor immunogene therapy. Here reported the collaboration of two types of CMNPs using a double‐layered spherical scaffold. This scaffold was prepared by stacking photosensitive hydrogels with two concentrations. After implantation, the two laye …