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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
14.08.2026journal-article

Sports Health: A Multidisciplinary Approach

Peroneal Reaction-Time Demonstrates a Greater Influence Than Peroneal Muscle Strength on Lateral Ankle Ligament Strain in People With Chronic Ankle Instability

Xinmeng Zhang, Qi Wang, Xiaoxue Zhu, Yujing Cao, Junjun Li, Wenqi Ran, Qipeng Song

Background: Lateral ankle sprains often damage the anterior talofibular (ATFL) and calcaneofibular (CFL) ligaments. Delayed peroneal muscle reaction time (reaction-time) and reduced peroneal muscle strength (strength) may increase the risk of recurrent sprains. Relationships between neuromuscular impairments and ligament strains remain unclear due to challenges in directly measuring ligament strains under dynamic conditions. Hypothesis: Reaction-time and strength are correlated significantly with ATFL and CFL strai …

14.08.2026journal-article

Health Promotion Practice

Factors Influencing Equitable Participation in a Provincially Implemented Older Adult Exercise Program in Canada: Qualitative Analysis Using the Health Equity Implementation Framework

Wendy S. Verity, Heather Foulds, Cari McIlduff, Daniel Fuller, Anne Leis

Background: Group-based exercise programs for older adults produce substantial health benefits, yet they often fail to reach equity-deserving populations in representative proportions. An understanding of local and systemic factors surrounding exercise programs is needed to guide strategies to reduce these gaps. Purpose: Our purpose was to understand the local and system-wide factors that influence equitable participation in the Forever . . . in motion (FIM) older adult exercise program in Saskatchewan, Canada. Met …

14.08.2026journal-article

Biomedicines

Dietary, Nutrient, and Supramolecular Nanofiber Modulation of the Liver Sinusoidal Clearance System in Metabolic Diseases and Aging

Binod Pokharel, Anokhi Kulkarni, Rebecca Drager, Fatima Atta Muhammad, Ouliana Ziouzenkova

In modern societies, the renewed concept of food as medicine coexists with unprecedented consumption of highly processed foods, food additives, environmental xenobiotics, and pharmacological agents, contributing to the increasing prevalence of metabolic and degenerative diseases and accelerated aging. Although modern pharmacotherapies have transformed disease management, long-term drug exposure introduces additional metabolic burdens, off-target effects, and cumulative toxicities that are profoundly influenced by n …

14.08.2026journal-article

New Zealand Medical Journal

Whitia Kia Ora: a culturally responsive model of Bicillin L-A® delivery for people with rheumatic fever in the Waikato region of Aotearoa New Zealand

Anneka Anderson, Monleigh Ikiua, Rachel Brown, Kim Arrowsmith, Tira Phillipson-Puna, Shannon Leilua, Manawa Rhinds, Julie Cooper, Matire Harwood, Rawiri McKree-Jansen, Alison Ahu, Dave Thompson, Julie Bennett

aim: Acute rheumatic fever (ARF) is an autoimmune response to group A Streptococcus (Strep A) infection that can lead to rheumatic heart disease (RHD). To prevent Strep A infection for people with ARF or RHD, clinical guidelines recommend monthly intramuscular penicillin (Bicillin L-A®) injections for at least 10 years. However, multiple barriers to accessing healthcare affect adherence. This research aimed to improve adherence by developing a Māori and Pacific–centred model of care. methods: Qualitative, Kaupapa M …

14.08.2026journal-article

Frontiers in Pharmacology

Protein farnesylation: from molecular mechanisms to therapeutic targeting in cancer, aging, and beyond

Jiacheng Lou, Danlu Zhang, Yingjie Wang

Protein farnesylation, catalyzed by farnesyltransferase (FTase), covalently attaches a 15-carbon farnesyl lipid to cysteine residues within C-terminal CaaX motifs. This modification governs the subcellular localization, protein–protein interactions, and activity of diverse eukaryotic proteins, including Ras GTPases, nuclear lamins, molecular chaperones, and kinetochore components. This review examines FTase enzymology, substrate recognition, and the sequential post-farnesylation processing by RCE1 and ICMT, alongsi …

14.08.2026journal-article

BMC Health Services Research

The UN Decade of healthy ageing in practice: A qualitative case study on perspectives of healthy ageing among older adults, healthcare professionals, and decision-makers in Norway

Mariya Bikova, Maria Nordheim Alme, Djenana Jalovcic, Hanne Tuntland

Abstract Background Global populations are ageing, making healthy ageing an increasingly important priority. In Norway, the number of people aged 70 and above is expected to double by 2050. The UN Decade of Healthy Ageing (2021–2030) guides Norway’s national programs on healthy ageing through its four action areas: combating ageism, age-friendly environments, integrated care and long-term care. The aim of this study is to explore how healthy ageing is understood and interpreted in Norway in light of the four action …

14.08.2026journal-article

Life

Effects of a Multi-Ingredient MCT–Leucine–Creatine-Based Supplement (TLN-01) on Muscle Mass, Strength, and Plasma Amino Acid Profiles in Older Adults with Sarcopenia: A Randomized Controlled Trial

Ding-Cheng Chan, Ming-Shi Shiao, Wei-Jia Huang, Chun-Feng Huang

Background: Sarcopenia, the age-related loss of muscle mass and strength, affects over 20% of older adults in Taiwan and contributes to frailty and functional decline. Nutritional supplementation offers a promising strategy for those unable to engage in structured exercise, yet multi-ingredient MCT–leucine–creatine-based interventions remain understudied in clinically defined sarcopenic populations. Methods: We conducted an 8-week randomized, double-blind, placebo-controlled trial at National Taiwan University Hosp …

14.08.2026journal-article

Revista Inclusiones

Estudo transversal do período pandêmico sobre quedas em pessoas idosas

Angela Jacques Bellini, Isis De Melo Ostroski, Alexia Andréa Fuzer Lira Pereira, Graziela Morgana Silva Tavares, Gilmar Moraes Santos

Verificar associações entre a ocorrência de quedas e preditores de mobilidade funcional, equilíbrio postural, medo de cair, massa óssea e qualidade de vida em pessoas idosas durante a pandemia de COVID-19. Estudo observacional transversal com 100 idosos (de 60 a 80 anos), classificados em caidores e não caidores. Avaliou-se: Equilíbrio postural (Composite do mCTSIB), mobilidade funcional (iTUG), medo de cair (FES-I), massa óssea (DEXA) e qualidade de vida (WHOQOL-Bref). Os principais achados indicam que o Composite …

14.08.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

SABERES AMAZÔNICOS EM DIÁLOGO: CULTURA DO BRINCAR E CONSTRUÇÃO DE CONHECIMENTOS ENTRE CRIANÇAS E PESSOAS IDOSAS

Nubia Pereira Brito Oliveira, Neila Barbosa Osório, Amanda Pereira Costa, Erick Henrique Silva Góes, Ruhena Kelber Abrão

Compreende-se a construção coletiva dos saberes amazônicos por meio da cultura do brincar em práticas intergeracionais desenvolvidas entre crianças da Educação Infantil e pessoas idosas na Universidade. Trata-se de uma pesquisa aplicada, de abordagem qualitativa, natureza exploratória e descritiva, fundamentada no método indutivo, que investiga as experiências educativas realizadas entre o Centro Municipal de Educação Infantil Amâncio José de Moraes e a Universidade da Maturidade da Universidade Federal do Tocantin …

14.08.2026journal-article

Research on Aging

Economic (In)security and Living Arrangements in Later Life: Heterogeneity by Race-Ethnicity

Seokmin Kim, Sung S. Park, Jan E. Mutchler

Changes in economic security and living arrangements among the diverse, aging U.S. population are not experienced uniformly. Using Health and Retirement Study data linked to the Elder Index TM —an income measure of older adult needs—we estimated discrete-time competing risks models to examine the first transition from economic security and independent living near retirement age (65–68) among community-dwelling older adults to: economic insecurity while living independently, doubling up (non-independent living by co …

14.08.2026journal-article

NIHR Open Research

Development of a multi-modal PeRsOnalised PrEhabilitation intervention for people with acute myeloid Leukaemia: the PROPEL trial

Louise H Hall, Gillian Prue, Laura J Miller, Rebecca J Beekin, Gordon McGregor, Christopher D Graham, John Pimm, Malcolm Brown, Dominic O'Connor, Annie Young, Simon Stanworth, Nils Rickardsson, Victoria Edwards, Nicola Gregson, Richard Powell, Alice Walker, Joanna Calder, Anna Mamwell, Eileen Stonock, Gillian Murphy, Janet Dunn

Background Acute Myeloid Leukaemia affects approximately 3,100 people annually in the UK. Individuals with high-risk myelodysplastic syndrome (MDS-EB2) receive similar treatment. Curative-intent therapy involves multiple courses of chemotherapy and may include haematopoietic stem cell transplant (HSCT). Treatment tolerance is challenging, with fatigue, muscle loss, poor appetite, and impaired psychological wellbeing common. Prehabilitation may support physical and psychological health, improving treatment tolerance …

14.08.2026journal-article

Frontiers in Aging Neuroscience

Plasma α-synuclein and QSM-derived susceptibility in Parkinson’s disease: associations with clinical features

Xingjun Li, Tianfei Luo, Jing Bai

Background The pathological interplay between α-synuclein aggregation and iron dysregulation is central to the neurodegenerative process in Parkinson’s disease (PD). Quantitative susceptibility mapping (QSM) allows in vivo assessment of regional brain iron burden, and blood assays enable measurement of plasma α-synuclein; however, their clinical relevance and mutual relationship remain insufficiently defined. Objective To evaluate plasma α-synuclein as a diagnostic biomarker (against controls) and to explore whethe …

14.08.2026journal-article

Medicine

Vitamin D deficiency and dementia risk in patients with chronic kidney disease

I-Wen Chen, Li-Chen Chang, Yi-Chen Lai, Chun-Ning Ho, Jheng-Yan Wu, Kuo-Chuan Hung

Patients with chronic kidney disease (CKD) face elevated dementia risk, and vitamin D deficiency (VDD) has emerged as a potential contributor to cognitive decline. This study investigated the association between VDD and dementia development in patients with CKD using real-world data. We conducted a retrospective cohort study using the TriNetX database, analyzing patients with CKD aged ≥50 years from January 2010 to December 2022. Patients were stratified by serum 25-hydroxyvitamin D levels as follows: VDD group (

14.08.2026journal-article

International Journal of Environmental Research and Public Health

Association Between Changes in Perceived Neighborhood and Cognitive Performance Within Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS) Black Adults

Alexa C. Allan, Alyssa A. Gamaldo, Roland J. Thorpe, Jennifer D. Roberts, Michele K. Evans, Alan B. Zonderman

Perceived neighborhood characteristics are related to cognitive performance. However, limited studies have examined how changes in neighborhood characteristics relate to cognitive performance, particularly among Black adults who are likely to experience changes in their residential social and physical environments. This study examined the association between changes in perceived neighborhood quality and concurrent, cross-sectional cognitive performance. An analytic sample of 592 Black adults (Mage = 56.22; 58% fema …

14.08.2026journal-article

Prosthesis

How Well Do the Sample Populations in Microprocessor-Controlled Prosthetic Knee Technology Research Represent People with Limb Absence? A Systematic Review

Omar A. Alharbi, Alex Dickinson, Chantel Ostler, Maggie Donovan-Hall

Background/Objectives: Studies consistently demonstrate that microprocessor-controlled prosthetic knees (MPKs) improve mobility and quality of life for people with lower limb loss or absence by enhancing balance and reducing falls. However, the extent to which these benefits apply across demographic groups remains unclear. Therefore, we conducted a literature review to evaluate how representative and transferable research on MPKs is across different populations, and which factors influence this. Methods: Using syst …

14.08.2026journal-article

Online Brazilian Journal of Nursing

Associação entre sexo, grupos etários e cuidados com a saúde de pessoas idosas no Brasil

Emily da Silva Eberhardt, Eliane Pinheiro de Morais, Jack Roberto Silva Fhon, Idiane Rosset

Objective: To analyze the association between sex, age groups, and health care among older adults in Brazil in the years 2013 and 2019. Method: A cross-sectional study using public data from the National Health Survey (PNS), which included 11,177 people aged 60 years or older in 2013 and 22,728 in 2019. The Chi-square test was used for the association analysis according to sex and age groups (60 to 69 years, 70 to 79 years, and 80 years or older). Results: Blood pressure and blood glucose monitoring, as well as med …

13.08.2026journal-article

European Review of Aging and Physical Activity

Distribution of device-measured 24-hour movement behaviours across the cognitive spectrum in older adults: the HUNT study

Karen Sverdrup, Paul Jarle Mork, Eling D. de Bruin, Linda Ernstsen, Gill Livingston, Kushang V. Patel, Geir Selbæk, Bjørn Heine Strand, Beatrix Vereijken, Gro Gujord Tangen

Abstract Background Key daily physical activities (e.g., standing and walking), postures (sitting and lying), and sleep constitute the 24-h day and have distinct health effects and functional implications. Traditionally studied separately, the distribution of these movement behaviours and sleep across the cognitive spectrum remains insufficiently characterised. We aimed to describe and compare the distribution of 24-h movement behaviours and sleep across the cognitive spectrum. Methods We analysed cross-sectional, …

13.08.2026journal-article

Frontiers in Cellular and Infection Microbiology

Probiotic supplementation as a nutritional strategy for the prevention and management of sarcopenia in older adults

De’en Wang, Wei Yang, Xiaofang Qin

Introduction Sarcopenia, defined as the loss of skeletal muscle mass, strength, and functional capacity over time, poses a significant health burden among older adults. A growing body of evidence indicates that the gut microbiota contributes to inflammation and metabolic regulation, mitochondrial function, and anabolic signaling, thereby shaping the gut–muscle axis. Probiotic supplementation has gained traction as a nutritional approach for the regulation of microbiome-derived metabolites. The present study aims to …

13.08.2026journal-article

Working with Older People

Enhancing acceptance of retirement villages in later life: a strategy-based dimensional analysis

Phui Fung Wong, Xin Yu Ling, Hong Kok Wang, Li Ping Yow, Pei Sin Lay

Purpose Population ageing is reshaping how older adults evaluate and make decisions about later-life living arrangements. Retirement villages (RVs) have emerged as a viable housing option that promotes independence, well-being and community engagement; however, their acceptance remains limited in many emerging ageing societies, particularly in developing countries where retirement living markets are constrained by financial, institutional and socio-cultural challenges. This study aims to examine strategies that enh …

13.08.2026journal-article

Revista de Neuro-Psiquiatría

Asociación entre las actividades de la vida diaria según el estatus de demencia en personas adultas mayores durante el aislamiento por COVID-19 en Lima: un análisis secundario

Pou K. Choy-Chura, Jorge L. Marin-Paredes, Yzavo S. Gutierrez-Campos, Katherine L. Marin-Pimentel, Fernando M. Runzer-Colmenares

Objetivo: Determinar la asociación entre las actividades básicas e instrumentales de la vida diaria según el estatus de demencia y problemas de memoria en adultos mayores durante el aislamiento por COVID-19 en Lima. Materiales y métodos: Análisis secundario, retrospectivo y de tipo cohorte. La población del estudio proviene del análisis secundario de la base de datos del estudio «Comprendiendo cómo el grado de fragilidad afectó a la evolución de COVID-19». Resultados: Se observó que la edad promedio de los adultos …

13.08.2026journal-article

Journal of Organizational Effectiveness: People and Performance

From goodwill to systems: HR professionals' perspectives on AI and neurodiverse workplace inclusion

Ichraq Fahim, Reda Tamanine, Fatima Elkansoussi, Asmae El Gharbaoui, Hasnaa Alami

Purpose This study explores how human resource (HR) professionals perceive the role of artificial intelligence (AI) in fostering workplace inclusivity for neurodiverse employees. It addresses the persistent gap between the neurodiversity paradigm, which reframes cognitive differences as strengths and organizational practices that remain fragmented, disclosure-dependent and inconsistently implemented. Design/methodology/approach A qualitative, exploratory approach was adopted using semi-structured interviews with 12 …

13.08.2026journal-article

The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences

Examining loneliness and purpose in life as mediators between discrimination and changes in episodic memory in midlife and older adults

Heather R Farmer, Elizabeth Wroten, Logan Szelestei, Mina Sajjadi, Jeffrey E Stokes

Abstract Objectives Discrimination is a stressor associated with worse cognition, but the pathways underlying this association are unclear. Moreover, discrimination may lead to exclusion and a reduced sense of belonging, which could increase loneliness and reduce purpose in life. We assess whether loneliness and purpose in life are mediators in the relationship between discrimination and episodic memory over an 8-year span. Methods Data were drawn from 6,155 respondents aged 51+ in the Health and Retirement Study ( …