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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
22.08.2026journal-article

Nutrients

Lifestyle Medicine as Co-Therapy During Incretin-Based Anti-Obesity Pharmacotherapy: Integrating Physical Activity, Nutrition, and Behavioral Strategies for Long-Term Success

Marta Mallardo, Antonietta Messina, Vincenzo Monda, Marco La Marra, Antonietta Monda, Salvatore Allocca, Maria Casillo, Girolamo Di Maio, Pasquale Perrone, Aurora Daniele, Marcellino Monda, Giovanni Messina, Fiorenzo Moscatelli, Rita Polito

Background/Objectives: Obesity is a chronic, progressive, and relapsing disease that requires long-term, multidisciplinary management rather than episodic weight-loss treatment. Although novel incretin-based anti-obesity pharmacotherapies, including GLP-1 receptor agonists and dual GIP/GLP-1 receptor agonists, have markedly improved the clinical management of obesity, weight reduction alone does not fully capture treatment success. Body composition, lean mass preservation, physical function, nutritional adequacy, p …

22.08.2026journal-article

Journal of Cardiovascular Development and Disease

Early Versus Late Initiation of Renal Replacement Therapy Impacts Early Mortality in Diabetic Patients with Acute Kidney Injury After Cardiac Surgery

Ozkan Ozler, Vedat Erentug

There are limited data on the optimal time of renal replacement therapy (RRT) after cardiac surgery, and published results are controversial. In our study, an answer was sought to the question of the correct timing of RRT in diabetic patients with post-cardiac surgery acute kidney injury (AKI). Forty-four adult patients with DM who required postoperative RRT were included in our single-center prospective study. According to the time of onset of RRT, the patients were divided into two groups: those whose RRT was ini …

22.08.2026journal-article

Applied Sciences

Feasibility of a Technology-Supported High-Intensity Interval Training Program for Occupational Drivers

Alam Zeb, An Neven, Chris Burtin, Lotte Janssens, Brent Peters, An-Marie Schyvens, Catharina Nina Van Oost, Timo Meus, Annick Timmermans, Jonas Verbrugghe

This study assessed the feasibility of a technology-supported high-intensity interval training (HIIT) program for occupational drivers. A multiphase feasibility study incorporating participant feedback was conducted in Flanders, Belgium, including consultation, pilot, and intervention phases. Occupational drivers were randomized to a HIIT group, an active control group (mindfulness program), or a passive control group (no intervention). The 16-week, equipment-free HIIT program consisted of two 15-min sessions per w …

22.08.2026journal-article

Journal of Physical Medicine and Rehabilitation

Paired Magnetic Resonance Imaging and Clinical Outcomes Following Intervertebral Differential Dynamics Therapy for Cervical and Lumbar Disc Bulges and Herniations: A Secondary Analysis of a Retrospective Cohort

Tyler Maitland Graham, John Graham

Background: Intervertebral Differential Dynamics (IDD) Therapy is used as a targeted, non-surgical decompression intervention for selected patients with disc-related spinal pain. A previously published cohort reported significant short-term improvements in pain and disability, while paired magnetic resonance imaging (MRI) outcomes were reserved for subsequent analysis. Objective: To evaluate paired MRI findings and clinical outcomes following IDD Therapy in adults with MRI-confirmed cervical or lumbar disc bulges a …

22.08.2026journal-article

Current Drug Safety

Safety of Chronic Proton Pump Inhibitor Therapy: An Updated Systematic Review of Serious Adverse Events

Harshitha Chowdary Chebrolu, Krishna Chaitanya Amerneni, Padmavathi R, Parveen Shazia, Anitha K, Pavani S, Sunil Kumar, Mohan Krishna Ghanta, Santenna Chenchula, Mythili Bai K, Madhavrao Chavan

Background: Proton Pump Inhibitors (PPIs) are widely prescribed for acid-related disorders and are generally considered safe for short-term therapy. However, growing evidence has raised concerns regarding Serious Adverse Events (SAEs) associated with long-term PPI use. This systematic review synthesizes current evidence on the spectrum of SAEs linked to prolonged PPI exposure. Methods: A comprehensive literature search was conducted in MEDLINE, Scopus, and the Cochrane Library from database inception to August 2025 …

22.08.2026journal-article

Diseases of the Esophagus

P1.035. Postoperative Acid-Suppressive Therapy Duration and Risk Factor of Gastroesophageal Reflux Disease Following Subtotal Esophagectomy

Yoshihisa Numata, Tomoyuki Okumura, Takeshi Miwa, Tatsuhiro Araki, Masakazu Nagamori, Naoya Takeda, Toru Watanabe, Shinichi Sekine, Isaya Hashimoto, Tsutomu Fujii

Abstract Topic Benign Disease: Iatrogenic Esophageal Disease, Perforation and Postsurgical Complications Background Gastroesophageal reflux disease (GERD) after esophagectomy is an important complication that impairs postoperative quality of life (QOL). However, factors associated with the incidence of GERD, particularly the impact of acid-suppressive medication use, remain unclear. Methods We retrospectively analyzed 106 patients who underwent esophagectomy for esophageal cancer at our institution between January …

22.08.2026journal-article

International Journal of Molecular Sciences

Geroprotective Effects of Drugs Modulating Metabolic Pathways: Perspectives of Pharmacology in Anti-Aging Therapy

Marta Grycan, Rafał Zyśk, Gabriela Grycan, Grzegorz Jakiel, Alicja Dudek, Grażyna Gromadzka

Aging is the strongest risk factor for chronic diseases such as cardiovascular diseases, cancer, diabetes, and neurodegenerative disorders. Advances in geroscience indicate that pharmacological modulation of conserved molecular pathways may extend healthspan and delay multimorbidity. A structured narrative review of the PubMed, Scopus, and Web of Science literature published between January 2010 and May 2026 was conducted, with seminal earlier studies retained where relevant. The review focused on molecular pathway …

22.08.2026journal-article

The Laryngoscope

Occupational HPV Exposure in Otolaryngology: A Scoping Review of Detection, Risk, and Prevention

Ying Jie Li, Alexander C. Moise, Amanda Hu

ABSTRACT Objectives To characterize the current evidence regarding occupational human papillomavirus (HPV) exposure in otolaryngology, including mechanistic evidence of plume contamination, clinical evidence of infection among healthcare workers, and preventive practices related to personal protective equipment (PPE) and vaccination. Methods This OSF‐registered PRISMA‐ScR review evaluated English‐language studies on occupational HPV exposure among otolaryngologists. The MEDLINE, EMBASE, SCOPUS, Web of Science, and …

22.08.2026journal-article

Diseases of the Esophagus

P1.072. Impact of Neoadjuvant Therapy on Survival After Esophagectomy for Squamous Cell Carcinoma: An International Multicenter Propensity Score Analysis

Simiao Lu, Yi Zhu, Qiuling Shi, Yongtao Han, Xuefeng Leng

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background The survival benefit of neoadjuvant therapy for esophageal squamous cell carcinoma (ESCC) remains controversial, as landmark trials were conducted predominantly in adenocarcinoma populations. This study evaluated the association between neoadjuvant therapy and long-term survival in a large international multicenter ESCC cohort using propensity score methods and multivariable Cox regression. Methods We retrospectively analyzed 2,449 pat …

22.08.2026journal-article

Diseases of the Esophagus

P1.116. Comparison Between Nivolumab + Ipilimumab, FOLFOX, and Nivolumab + FOLFOX Therapy as First-Line Therapy for Cisplatin-Unfit Advanced Esophageal Squamous Cell Carcinoma

Nozomu Ogura, Shun Yamamoto, Ryuichi Morita, Hiroshi Imazeki, Hideaki Takahashi, Yoshitaka Honma, Daisuke Kurita, Koshiro Ishiyama, Hiroyuki Daiko, Yasuyuki Seto, Ken Kato

Abstract Topic Esophageal Cancer: Non-Surgical Treatment of Esophageal Cancer Background Nivolumab plus platinum-based chemotherapy and nivolumab plus ipilimumab (Nivo+Ipi) therapy are standard first-line treatments for advanced esophageal squamous cell carcinoma (ESCC). However, patients with renal or cardiac dysfunction and elderly patients might be unfit for cisplatin-containing regimens. Therefore, leucovorin, 5-FU, and oxaliplatin (FOLFOX), Nivo+Ipi, and nivolumab plus FOLFOX (Nivo+FOLFOX) therapy might be alt …

22.08.2026journal-article

BMC Urology

The double-decking method for rezūm water vapor therapy in benign prostatic hyperplasia: volumetric, functional, and dosimetric outcomes

Ming-Jui Tseng, Ka-Lun Lo, Chi-Hsiang Wu, Shih-Ying Lin, Chih-Jen Wang, Chen-Yueh Wen

Abstract Background Lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) significantly impact quality of life in aging men. Conventional Rezūm water vapor therapy consistently achieves only a modest 25–30% prostate volume reduction, leaving a clinically meaningful therapeutic gap—particularly for larger glands where single-plane periurethral injection fails to achieve adequate thermal coverage of the entire transition zone. Objectives To evaluate the efficacy and safety of a dual-laye …

22.08.2026journal-article

International Journal of Language and Literary Studies

Language Choice, Mixed Inner Speech, and Code-Switching in Putonghua-Dialect Speakers

Ran Qiao

Inner speech is usually treated as private cognition, yet its language may reflect socially organized repertoires. This mixed-methods study examined language choice, mixed inner speech, and within-episode code-switching among Putonghua–dialect users in China. Phase 1 involved 360 adults completing a fully crossed 2 × 3 × 2 vignette task manipulating formality, imagined interlocutor, and emotional intensity; 90 entered a seven-day experience-sampling phase, 79 met the confirmatory compliance threshold, and 30 comple …

22.08.2026journal-article

International Journal of Translational Medicine

Changes in ANA/ENA and Anti-dsDNA Autoantibodies During Adalimumab Therapy in Patients with Psoriasis: A Single-Centre Retrospective Study

Anna Sardiko, Ilze Upeniece, Ilvija Vasiljeva

Background and Objectives: Tumour necrosis factor alpha (TNF-α) inhibitors are widely used for moderate-to-severe psoriasis and are known to induce autoantibody formation in a proportion of treated patients. This study evaluated changes in ANA/ENA and anti-dsDNA antibody levels in psoriasis patients receiving adalimumab therapy during the first 12 months of treatment. Materials and Methods: A retrospective single-centre study was conducted at the Dermatology and Sexually Transmitted Diseases Clinic of Riga 1st Hosp …

22.08.2026journal-article

Georgian Medical Journal

Methodological considerations in evaluating Tskaltubo low-radon nitrogen mineral bath therapy for osteoarthritis

Areesha Sajjad

This Letter to the Editor discusses methodological considerations in the evaluation of Tskaltubo low-radon nitrogen mineral bath therapy for osteoarthritis, with particular attention to study design, control groups, blinding, outcome selection, disease-severity stratification, and long-term follow-up. It comments on the article by Shavianidze et al. published in Georgian Medical Journal (2026) 1(1):99–114. Keywords: osteoarthritis; balneotherapy; Tskaltubo; low-radon mineral baths; methodology; clinical research; L …

22.08.2026journal-article

Diseases of the Esophagus

P1.103. Evaluation of the Efficacy of Local Therapy for Postoperative Oligo-Recurrence in Esophageal Squamous Cell Carcinoma

Ryo Shibayama, Kentoku Fujisawa, Yusuke Ogawa, Hayato Shimoyama, Shusuke Haruta, Masaki Ueno

Abstract Topic Esophageal Cancer: Management of Metastatic Cancer Background Postoperative recurrence of esophageal squamous cell carcinoma (ESCC) is associated with poor prognosis. Among recurrent patterns, oligo-recurrence (OR) has attracted attention because long-term survival may be achieved by combining systemic therapy with local treatments. However, the optimal treatment strategy for OR remains controversial. Methods We retrospectively analyzed patients with postoperative OR of ESCC who underwent curative es …

22.08.2026journal-article

Journalism and Media

Don’t Believe the Hype: Methodological Approaches for Applying LLM-Assisted Content Analysis to Reported Speech in Journalism

Jessy de Cooker

To better understand how journalists represent sources, it is necessary to systematically study the use of reported speech in news coverage. This paper presents a method for LLM-assisted content analysis to identify and classify reported speech in Dutch newspapers automatically. The study evaluates a three-step procedure utilising role-based instructions to prompt the model as a professional journalist. First, a codebook for identifying citation structures and source types was developed with LLM support and then ma …

22.08.2026journal-article

International Journal of Stroke

The future of high-dose, high-intensity neurorehabilitation: Consensus-based core recommendations from the fourth Stroke Recovery and Rehabilitation Roundtable

Meret Branscheidt, Wala Jaser Mahmoud, Christoph Bauer, Juan Camillo Cortes Ramirez, Ronald Cotton, Steven C Cramer, Sebastian Gallegos Berrios, Gert Kwakkel, Olivier Lambercy, Kate Laver, Alessandro Picelli, Nancy Margaret Salbach, John M. Solomon, Robert Teasell, Tamaya Van Criekinge, Vivian Weerdesteyn, John W Krakauer

Objective: Convergent evidence indicates that high-dose, high-intensity rehabilitation (HDHI) improves outcomes beyond usual care after stroke, yet implementation remains limited. While questions of optimal dose, timing, and delivery format continue to be refined, the biological plausibility and clinical rationale for HDHI are well established. The fourth Stroke Recovery and Rehabilitation Roundtable convened to identify principal barriers to wider HDHI uptake and derive actionable solutions. Methods: Sixteen inter …

22.08.2026journal-article

Diseases of the Esophagus

OA01.1. Invited Lecture: Organ-Preserving Therapy for Higher Stage Esophageal Cancer Using Endoscopic Submucosal Dissection (ESD): Endoscopic Outcomes From OPERA-RADIO Phase 1 Clinical Trial

Professor Biniam Kidane, Dr Julian Kim, Dr Vivian Lu, Dr Stephen Gowing, Jasvir Dhaliwal, Dr Shantanu Banerji

Abstract Topic Esophageal Cancer: Non-Surgical Treatment of Esophageal Cancer Background Esophagectomy is the mainstay of curative for esophageal cancer but comes with high risk for complications, especially in comorbid and frail patients. The OPERA RADIO trial aimed to assess the feasibility and safety of organ-preserving therapy with combining endoscopic submucosal dissection (ESD) and chemoradiotherapy. We report here the endoscopic/surgical outcomes of this trial. Methods OPERA-RADIO (NCT05667298) is a phase I …

22.08.2026journal-article

Diseases of the Esophagus

P1.218. Early Results of Shifting From CROSS to FLOT for Neoadjuvant Therapy Before Esophagectomy

Rishindra M Reddy, Margaret Lasonde, Meganne Ferrel, Njikem Fomengia, Dani Ahmetovic, Tejas Godbole, Daniel Lee, Jules Lin, Chigozirim Ekeke, David D Odell, Andrew C Chang, Samantha Savitch, Kiran Lagisetty

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background There has been a shift from CROSS (C) neoadjuvant chemoradiation to FLOT (F) perioperative chemotherapy for esophageal and gastro-esophageal junction adenocarcinomas. We hypothesized that the shift to FLOT would be associated with higher pathologic complete response rates and potentially lower rates of post-operative anastomotic leak. Methods Data for patients receiving esophagectomy for esophagea …

22.08.2026journal-article

Diseases of the Esophagus

P1.066. Prognostic Equivalence of ypN and pN Staging in Esophageal Cancer After Neoadjuvant Therapy: A Multicenter Cohort Study of 2,545 Patients

Simiao Lu, Xuefeng Leng

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Current staging systems apply ypN and pN categories interchangeably after neoadjuvant therapy plus esophagectomy; however, their prognostic equivalence has not been rigorously established. We investigated whether ypN0–3 confers equivalent disease-free survival (DFS) to pN0–3. Methods We analyzed 2,545 consecutive esophagectomy patients from three high-volume centers with complete DFS data. Patients were stratified by treatment type …

22.08.2026journal-article

Advanced Materials

Hydrogel‐Interfaced Active Rehabilitation System: From Materials Design and Architecture to Applications

Haofeng Chen, Ranzi Si, Yibing Luo, Yiqun Gu, Bo‐Ru Yang, Qiuhua Yu, Kai Tao, Chuhuai Wang, Fengwei Huo, Jin Wu

ABSTRACT Driven by the pursuit of superior therapeutic efficacy and patient autonomy, healthcare is shifting toward proactive “active rehabilitation”. Conductive composite hydrogels, featuring tissue‐mimetic mechanics and multi‐modal sensing capabilities, have emerged as ideal bio‐electronic interfaces for these systems. This review systematically provides a comprehensive overview of hydrogel‐interfaced active rehabilitation systems, progressing from fundamental material design and system architecture to applicatio …

22.08.2026journal-article

Angewandte Chemie

MitoGPS: A Mitochondrial DNA G‐Quadruplex‐Targeting Strategy for Tumor‐Preferential Type I Photodynamic Therapy

Yu‐Hui Guo, Yao‐Hui Shi, Pei‐Min Huang, Gui‐Xue Tang, Shu‐Min Xu, Mao‐Lin Li, Jia‐Hao Yuan, Xiu‐Cai Chen, Zhi‐Shu Huang, Yi‐Yong Yan, Jia‐Heng Tan, Jin‐Wu Yan, Shuo‐Bin Chen

ABSTRACT Photodynamic therapy (PDT) is a clinically promising, minimally invasive cancer treatment offering precise spatiotemporal control. However, achieving preferential tumor accumulation remains a critical challenge, which limits therapeutic efficacy and induces off‐target toxicity. Here, we introduce the mitoGPS (mitochondrial G‐quadruplex–targeting photosensitizer) strategy, a rational design framework for developing photosensitizers (PSs) with prolonged intratumoral retention through targeting mitochondrial …

22.08.2026journal-article

Cancers

Biomaterial Techniques for Enhancing CAR-T Cell Therapy of Solid Tumours

Kai Chilvers, John Maher

Background/Objectives: Chimeric antigen receptor (CAR)-T cell therapy has achieved substantial clinical success in haematological malignancies but has shown limited efficacy against solid tumours. Key barriers include inadequate tumour trafficking, immunosuppressive tumour microenvironments, poor selectivity and heterogeneity of antigen expression, and challenges related to safety and manufacturing. Biomaterial-based technologies have emerged as a potential strategy to address many of these limitations. This review …

22.08.2026journal-article

International Journal of Innovative Science and Research Technology

Beyond the Steering Wheel: Occupational Stress, Organizational Well-Being and Workforce Resilience Among Employees of the Telangana State Road Transport Corporation

Aluvala Ravi, Md. Rafi

Stress at work has become an important organizational and public health problem, and can affect employee health, organizational performance and service quality in public transportation. The current study provides a detailed conceptual discussion on occupational stress of employees in Telangana State Road Transport Corporation (TGSRTC) amidst growing complexities of operations, technologization and changing demands of the work environment. The main aim of the study is to synthesize the current theories and research …