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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
14.08.2026journal-article

International Journal of Science and Healthcare Research

Effectiveness of the Tailored Activity Program on Basic Activities of Daily Living Among People living with Dementia and Its Impact on Caregiver Burden

Monisha Popali, Rajul Daftary

Background: Dementia is a progressive neurodegenerative disorder characterized by declining functional independence and increasing caregiver burden. Although the Tailored Activity Program (TAP) has shown promising benefits in improving daily functioning through individualized, occupation-based interventions, evidence regarding its applicability within the Indian healthcare setting remains limited. Objective: To evaluate the effectiveness of the Tailored Activity Program in improving basic activities of daily living …

14.08.2026journal-article

International Journal of Molecular Sciences

The Brain-Muscle Axis in Neurodegeneration: Linking Dementia, Sarcopenia, and Exercise-Mediated Neuroprotection

Garima Paul, Mehek Sharma, Diana M. Asante, Deborah A. Jehu, Mohammad Badruzzaman Khan, Carlos Isales, Sadanand Fulzele

Age-related dementia is commonly associated with several secondary complications such as sarcopenia. To date, the correlation between dementia and sarcopenia is not completely understood. This review summarizes the correlation between dementia and sarcopenia using human clinical and observational studies. We also summarize the impact of exercise on these two conditions. We performed a narrative search with systematic elements using PubMed, Embase, Web of Science, and Google Scholar. In this review, we included stud …

14.08.2026journal-article

The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences

Perceived Fatigability and Fall Risk in Aging with and without Multiple Sclerosis: A Prospective Cohort Study

Di-Hua Luo, Roee Holtzer

Abstract Background Fatigue and falls are prevalent and disabling in both aging and older adults with multiple sclerosis (OAMS). However, clinically useful, modifiable predictors of fall risk remain insufficiently established. Perceived fatigability has been shown to cross-sectionally correlate with poorer cognitive and mobility outcomes in normative aging and OAMS, but its prospective relationship with falls is unclear. We examined whether baseline perceived fatigability predicts falls during longitudinal follow-u …

14.08.2026journal-article

Frontiers in Aging

Proteomics of aging: biomarkers for physiological systems and diseases

Ying Luo, Yu-Lin Xiao, Jie-Hua Chen, Hongjue Wang, Shuhong Luo, Hua Dong, Ruo-Pan Huang

Aging is a progressive, multisystem process characterized by declining physiological resilience and increased susceptibility to chronic diseases. Recent advances in high-throughput proteomics have enabled comprehensive mapping of age-related changes across circulating proteins, revealing dynamic and non-linear trajectories that reflect biological rather than chronological aging. This review synthesizes current evidence on proteomic biomarkers across major physiological systems, including the immune, metabolic/endoc …

14.08.2026journal-article

Annals of African Medicine

Effect of Mustard Plaster on Knee Pain Perception among Old People with Osteoarthritis

Nikitaben Dahyabhai Patel, Arti Prasad Muley

Abstract Background: Osteoarthritis (OA) is a chronic degenerative joint disorder commonly affecting older adults and is characterized by cartilage deterioration, joint stiffness, chronic pain, and reduced functional ability. As long-term pharmacological therapy may have limitations and adverse effects, nonpharmacological interventions are increasingly being explored for pain management. Mustard plaster is a traditional topical remedy believed to improve local blood circulation and reduce joint pain. Materials and …

14.08.2026journal-article

Frontiers in Aging Neuroscience

A male rat model integrating hypertension, chronic cerebral hypoperfusion, and aging recapitulates multimodal cerebral small vessel disease phenotypes

Zhiwei Feng, Shan Han, Yanyi Li, Zhenzhen Li, Yige Tu, Bin Wu, Shengjie Zhu, Qin Zheng, Wenjun Sun

Background Cerebral small vessel disease (CSVD) usually develops under the combined influence of vascular risk factors, chronic perfusion insufficiency, and age-related brain vulnerability; however, animal models driven by a single insult do not fully reproduce this multifactorial clinical context. Methods We established a composite CSVD rat model by combining spontaneous hypertension, bilateral common carotid artery stenosis (BCAS)-induced chronic cerebral hypoperfusion, and D-galactose (D-gal)-induced aging-relat …

14.08.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

PERFIL EPIDEMIOLÓGICO DAS HEPATITES VIRAIS POR TRANSMISSÃO SEXUAL EM IDOSOS NO BRASIL ENTRE 2013 E 2023

Vinícius Rosa Garbin, Julia Telles Gonzaga

As hepatites virais constituem importante problema de saúde pública em razão das complicações crônicas associadas, como cirrose hepática e carcinoma hepatocelular. Nas últimas décadas, o envelhecimento populacional e a manutenção da atividade sexual em idades mais avançadas modificaram o perfil epidemiológico dessas infecções, evidenciando a relevância da transmissão sexual entre pessoas idosas. Este estudo teve como objetivo analisar o perfil epidemiológico das hepatites virais por transmissão sexual em idosos no …

14.08.2026journal-article

Advances in Translational Research

Ovarian-derived signals reprogram hepatic lipid metabolism in aging: Implications for therapeutic targeting of metabolic dysfunction

Nathan D. McCoy, Michael T. Kinter, Augusto Schneider, Fabiola Santos, Michal M. Masternak, Jeffrey B. Mason

Abstract Background and Aim Aging in mammals is a complex, multifaceted process involving the progressive decline of physiological functions, in which energy metabolism plays a pivotal role. β -oxidation—the primary pathway for converting fatty acids into energy—is tightly linked to aging and to female reproductive senescence. In the present study, we investigated how ovarian tissue remodels hepatic proteins central to the β -oxidation pathway. Methods Liver proteomes were analyzed in CBA/J control mice at 4, 13, 2 …

14.08.2026journal-article

Journal of the American Geriatrics Society

Prevalence and Predictors of Non‐Frailty Among Homebound Older Adults

Orla C. Sheehan, Katherine A. Ornstein, Mary Louise Pomeroy, Hanna Charankevich, Jennifer M. Reckrey, Christine S. Ritchie, Bruce Leff

ABSTRACT Background Older adults who are homebound, defined as those who rarely or never leave home without assistance or difficulty, experience high levels of multimorbidity, functional impairment, and mortality. Yet their needs remain poorly served by current care delivery models. While research on homebound older adults implies that these individuals are universally frail, this assumption has never been tested empirically. We aimed to better characterize the non‐frail homebound older adult population. Methods Us …

14.08.2026journal-article

Journal of Clinical Medicine

Association Between Immediate Postoperative Pulse Pressure and Three-Year All-Cause Mortality After Hip Fracture Surgery in Older Adults: A Post Hoc Analysis of a Prospective Cohort

Feng Gao, Ruijiang Li, Yimin Chen, Shanbin Xu, Yixiao Chen, Gang Liu, Jing Zhang, Minghui Yang, Xinbao Wu

Objectives: The prognostic relevance of postoperative blood pressure after return to the ward is unclear. In this exploratory post hoc analysis, we investigated the associations of postoperative systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and pulse pressure (PP) with three-year all-cause mortality in older hip fracture patients. Methods: This single-centre post hoc analysis used prospectively collected data from patients aged 65 years or older who underwent hip fract …

14.08.2026journal-article

Foods

Changes in Quality Characteristics, Microbial Communities, and Metabolomic Profiles of Mianning Ham During Different Aging Periods

Yuejia Deng, Zhenghao Wang, Jiaxin Han, Lin Zhou, Xinhui Wang, Jing Zhang, Bingliang Liu, Weijun Chen

Mianning ham is a traditional dry-cured ham from southwestern China, but the coordinated relationships among quality changes, microbial succession, and nonvolatile metabolite remodeling during long-term ripening remain poorly understood. Therefore, samples of Mianning ham aged for one, two, three, and four years were comparatively analyzed. High-throughput sequencing was used to characterize microbial community composition, and untargeted metabolomics was applied to analyze differential metabolite changes and their …

14.08.2026journal-article

The Journal of Social Encounters

Theology of the People as Modernity’s Alternative: A Review Essay

William J. Collinge

In Modernity’s Alternative, Rocco Buttiglione presents the Argentinian theology of the people as an alternative to modernity as it has developed in Europe and North America. After an introduction, the first main part of this review essay discusses Buttiglione’s account of the development of the theology of the people and the major figures in it and how the apparition of Our Lady of Guadalupe marks the beginning of an alternative modernity. The second section considers Buttiglione’s parallel between Christian Platon …

14.08.2026journal-article

Frontiers in Medicine

Acupuncture for nummular eczema of the lower legs in an older adult: a case report

Jinyuan Pan, Hongmin Yu, Wenjia Ye, Yiyun Liang

Background Nummular eczema, also known as nummular dermatitis or discoid eczema, is a chronic inflammatory dermatosis characterized by coin-shaped or discoid eczematous plaques with pruritus, most commonly affecting the extremities, particularly the lower legs. Persistent itch, barrier dysfunction, and repeated scratching may impair sleep and quality of life. Direct evidence for acupuncture in the treatment of nummular eczema remains limited. Case presentation A 68-year-old woman presented with symmetrical coin-sha …

14.08.2026journal-article

Medicine

Associations of sleep duration variability and depressive symptoms with gastrointestinal disease among middle-aged and older adults

Jian-hao Zheng, Ling-yan Qiu, Ding Shi, Xiao-xia Xi

The relationship between variability in sleep duration and gastrointestinal disorders remains insufficiently explored. This study aimed to examine this connection and evaluate the potential mediating influence of depressive symptoms on this association. This research utilized data were obtained from the China Health and Retirement Longitudinal Study (CHARLS) and Health and Retirement Study (HRS). The association between gastrointestinal diseases and changes in sleep duration was explored using quartile grouping, re …

14.08.2026journal-article

OSMANGAZİ JOURNAL OF MEDICINE

Alzheimer Hastalığında Aβ ve Tau'nun İkili Doğası: Sinaptik Budama, Aktin Disfonksiyonu ve Homeostatik Restorasyon

Hilal Karakurt, Merve Yunak, Fahrettin Afşin Sarı, Aybars Kökce

Alzheimer Hastalığının (AH) paradigması, geleneksel amiloid kaskad hipotezinden "homeostatik çöküş" anlayışına kaymaktadır. Bu derleme, doğal immünite, metabolik homeostaz ve sinaptik plastisitenin düzenleyicileri olan Amiloid Beta (Aβ) ve Mikrotübül İlişkili Protein Tau'nun fizyolojik rollerinden patolojik sürece dahil olma mekanizmalarını incelemektedir. Patolojik koşullarda hiperfosforile Tau ile Aβ oligomerleri arasındaki sinerjik etkileşim, aktin-mikrotübül aksını destabilize eder; statik kofilin-aktin çubukla …

14.08.2026journal-article

Science and Innovation

PSYCHOMOTOR THERAPY COMBINED WITH COGNITIVE-BEHAVIORAL TECHNIQUES FOR NEUROTIC SYMPTOMS IN VASCULAR DEMENTIA: A PROSPECTIVE COMPARATIVE PILOT STUDY

S Karakhonova

Neuropsychiatric symptoms are common in vascular cognitive impairment and can complicate rehabilitation and long-term care. This 30-day prospective comparative pilot study evaluated two multimodal regimens for neurotic symptoms in patients with mild-to-moderate vascular dementia. Forty-six patients were enrolled, and 42 had complete baseline and end-of-treatment records for comparative analysis: 20 received basic neuroprotective therapy, rational psychotherapy, and temgicoluril (Adaptol), whereas 22 received basic …

14.08.2026journal-article

Frontiers in Public Health

Frailty and nutritional status as prognostic factors in older adults with heart failure: a public health perspective

Jing Li, Meiling Liu, Jingyan Wang

Background Heart failure is a common cardiovascular disease among older adults. Combined with frailty, it may aggravate the patient's condition and affect the prognosis. Nutritional status is important in older patients, but its relationship to frailty associated with heart failure is not fully understood. Methods This single-center retrospective study initially screened 236 older patients with heart failure who were admitted to Yuncheng Central Hospital in Yuncheng, Shanxi Province, China, between March 2020 and F …

14.08.2026journal-article

Simbólica - Revista de Filosofia da Cultura e Estudos Interdisciplinares

Diálogo ao anoitecer em um campo de prisioneiros de guerra na Rússia entre alguém mais jovem e alguém mais velho

Martin Heidegger, Lucas Carvalho Lima Teixeira

Trata-se de uma tradução do diálogo filosófico de Martin Heidegger intitulado Abendgespräch in einem Kriegsgefangenenlager in Rußland zwischen einem Jüngeren und einem Älteren, acompanhada de uma introdução de circunstanciação temática.

14.08.2026journal-article

Sports Health: A Multidisciplinary Approach

Peroneal Reaction-Time Demonstrates a Greater Influence Than Peroneal Muscle Strength on Lateral Ankle Ligament Strain in People With Chronic Ankle Instability

Xinmeng Zhang, Qi Wang, Xiaoxue Zhu, Yujing Cao, Junjun Li, Wenqi Ran, Qipeng Song

Background: Lateral ankle sprains often damage the anterior talofibular (ATFL) and calcaneofibular (CFL) ligaments. Delayed peroneal muscle reaction time (reaction-time) and reduced peroneal muscle strength (strength) may increase the risk of recurrent sprains. Relationships between neuromuscular impairments and ligament strains remain unclear due to challenges in directly measuring ligament strains under dynamic conditions. Hypothesis: Reaction-time and strength are correlated significantly with ATFL and CFL strai …

14.08.2026journal-article

New Zealand Medical Journal

Whitia Kia Ora: a culturally responsive model of Bicillin L-A® delivery for people with rheumatic fever in the Waikato region of Aotearoa New Zealand

Anneka Anderson, Monleigh Ikiua, Rachel Brown, Kim Arrowsmith, Tira Phillipson-Puna, Shannon Leilua, Manawa Rhinds, Julie Cooper, Matire Harwood, Rawiri McKree-Jansen, Alison Ahu, Dave Thompson, Julie Bennett

aim: Acute rheumatic fever (ARF) is an autoimmune response to group A Streptococcus (Strep A) infection that can lead to rheumatic heart disease (RHD). To prevent Strep A infection for people with ARF or RHD, clinical guidelines recommend monthly intramuscular penicillin (Bicillin L-A®) injections for at least 10 years. However, multiple barriers to accessing healthcare affect adherence. This research aimed to improve adherence by developing a Māori and Pacific–centred model of care. methods: Qualitative, Kaupapa M …

14.08.2026journal-article

Frontiers in Pharmacology

Protein farnesylation: from molecular mechanisms to therapeutic targeting in cancer, aging, and beyond

Jiacheng Lou, Danlu Zhang, Yingjie Wang

Protein farnesylation, catalyzed by farnesyltransferase (FTase), covalently attaches a 15-carbon farnesyl lipid to cysteine residues within C-terminal CaaX motifs. This modification governs the subcellular localization, protein–protein interactions, and activity of diverse eukaryotic proteins, including Ras GTPases, nuclear lamins, molecular chaperones, and kinetochore components. This review examines FTase enzymology, substrate recognition, and the sequential post-farnesylation processing by RCE1 and ICMT, alongsi …

14.08.2026journal-article

Biomedicines

Dietary, Nutrient, and Supramolecular Nanofiber Modulation of the Liver Sinusoidal Clearance System in Metabolic Diseases and Aging

Binod Pokharel, Anokhi Kulkarni, Rebecca Drager, Fatima Atta Muhammad, Ouliana Ziouzenkova

In modern societies, the renewed concept of food as medicine coexists with unprecedented consumption of highly processed foods, food additives, environmental xenobiotics, and pharmacological agents, contributing to the increasing prevalence of metabolic and degenerative diseases and accelerated aging. Although modern pharmacotherapies have transformed disease management, long-term drug exposure introduces additional metabolic burdens, off-target effects, and cumulative toxicities that are profoundly influenced by n …

14.08.2026journal-article

BMC Health Services Research

The UN Decade of healthy ageing in practice: A qualitative case study on perspectives of healthy ageing among older adults, healthcare professionals, and decision-makers in Norway

Mariya Bikova, Maria Nordheim Alme, Djenana Jalovcic, Hanne Tuntland

Abstract Background Global populations are ageing, making healthy ageing an increasingly important priority. In Norway, the number of people aged 70 and above is expected to double by 2050. The UN Decade of Healthy Ageing (2021–2030) guides Norway’s national programs on healthy ageing through its four action areas: combating ageism, age-friendly environments, integrated care and long-term care. The aim of this study is to explore how healthy ageing is understood and interpreted in Norway in light of the four action …

14.08.2026journal-article

Health Promotion Practice

Factors Influencing Equitable Participation in a Provincially Implemented Older Adult Exercise Program in Canada: Qualitative Analysis Using the Health Equity Implementation Framework

Wendy S. Verity, Heather Foulds, Cari McIlduff, Daniel Fuller, Anne Leis

Background: Group-based exercise programs for older adults produce substantial health benefits, yet they often fail to reach equity-deserving populations in representative proportions. An understanding of local and systemic factors surrounding exercise programs is needed to guide strategies to reduce these gaps. Purpose: Our purpose was to understand the local and system-wide factors that influence equitable participation in the Forever . . . in motion (FIM) older adult exercise program in Saskatchewan, Canada. Met …