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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
22.08.2026journal-article

Journal of the American Chemical Society

In Situ Construction of a Reticulated Peptide Scaffold via Responsive Self-Assembly and Proximal Covalent Labeling for Enhanced Tumor Imaging and Therapy

Ruxin Feng, Yunfeng Qiu, Yang Zhao, Rixin Wang, Weilu Xu, Jinhui Ning, Yumin Li, Juyue Zhou, Dingqing Feng, Suying Xu, Leyu Wang

Abstract Precise imaging and specific retention of therapeutic agents at solid tumors were particularly desirable yet hindered by limited specificity and fast diffusion. Herein, we established a dual-trigger-mediated synergistic strategy to form a reticulated peptide network in situ by functional peptide (CL-YPFG) through responsive self-assembly and covalent labeling for prolonged imaging and boosted accumulation of drugs. Specifically, the CL-YPFG underwent morphology transformation from nanoparticles to nanofibe …

22.08.2026journal-article

Angewandte Chemie International Edition

MitoGPS: A Mitochondrial DNA G‐Quadruplex‐Targeting Strategy for Tumor‐Preferential Type I Photodynamic Therapy

Yu‐Hui Guo, Yao‐Hui Shi, Pei‐Min Huang, Gui‐Xue Tang, Shu‐Min Xu, Mao‐Lin Li, Jia‐Hao Yuan, Xiu‐Cai Chen, Zhi‐Shu Huang, Yi‐Yong Yan, Jia‐Heng Tan, Jin‐Wu Yan, Shuo‐Bin Chen

ABSTRACT Photodynamic therapy (PDT) is a clinically promising, minimally invasive cancer treatment offering precise spatiotemporal control. However, achieving preferential tumor accumulation remains a critical challenge, which limits therapeutic efficacy and induces off‐target toxicity. Here, we introduce the mitoGPS (mitochondrial G‐quadruplex–targeting photosensitizer) strategy, a rational design framework for developing photosensitizers (PSs) with prolonged intratumoral retention through targeting mitochondrial …

22.08.2026journal-article

Diagnostics

Ultrasound-Visible 3D Nickel–Titanium Clip for Tumor Localization After Neoadjuvant Therapy in Early Breast Cancer: A Prospective Multicenter Real-World Study

Mattea Reinisch, Efstathia Cremer, Kilian Pankert, Diana Weber, Volker Hanf, Katja Engellandt, Sebastian Hentsch, Cordula Müller, Peter Dall, Matthias Losch, Petra Deuschle, Alexander Traut, Satyen Shenoy, Anita Engel, Dorothea Schindowski, Sherko Kuemmel, Simona Gipe

Background: Neoadjuvant systemic therapy (NST) enables tumor downsizing and increases the feasibility of breast-conserving surgery (BCS) in patients with early breast cancer (EBC). Reliable tumor localization after NST remains challenging, particularly in patients with a complete clinical response. If clips are not visible on ultrasound, stereotactic mammography-guided wire localization is required, which involves additional radiation exposure and may increase patient discomfort and procedural complexity. The 3D-sh …

22.08.2026journal-article

Cancers

Myeloid-Mediated Immunoregulation and Resistance to Immune Checkpoint Inhibitor Therapy Across Squamous Cell Carcinomas: Mechanisms and Reprogramming Strategies

Jaafar A. Hadi, Zohra N. Nizami, Ahmed Tajmim Noor, Abdullah A. Osman, Jeffrey N. Myers

Immune checkpoint inhibitors (ICIs) targeting PD-1/PD-L1 have improved outcomes across squamous cell carcinomas (SCCs) of the head and neck, lung, esophagus, and skin, yet durable responses remain confined to a subset of patients in every subtype. Objective response rates vary substantially across SCCs despite overlapping genomic alterations, comparable tumor mutational burden, and high PD-L1 expression, indicating that tumor-intrinsic biomarkers alone do not explain this variability. Growing evidence points to the …

22.08.2026journal-article

Journal of Back and Musculoskeletal Rehabilitation

TENS with proprioceptive-visual training on gait parameters in children with spastic diplegic cerebral palsy: A randomized controlled trial

Mostafa S Ali, Mahmoud Usama

Objective This study aimed to evaluate the effect of TENS with proprioceptive—visual training on gait parameters in children with spastic diplegic cerebral palsy. Methods Two groups of thirty diplegic CP children, ages 4 to 6, were randomly assigned to receive proprioceptive-visual training as the control group and TENS with proprioceptive—visual training as the research group. For eight weeks, both groups received therapy three times a week. Prior to and during the intervention period, each participant had an eval …

22.08.2026journal-article

American Journal of Occupational Therapy

Co-Occupational Participation and Musculoskeletal Health in Mothers: A 7-Day Diary Study

Gamze Ayas, Esra Akı

Importance Postpartum musculoskeletal disorders are prevalent, yet ergonomic approaches often overlook the temporal organization of mother–infant co-occupations. Examining weekly care patterns may help identify patterns relevant to occupational therapy assessment and future intervention research. Objective To examine associations between weekly co-occupational exposure patterns and musculoskeletal disability among postpartum women. Design Cross-sectional study using a 7-day co-occupational participation log. Settin …

22.08.2026journal-article

Diseases of the Esophagus

PD09.07. Impact of Type 2 Diabetes on Outcomes of Neoadjuvant Therapy and Surgery for Esophageal Cancer: A Multi-Center Retrospective Study

Xipeng Wang, Zhichao Liu, Xuefeng Leng, Xinmin Li, Jingwen Zhang, Xiaoting Yu, Wei Guo, Chengqiang Li, Yongtao Han, Zhigang Li, Hecheng Li, Yuqin Cao

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background The prognostic impact of type 2 diabetes in esophageal cancer patients receiving neoadjuvant therapy followed by surgery remains unclear. We evaluated its association with perioperative outcomes and long-term survival. Methods We retrospectively analyzed 1,099 patients who underwent neoadjuvant therapy followed by surgery between 2013 and 2024 across three high-volume centers. Type 2 diabetes was …

22.08.2026journal-article

Diseases of the Esophagus

P1.131. Total Neoadjuvant Therapy for Lymph Node-Positive Adenocarcinoma of the OESophagus and Oesophagogastric Junction, Phase-II Multicentre Randomized Controlled Trial Protocol

Esmeede Bruijn, Charlene van der Zijden, Bas Wijnhoven, Joost Nuyttens, Sjoerd Lagarde, Bianca Mostert

Abstract Topic Esophageal Cancer: Oncology/Radiation Therapy Background Neoadjuvant chemoradiotherapy (nCRT) and perioperative chemotherapy both form standard treatment for locally advanced oesophageal adenocarcinoma. By combining both therapies as Total Neoadjuvant Therapy (TNT), the local effect of nCRT and the systemic effect of chemotherapy could potentially lead to better disease control. Methods The TNT-OES-2 trial is a phase-II multicentre randomized controlled trial which combines neoadjuvant chemoradiother …

22.08.2026journal-article

Journal of Oncology Pharmacy Practice

Best practices to master robotic preparation of ready-to-administer systemic anticancer therapy in hospital pharmacies

M. Crul, C. Polidori, D. Paolucci, A. Rieutord, P. Salinas Silva, L. Bredesen Hatlelid, A. Riffle, G. Eggers, L. Amerine, I. Kraemer

Automated reconstitution or preparation of systemic anticancer therapy has gained traction in the past decade. Transitioning from traditional manual workflows to fully automated production offers multiple benefits: decreased pharmacy staff workload, reduced risk of repetitive strain injuries, minimized medication errors, and lower risk of occupational exposure to hazardous medicinal products, especially when the robotic preparation areas are fully enclosed. Several elements can facilitate efficient implementation a …

22.08.2026journal-article

Diseases of the Esophagus

OA03-RF01.01. Patterns and Predictors of Recurrence in Patients With Esophageal Cancer Who Achieve Pathological Complete Response to Multimodal Therapy

Yuxin Yang, Zhigang Li

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Neoadjuvant chemoradiotherapy (nCRT) and chemoimmunotherapy (nICT) are increasingly used for locally advanced esophageal squamous cell carcinoma. Although pathological complete response (pCR) is associated with favorable survival, nearly one third of pCR patients still experience recurrence. This study aimed to identify risk factors and recurrence patterns in this population. Methods We retrospectively reviewed 392 patients who achieve …

22.08.2026journal-article

Sağlık Bakım ve Rehabilitasyon Dergisi

Family-Centered Approaches in Auditory Rehabilitation for Children and Adults with Hearing Loss: A Review of Conceptual Frameworks and Outcomes

Tuğba Ural

Hearing loss is a significant public health issue that affects individuals’ communication skills, language development, and social participation. Auditory rehabilitation is a multidimensional process aimed at reducing these effects and improving communicative functioning, and it is currently addressed within a biopsychosocial framework. In this context, not only the individual’s auditory performance but also their interaction with environmental and familial factors constitutes essential components of the rehabilita …

22.08.2026journal-article

Diseases of the Esophagus

P1.005. Preliminary Pilot Study Cohort Results - Cost-Effective Surveillance Strategies and Prediction of Cancer Recurrence After Endoscopic Therapy for Barrett’s Esophagus (Endeavor)

Martin Wyckmans, Rene Thieme, Rui Neves, Jennifer Kluczny, Henrik Maltzman, Fredrik Klevebro, Nikolas Stoecklein, Federica Ungaro, Alberto Barchi, Jacintha O'Sullivan, Dermot O'Toole, Jessie Elliott, Guillaume Piessen, Julien Branche, Veerle Coupé, Marjolein Greuter, Piotr Twardowski, Thomas Botelberge, Guido Van Hal, Costanza Di Patrizi, Nastaran Riahi Dehkordi, Dominiek De Wulf, Stefan Van Dongen, Ann Driessen, Elisabeth Macken, Souad Bouhadan, Pieter Dewint, Sanne Hoefnagel, Michael Achiam, Laser Bazancir, David Tate, Magnus Nilsson, Sheila Krishnadath

Abstract Topic Esophageal Cancer: Barrett‘s Esophagus: High-Grade Dysplasia and Early Invasive Cancer Background In many European countries, esophageal adenocarcinoma (EAC) incidence is increasing [1]. Barrett’s esophagus(BE), strongly associated with EAC, can progress via dysplasia to early and invasive adenocarcinoma [2]. Endoscopic treatment is the mainstay for early mucosal cancer (T1a/b) but requires intense post-treatment surveillance [3]. This results in overtreatment in most, and undertreatment in only a su …

22.08.2026journal-article

Diseases of the Esophagus

PD07.06. Lymphovascular and Perineural Invasion Identifies High-Risk Disease and Candidates for Postoperative Therapy After Neoadjuvant Immunochemotherapy in Esophageal Squamous Cell Carcinoma

Taidui Zeng, Yizhou Huang, Maohui Chen, Chun Chen, Bin Zheng

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Despite increasing use of neoadjuvant chemoimmunotherapy (nCIT) for locally advanced esophageal squamous cell carcinoma (ESCC), postoperative risk stratification remains suboptimal. Lymphovascular invasion (LVI) and perineural invasion (PNI) represent markers of aggressive tumor biology, yet their combined prognostic value and implications for adjuvant treatment in the nCIT setting have not been fully clarified. This study investigated …

22.08.2026journal-article

Meditsinskiy sovet = Medical Council

Serum levels of sCD163 and IL-38 in assessing the risk of symptomatic hemorrhagic transformation after reperfusion therapy of ischemic stroke

S. D. Kazakov, D. M. Plotnikov, A. F. Kanev, E. M. Kamenskih, V. M. Alifirova

Introduction. Symptomatic hemorrhagic transformation (sHT) is associated with poor outcome in ischemic stroke (IS). The search for predictors of sHT for personalized forecasting of this complication is a relevant task. Aim. To evaluate the prognostic significance of serum concentrations of soluble CD163 (sCD163) and interleukin-38 (IL-38) for assessing the risk of sHT development. Materials and methods. A prospective cohort study was conducted, which included 86 patients with IS in the carotid territory who receive …

22.08.2026journal-article

Diseases of the Esophagus

OA03-RF01.02. Clinical Significance of Endoscopic Sub-Classification “Remarkable Response (RR)” After Neoadjuvant DCF Therapy in Esophageal Squamous Cell Carcinoma

Takeaki Yamazaki, Tomohiro Kadota, Kazuma Sato, Hironori Sunakawa, Keiichiro Nakajo, Daisuke Kotani, Takashi Kojima, Shingo Sakashita, Takeo Fujita, Tomonori Yano

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background In esophageal squamous cell carcinoma (ESCC), the importance of endoscopic assessment of tumor response after neoadjuvant chemotherapy has been reported. The Japanese Classification of Esophageal Cancer has introduced a new endoscopic sub-classification, “Remarkable response (RR),” but its clinical significance has not been fully clarified. Methods We retrospectively analyzed patients with resectable locally advanced ESCC (cT2–3/N0–3/M …

22.08.2026journal-article

Open Forum Infectious Diseases

Challenging the Concept of Uncomplicated Candidemia for Shorter Courses of Antifungal Therapy

Matthaios Papadimitriou-Olivgeris, Laurence Senn, Alix Coste, Frédéric Lamoth

Abstract Background A recent proposal introduced criteria to distinguish uncomplicated from complicated candidemia and identify patients who might be candidates for a shortened (7-day) course of antifungal therapy. We evaluated the feasibility and potential impact of this strategy in a real-world cohort. Methods This retrospective study included patients with candidemia at Lausanne University Hospital (2015–2024). We estimated the sample size required for a randomized non-inferiority trial comparing 7 vs 14 days of …

22.08.2026journal-article

Diseases of the Esophagus

P1.117. Photodynamic Therapy for Esophageal Cancer: A Single-Center Experience With Clinical Outcomes

YOUNGGI JUNG, JAEHO CHUNG, EUNJUE YI, HYOJUNG KIM, SUNGHO LEE, Jieon Kim

Abstract Topic Esophageal Cancer: Non-Surgical Treatment of Esophageal Cancer Background Photodynamic therapy (PDT) is a minimally invasive local treatment that selectively destroys malignant cells with minimal systemic toxicity. It has emerged as an alternative therapeutic option for superficial esophageal lesions such as carcinoma in situ or high-grade dysplasia, and as a palliative or salvage modality in inoperable cases. This study aimed to evaluate the clinical outcomes and safety of PDT in patients with esoph …

22.08.2026journal-article

Diseases of the Esophagus

PD01.08. Optimizing Postoperative Systemic Therapy Following Neoadjuvant Chemoimmunotherapy and Resection for Locally Advanced Esophageal Cancer: A Multicenter Real-World Analysis

Yizhou Huang, Maohui Chen, Zhenyuan Yang, Taidui Zeng, Chun Chen, Bin Zheng

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Neoadjuvant chemoimmunotherapy (nICT) followed by surgical resection has emerged as a standard approach for locally advanced esophageal cancer. However, the role and optimal modality of postoperative immunotherapy in patients who have already received immune checkpoint blockade remain uncertain, particularly outside the context of prospective trials. We sought to evaluate the impact of different adjuvant immunotherapy strategies on sur …

22.08.2026journal-article

MedComm

DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy

Xuanxuan Yu, Yuqin Jin, Baochao Li, Jie Deng, Yiwen Zhou, Jinglun Zhang, Huang Li

ABSTRACT Immune surveillance hinges on the precise regulation of molecular sentinels to maintain the equilibrium between physiological homeostasis and pathological distress. Central to this process is the sensing of exogenous pathogen‐associated molecular patterns (PAMPs) and endogenous damage‐associated molecular patterns (DAMPs), or alarmins. Traditionally, PAMPs and DAMPs were categorized as triggers for local protective host defense or maladaptive inflammatory cascades. Recent insights have unveiled an expanded …

22.08.2026journal-article

Asian Journal of Pediatric Research

From a Recurrent FGFR3 Variant to Isoform-Selective Kinase Inhibition: A Critical Appraisal of Targeted Therapy in Paediatric Achondroplasia

Stefan Bittmann, Elisabeth Luchter, Elena Moschüring-Alieva

Achondroplasia arises almost invariably from a single recurrent gain-of-function variant in the gene encoding fibroblast growth factor receptor 3, and has therefore become a reference case for genotype-directed drug development in paediatric rare disease. Within five years the field has moved from a single approved subcutaneous peptide analogue to a competitive landscape containing long-acting prodrugs of C-type natriuretic peptide, an orally administered pan-fibroblast growth factor receptor 1 to 3 tyrosine kinase …

22.08.2026journal-article

Diseases of the Esophagus

P1.190. Residual Disease Subgroups and Survival After Trimodality Therapy for Esophageal Squamous Cell Carcinoma - Observational Study

Abhijit Talukdar, Dibyajyoti Deka, Jyotiman Nath, Anupam Sarma, Yanpothung Yantham, Jaideep Baddam

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background For locally advanced oesophageal squamous cell carcinoma (ESCC) managed with trimodality therapy, the prognostic significance of different patterns of residual disease within the non-pathological complete response (non-pCR) population remains incompletely defined. This study applied a four-group pathological response classification to evaluate whether the anatomical distribution of residual diseas …

22.08.2026journal-article

Nutrients

Lifestyle Medicine as Co-Therapy During Incretin-Based Anti-Obesity Pharmacotherapy: Integrating Physical Activity, Nutrition, and Behavioral Strategies for Long-Term Success

Marta Mallardo, Antonietta Messina, Vincenzo Monda, Marco La Marra, Antonietta Monda, Salvatore Allocca, Maria Casillo, Girolamo Di Maio, Pasquale Perrone, Aurora Daniele, Marcellino Monda, Giovanni Messina, Fiorenzo Moscatelli, Rita Polito

Background/Objectives: Obesity is a chronic, progressive, and relapsing disease that requires long-term, multidisciplinary management rather than episodic weight-loss treatment. Although novel incretin-based anti-obesity pharmacotherapies, including GLP-1 receptor agonists and dual GIP/GLP-1 receptor agonists, have markedly improved the clinical management of obesity, weight reduction alone does not fully capture treatment success. Body composition, lean mass preservation, physical function, nutritional adequacy, p …

22.08.2026journal-article

Journal of Cardiovascular Development and Disease

Early Versus Late Initiation of Renal Replacement Therapy Impacts Early Mortality in Diabetic Patients with Acute Kidney Injury After Cardiac Surgery

Ozkan Ozler, Vedat Erentug

There are limited data on the optimal time of renal replacement therapy (RRT) after cardiac surgery, and published results are controversial. In our study, an answer was sought to the question of the correct timing of RRT in diabetic patients with post-cardiac surgery acute kidney injury (AKI). Forty-four adult patients with DM who required postoperative RRT were included in our single-center prospective study. According to the time of onset of RRT, the patients were divided into two groups: those whose RRT was ini …

22.08.2026journal-article

Applied Sciences

Feasibility of a Technology-Supported High-Intensity Interval Training Program for Occupational Drivers

Alam Zeb, An Neven, Chris Burtin, Lotte Janssens, Brent Peters, An-Marie Schyvens, Catharina Nina Van Oost, Timo Meus, Annick Timmermans, Jonas Verbrugghe

This study assessed the feasibility of a technology-supported high-intensity interval training (HIIT) program for occupational drivers. A multiphase feasibility study incorporating participant feedback was conducted in Flanders, Belgium, including consultation, pilot, and intervention phases. Occupational drivers were randomized to a HIIT group, an active control group (mindfulness program), or a passive control group (no intervention). The 16-week, equipment-free HIIT program consisted of two 15-min sessions per w …