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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

Sanatorium Medical Journal

Approach to Hemoptysis: Etiology, Diagnosis, and Management

Emire Pinar Seyfettin Celik

Hemoptysis is defined as the expectoration of blood originating from the pulmonary or bronchial vasculature into the airway. It may range from mild blood-streaked sputum to life-threatening massive bleeding that demands urgent intervention. Although minor hemoptysis is far more common, massive hemoptysis carries a high risk of mortality primarily due to asphyxiation rather than exsanguination. Identifying the underlying etiology is often complex, as causes vary by geography and comorbid conditions. In low and middl …

01.09.2026journal-article

Clinics in Shoulder and Elbow

Preoperative hyperglycemia within 24 hours of surgery is associated with adverse outcomes after rotator cuff repair

Yoli Meydan, Kenny Ling, Bryan Chen, James Gallagher, Edward Wang

Background: Rotator cuff repair (RCR) is a common orthopedic procedure that relies on proper tendon healing for good outcomes. While hyperglycemia is known to worsen outcomes in other surgeries, its effects on RCR remain underexplored. We investigated whether preoperative hyperglycemia is associated with increased complication rates following RCR using a large, multi-institutional database. Methods: Using the TriNetX Research Network, we identified patients who underwent primary RCR between May 2005 and May 2024. P …

01.09.2026journal-article

S.S. Korsakov Journal of Neurology and Psychiatry

Ketogenic diet in the treatment of drug-resistant epilepsy in children: Assessment of clinical efficacy, health care resource consumption, and direct medical costs

E.G. Lukyanova, A.G. Tolkushin, S.O. Ayvazyan, K.V. Osipova, E.A. Pyrieva, A.I. Krapivkin, V.A. Zhestkov

Objective. To evaluate the impact of the ketogenic diet (KD) on clinical outcomes, health resource consumption, including medication burden, hospitalization rates, and outpatient care, and direct medical costs (DMCs) in pediatric patients with drug-resistant epilepsy (DRE). Material and methods. A retrospective, non-interventional observational study was conducted at a specialized medical center. Data were collected from 58 children diagnosed with DRE: 29 patients received the ketogenic diet, while 29 patients comp …

01.09.2026journal-article

Physics in Medicine & Biology

Robustness of radiomics-based machine learning to real-world MRI distribution shifts: a phantom study

Sarmad Ahmad Khan, Simon Bernatz, Zahra Moslehi, Florian Buettner

Abstract Objective. This study systematically investigates the robustness of radiomics-based machine learning models to distribution shifts caused by variations in MRI acquisition protocols and image segmentation strategies, and evaluates strategies for maintaining predictive performance and uncertainty calibration under such shifts. Approach . Using a controlled phantom comprising 16 fruits of four types, we acquired images across five MRI sequences (T2-HASTE, T2-TSE, T2-MAP, T1-TSE, T2-FLAIR) with multiple scans, …

01.09.2026journal-article

IECCMEXICO

Precision-Guided Minimally Invasive Neurosurgery: Anatomical Accuracy, Patient Selection, and Contemporary Challenges

Andrés Omar Triviño Pinto, Brian Alejandro Berdugo Vargas, Alejandra Mendoza Ortiz, Adrian Jhair Flores Equilea, Natalia Restrepo Hinestrosa, Luis Roberto Hernández Mercado, Erick Fernando Flores García, Mariana Lineth Orozco Ricardo, Giliana Paola Velasquez Londoño

Image-guided minimally invasive neurosurgery has transformed the management of intracranial lesions by integrating advanced imaging, neuronavigation, stereotactic planning, intraoperative visualization, and reduced surgical corridors. The objective of this study was to analyze the anatomical precision, patient-selection criteria, clinical outcomes, and current limitations associated with minimally invasive image-guided neurosurgical approaches. A structured integrative review based on the scientific method was cond …

01.09.2026journal-article

Obesity Science & Practice

Patient‐Reported Continuity of GLP‐1 Receptor Agonist Therapy

You Chen, Gracie Piantek, Xinmeng Zhang, Yubo Feng, Chao Yan, Jason M. Samuels, S. Trent Rosenbloom, Danxia Yu, Laurie L. Novak, Gitanjali Srivastava

ABSTRACT Objective Use of GLP‐1 receptor agonists is associated with significant weight loss in many individuals. Discontinuation is associated with weight regain. Patients' experience with this is not well characterized. This study describes the patient experience of continuity of care. Methods A cross‐sectional electronic survey was administered to adults identified from an academic medical center's electronic health records as having at least one GLP‐1 RA prescription in the preceding 6 years and a subsequent pr …

01.09.2026journal-article

Microbiology Spectrum

Comparative evaluation of probe-capture and conventional metagenomic sequencing across multiple clinical sample types, with analysis of paired bronchoalveolar lavage fluid and blood samples

Xiao Liu, Xiaoai Fan, Wanting Wu, Weiping Ni, Yingxue Hu, Qinghui Yang, Jinxing Wei, Fang Yan, Xiaoshu Chen, Jianrong Yang, Bingxue Hu, Xiaodan Yu, Wenjuan Li

ABSTRACT Conventional metagenomic next-generation sequencing (mNGS) suffers from host nucleic acid interference and poor performance in low-biomass samples. Probe-capture metagenomic sequencing (PC-mNGS), which enriches microbial targets via hybridization probes, shows superior sensitivity but lacks systematic multi-sample evaluations. This study compared PC-mNGS and mNGS across diverse clinical specimens (bronchoalveolar lavage fluid [BALF], blood, cerebrospinal fluid [CSF]) and assessed the clinical utility of pa …

01.09.2026journal-article

Microbiology Spectrum

Development and clinical validation of a CRISPR/Cas9-engineered reporter phage cocktail for rapid detection of Escherichia coli in urine

Zhiyun Hao, Qiang Zhao, Yi Zhong, Minwei Li, Chengbin Wang, Chi Wang

ABSTRACT Urinary tract infections are one of the most common infectious diseases, with Escherichia coli as the predominant pathogen. Traditional diagnostic methods fail to meet clinical demands for rapid and specific detection. Here, we developed an efficient urine E. coli detection strategy via a reporter phage cocktail. Four reporter phages (T2:: Nluc , T4:: Nluc , T5:: Nluc , T6:: Nluc ) were constructed by the CRISPR/Cas9 system combined with homologous recombination. One-step growth curves, optimal multiplicit …

01.09.2026journal-article

Journal of Human Immunity

The clinical utility of exome sequencing for risk stratification in celiac disease

Talha Asif, Michele Akalay, Wendy K. Chung, Peter H.R. Green, Xiao-Fei Kong

The potential utility of genetic testing among individuals with a positive celiac disease (CeD) family history remains limited. We performed whole-exome sequencing in a cohort of 107 cases with CeD and 117 unaffected relatives from 66 families. We assessed fourteen HLA-DQ genotypes, based on combinations of four risk haplotypes. Our cohort was predominantly of European ancestry (87%). Compared with at-risk controls, CeD cases showed a significant enrichment of high-risk (22.4 vs. 10.3%) and moderate-risk (64.4 vs. …

01.09.2026journal-article

Cancers

Comorbidity Burden and Survival After Primary Surgery for Oral Cavity Squamous Cell Carcinoma: Tumor Stage as an Effect Modifier

Mateusz Szewczyk, Krzysztof Przybylski, Bartosz Nowak, Bartosz Wojtera, Dominika Wojnar, Damian Rusek, Jakub Pazdrowski

Background/Objectives: To evaluate the association between comorbidity burden, quantified using the Charlson Comorbidity Index (CCI), and overall survival (OS) and disease-free survival (DFS) in patients treated surgically for oral cavity squamous cell carcinoma (OCSCC), and to determine whether this association is modified by tumor stage. Methods: We retrospectively analyzed 325 patients treated with primary surgery for OCSCC at a single institution (2009–2021). CCI was scored excluding the index malignancy compon …

01.09.2026journal-article

Journal of Separation Science

A Metabolism‐Oriented Strategy for Systematic Analysis of the Pharmacological Material Basis of Classic Traditional Chinese Medicine Formulas: Taking Wuao Sanzi Decoction as an Example

Jin‐Jin Liao, Yang‐Dan Liu, Lan‐Ying Gao, Gui‐Zhong Xin, Yuan Cao, Zi‐Qi Shi

ABSTRACT Deciphering the pharmacodynamic material basis of classical traditional Chinese medicine (TCM) formulas remains a critical challenge, owing to their multicomponent nature, multitarget interactions, and intricate in vivo metabolic fates. To address this issue, a metabolism‐oriented strategy was established and applied to Wuao Sanzi Decoction (WASZD), a classic TCM formula for respiratory diseases such as asthma. Ultra‐high‐performance liquid chromatography coupled with quadrupole time‐of‐flight tandem mass …

02.09.2026journal-article

The Oncologist

62 Patient Experience with Clinical Trials: Results from the International Kidney Cancer Coalition Global Patient Survey

Eric Jonasch, Stênio de Cássio Zequi, Axel Bex, Deborah Maskens, Margaret Hickey, Karin Kastrati, Christine Collins, Michael Jewett

Abstract Background Clinical trials are essential for advancing cancer care, yet patient participation remains suboptimal worldwide. While structural and clinician-reported barriers are well described, patient perspectives across diverse geographic and socioeconomic settings are less understood. The International Kidney Cancer Coalition (IKCC) conducts a biennial Global Patient Survey (GPS) to assess patient and caregiver experiences with kidney cancer, including clinical trials, to identify unmet needs and inform …

01.09.2026journal-article

Anesthesia & Analgesia

Autonomic Vulnerability, Intraoperative Hypotension Burden, and Myocardial Injury After Noncardiac Surgery in Older Adults: A Propensity Score-Matched Retrospective Cohort Study

Cheol Lee, Hansol Hong, Gyumin Choi

BACKGROUND: Myocardial injury after noncardiac surgery (MINS) is common and often clinically silent. Older adults with diabetes mellitus (DM) and/or hypertension (HTN) may have autonomic dysfunction that impairs hemodynamic compensation during surgical stress. We hypothesized that a preoperatively identifiable autonomic vulnerability phenotype would be associated with adjudicated ischemic MINS after major noncardiac surgery and that this association would be amplified at higher intraoperative hypotension (IOH) burd …

01.09.2026journal-article

Plastic and Reconstructive Surgery - Global Open

Dynamic External Distraction Device for Proximal Phalangeal Head Intra-articular Fracture

Tzu-Chi Tseng, Kun-Han Lee, Jung-Pan Wang

Dynamic distraction external fixation (DDEF) is commonly used for proximal interphalangeal joint fractures based on the principle of ligamentotaxis. However, this mechanism may be limited when fracture fragments lack soft tissue attachment. We present a 14-year-old girl with a depressed intra-articular fracture of the proximal phalanx head and joint stiffness, treated 5 weeks after injury using DDEF. Despite delayed treatment and minimal ligamentous connection, the fragment was successfully elevated and healed. We …

01.09.2026journal-article

Medicina Fluminensis

Novi konceptualni okvir cerebralne paralize

Ana Katušić

Cerebralna paraliza već desetljećima zauzima središnje mjesto u dječjoj neurologiji i rehabilitaciji, no njezino se određenje kontinuirano razvijalo. Od prvih opisa do međunarodnog konsenzusa iz 2007. godine, koncept cerebralne paralize mijenjao se u skladu sa znanstvenim spoznajama i društvenim promjenama. Napredak u razumijevanju genetskih i upalnih mehanizama, prepoznavanje raznolikosti u kliničkoj slici te sve snažnija uključenost osoba koje žive s cerebralnom paralizom doveli su do prijedloga novog određenja. …

01.09.2026journal-article

Journal of Obstetrics and Gynaecology Research

DNA Methylation Testing in Cervical Cancer: A Triage Tool for HPV ‐Based Screening and Post‐Treatment Surveillance

Yuance Xu, Xiaoting Zhou, Lina Guo, Rongjun Lyu

ABSTRACT Background High‐risk HPV screening achieves high sensitivity but low specificity, resulting in excessive colposcopy referrals. DNA methylation biomarkers could refine risk stratification across the cervical cancer care continuum. Objective To evaluate the diagnostic performance and clinical implementation of DNA methylation testing in HPV‐positive triage and post‐treatment surveillance. Methods Narrative review of prospective cohorts and randomized trials (2013–2024) evaluating methylation markers in cervi …

01.09.2026journal-article

Cancer Medicine

Eosinophil Proportion May Serve as a Candidate Biomarker for Adverse Events in Patients With Urothelial Carcinoma Treated With Enfortumab Vedotin

Kunihiro Odagiri, Toshiharu Morikawa, Taku Naiki, Yosuke Sugiyama, Yoshihiko Tasaki, Yoshihisa Mimura, Aya Naiki‐Ito, Takashi Nagai, Toshiki Etani, Keitaro Iida, Daiki Ishikawa, Yusuke Noda, Nobuhiko Shimizu, Maria Aoki, Masakazu Gonda, Rika Banno, Hiroki Kubota, Ryosuke Ando, Yukihiro Umemoto, Noriyasu Kawai, Yoko Furukawa‐Hibi, Takahiro Yasui

ABSTRACT Enfortumab vedotin (EV) is a crucial treatment for patients with metastatic urothelial carcinoma (mUC). However, a significant proportion of patients experience adverse events (AEs). The identification of biomarkers for AEs is imperative for the detection and treatment of AEs at an early stage. In this exploratory study, we aimed to identify biomarkers of AEs in patients with mUC treated with EV. We retrospectively examined 10 factors identified from the data of 116 patients with mUC treated with EV to ide …

01.09.2026journal-article

International Journal of Health Management Review

SURGICAL AND ORTHODONTIC TREATMENT OF TEMPOROMANDIBULAR JOINT ANKYLOSIS

Giacomo Gobbo Trojan, Pamela Rufina Stefanello Wideck, Isabella Rayane de Souza Torres, Lívia Numeriano de Sá Gomes Vilarim, Victoria Carminatti Silveira, Rene Rodrigues Vieira, Maria Eduarda Cardoso Malheiros de Sena, Rebeca Pires de Castro, Laís Gomes do Nascimento

Temporomandibular joint (TMJ) ankylosis is characterized by the bony, fibrous, or fibro-osseous fusion of articular surfaces, resulting in severe limitation of mouth opening and compromising masticatory and phonatory functions, as well as oral hygiene. When it manifests during childhood or persists for extended periods, it can lead to craniofacial developmental disorders, such as facial asymmetry, micrognathia, retrognathism, and malocclusions. This study aimed to analyze the main surgical and orthodontic approache …

01.09.2026journal-article

Journal of Korean Medicine

Characteristics of Post-Traumatic Stress Symptoms among Residents in Temporary Shelters Following the 2025 Uiseong Wildfire

Jin Suk Koo

Objectives: This study aimed to assess the level of post-traumatic stress disorder (PTSD) among residents who stayed in temporary shelters following the 2025 Uiseong wildfire and to examine differences in symptom severity according to sociodemographic characteristics. The findings are intended to provide baseline data for establishing shelter-based post-disaster mental health monitoring systems and community-centered intervention strategies.Methods: A cross-sectional survey was conducted with 100 wildfire survivors …

01.09.2026journal-article

Multiple Sclerosis Journal

Impact of multiple sclerosis symptoms survey: Patient-reported data on the prevalence, burden, and management of multiple sclerosis symptoms in Europe

Peter Feys, Patricia Moghames, Elisabeth Kasilingam, Rachel King, Tommaso Manacorda, Magda Fonseca, Emma Rogan, Daphne Kos

Background: To optimize the care of people with multiple sclerosis in Europe, the European Multiple Sclerosis Platform aimed to gather vital evidence from people with multiple sclerosis to understand prevalence, burden, and symptom management. Methods: An online survey was distributed by 24 European Multiple Sclerosis Platform–associated multiple sclerosis organizations across 22 countries. Descriptive statistics were applied. Results: Data from 17,151 people with multiple sclerosis revealed a mean of 13.7 symptoms …

03.09.2026journal-article

European Heart Journal Supplements

Diagnosis and outcomes of cardiac amyloidosis in Egypt: a tertiary care facility experience

Rasha Mohamed Abayazeed, Ingy Etman, Mahmoud Hassanein, Hagar Mahmoud Kamal, Mohamed Elsakhawy, Ahmed Abdelaaty, Maram Allam, Nouran Soror, Ashraf Elghandour, Mohamed H Elbahoty, Sara Salama, Osama Mohammed Refai, Noha Elkholy

Abstract Background Cardiac amyloidosis is an infiltrative cardiomyopathy caused by extracellular deposition of insoluble amyloid fibrils. Despite the growing global recognition of cardiac amyloidosis and the recent development of targeted therapeutic strategies for specific amyloidosis subtypes, demographic and epidemiological data regarding cardiac amyloidosis in Egypt remain limited. Objectives To describe the demographic and clinical characteristics of cardiac amyloidosis in Egyptian patients; and to identify d …

01.09.2026journal-article

Jurnal Ilmu Kehutanan

Exploration of Plants Utilization for Traditional Medicine by the Dayak Laya Sub-tribe in Petuo Hamlet, West Kalimantan, Indonesia

Putri Putri, Syamswisna Syamswisna, Hayatul Fajri

The Dayak Laya sub-tribe in Petuo Hamlet maintains traditional knowledge of medicinal plants for healthcare. This research aimed to explore the medicinal plants traditionally used by them. A qualitative approach was adopted in this research. Primary data were collected through semi-structured interviews, field observations, and documentation. Informants were selected using a snowball sampling. Secondary data was collected through literature reviews to enrich the primary data. Meanwhile, plant specimens were collect …