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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
14.08.2026journal-article

Gerodontology

Denture Stomatitis and Its Associations Among Older Adults in the United Arab Emirates

Nabeel H. Alsabeeha, Rahul S. Patil, Rubina T. Ali, Manal Awad, Momen A. Atieh

ABSTRACT Background Denture stomatitis is a common oral mucosal lesion among older adults wearing removable prostheses. Its prevalence and associated risk factors, however, vary across populations. Objective To describe denture stomatitis and its associations with patient‐ and prosthesis‐related factors among older adults wearing removable dentures in the United Arab Emirates. Methods 280 patients wearing 492 removable dentures were examined in a specialty dental facility in Ras Al‐Khaimah, United Arab Emirates. Cl …

14.08.2026journal-article

Frontiers in Aging Neuroscience

Exercise alone or combined with functional foods in aging and age-related diseases: targeting DNA damage, repair pathways, and genome integrity

Ying Ma, Xuejun Li, He Chen, Rongchang Fan

Aging is fundamentally associated with the gradual accumulation of DNA damage, which is instrumental in the initiation and advancement of age-associated pathologies, including neurodegenerative conditions such as Alzheimer’s disease and Parkinson’s disease. Recent studies indicate that lifestyle modifications—especially the consumption of functional foods and participation in consistent physical exercise—can influence cellular and molecular processes related to DNA repair, reduction of oxidative stress, and mainten …

14.08.2026journal-article

Frontiers in Medicine

Serum metabolic characteristics of interstitial lung disease: a potential link between endocrine aging and gut-derived metabolites

Lu Liu, Xinyi Wang, Jinling Xiao, Yandong Li, Shihuan Yu

Objective To analyze differences in serum metabolic profiles between patients with interstitial lung disease (ILD) and healthy controls in northern China using untargeted metabolomics techniques, to identify differentially expressed metabolites and key dysregulated pathways, and to identify potential metabolic biomarkers. Methods Thirty patients with interstitial lung disease (ILD) and 30 healthy controls were enrolled. Untargeted metabolomics analysis was performed using LC-MS/MS in both positive and negative ion …

14.08.2026journal-article

PLOS One

Seasonal differences in depressive affect, worry-related sleep disturbance, and low energy among UK young people

Xu Guan, Qi Ding, Yanzhi Li

Seasonal differences in young people’s mental health may be concentrated in specific symptoms. This population-based repeated cross-sectional study examined winter–non-winter differences in depressive affect, worry-related sleep disturbance and low energy among people aged 16–24 years in the United Kingdom. Understanding Society Calendar Year Datasets were analysed for 2022–2023, with extensions covering 2020–2023. Winter was defined as an interview data in December, January or February. The primary outcome was the …

14.08.2026journal-article

European Modern Studies Journal

Socio-demographic Factors Associated with Weight Gain Following Transition to Dolutegravir-Based Regimens Among People Living with HIV in Homa Bay County, Kenya

Michael Abukuse, David Sang, David Masinde

Background. Weight gain after transitioning to dolutegravir (DTG)-based regimen is an issue for people living with HIV (PLHIV). Although DTG enhances virological results, it causes weight gain leading to overweight. Accordingly, this study explored socio-demographic factors associated to weight gain among PLHIV after transitioning to DTG based regimens in Homa Bay County, Kenya. Method. A mixed-design quantitative study with retrospective cohort and cross-sectional design was performed in seven public health facili …

14.08.2026journal-article

Frontiers in Psychiatry

Building an early warning model for the risk of suicide attempt in people with depression based on machine learning: a single-centre study

Mian Zhang, Wen Liu, Wenzhi Pei, Long Chen, Min Pan, Anzhen Wang, Boyu Zhang, Xialong Cheng, Wen Xie

Background Attempted suicide is one of the most serious clinical consequences for patients with depression, and early identification of high-risk individuals is crucial for preventing suicide deaths. Traditional clinical assessment often relies on subjective judgment, lacking objective biological markers and multi-dimensional data integration analysis. Objective This study aims to use machine learning algorithms to integrate demographic characteristics, clinical symptom scales, and blood biochemical indicators to c …

14.08.2026journal-article

Alzheimer's & Dementia: Behavior & Socioeconomics of Aging

Clinical Alzheimer's biomarker disclosure experiences among patients and family members

Melany Medina, Eunji Russ, Megan G. Witbracht, Dianxu Ren, Melissa L. Knox, Gil D. Rabinovici, Jennifer H. Lingler, Joshua D. Grill

Abstract INTRODUCTION Few data are available on real‐world experiences of receiving biomarker‐informed Alzheimer's disease and related dementias (ADRD) diagnoses. METHODS We examined the frequency of in‐person versus remote disclosure and the duration of the clinical interaction among 63 dyads, including 19 patients and 44 family members receiving amyloid imaging results through the neNw Imaging Dementia—Evidence for Amyloid Scanning (IDEAS) study. RESULTS In‐person disclosure ( n = 36) was most common and similar …

14.08.2026journal-article

Frontiers in Psychology

Psychological resilience and depressive symptoms among family caregivers of disabled people: the mediating role of caregiver burden and the moderating role of family functioning

Zhuoya Yang, Kexin Wei, Chong Wang, Yitong Liu, Yuexia Gao, Miaomiao Zhao, Fang Lu, Yaqin Zhong

Background Family caregivers of disabled older adults frequently face significant challenges that are associated with their mental health. Psychological resilience and family functioning may be associated with depressive symptoms among this population. Nevertheless, the mechanisms behind this relationship have received limited attention. In this study, we examined whether caregiver burden serves as a mediating factor and family functioning as a moderating factor in the link between psychological resilience and depr …

14.08.2026journal-article

Frontiers in Medicine

Three-month biomarker changes after spirulina with or without nursing-led dietary management in older adults with coronary artery disease: a prospective nonrandomized comparative study

Juan Zhang, Qingyi Xu, Yinxia Dou, Jing Chen, Qing Li

Background Spirulina has been studied as a low-cost nutritional supplement, but evidence in older adults with coronary artery disease is limited and nonrandomized comparisons are vulnerable to healthy-adherer and treatment-selection bias. Methods We conducted a single-center, prospective, nonrandomized interventional comparison of conventional nursing care, spirulina plus routine dietary guidance, and structured nursing-led dietary management plus spirulina (88 participants per group). Group assignment was fixed at …

14.08.2026journal-article

Japanese Journal of Applied Physics

Precise evaluations of aging effect and phenomenology in the paraelectric phase of Pb(Mg 1/3 Nb 2/3 )O 3 –PbTiO 3

Makoto Iwata, Hisaka Matsushita, Koki Gyobu, Kohei Satoh, Yoshinori Takikawa

The aging effect on permittivity as a function of time and temperature was precisely evaluated in the paraelectric phase of 70.5%Pb(Mg 1/3 Nb 2/3 )O 3 –29.5%PbTiO 3 (PMN–29.5%PT). It was newly found that there are two relaxation processes for the aging effect. The time dependence of permittivity at each setting temperature could be analyzed, assuming a linear combination of two Williams–Watts functions. Experimental results on the aging effect were analyzed on the basis of the phenomenological theory, qualitatively …

14.08.2026journal-article

Frontiers in Aging Neuroscience

Effects of Tai Chi on functional performance and fall-related psychological outcomes in Parkinson’s disease: a systematic review and meta-analysis

Fusen Wang, Tongtong Hao

Objective To systematically evaluate the effects of Tai Chi on objective motor performance and subjective fall-related psychological outcomes in patients with Parkinson’s disease (PD), and to examine whether intervention characteristics influence the magnitude of therapeutic effects. Methods Randomized controlled trials (RCTs) investigating Tai Chi interventions in patients with PD were identified through searches of electronic databases from inception to April 2026. The methodological quality and risk of bias were …

14.08.2026journal-article

GeroScience

Reduced dynamic functional connectivity in older ages: are older brains less adaptable?

Natalia Zhukova, Camilla Mendl-Heinisch, Christiane Jockwitz, Svenja Caspers

Abstract Understanding how brain connectivity reorganizes with age is essential for characterizing healthy aging. While static functional connectivity (sFC) has revealed broad age-related shifts in network segregation and integration, recent work underscores the need to examine how these patterns dynamically fluctuate over time to better understand cognitive decline and resilience in aging. The present resting-state fMRI study was conducted to enhance comprehension of the temporal variability and dynamics of the br …

14.08.2026journal-article

Frontiers in Public Health

A real-world pattern on the long-term durability of the immune response to hepatitis B vaccination among people living with HIV in China: an 8.5-year retrospective study

Honghong Yang, Xiang Du, Lvlang Zhang, Tongxin Li, Pengle Guo, Jingmin Nie

The long-term durability of the immune response after primary hepatitis B (HBV) vaccination in people living with HIV (PLWH) remains unclear. This real-world study aimed to assess HBV vaccination immunogenicity in PLWH and explore the factors influencing long-term immunogenicity. A total of 195 PLWH with baseline anti-HBs < 10 IU/mL who received ≥1 dose of Heplisav-B vaccine and underwent anti-HBs measurement at 7–9 months after the first dose were retrospectively analyzed. Longitudinal follow-up of 1.5–8.5 years w …

14.08.2026journal-article

Frontiers in Aging Neuroscience

Multimodal characterization of cortical hyperexcitability as a driver of cognitive decline in neurocognitive disorders: study protocol for the LENDÜLET Neurocognitive Research Project

András Attila Horváth

Introduction Cognitive impairment is a major source of disability in neurodegenerative conditions, and it is also highly prevalent in autism spectrum disorder and attention-deficit/hyperactivity disorder. Across these conditions, subclinical epileptiform activity and resting-state functional hyperactivity have been repeatedly described, suggesting a shared state of cortical hyperexcitability. The LENDÜLET Neurocognitive Research Project aims to determine the incidence and multimodal characteristics of cortical hype …

14.08.2026journal-article

Journal of Medical Internet Research

Effects of a Safety User Interface Bundle on Verification Intentions in Generative AI Chat Use Among Older Chinese Adults: Randomized Vignette Survey

Jun'an Yu, Jun Chen, Anjie Ren, Hui Duan, Hua Meng, Zhuo Gao

Abstract Background Generative AI chat systems are increasingly used for everyday information seeking, but plausible errors and omissions can mislead users when outputs are accepted without scrutiny. Interface-level safety cues may help users calibrate trust and engage in verification; yet, evidence in older Chinese adults remains limited. Objective This study aimed to test whether adding a safety user interface (UI) bundle to a generative AI chat interface increases verification intention among older Chinese adult …

14.08.2026journal-article

International Journal of Science and Healthcare Research

Effectiveness of the Tailored Activity Program on Basic Activities of Daily Living Among People living with Dementia and Its Impact on Caregiver Burden

Monisha Popali, Rajul Daftary

Background: Dementia is a progressive neurodegenerative disorder characterized by declining functional independence and increasing caregiver burden. Although the Tailored Activity Program (TAP) has shown promising benefits in improving daily functioning through individualized, occupation-based interventions, evidence regarding its applicability within the Indian healthcare setting remains limited. Objective: To evaluate the effectiveness of the Tailored Activity Program in improving basic activities of daily living …

14.08.2026journal-article

International Journal of Molecular Sciences

The Brain-Muscle Axis in Neurodegeneration: Linking Dementia, Sarcopenia, and Exercise-Mediated Neuroprotection

Garima Paul, Mehek Sharma, Diana M. Asante, Deborah A. Jehu, Mohammad Badruzzaman Khan, Carlos Isales, Sadanand Fulzele

Age-related dementia is commonly associated with several secondary complications such as sarcopenia. To date, the correlation between dementia and sarcopenia is not completely understood. This review summarizes the correlation between dementia and sarcopenia using human clinical and observational studies. We also summarize the impact of exercise on these two conditions. We performed a narrative search with systematic elements using PubMed, Embase, Web of Science, and Google Scholar. In this review, we included stud …

14.08.2026journal-article

The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences

Perceived Fatigability and Fall Risk in Aging with and without Multiple Sclerosis: A Prospective Cohort Study

Di-Hua Luo, Roee Holtzer

Abstract Background Fatigue and falls are prevalent and disabling in both aging and older adults with multiple sclerosis (OAMS). However, clinically useful, modifiable predictors of fall risk remain insufficiently established. Perceived fatigability has been shown to cross-sectionally correlate with poorer cognitive and mobility outcomes in normative aging and OAMS, but its prospective relationship with falls is unclear. We examined whether baseline perceived fatigability predicts falls during longitudinal follow-u …

14.08.2026journal-article

Frontiers in Aging

Proteomics of aging: biomarkers for physiological systems and diseases

Ying Luo, Yu-Lin Xiao, Jie-Hua Chen, Hongjue Wang, Shuhong Luo, Hua Dong, Ruo-Pan Huang

Aging is a progressive, multisystem process characterized by declining physiological resilience and increased susceptibility to chronic diseases. Recent advances in high-throughput proteomics have enabled comprehensive mapping of age-related changes across circulating proteins, revealing dynamic and non-linear trajectories that reflect biological rather than chronological aging. This review synthesizes current evidence on proteomic biomarkers across major physiological systems, including the immune, metabolic/endoc …

14.08.2026journal-article

Annals of African Medicine

Effect of Mustard Plaster on Knee Pain Perception among Old People with Osteoarthritis

Nikitaben Dahyabhai Patel, Arti Prasad Muley

Abstract Background: Osteoarthritis (OA) is a chronic degenerative joint disorder commonly affecting older adults and is characterized by cartilage deterioration, joint stiffness, chronic pain, and reduced functional ability. As long-term pharmacological therapy may have limitations and adverse effects, nonpharmacological interventions are increasingly being explored for pain management. Mustard plaster is a traditional topical remedy believed to improve local blood circulation and reduce joint pain. Materials and …

14.08.2026journal-article

Frontiers in Aging Neuroscience

A male rat model integrating hypertension, chronic cerebral hypoperfusion, and aging recapitulates multimodal cerebral small vessel disease phenotypes

Zhiwei Feng, Shan Han, Yanyi Li, Zhenzhen Li, Yige Tu, Bin Wu, Shengjie Zhu, Qin Zheng, Wenjun Sun

Background Cerebral small vessel disease (CSVD) usually develops under the combined influence of vascular risk factors, chronic perfusion insufficiency, and age-related brain vulnerability; however, animal models driven by a single insult do not fully reproduce this multifactorial clinical context. Methods We established a composite CSVD rat model by combining spontaneous hypertension, bilateral common carotid artery stenosis (BCAS)-induced chronic cerebral hypoperfusion, and D-galactose (D-gal)-induced aging-relat …

14.08.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

PERFIL EPIDEMIOLÓGICO DAS HEPATITES VIRAIS POR TRANSMISSÃO SEXUAL EM IDOSOS NO BRASIL ENTRE 2013 E 2023

Vinícius Rosa Garbin, Julia Telles Gonzaga

As hepatites virais constituem importante problema de saúde pública em razão das complicações crônicas associadas, como cirrose hepática e carcinoma hepatocelular. Nas últimas décadas, o envelhecimento populacional e a manutenção da atividade sexual em idades mais avançadas modificaram o perfil epidemiológico dessas infecções, evidenciando a relevância da transmissão sexual entre pessoas idosas. Este estudo teve como objetivo analisar o perfil epidemiológico das hepatites virais por transmissão sexual em idosos no …

14.08.2026journal-article

Advances in Translational Research

Ovarian-derived signals reprogram hepatic lipid metabolism in aging: Implications for therapeutic targeting of metabolic dysfunction

Nathan D. McCoy, Michael T. Kinter, Augusto Schneider, Fabiola Santos, Michal M. Masternak, Jeffrey B. Mason

Abstract Background and Aim Aging in mammals is a complex, multifaceted process involving the progressive decline of physiological functions, in which energy metabolism plays a pivotal role. β -oxidation—the primary pathway for converting fatty acids into energy—is tightly linked to aging and to female reproductive senescence. In the present study, we investigated how ovarian tissue remodels hepatic proteins central to the β -oxidation pathway. Methods Liver proteomes were analyzed in CBA/J control mice at 4, 13, 2 …

14.08.2026journal-article

Journal of the American Geriatrics Society

Prevalence and Predictors of Non‐Frailty Among Homebound Older Adults

Orla C. Sheehan, Katherine A. Ornstein, Mary Louise Pomeroy, Hanna Charankevich, Jennifer M. Reckrey, Christine S. Ritchie, Bruce Leff

ABSTRACT Background Older adults who are homebound, defined as those who rarely or never leave home without assistance or difficulty, experience high levels of multimorbidity, functional impairment, and mortality. Yet their needs remain poorly served by current care delivery models. While research on homebound older adults implies that these individuals are universally frail, this assumption has never been tested empirically. We aimed to better characterize the non‐frail homebound older adult population. Methods Us …