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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
29.08.2026journal-article

Journal of Medical Ultrasonics

Does the addition of contrast-enhanced ultrasonography to B-mode ultrasonography improve diagnostic accuracy for breast cancer? A systematic review and meta-analysis

Shotaro Inoue, Kazuaki Nakashima, Kazutaka Nakashima, Tomonari Kunihisa, Koichi Hirokaga, Kaori Tane, Yoshihito Goto, Takeo Nakayama

Abstract Purpose This study aimed to determine whether the addition of contrast-enhanced ultrasonography (CEUS) to B-mode ultrasonography improves diagnostic accuracy in differentiating benign from malignant breast lesions. Methods A comprehensive literature search was performed using PubMed (MEDLINE), Ichushi, and the Cochrane Library up to July 2025. Eligible studies assessed the diagnostic performance of CEUS for suspected breast cancer, with histopathology as the reference standard. Pooled sensitivity, specific …

29.08.2026journal-article

Turkish Journal of Cerebrovascular Diseases

Evaluation of inflammatory parameters in patients with acute distal middle cerebral artery occlusion treated with intravenous thrombolytic treatment

Recep Dönmez, Oruç Şahin

Objective: The aim of this study was to evaluate the association of various inflammatory parameters with early neurologic damage and three-month functional outcomes in patients with acute distal middle cerebral artery (MCA) occlusion who received intravenous thrombolytic treatment (IV tPA). Materials and Methods: This retrospective exploratory study included 75 patients who underwent IV tPA for distal MCA infarction and had complete clinical and laboratory data. Inflammatory indices were calculated from blood param …

29.08.2026journal-article

Information

Refined Graph-Guided Fusion Network for Explainable Multimodal Lung Cancer Classification Using CT Imaging and Semantic Features

Adiba Jafar, Raheela Asif, Syed Muslim Jameel

Classifying benign and malignant lung nodules from computed tomography (CT) images remains difficult because lung nodules can be hard to classify, and unimodal models cannot capture complementary diagnostic information. Despite the success of deep learning, existing methods rely only on image information and miss semantic information that can be obtained from an expert radiologist’s knowledge. Hence, the authors propose a new multimodal lung nodule classification model in this study, named the Graph-Guided Fusion N …

29.08.2026journal-article

Güncel Hemşirelik Araştırmaları Dergisi

Analysis of Scientific Publications on the Use of Artificial Intelligence in Childhood Cancer: A Descriptive Study

Bahar Aksoy, Şule Şenol, Süleyman Bilgin, Ali Coşkun Çoşar

Aim: This study aimed to analyze the scientific literature on the use of artificial intelligence (AI) in childhood cancers through a bibliometric approach, combining descriptive analyses with analytical synthesis to identify publication trends, leading countries, journals, institutions, and major research themes.Methods: A bibliometric analysis was conducted using publications retrieved from the Web of Science Core Collection database between 2003 and 2025. A total of 1.091 publications were included in the analysi …

29.08.2026journal-article

Journal of Pharmaceutical Health Care and Sciences

Association of telephone follow-up–based prescription proposals initiated by community pharmacists with oncology-related professional certification on quality of life of cancer patients receiving outpatient chemotherapy: a single-center observational study

Toshiki Nakamura, Kazunori Tamegai, Takeshi Sakamoto, Michinori Sakai, Masahiko Kimura, Takeshi Hirayama

Abstract Background The association of prescription proposal after telephone follow up (TFU) initiated by health insurance-covered pharmacy-based pharmacists (hereinafter “community pharmacists”) having oncology-related professional certification with patients’ quality of life (QOL) has not been elucidated. This study investigated changes in QOL before and after prescription proposals following TFUs in cancer patients receiving outpatient chemotherapy. Methods Cancer patients undergoing outpatient chemotherapy, who …

29.08.2026journal-article

African Journal of Pharmacy and Alternative Medicine

Efficacy of Senna occidentalis Leaf Extracts in the Treatment of Bacterial Gastroenteritis

Esther GEORGE NYADZUA, Onyango EVANDER OCHIENG, Lunani KEITH WAKASIAKA, Uhuru FAITH BERYL, Kariuki JOSHUA, Rop MOSES KIPLIMO, Titus SUGE, Michael WALEKHWA

Bacterial gastroenteritis remains a significant global health challenge due to the rising issue of antibiotic resistance and the high cost of conventional drugs, especially in low-resource settings. Addressing this gap, this study evaluated the efficacy of Senna occidentalis leaf extracts in treating bacterial gastroenteritis through an in vitro laboratory-based experimental design. Before the commencement of the study, an Ethical clearance certificate and a permit to conduct the study were sought from Kabarak Univ …

29.08.2026journal-article

BMC Cancer

Continued high mortality following diagnosis of HIV-associated Kaposi sarcoma in East Africa in the “Treat All” antiretroviral therapy era ― 2021-2024

Helen Byakwaga, Aggrey Semeere, Megan Wenger, Esther Freeman, Miriam Laker-Oketta, Elyne Rotich, Beatrice P. Mushi, Matthew Ssemakadde, Hilda Muwando, Bronia Mwine, Racheal Ayanga, Celestine Lagat, Sigrid Collier, Zainab Illonga, Robert Lukande, Philippa Kadama-Makanga, Pendo Ibrahim, Linda Chemutai, Toby Maurer, Charles Kasozi, Winnie Muyindike, Elia Mmbaga, David V. Glidden, Samson Kiprono, Kara Wools-Kaloustian, Andrew Kambugu, Jeffrey Martin

Abstract Background Stage at time of diagnosis and survival after diagnosis are critical parameters regarding control of any cancer in any geographical setting. In earlier research focusing on the initial years of the “Treat All” era (2016–2019), we found that HIV-associated Kaposi sarcoma (KS) in East Africa continued to be diagnosed at advanced stage of disease and conferred high mortality. Given the potential for broader implementation of “Treat All” as well as the announcement of National Comprehensive Cancer N …

29.08.2026journal-article

BMC Cancer

NU7441 reveals DNA-PK and BRD4 convergence as a therapeutic vulnerability in ovarian cancer

Julie A. Disharoon, Brandon C. Johnson, Elizabeth A. Ampolini, Natasha L. Curry, Abigail F. Quesnelle, Joe R. Delaney, David T. Long

Abstract BRD4 and DNA-PK play critical roles in regulating DNA repair, genome integrity, and cellular growth and proliferation, highlighting their potential as targets for cancer therapy. BRD4 is upregulated in multiple cancers, including ovarian cancer, where its expression increases during tumor development and correlates with poorer overall and progression-free survival. In this study, we provide evidence that NU7441, traditionally classified as a selective DNA-PK inhibitor, also functions as a BRD4 inhibitor by …

29.08.2026journal-article

BMC Complementary Medicine and Therapies

Chinese herbal medicine (Yiqi Huayu Jiedu Decoction) combined with chemotherapy for preventing postoperative recurrence and metastasis in elderly gastric cancer patients: protocol for a multicenter, double-blind, randomized, placebo-controlled trial

Peipei Yang, Jian Wang, Xiaoyu Wu, Ju Yang, Yan Sun, Xiaowei Wei, Jun Wu, Zhengxiang Han, Yanzhi Bi, Zhenguo Zhao, Ran Yang, Mengzhu Yang, Peng Shu

Abstract Introduction Gastric cancer (GC) has a generally unfavorable prognosis. Elderly patients often tolerate dual-drug chemotherapy poorly, experience limited benefits from monotherapy, and face high rates of postoperative recurrence and metastasis. To address this unmet clinical need, this study evaluates the efficacy and safety of Yiqi Huayu Jiedu Decoction (YHJD) combined with chemotherapy in preventing recurrence and metastasis in elderly patients with stage II/III GC after surgery. Method This is a multice …

29.08.2026journal-article

Journal of Interpersonal Violence

A Voluntary Prison-Hospital Treatment Program for Individuals Convicted of Sexual Offenses: A Prospective Evaluation Study

Patrick Lussier, Guillaume Masson, Guy Giguère, Maude Payant

In 2008, the provincial government approved a project for the implementation of a specialized treatment program (PETRAAS) in a prison setting in Quebec, Canada, for individuals convicted of sexual offenses. Dubbed a “prison-hospital,” the program was launched 2 years later as a joint initiative by the Ministry of Health and the Ministry of Public Safety to address the lack of a treatment program in provincial detention facilities for individuals serving short custodial sentences. Since 2010, PETRAAS offers a volunt …

29.08.2026journal-article

Genes

Transcriptional Heterogeneity Underlying Cancer Cell Migration Converges on Shared Regulatory Programs

Ismael Ortiz, Paul V. Taufalele, Victor L. Dunagan, Samantha S. Hodge, Jing Wang, Qi Liu, Cynthia A. Reinhart-King

Background/Objectives: Cancer cell migration is a hallmark of cancer and is associated with metastasis. While large-scale functional screens have identified regulators of migration, less is known about how intrinsic transcriptional heterogeneity drives highly migratory phenotypes within individual cancer models or whether these transcriptional changes are conserved across different models of varying tissues of origin. This study aims to define shared and cell line-specific transcriptional programs associated with c …

29.08.2026journal-article

Materials

Influence of Temperature on FLD and CLD Damping Treatment

Piotr Łabuński, Lucjan Witek, Paweł Obal

The damping capabilities of viscoelastic materials depend heavily on the operating temperature. Since these materials are used for passive vibration damping, it is necessary to determine the damping properties of selected materials across a range of temperatures. This paper presents the results of an experimental investigation into the effect of temperature on the damping performance of viscoelastic materials applied to aluminium cantilever beams using free-layer damping (FLD) and constrained-layer damping (CLD) te …

29.08.2026journal-article

Vaccines

From Universal Aspiration to Precision Immunization: A Hypothesis Framework for Antigen-Defined, HLA-Restricted Cancer Vaccines

Sarfaraz K. Niazi

Cancer vaccination addresses four distinct problems: preventing oncogenic infection, intercepting premalignant clones, clearing molecular residual disease, and treating established cancer. This hypothesis framework proposes seven sequential gates for antigen-defined, HLA-restricted T-cell vaccines: tumor specificity, natural peptide–HLA presentation, population coverage, persistence under immune selection, selective T-cell recognition, manufacturability, and randomized clinical benefit. The proposed architecture co …

29.08.2026journal-article

BMC Cancer

Establishing non-inferiority of rituximab plus lenalidomide in the treatment of advanced previously untreated follicular lymphoma

Jemma Perks, Alex Allen, Caroline Farmer, Sophie Robinson, G. J. Melendez-Torres

Abstract Background and purpose The current standard of care for first-line treatment for people with advanced (stage 3 or 4) follicular lymphoma (FL) is chemotherapy plus rituximab. Rituximab plus lenalidomide is an oral treatment which has been shown to be an effective alternative treatment. In order to support a license extension application for lenalidomide in this indication, NHS England considered the re-analysis of the RELEVANCE trial to determine whether the treatments can be shown to be statistically and c …

29.08.2026journal-article

Journal of Food Science

Dietary‐Derived Corchorus olitorius L. Extract Suppresses KRAS‐Mutant Pancreatic Cancer by Activating Ferritinophagy‐Dependent Ferroptosis

Chiao‐Yun Tseng, Hui‐Hsuan Lin, Charng‐Cherng Chyau, Pei‐Rong Yu, Yu‐Hsuan Liang, Yueching Wong, Jing‐Hsien Chen

ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by frequent activating mutations in the Kirsten rat sarcoma viral oncogene homologue (KRAS) and limited therapeutic options. Corchorus olitorius L., a traditional edible plant widely consumed in Asia, possesses documented anti‐inflammatory properties; however, its anticancer potential remains unclear. This study investigated whether Corchorus olitorius L. leaf extract (COE) induces ferroptosis in KRAS‐mutant pancreatic …

29.08.2026journal-article

Discover Computing

High-performance next-generation screening technology system using teaching–learning-based optimization for cancer detection

Alok Kumar Shukla, Shubhra Dwivedi, Sunil Kumar Singh, Neeraj Kumar Sharma

Abstract Early and accurate detection of breast cancer remains challenging due to high-dimensional clinical data, feature redundancy, and limitations of existing diagnostic decision systems. To address these issues, this study proposes a hybrid feature selection and classification framework that improves prediction performance while reducing overfitting. The method combines a filter-based ReliefF algorithm with a wrapper-based Teaching–Learning-Based Optimisation (TLBO), referred to as Re-wTLBO, to identify a compa …

29.08.2026journal-article

Advanced Science

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Lei Wang, Xiaoyan Li, Yiran Liang, Yifei Wang, Yuhan Jin, Jianing Wang, Dan Luo, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Wenjing Zhao, Bing Chen, Lijuan Wang, Qifeng Yang

ABSTRACT Triple‐negative breast cancer (TNBC) is characterized by high metastatic tendency and poor prognosis, largely driven by dynamic crosstalk between cancer cells and the tumor microenvironment (TME). Cancer‐associated fibroblasts (CAFs) are a major component of the TME, yet their functional contributions to TNBC progression remain incompletely understood. In this study, we isolated exosomes from patient‐derived CAFs and normal fibroblasts (NFs), and profiled their circRNA content using RNA sequencing. circFAD …

29.08.2026journal-article

Maltepe Tıp Dergisi

Letrozole-Induced Hypersensitivity Pneumonitis: A Rare but Serious Pulmonary Complication in Breast Cancer Therapy

Beyza Ekinci, Eylem Tunçay, Elif Torun Parmaksız

65 yaşında, hipertansiyon ve meme kanseri öyküsü bulunan kadın hasta, onkoloji bölümü tarafından kliniğimize yönlendirildi. Başlangıçta asemptomatik olduğu bildirilen hastanın, son dönemlerde ilerleyici nefes darlığı ve öksürük şikayeti mevcuttu. Bir yıldır günde 2.5 mg letrozol kullanmaktaydı. Ayrıntılı sorgulamada, uzun süreli ev temizliği işi yaptığı öğrenildi. Bilgisayarlı tomografi (BT) taramalarında, bilateral kalıcı buzlu cam opasiteleri saptandı ve bu bulguların letrozol kaynaklı aşırı duyarlılık pnömonisin …

29.08.2026journal-article

Human Genetics

Expected costs and benefits of genetic counselling and germline genetic testing in metastatic prostate cancer

Michiel Vlaming, Lambertus A. L. M. Kiemeney, Wouter Koole, Inge M. van Oort, Eveline M. A. Bleiker, Margreet G. E. M. Ausems, Geert W. J. Frederix

Abstract Identifying pathogenic germline variants in men with metastatic prostate cancer is important for therapeutic options and for identifying relatives who may have a high cancer risk. To keep genetic testing costs manageable, it is important to identify which patients should be selected for testing. In this study, we compared expected costs and number of identified pathogenic variants in two scenarios: offering genetic testing to all men with metastatic prostate cancer versus testing only those with additional …

29.08.2026journal-article

BMC Cancer

Prognostic value of circulating tumor DNA and copy-number alterations in patients receiving tandem [225Ac]Ac-/[177Lu]Lu-PSMA-617 therapy for metastatic castration-resistant prostate cancer: a prospective observational study

Mariam Amghar, Thomas Hielscher, Tobias Rausch, Hilal Özgür, Ulrike Bauder-Wüst, Hendrik Rathke, Frank Bruchertseifer, Alfred Morgenstern, Mareike Roscher, Vladimír Beneš, Clemens Kratochwil, Martina Benešová-Schäfer

Abstract Background Prostate-specific membrane antigen-targeted radioligand therapy (PSMA-RLT) demonstrates clinical efficacy in metastatic castration-resistant prostate cancer (mCRPC), yet robust biomarkers for dynamic treatment monitoring and resistance remain lacking. We investigated circulating tumor DNA (ctDNA)-derived tumor fraction (TFx) and genome-wide copy-number alterations (CNAs) as non-invasive biomarkers of treatment response and resistance biology. Methods Seventy-eight patients with advanced mCRPC re …

29.08.2026journal-article

Asian Journal of Research in Infectious Diseases

Facility Level Factors Influencing Adherence to TB Treatment in Mwingi East Sub County, Kitui County, Kenya

Jacinta Maluki Mumbe, Japheth Mativo Nzioki, Joseph Mutai, Alex Karuiru Ndiritu

Background: Tuberculosis treatment adherence is essential for successful treatment outcomes and control of drug resistance. This study assessed facility-level factors influencing adherence to tuberculosis treatment in Mwingi East Sub-County, Kitui County, Kenya. Methods: A descriptive cross-sectional study was conducted in Nguni and Waita health centres from January to March 2022. A sample of 148 participants was included, with 74 participants selected from each facility. The two facilities were purposively selecte …

29.08.2026journal-article

Journal of Cancer Education

Self-skin Examination for Skin Cancer Detection in High-risk Populations: A Diagnostic Accuracy Study and Implications for Cancer Education

Mike Climstein, Michael Stapelberg, Ian Miller, Nedeljka Rosic, Jeremy Hudson, Paul Coxon, Nathanial Milani, Chris Robinson, Guillermo De Castro-Maqueda, Joe Walsh

Abstract Background/Purpose: Aquatic populations experience high cumulative ultraviolet radiation exposure and elevated skin cancer risk. Self-skin examination is widely promoted within cancer education strategies; however, its diagnostic accuracy in high-risk groups remains unclear. Method: Adults (≥ 18 years) participating in surfing or outdoor swimming (≥ 1 h/week) underwent full-body skin examination by an accredited skin cancer doctor. Prior to examination, participants identified any lesion(s) of concern, ref …

29.08.2026journal-article

South African Journal of Oncology

Assessing shift in breast cancer stage from the anatomical staging classification to the clinical prognostic staging system

Rahmiz R. Thomas, Tahlia Naidoo, Uchechukwu A.N. Izegbu, Neo H. Mabe, Tanya Augustine, Jenny Edge

Background: Breast cancer is the most frequently diagnosed malignancy among women and a significant health burden in South Africa. The American Joint Committee on Cancer (AJCC) 8th Edition incorporates biological markers (oestrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 [HER2] status and tumour grade) into conventional tumour, node, metastasis staging. Evidence from low-income and middle-income settings with high HIV prevalence remains limited. Aim: We compared the anatomical stag …

29.08.2026journal-article

Bulletin of Mathematical Biology

Eco-Evolutionary Dynamics of Proliferation Heterogeneity: A Phenotype-Structured Model for Tumor Growth and Treatment Response

Lara Schmalenstroer, Haojun Chen, Russell C. Rockne, Farnoush Farahpour

Abstract Intra-tumor heterogeneity in proliferation rates fundamentally influences cancer progression and treatment resistance. To investigate how continuous phenotypic variation shapes eco-evolutionary dynamics, we develop a phenotype-structured partial differential equation framework that explicitly models proliferation heterogeneity as a dynamic trait. Our model integrates three key biological principles: (1) phenotypic diffusion capturing heritable variation in proliferation rates, (2) global resource competiti …