Advances in Translational Research
Nuclear transcriptional regulation of mitochondria in the aging heart: From mechanisms to targeted therapeutic strategies
Abstract The concept of mitochondrial functional decline in the aging heart was proposed decades ago, however, the underlying mechanisms are still not well established. Now more than ever, emerging research on cardiac mitochondria is revealing how these essential organelles play a pivotal role in maintaining cardiac health through transcriptional regulation of mitochondrial function during aging. Because the majority of mitochondrial proteins are encoded by nuclear genes, transcriptional regulation within the nucle …