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22 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
29.08.2026journal-article

Angewandte Chemie

An Engineering‐Editable Hybrid Membrane‑Camouflaged DNA Origami Drug Enables Checkpoint Blockade and Immune Activation for Triple‐Negative Breast Cancer Immunotherapy

Xiaqing Gong, Han Yuan, Ying Fang, Mingming Song

ABSTRACT The clinical response to immunotherapy in triple‐negative breast cancer (TNBC) is often limited by the immunosuppressive microenvironment, immune cell exhaustion, and multidrug resistance. Through a high‐throughput screen of 2,500 FDA‐approved drugs using a three‐dimensional tumor organoid platform, we identified thonzonium bromide (THO) as an inducer of gasdermin D (GSDMD)‐mediated pyroptosis, which results in the release of damage‐associated molecular patterns (DAMPs) to activate antitumor immunity. To a …

29.08.2026journal-article

Risk Analysis

A Bayesian Model for Estimation of Virus Reduction in Potable Reuse Treatment Trains and Quantitative Microbial Risk Assessment of Waterborne Viral Pathogens

Jack F. Schijven, Peter F. M. Teunis, Walter Q. Betancourt

ABSTRACT Understanding virus occurrence and reduction at advanced treatment facilities for potable water reuse constitutes a high‐priority research need to protect human health and to enhance available water supply alternatives. The objectives were to (1) determine log reduction values (LRVs) of 15 viruses by advanced wastewater treatment; (2) evaluate suitability of the final wastewater effluent for potable reuse; (3) evaluate viruses or groups of viruses as indicators of wastewater treatment efficiency. Reduction …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Clinical Characteristics and Outcomes of Respiratory Viral Infections in Pediatric Cancer Patients, Single center experience

Mona Mohammed, Yassin Taher, Maha Mohammed, Naiven Mohamed, Nehad Abd Elfatah, Marwa Jamal, Omnya Ahmed, Amira Sameh, Mohamed Kamal, Youssef Madney

Abstract Background Respiratory viral (RV) infections cause morbidity and mortality in immunocompromised pediatric patients undergoing cancer treatment. The burden of RV infections in pediatric oncology populations from low- and middle-income countries (LMICs) remain limited. We aimed to detect the prevalence of viruses causing respiratory infections among pediatric patients with cancer and guide empiric therapy and improve patient outcomes. Methods Retrospectively we collected nasopharyngeal swabs and clinical and …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Epidemiology of and antibacterial resistance in Gram-negative bloodstream infections among children with cancer and hematopoietic cell transplant recipients

Alexander Pruett, Jose Ferrolino, Ronald Dallas, Yilun Sun, Elisabeth Adderson

Abstract Background Bacteremia occurs in up to 30% of febrile neutropenic children receiving cancer therapy or hematopoietic cell transplant (HCT) and 14% of patients with non-neutropenic fever. Increasing antimicrobial resistance among Gram-negative pathogens is a challenge to providers, who seek to limit broad-spectrum antibacterial use while providing timely and effective empiric therapy. Experts recommend that the epidemiology of GN bloodstream infections (GNBSI) should be considered in developing guidelines fo …

29.08.2026journal-article

Journal of Orthopaedic Science and Research

The Role of Biopsy Accuracy in the Treatment of Musculoskeletal Tumors

Hannah Werner, Bennie Lindeque

Background: The accurate treatment of Musculoskeletal (MSK) tumors necessitates appropriate timely biopsy of the mass of interest. With regards to malignant neoplasms biopsy plays a crucial role in the direction of treatment courses and patient outcome. Methods: This is a retrospective single-center chart review of 924 biopsies from 2013-2023. Patients included were between 18-85 with MSK tumors that necessitated biopsy and subsequent surgical treatment. Biopsy and final resection histopathology reports were compar …

29.08.2026journal-article

Children

Implementation and Delivery of a Comprehensive Bereavement Program in Pediatric Palliative Oncology

Yash C. Jani, Anna Lange, Miracle Naylor, Katherine Lee, Linda M. Radbill, Katharine E. Brock

Background/Objectives: Bereavement care is widely endorsed as a standard of pediatric oncology and palliative care, yet it remains inconsistently implemented across pediatric oncology programs in the United States, and few programs have reported longitudinal delivery metrics. We aim to describe the iterative development and delivery of a multi-component bereavement program within an outpatient pediatric palliative oncology (PPO) program, characterize the population served, and benchmark delivery against national gu …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Candidemia Among Pediatric Cancer Patients: Clinical Features, Resistance Pattern, and Treatment Outcome

Youssef Madney, Reham Khedr, Hanfy Hafiz, Naglaa Adel, Mervat Elanany, Khaled Alsheshtawi, Lobna Shalaby, Alaa El Haddad

Abstract Background Candidemia presents a significant challenge for pediatric cancer patients, especially with the increasing incidence of echinocandin-resistant Candida and breakthrough candidemia. Recent data highlight a notable shift in the epidemiology of candidemia, with a predominance of non-albicans species, such as C. glabrata, C. parapsilosis, and C. tropicalis, over C. albicans. The incidence of invasive disseminated candidiasis among children ranges from 9% to 10% and is linked to mortality rates between …

29.08.2026journal-article

Turkish Journal of Cerebrovascular Diseases

Disease of cervical arteries: contemporary imaging, medical management and endovascular treatment

Ezgi Yılmaz, Alper Eren, Özlem Aykaç, Yasemin Dinç, Nazım Kızıldağ, Demet Funda Baş, Talip Asil

Cervical artery diseases, encompassing both atherosclerotic and non-atherosclerotic disorders of the carotid and vertebral arteries, remain a major cause of ischemic stroke and transient ischemic attack (TIA) worldwide. Although luminal stenosis has traditionally guided diagnostic and therapeutic decision-making, recent advances have shifted the focus toward comprehensive vascular assessment, incorporating plaque vulnerability, vessel wall pathology, inflammatory activity, and individualized cerebrovascular risk st …

29.08.2026journal-article

The American Surgeon™

Predictive Value of Preoperative Chest Computed Tomography-Measured Diaphragm Thickness Combined With Pulmonary Function for Postoperative Pulmonary Complications After Anatomic Lung Resection in Elderly Patients With Clinical Stage I Non-Small Cell Lung Cancer

Zhenqiang Wei, Dongshan Wei, Kai Wu

Background Postoperative pulmonary complications (PPCs) remain a major cause of adverse recovery after lung resection in elderly patients with early-stage non-small cell lung cancer (NSCLC). This study evaluated the predictive value of preoperative chest computed tomography (CT)-measured diaphragm thickness combined with pulmonary function for PPCs after anatomic lung resection. Methods In this single-center retrospective study, 248 patients aged 65 years or older with clinical stage I NSCLC who underwent lobectomy …

29.08.2026journal-article

JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI)

The Use of Health Education Media to Improve Knowledge and Treatment Adherence among Tuberculosis Patients at the Pringsewu Community Health Center, Lampung

Dinda Annisa, Iga Mayola Pisacha, Mida Pratiwi, Sulistia Suryaman

Tuberculosis (TB) remains a serious public health problem. Low levels of knowledge and non-adherence to treatment are major factors contributing to treatment failure and an increased risk of drug resistance. This study aims to analyze the effect of education on the knowledge and adherence of tuberculosis patients. A pre-experimental study design with a one-group pre-test and post-test design was used, employing total sampling of 35 patients. Data were collected using a validated TB knowledge questionnaire and the M …

29.08.2026journal-article

Journal of Clinical Questionon

Bispecific Antibodies Targeting PD-1/PD-L1 and VEGF in Non-Small Cell Lung Cancer

Aleena Kuriakose, Salem Gogah, Elina Beleva

Immune checkpoint inhibition has transformed the treatment of advanced non-small cell lung cancer (NSCLC), but primary and acquired resistance remain common. Vascular endothelial growth factor (VEGF) contributes to both tumor angiogenesis and immune suppression by promoting abnormal vasculature, limiting lymphocyte trafficking, and fostering an immunosuppressive tumor microenvironment. These complementary mechanisms provide a rationale for simultaneously targeting the programmed cell death protein 1 (PD-1)/programm …

29.08.2026journal-article

The Turkish Journal of Pediatrics

Frequency of gastroptosis and gastroparesis in children with treatment-resistant dyspepsia and duodenogastric reflux: a prospective study

Melike Arslan, Edibe Gözde Başaran, Coşkun Fırat Özkeçeci, Bekir Nihat Doğrul, Necati Balamtekin

Background. Studies on gastroptosis and gastroparesis in children are limited. This prospective study aimed to evaluate the frequency of gastroptosis and gastroparesis and their association with duodenogastric reflux (DGR) and treatment-resistant dyspeptic symptoms in children. Methods. The study evaluated pediatric patients aged 2-18 years with dyspepsia who underwent upper gastrointestinal endoscopy between March 2020 and June 2022. Fluoroscopy and gastric emptying scintigraphy were performed in 88 patients (50 w …

29.08.2026journal-article

Mathematics

Can IL-10 Inhibitor Therapy Alongside MDT Enhance Leprosy Treatment? A Comprehensive Mathematical Study

Salil Ghosh, Huina Zhang, Satyajit Mukherjee, Xianbing Cao, Amit Kumar Roy, Priti Kumar Roy

Leprosy is characterized by complex biological and cellular interactions, driven primarily by the interplay between Th1 and Th2 cells. In this study, we develop a deterministic mathematical model to investigate the interactions among healthy and infected Schwann cells, M. leprae bacteria, and Th1–Th2 immune responses. The positivity and boundedness of the proposed five-dimensional system are established, and the disease persistence condition is characterized in terms of the basic reproduction number (R0). The exist …

29.08.2026journal-article

International Journal of Research in Medical Sciences

Clinical readiness and generalizability of artificial intelligence in implant dentistry: a systematic review of diagnostic accuracy, treatment planning, prognosis and external validation

Rohit Raghavan, Shajahan P. A., Akash R.

Artificial intelligence (AI) is increasingly being incorporated into digital dentistry. In implant dentistry, machine-learning and deep-learning systems have been investigated for radiographic diagnosis, anatomical segmentation, treatment planning, prosthetically driven implant positioning, and prediction of implant-related outcomes. To systematically evaluate the clinical applications of AI in implant dentistry, with particular emphasis on diagnostic accuracy, treatment planning, prognosis, external validation, ge …

29.08.2026journal-article

SAS Journal of Medicine

Iron Deficiency Anemia in Children and Adolescents: Epidemiology, Risk Factors, Clinical Manifestations, Diagnosis, Treatment, and Prevention

Mohammad Koblan Abedraboh Alshwawreh, Nader Emad Mousa Hijazeen

Iron deficiency anemia (IDA) is the most common nutritional deficiency and the leading cause of anemia worldwide, affecting infants, children, and adolescents disproportionately. IDA remains a significant public health concern because of its high prevalence and its potential impact on growth, neurodevelopment, cognitive function, physical performance, and quality of life. The etiology of pediatric IDA is multifactorial and includes inadequate dietary iron intake, increased iron requirements during periods of rapid …

29.08.2026journal-article

Familial Cancer

The identification of a PRKACA duplication at 19p13.12 in a female with PPNAD and thyroid carcinoma after a 20-year diagnostic journey

Marjoleine F. Broekema, Florian Violon, Patricia Vaduva, Maartje Vogel, Nicole de Leeuw, Fenne Komdeur

Abstract Rare pathogenic variants affecting components of the evolutionary conserved cAMP/protein kinase A (PKA) signalling pathway are implicated in a spectrum of adrenocortical disorders. Germline inactivating PRKAR1A variants leading to constitutive PKA activation, underlie primary pigmented nodular adrenocortical disease (PPNAD) in Carney complex. More recently, several patients with PPNAD and other types of bilateral nodular adrenal disease (BNAD) have been diagnosed with rearrangements in chromosome 19 at ban …

29.08.2026journal-article

Medicina

Serum Trace Elements and Self-Reported Physician-Diagnosed Tumor History: A Secondary Cross-Sectional Analysis of the Exposure Study on Susceptible People (SPES)

Carlo Buonerba, Paolo Montuori, Ernesto Esposito, Maria Triassi, Pellegrino Cerino

Background and Objectives: SPES was a 2016–2017 regional biomonitoring program. We conducted a secondary cross-sectional analysis of associations between current serum trace-element distributions and heterogeneous, self-reported physician-diagnosed tumor history, rather than registry-confirmed or incident cancer. Materials and Methods: Among 4137 questionnaire responders, 86 reported a tumor history. Mixed-effects logistic models for 20 channels were adjusted for age, sex, smoking, and geographic cluster and pooled …

29.08.2026journal-article

Blood Cancer Journal

Infection burden among patients with triple-class–exposed RRMM receiving non–T-cell–redirecting therapies: a US claims study

Samer Al Hadidi, Eric Chinaeke, Jinghua He, Helen Pai, Agne Paner-Straseviciute, Ibrahim Saber, Jessica Fowler, Tonya Le Blanc, Niodita Gupta-Werner, Xinke Zhang, Shuchita Kaila

Abstract Triple-class–exposed (TCE) relapsed/refractory multiple myeloma (RRMM) is associated with cumulative immunosuppression and heightened infection risk. In this longitudinal, retrospective, observational study, US claims data from the Komodo Healthcare Map (KHM; n = 2702; median follow-up, 9.5 months) and the All-Payer Claims Data (APCD; n = 1755; median follow-up, 14.9 months) were used to assess infection burden in patients with TCE RRMM receiving non-bispecific antibody therapies after ≥4 prior lines of th …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

A Silent Enemy? Correlation Between Carbapenemase-Producing Enterobacteriaceae Colonization and Subsequent Bacteremia in Pediatric Hematology-Oncology Patients

Maria Ines Sormani, Valeria Torre, Alejandra Maricel Alancay, Sofia Esposto, Yanina Lagala, Mara Maydana, Anastasia Elena Regalado, Fiorella Lovano, Marcio Fagnani, Micaela Pichinenda, Federico Ploszaj, Wendy Rodriguez, Mariel Garcia, Valeria Uriarte, Fernanda Sosa, Sebastian Oderiz, Cecilia Vescina, Maria Victoria Fasano, Juan Morales

Abstract Introduction Infections by multidrug-resistant Gram-negative bacilli (MDR-GNB) result in increased morbidity and mortality among children with cancer. Objectives To determine the prevalence of carbapenemase-producing Enterobacteriaceae (CPE) in rectal swab (RS) cultures in children with cancer and its correlation with blood cultures during bacteremia episodes. Methods Retrospective, descriptive study. It included surveillance rectal swabs for CPE in patients under 18 years of age with cancer at a tertiary …

29.08.2026journal-article

Discover Oncology

Targeting the DNA damage response to reshape the tumor immune microenvironment

Wenge Li, Xin Yu

Abstract The DNA damage response (DDR) maintains genome stability through coordinated DNA repair, replication-stress signaling, and cell-cycle control. In cancer, DDR dysregulation promotes genomic instability, clonal evolution, and treatment resistance, while simultaneously creating therapeutically exploitable vulnerabilities. DDR alterations also reshape the tumor immune microenvironment by influencing cytosolic nucleic-acid sensing, neoantigen generation, antigen presentation, inflammatory signaling, and immune …

29.08.2026journal-article

Journal of Neuro-Oncology

Radiological response of primary central nervous system lymphoma after corticosteroid therapy and its predictive value on overall survival: a multicenter study

Florian Scheichel, D. Pinggera, T. Rossmann, B. Popadic, S. Aspalter, V. Schön, A. Woehrer, M. M. Dorostkar, C. Dorfer, C. F. Freyschlag, F. Marhold

Abstract Background Primary Large-B-Cell Lymphoma of the CNS (PCNS-LBCL) is a rare, aggressive tumor often sensitive to corticosteroid therapy (CST). This multicenter study investigated the spectrum of radiological responses to routine CST and evaluated its impact on patient prognosis. Methods The researchers utilized a prospective cohort of 18 patients for volumetric MRI analysis and a combined prospective-retrospective cohort of 31 patients for 2D tumor analysis. Patients received CST post-biopsy, with follow-up …

29.08.2026journal-article

Genes

Clinical Insights into RELA-Associated Disease: From Genotype to Phenotype and Exploring Treatment

Chun Pan, Cuifang Zheng, Yuhuan Wang, Jieru Shi, Lin Wang, Ying Huang

Background/Objectives: RELA encodes the p65 subunit of NF-κB and plays a critical role in immune regulation, epithelial protection, and anti-apoptotic signaling. Pathogenic RELA variants cause monogenic immune dysregulation with heterogeneous clinical manifestations. However, genotype–phenotype relationships and optimal treatment strategies remain incompletely defined. Methods: We conducted a comprehensive literature-based analysis of reported individuals with RELA variants and additionally described a family carry …