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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Reducing Central Line Associated Blood Stream Infections in a Tertiary Care Paediatric Oncology Unit: A Quality Improvement Study

M Jyothi, Anusha Hegde, Vandana Bharadwaj, Sangeeta Sheela, GM Vanitha, Sunu Padmanabhan, Savitha Nagaraj, Anand Prakash

Abstract Background The Pediatric Oncology unit of a tertiary care teaching hospital in India found that central line-associated bloodstream infections (CLABSIs) appeared to cause delays in chemotherapy, increased intensive care admissions, higher treatment costs, increased morbidity, and mortality among children on cancer chemotherapy. However, accurate data on CLABSI rates in the unit were not available. Hence, a quality improvement (QI) project was undertaken with the aim of estimating the burden of CLABSI in th …

29.08.2026journal-article

Maltepe Tıp Dergisi

Long-Term Outcomes of Conservative Treatment in Traumatic Carotid Artery Dissection: A Case Report

Birol Özkal, Kadir Timuçin Turgutoğlu

Amaç: Travmatik karotis arter diseksiyonu (TCAD), künt servikal travma sonrası ortaya çıkabilen nadir ancak ciddi nörolojik sonuçlara yol açabilen bir vasküler yaralanmadır. Beş yılı aşan uzun dönem takip verilerinin sınırlı olması, doğal seyir ve konservatif tedavinin etkinliği hakkındaki bilgi eksikliğini sürdürmektedir. Bu çalışmanın amacı, konservatif tedavi altında altı yıl boyunca yaklaşık %90 düzeyinde stabil kalan sağ internal karotis arter TCAD olgusunu sunmak ve uzun dönem yönetim yaklaşımlarına katkıda b …

29.08.2026journal-article

Cancers

Comprehensive Genomic Profiling Reveals the Mutational Spectrum and Clinical Significance of BRCA1/2 and Other Cancer-Susceptibility Genes in Breast Cancer Patients from Southern Tunisia

Nihel Ammous-Boukhris, Rania Abdelmaksoud-Dammak, Wala Ben Kridis, Dorra Ben-Ayed-Guerfali, Souhir Guidara, Ameni Feki, Hassen Kamoun, Afef Khanfir, Jamel Daoud, Gérard-Hubert Lizard, Ali Gargouri, Raja Mokdad-Gargouri

Background/Objectives: This study aims to investigate the mutational spectrum of BRCA1 and BRCA2 genes in a cohort of breast cancer (BC) patients from southern Tunisia, and to evaluate their clinical and prognostic significance. Additionally, this study explores the contribution of other cancer predisposition genes and the prevalence of variants of uncertain significance (VUS). Results: Among the 165 patients included, pathogenic or likely pathogenic variants (P/LPVs) in BRCA1/BRCA2 were identified in 19 cases (11. …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Neonatal Infectious Harm Reduction Benefits of Maternal Substance Use Treatment: A Dyad-Based Retrospective Review

Lindsey E Hastings, Ellen F Eaton, Rachel G Sinkey, Claudette L Poole

Abstract Background Substance use disorders (SUD) in pregnancy can disrupt routine prenatal care and have been linked to increased risk of congenital syphilis as well as perinatal exposure to hepatitis C (HCV) and human immunodeficiency virus (HIV). Moreover, inconsistent adherence to universal HCV maternal screening recommendations, fragmented care, and frequent removal of infants for child welfare often make timely identification of maternal HCV or syphilis infection challenging and follow-up screening of exposed …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Risk Factors for the Development of Bacteremia in Pediatric Hemato-Oncology Patients in a Public Third Level Hospital

Alejandra Camila Espinoza-Quiroz, Juan Pablo Rodriguez-Auad, Miguela A Caniza

Abstract Background The use of intensive chemotherapy has improved childhood cancer survival but increases severe neutropenia and the risk of infections. Several studies have identified factors that predispose patients to bacteremia and prolonged hospitalization, some of these factors were thrombocytopenia, central venous catheter use, and profound neutropenia. Identifying these factors allows for risk stratification and optimization of antibiotic management in children with cancer and febrile neutropenia. We studi …

29.08.2026journal-article

ACR Open Rheumatology

Reduction of CXCR3 + CCR6 + CD4 + T Cells and IL ‐17+ RORγt + CD4 + T Cells During Secukinumab Treatment Identifies Patients With Axial Spondyloarthritis Responsive to Subsequent Biologic Therapy

Addison Pacheco, Patricia Remalante‐Rayco, Nigil Haroon, Denis Poddubnyy, Robert D. Inman

Objective We recently reported an immune profile that stratifies patients with axial spondyloarthritis based on clinical response to secukinumab. We now undertake an exploratory study on the secukinumab nonresponder patients to determine if immunologic changes occur during their initial secukinumab treatment that could determine their next biologic response. Methods At the clinician's discretion, 18 patients who did not respond to secukinumab were either switched to a tumor necrosis factor inhibitor (TNFi; n = 8) o …

29.08.2026journal-article

The FASEB Journal

Explainable Deep Learning of Transcriptomes Prioritizes Candidate Biomarkers With Preferential Performance in Gastric Cardia Cancer Cohorts

Jinling Xu, Chunfeng Li

ABSTRACT Gastric cardia adenocarcinoma is biologically distinct from distal disease, but deployable molecular markers remain scarce. We investigated whether explainable deep learning applied to public transcriptomes could nominate diagnostic and survival‐associated candidates. We developed and externally evaluated an explainable transcriptome‐based classifier. The Asian Cancer Research Group SuperSeries GSE66229 (300 tumors and 100 patient‐matched non‐tumor tissues) underwent robust multi‐array average preprocessin …

29.08.2026journal-article

Advanced Materials

Switching Peroxymonosulfate Redox Routes by Manipulating Spinel Tetrahedral and Octahedral Site Activity for Multi‐Scenario Wastewater Treatment

Zhiyong Zhao, Yuanyuan Lv, Jiachen Zhang, Shuai Yue, Mengxue Yang, Yanxiao Li, Weitao Liu, Pengfei Wang, Sihui Zhan

ABSTRACT For diverse wastewater treatment scenarios, achieving controllable switching of reactive oxygen species within a unified catalytic system remains a major challenge. Here, an inert cation substitution strategy is proposed to regulate tetrahedral and octahedral Co activity in Co 3 O 4 , enabling controllable switching between radical and nonradical pathways. Octahedral‐Co‐enriched ZnCo 2 O 4 (ZCO) selectively directs peroxymonosulfate (PMS) activation toward the 1 O 2 pathway (95.8% contribution), whereas te …

29.08.2026journal-article

Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer)

Enhancing Antimalarial Treatment Adherence: A Systematic Review of Multifaceted Intervention Strategies

Elisa Nugraha Haryadi Salakay, Grace Novylian Tandialo, Ricky Lazarus Rumboirusi, Grace Fitriana Primasari Hau Mahu

Background: Despite the availability of effective antimalarial medications, poor adherence remains a significant obstacle in malaria control, particularly in endemic areas. Numerous interventions have sought to enhance adherence; however, a clear understanding of their effectiveness is lacking. Objective: This systematic review aimed to evaluate the effectiveness of intervention strategies to improve adherence to antimalarial treatments and identify the contextual factors that influence them. Method: Following the …

29.08.2026journal-article

Modern Rheumatology

Clinical Characteristics of Enthesitis-Related Arthritis and Outcomes of Treatment with Salazosulfapyridine

Yuko Akutsu, Yuko Hayashi, Masaaki Mori, Masaki Shimizu

Abstract Objectives Enthesitis-related arthritis (ERA), characterized by chronic arthritis and/or enthesitis, is a relatively rare subtype of juvenile idiopathic arthritis (JIA). Achieving sustained disease control can be challenging. We aimed to characterize ERA and to evaluate the efficacy of salazosulfapyridine (SASP) treatment. Methods We retrospectively reviewed 23 patients with ERA treated in our institute between 2015 and 2025. Clinical characteristics, laboratory findings, and treatment courses were analyze …

29.08.2026journal-article

Journal of Personalized Medicine

Molecular Residual Disease in Non-Small Cell Lung Cancer: Technology or Patient Outcomes?

Paul R. Walker

Molecular residual disease (MRD) testing approaches with plasma next-generation sequencing (NGS) testing to identify circulating tumor DNA (ctDNA) in resectable-stage non-small cell lung cancer (NSCLC) are evolving. The MRD concept is to better guide perioperative systemic treatment and identify recurrent NSCLC before symptomatic radiographic recurrences. Multiple tumor-informed assays are available with technology driving lower levels of ctDNA detection. However, it remains unclear that individual patients derive …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

It Takes Two to Tango: Impact of a Reverse Two-Step Algorithm for Clostridioides difficile Infection Diagnosis in Pediatric Oncology and Hematopoietic Cell Transplant Populations

Dolores Freire Jijon, Christopher P Ouellette, Stacie Rhoades, Eunkyung Song

Abstract Background Implementation of a reverse two-step algorithm (RTSA) for diagnosing C. difficile infection (CDI) in the adult population has improved diagnostic accuracy and reduced CDI-directed antibiotic exposure. The impact of the RTSA in pediatric CDI is unknown. This study aimed to evaluate the impact of RTSA implementation on CDI rates, anti-C. difficile antibiotic exposure, and clinical outcomes among hospitalized pediatric oncology and hematopoietic stem cell transplantation (HCT) patients. Methods In …

29.08.2026journal-article

International Journal of Veterinary and Animal Research (IJVAR)

Molecular Effects of Selected Copper Compounds on Novel Oncogenic Signaling Marker Expression in Cancer Cells

Salih Erat, Alparslan Kadir Devrim, Ali Şenol, Büşra Moran, Canan Çakır Çoban, Elisha Apatewen Akanbong

This study evaluated the cytotoxic, apoptotic, and gene expression–modulatory effects of CuSO4, CuCl2, and CuCO3 on L929 fibroblasts, DLD-1 colorectal cancer cells, and Capan-1 pancreatic cancer cells. Cells were exposed to concentrations ranging from 7.8 to 500 µM for 24 h. Cell viability was assessed by MTT assay, apoptosis/necrosis by double staining, and gene expression (EZH2, PGK1, HER2, USP28, AURKA, HPRT1, ER-α) by qPCR. At 500 µM, CuSO4, CuCl2, and CuCO3 showed no significant cytotoxicity in L929 cells, wit …

29.08.2026journal-article

Cancer

Adjuvant CDK4/6 inhibitors in early‐stage breast cancer: Clinical evidence and considerations for risk stratification and treatment selection

Austin D. Williams, Anna Weiss

Abstract Hormone receptor–positive, human epidermal growth factor receptor 2–negative breast cancer is the most common biologic subtype and carries a persistent risk of recurrence, particularly in patients with high‐risk, early‐stage disease. Cyclin‐dependent kinase 4 and 6 inhibitors, initially established as a standard component of first‐line therapy in the metastatic setting based on improvements in progression‐free and overall survival, have since been evaluated in the adjuvant setting. While adjuvant palbocicl …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Blood Gene Expression Profiles for Early Identification of Sepsis in Children with Cancer and Episodes of Fever and Neutropenia

Sandra Castejon-Ramirez, Juan Pablo Torres, Zhaohui Xu, Veronica De la Maza, Mauricio Farfan, Milena Villarroel, Juan Tordecilla, Marcela Zubieta, Ana Maria Alvarez, Carmen Aviles, Tamara Viviani, Maria Elena Santolaya, Octavio Ramilo, Asuncion Mejias

Abstract Background Invasive bacterial infections are a leading cause of mortality in children with cancer and febrile neutropenia (FN). Clinical tools have been developed to predict sepsis in this population but the added value of comprehensive biomarkers such as RNA expression profiling remains unclear. This study aimed to determine the utility of transcriptome profiling for early sepsis identification in children with cancer and FN. Methods Prospective, multicenter study conducted over three years in 6 hospitals …

29.08.2026journal-article

The Turkish Journal of Pediatrics

Long-term outcomes and prognostic factors in pediatric Wilms tumor: a 47-year single-center experience

Oğuz Salih Dinçer, Alper Uygun, Ayhan Dağdemir, Merve Ecem Öğretici Çolak, İbrahim Kartal

Introduction. Wilms tumor is the most common renal malignancy in children. Survival rates now exceed 90% with multimodal therapy. This study aims to retrospectively analyze 104 pediatric Wilms tumor patients diagnosed over a 47-year period at our institution, examining demographic characteristics, tumor staging, treatment modalities, complications, recurrence rates, and survival outcomes. Materials and Methods. This retrospective single-center study included 104 pediatric patients diagnosed with Wilms tumor between …

29.08.2026journal-article

Cell Death Discovery

ApoA2 promotes tumor metastasis and drug resistance in hepatocellular carcinoma by activating the HMGB1/IL-17A axis

Zhou Fu, Fuyi Zhu, Zhendong Fu, Chengmeng Wang, Tao Guan, Yudong Yuan, Su Zhang, Ti Zhang

Abstract Anti-angiogenic therapy is a standard first-line treatment for advanced hepatocellular carcinoma (HCC), but drug resistance remains a major obstacle to its long-term efficacy. Our previous study found that apolipoprotein A2 (ApoA2) was highly expressed in anti-angiogenic drug-resistant HCC. However, the mechanism underlying ApoA2-mediated resistance to anti-angiogenic therapy remains unclear. Here, ApoA2 overexpression markedly promoted HCC cell proliferation, inhibited lenvatinib-induced apoptosis in vitr …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Chemotherapy Outcomes Among Pediatric Cancer Patients with Active COVID-19 Infection in a Tertiary Hospital

Meg B Tuazon, Mary Crist D Jamora

Abstract Background The impact of COVID-19 on pediatric cancer patients undergoing chemotherapy remains a significant concern due to their immunocompromised state. Balancing the risks of chemotherapy-induced immunosuppression against the dangers of delaying cancer treatment is a critical challenge, with limited evidence to guide practice. Objective This study aimed to describe the clinico-demographic characteristics and determine the post-chemotherapy outcomes of pediatric cancer patients with active COVID-19 infec …

29.08.2026journal-article

Polymers

Localized Hydrogel-Based Therapeutics: A Strategic Approach to Mitigating Postoperative Recurrence in Breast Cancer

Kiran Kainat, Muhammad Saif Ur Rahman, Muhammad Shoaib, Shanshan Xu

Cancer remains one of the leading causes of death globally, and breast cancer is the most frequently diagnosed cancer in women. Even though surgical excision is the main treatment of solid tumors, recurrence and metastasis to another location postoperatively provide lasting therapeutic challenges. Systemic adverse effects and a lack of sufficient drug bioavailability at the resection site can often hinder traditional adjuvant modalities, especially chemotherapy and radiotherapy. To address these drawbacks, localize …

29.08.2026journal-article

Fluctuation and Noise Letters

Numerical Treatment of Stochastic-Deterministic SIRS Epidemic Differential Model with Impact of Saturated Incidence Using Implicit/Stochastic RK and Euler–Maruyama Computing Paradigm

Nabeela Anwar, Iftikhar Ahmad, Hijab Javaid, Adiqa Kausar Kiani, Muhammad Shoaib, Muhammad Asif Zahoor Raja

This paper involves the numerical exploration of both stochastic and deterministic SIRS epidemic models with saturated incidence rates. The implicit Runge–Kutta method, Euler–Maruyama method and stochastic Runge–Kutta methods are employed to analyze the dynamic patterns of the epidemic. The deterministic model is formulated using an ordinary differential system and is deep-seated in the well-established classical SIRS epidemic framework. A stochastic model is formulated by incorporating the elements of white noise …

29.08.2026journal-article

Journal of Gastrointestinal and Liver Diseases

C-reactive Protein Apheresis: A Novel Treatment Approach in Acute Necrotising Pancreatitis

Felix Götzinger, Michael Kunz, Felix Mahfoud, Michael Böhm, Andreas Link

Acute necrotizing pancreatitis is a severe condition associating with high morbidity and mortality. In most cases, supportive therapy is the only available therapeutic option. Herein, we report a case of a 29-year-old male who presented with severe acute necrotizing pancreatitis caused by hypertriglyceridemia, who consequently developed acute respiratory distress syndrome and multi-organ failure. We used an off-label C-reactive protein apheresis to target the sterile inflammatory reactions additional to optimal sup …

29.08.2026journal-article

International Journal of Research in Medical Sciences

A comparative analysis on safety and efficacy of telmisartan and ramipril in treatment of hypertension in a tertiary care hospital

Wajid Gulzar, Mudasir Manzoor Dar, Amritpal Singh, Peer Samiq Masoodi, Shah Samreen, Uma Jyoti

Background: Hypertension is a major global health challenge and an important risk factor for cardiovascular disease. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are commonly used first-line antihypertensive agents. This study evaluated the safety and efficacy of telmisartan and ramipril in patients with hypertension at a tertiary care hospital. Methods: This prospective observational study included 113 adult patients with hypertension who received either telmisartan (n= …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Clinical Characteristics and Outcomes of Respiratory Viral Infections in Pediatric Cancer Patients, Single center experience

Mona Mohammed, Yassin Taher, Maha Mohammed, Naiven Mohamed, Nehad Abd Elfatah, Marwa Jamal, Omnya Ahmed, Amira Sameh, Mohamed Kamal, Youssef Madney

Abstract Background Respiratory viral (RV) infections cause morbidity and mortality in immunocompromised pediatric patients undergoing cancer treatment. The burden of RV infections in pediatric oncology populations from low- and middle-income countries (LMICs) remain limited. We aimed to detect the prevalence of viruses causing respiratory infections among pediatric patients with cancer and guide empiric therapy and improve patient outcomes. Methods Retrospectively we collected nasopharyngeal swabs and clinical and …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Epidemiology of and antibacterial resistance in Gram-negative bloodstream infections among children with cancer and hematopoietic cell transplant recipients

Alexander Pruett, Jose Ferrolino, Ronald Dallas, Yilun Sun, Elisabeth Adderson

Abstract Background Bacteremia occurs in up to 30% of febrile neutropenic children receiving cancer therapy or hematopoietic cell transplant (HCT) and 14% of patients with non-neutropenic fever. Increasing antimicrobial resistance among Gram-negative pathogens is a challenge to providers, who seek to limit broad-spectrum antibacterial use while providing timely and effective empiric therapy. Experts recommend that the epidemiology of GN bloodstream infections (GNBSI) should be considered in developing guidelines fo …