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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Chronic Wound Care Management and Research

Expert Roundtable Recommendations on Wound-Bed Optimization in Difficult-to-Heal Wounds: Clinical Positioning of ON101 From a U.S. Multidisciplinary Roundtable

John Lantis, Michael Desvigne, Laura Pfendler, Mark Suski, Greg Bohn, Zwelithini Tunyiswa, Mervin Low, Abigail Chaffin, Brock Liden

Diabetic foot ulcers (DFUs) remain a major clinical and economic challenge and may persist within a dysregulated wound microenvironment characterized by persistent inflammation, impaired cellular signaling, microbial biofilm burden, and failure to progress through normal healing pathways. ON101 is a provider- directed topical wound-bed optimization matrix developed to support progression toward closure in difficult-to-heal DFUs. To review the available evidence and develop structured expert roundtable recommendatio …

02.09.2026journal-article

Florida Journal of Emergency Medicine

The Silent Snowstorm: Complete Hydatidiform Mole Presenting as Asymptomatic Pregnancy of Unknown Location

Maya Itani, Christopher Maguire

Gestational trophoblastic disease (GTD) encompasses a spectrum of hyperproliferative disorders, including molar pregnancy. While GTD classically presents with hyperemesis or vaginal bleeding, early diagnosis can be challenging when the patient is asymptomatic, presenting instead as a pregnancy of unknown location (PUL). This report details a 17-year-old G1P0 who initially presented to the emergency department at an estimated 7 weeks’ gestation as a fully asymptomatic PUL following a non-diagnostic outpatient ultras …

02.09.2026journal-article

British Journal of Community Nursing

Transforming wound care: the role of AI in achieving clinical and financial outcomes

Jackie Stephen Haynes, James Burford

Wound care has significant associated challenges in clinical practice, particularly for chronic wounds such as venous leg ulceration, pressure ulceration and diabetic foot ulceration. This article discusses the emerging and current applications of artificial intelligence in wound care, including wound image analysis, infection detection, predictive modelling and decision support systems. The article explores how artificial intelligence technologies are being leveraged to enhance accuracy and efficiency in wound ass …

02.09.2026journal-article

The Journal of Infectious Diseases

A Patient-Derived iPSC-Based Model Reveals Neural Lineage-Specific Transcription of Endogenous HHV-6B

Hiroki Miura, Tomoki Inagaki, Tamae Ohye, Akiko Yoshikawa, Takayuki Murata, Naoki Yahata, Yoshiki Kawamura, Yotaro Kondo, Jun-ichi Kawada, Masaru Ihira, Yuki Higashimoto, Yoshitaka Sato, Yoshihiro Izumiya, Tetsushi Yoshikawa

Abstract Background Endogenous human herpesvirus 6 (eHHV-6), in which the entire viral genome is integrated into human chromosomes, is present in approximately 1% of the population and has been associated with various clinical conditions, including neurological disorders. However, its biological significance remains unclear due to the lack of appropriate experimental models. Methods We established a patient-derived induced pluripotent stem cell (iPSC)–based tissue culture model using lymphoblastoid cell lines from …

02.09.2026journal-article

BMC Medicine

A fully automated deep learning pipeline system for carotid plaque segmentation and vulnerability classification on multi-contrast MRI: a multicenter study

Qun Gai, Yue Zhang, Jinxu Liu, Zhaojin Fu, Jinglin Zhou, Mengze Zhang, Fan Yu, Mengmeng Feng, Senhao Zhang, Rui Qin, Chong Zheng, Ximing Wang, Yi Dai, Xiqing Wu, Jie Lu

Abstract Background Carotid vulnerable plaque rupture is a major cause of ischemic stroke. However, accurate identification of high-risk plaques using medical images heavily relies on radiologists’ expertise. This study aimed to develop an artificial intelligence (AI) system for automated segmentation and classification of carotid plaques using high-resolution vessel wall imaging (HR-VWI) to assist in diagnostic workflow. Methods A total of 1610 carotid arteries from 1315 patients who underwent multi-contrast HR-VW …

02.09.2026journal-article

Journal of Clinical Nursing

Evasiveness in Everyday Hospital Palliative Care Practice: A Focused Ethnography

Carolien van Leussen, Evelien Kuip, Renske Kruizinga, Els van Wijngaarden

ABSTRACT Aim To develop a practice‐based understanding of how everyday hospital routines, professional norms and organizational conditions influence the provision of palliative care for patients approaching the end of life. Design Focused ethnography informed by practice theory. Methods This study involved approximately 311 h of observation of healthcare professionals across several departments of a Dutch university hospital from January to September 2024. Data analysis followed an inductive, iterative process info …

02.09.2026journal-article

Polymers

A Flexible Wearable Multisensing Patch Integrating SWCNT-PtNPs Nanocomposites for Non-Invasive Clinical Biomarkers Monitoring in Sweat

Lucian-Gabriel Zamfir, Petru Epure, Ioana Cătălina Gîfu, Iuliana Răut, Mariana Constantin, Cristina Firincă, Nicoleta-Olguța Corneli, Mihaela Doni, Ana-Maria Gurban

The integration of enzyme-loaded polymeric matrices with carbon-based nanomaterials and metallic nanoparticles into wearable multisensing patches, coupled with miniaturized portable detection devices, enables real-time, highly sensitive, and simultaneous monitoring of key clinical biomarkers (e.g., glucose, lactate, and H2O2) in clinical and point-of-care applications. Multiplex biosensors were fabricated by modifying screen-printed carbon paste electrodes (SPEs) with different composite nanomaterials based on carb …

02.09.2026journal-article

Current Opinion in Pulmonary Medicine

Disparities in sleep-disordered breathing: epidemiology, mechanisms, and pathways toward equity– a narrative review

Adrianna Elashker, Justin A. Fiala

Purpose of review Sleep-disordered breathing (SDB), encompassing obstructive sleep apnea (OSA) and related conditions, affects tens of millions of individuals in the United States and is associated with substantial cardiovascular, metabolic, and neurocognitive morbidity. However, the burden of SDB is not equally distributed across racial, ethnic, and socioeconomic groups, with significant disparities in referral, diagnosis, and treatment of these conditions within traditionally underserved populations. Recent findi …

02.09.2026journal-article

Journal of Public Health and Preventive Medicine

Chronic disease comorbidity patterns among elderly Chinese based on CHALS data and their impact on daily living ability

Jianing Zhang, Haoyu Liu, Mengqi Li, Zeyuan Wang, Yutong Chen

Objective: To analyze the current prevalence and clustering patterns of chronic comorbidities among elderly people in China, explore the association between different comorbidity patterns and impairment of basic daily living ability (BADL) and instrumental ability of daily living (IADL), and test the moderating effects of physical exercise and social support, providing empirical evidence for formulating precise elderly health management strategies. Methods: Using cross-sectional data from the 2018 China Health and …

02.09.2026journal-article

Problems of Gathering Treatment and Transportation of Oil and Oil Products

PHYSICAL AND MATHEMATICAL MODEL AND CALCULATION METHOD FOR TWO-PHASE FLOW OF A GAS-CONDENSATE MIXTURE IN A GATHERING PIPELINE SYSTEM

A.B. Shabarov, E.A. Padin, L.A. Puldas, M.A. Aleksandrov

This paper proposes a physical and mathematical model of two-phase gas condensate flow in a pipeline system. The presented model is characterized by a comprehensive description of hydraulic and thermal losses. An algorithm for numerically solving the system of the proposed model equations is described. The model was tested using a section of a gas gathering system (GGS) at a large gas condensate field. It is shown that the developed model has a high degree of convergence in terms of pressure and temperature drop ac …

02.09.2026journal-article

Journal of Translational Medicine

Single-cell and single-nucleus transcriptomics of the dorsal root ganglion in neuropathic pain: cell-state remodeling and translational prospects

Xu-Ran Liao, Huan Zheng, Jiang-Yuan Luo, Bi-Xin Zheng

Abstract Neuropathic pain remains a major unmet clinical challenge, as current therapies provide limited efficacy and poor tolerability. A major obstacle to developing effective analgesics is the pronounced cellular and molecular heterogeneity of the dorsal root ganglion (DRG), which integrates neuronal, glial, immune, and stromal responses to injury. Recent advances in single-cell RNA sequencing (scRNA-seq) and single-nucleus RNA sequencing (snRNA-seq) have enabled cell-type-resolved analyses of these responses an …

02.09.2026journal-article

Revista de Geopolítica

MARKETING DIGITAL E CAPTAÇÃO DE PACIENTES EM PSICOLOGIA: OS LIMITES ÉTICOS DA RESOLUÇÃO CFP DIANTE DA PUBLICIDADE EM REDES SOCIAIS

Pedro Paulo Martins De Lira, Rafaella Corrêa

As redes sociais tornaram-se o principal canal de divulgação profissional e de captação de pacientes em Psicologia, colocando em tensão a lógica do marketing, orientada ao alcance e à conversão, e a lógica do cuidado, fundada na vulnerabilidade, no sigilo e na autonomia de quem busca ajuda. Este artigo analisa os limites éticos dessa prática à luz do marco normativo do Conselho Federal de Psicologia, articulando o Código de Ética, as regras de publicidade da Resolução CFP 03/2007, os critérios da Nota Técnica CFP 1 …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Does Doxycycline Benefit Intensified Hygiene Measures in Patients with Filarial Lymphedema? A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Asia Batool, Makhzan Ali Akbar, Fakhar E. Mahin, Muhammad Sharjeel Abbas, Muhammad Huzaifa Khattak, Bilal Wazir Khan, Meer Murtaza, Nayab Magsi, Tayyaba Ikram Kazi, Muhammad Maaz Amjad, Humaira Bibi, Zohaa Fazal, Muhammad Ahsan, Mehtab Ali

ABSTRACT. Lymphatic filariasis is a vector-borne infectious disease, most commonly caused by Wuchereria bancrofti , that affects 120 million people. It invades the lymphatic system of humans, who are the definitive hosts. We compared the administration of doxycycline with intensified hygiene measures alone in patients diagnosed with bancroftian filariasis. We searched PubMed, Scopus, and Embase and included 12 randomized controlled trials. A random-effects model was used to calculate the mean difference (MD)/risk r …

02.09.2026journal-article

European Journal of Emergency Medicine

Prehospital versus in-hospital unfractionated heparin in ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: a systematic review and meta-analysis

Yee-Jen Wu, Hung-Ju Lin, Yen-Hung Lin, Chi-Sheng Hung

Background and importance In patients with ST-segment elevation myocardial infarction (STEMI), myocardial loss continues until coronary reperfusion is achieved. Objective To evaluate whether prehospital administration of unfractionated heparin (UFH) improves preprocedural infarct-related artery patency and clinical outcomes in patients undergoing primary percutaneous coronary intervention (PCI). Design Systematic review and meta-analysis. Electronic databases (PubMed, EMBASE, CENTRAL, and Web of Science) and clinic …

02.09.2026journal-article

Journal of Chemical Technology and Metallurgy

STUDY OF WEAR RESISTANCE OF METAL ALLOY 100Cr6 AS A RESULT OF VARIOUS HEAT TREATMENT MODES

Boyan Yordanov, Iliyan Mitov, Todor Todorov, Rositsa Gavrilova

This study investigates the abrasive wear resistance of 100Cr6 (AISI 52100) bearing steel under three distinct heat treatment conditions: spheroidising annealing (as-delivered), normalising at 880°C, and oil quenching from 840°C followed by low-temperature tempering at 160°C. Cylindrical specimens were subjected to abrasive wear testing using a silicon carbide disc (P80 grit) under a constant load of 450 g over test durations of 25 and 60 min. Wear resistance was evaluated by the mass loss method, and microstructur …

02.09.2026journal-article

American Journal of Physiology-Cell Physiology

Crosstalk between SARS-CoV-2 and the angiotensin system: Clinical implications

Safa Kinaneh, Shadi Hamoud, Yara Knany, Samuel N. Heyman, Zaid Abassi

ACE2, serving as a receptor to SARS-CoV-2, is a key player in RAAS. Consequent ACE2 depletion disrupts the balance between the Ang II/ AT1R and Ang (1-7)/MasR arms of the angiotensin system, promoting intense inflammation. A crosstalk existing between the angiotensin system and ACE2/spike proteins may affect the infection severity, with potential therapeutic implications. Evaluating such potential interactions and their relevance to the severity of COVID-19, which is directly affected by ACE2 abundance or indirectl …

02.09.2026journal-article

Journal of Participatory Medicine

A Parent-Facing Decision Aid About Childhood Vaccination: Co-development Study Adapting a Shared Decision-Making Approach to Support Evidence-Guided Decision-Making

Daphne Bussink-Voorend, Lisa Vandeberg, Jeannine LA Hautvast, Glyn Elwyn, Marlies EJL Hulscher

Background Childhood vaccination rates are declining, and more parents are becoming hesitant about vaccinating their children. Higher levels of vaccine hesitancy occur among parents with lower levels of educational attainment, who are also likely to have lower levels of health literacy. Objective We aimed to develop a web-based decision aid, considered a shared decision-making (SDM) approach, to inform and support Dutch parents in their decision-making about routine childhood vaccination, prioritizing the needs of …

02.09.2026journal-article

JAMA Surgery

Workload and Perceived Burden From a National Survey of Surgeons

Saffanat Sumra, Anirudh S. Margasahayam, Thomas M. Li, Yash V. Shroff, Lillian M. Knuttila, Rachel M. C. Prosser, Sanjana Anand, Paul Adam Gonzales, Catherine Lee, Mary L. Brandt, Patrick J. O’Neill, Michael J. Sutherland, Yue-Yung Hu, Patricia Turner, Veronica F. Sullins, Carter C. Lebares

Importance Surgeon workload is substantial, but data characterizing perceived burden are scarce, limiting workforce planning, surgeon well-being, and patient safety. Objective To characterize surgeon workload and factors associated with perceived burden. Design, Setting, and Participants This was a national, anonymous, cross-sectional survey distributed to US surgeon members of the American College of Surgeons (ACS) between September and November 2024 through the ACS listserv. The study included clinically active U …

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02.09.2026journal-article

The Journal of Knee Surgery

Pulsed Electrical Stimulation for Knee Osteoarthritis: Reappraisal of a 21-Year Clinical Development Program

Michael A. Mont, Chase W. Smitterberg, Javad Parvizi, Thomas Zizic

Abstract Knee osteoarthritis (OA) remains a leading cause of pain and disability, yet few nonoperative therapies have demonstrated durable clinical benefit or potential effects on structural disease progression. Pulsed electrical stimulation (PES) was investigated extensively over two decades, but this evidence has received little attention in the contemporary era of disease-modifying OA research. A structured evidence synthesis was performed of five principal prospective clinical investigations evaluating capaciti …

02.09.2026journal-article

Experimental & Molecular Medicine

Oxygen-dependent subcellular redistribution of PHD3 links the hypoxic microenvironment to mitochondrial metabolic reprogramming in ccRCC

Jaelim Sim, Soyeon Lim, Changjun Lee, Hani Jieun Kim, Wonseok Lee, Hyeonki Kim, Hojun Lee, Kimyeong Kim, Mahesh Kumar Teli, Kyeong Beom Jo, Jacob Wright, Jee Soo Park, Myung Eun Lee, Minsun Jung, Minsoo Noh, Dae-Kyum Kim, Mi-Hyun Kim, Dong Wook Choi, Tae Su Choi, Won Sik Ham, Hunsang Lee, Haejin Yoon

Abstract Clear cell renal cell carcinoma (ccRCC) is characterized by profound metabolic dysregulation, with both prolyl hydroxylase domain protein 3 (PHD3) and pyruvate carboxylase (PC) independently implicated in disease progression. Although each influences patient outcomes, a direct mechanistic interplay between these two regulators has remained elusive. Here, we uncover a novel regulatory axis involving PHD3 and PC by identifying an unexpected subcellular behavior of PHD3, namely, its dual localization to the c …

02.09.2026journal-article

Advanced Healthcare Materials

A Modular Prussian Blue Nanozyme‐Based Microneedle Platform With Flexible Therapeutic Formulations for Localized Treatment of Traumatic Brain Injury

Xiang Wang, Ge Gao, Jinhua Li, Yilong Wang

ABSTRACT Secondary injury after traumatic brain injury (TBI) is characterized by excessive reactive oxygen species (ROS) production and persistent neuroinflammation, which remain difficult to control using a single therapeutic agent. Herein, a dissolvable microneedle platform based on Prussian blue (PB) nanoparticles was developed to locally deliver curcumin (Cur) or edaravone (EDA) into injured brain tissue through a transiently disrupted blood–brain barrier. The microneedles were fabricated from hyaluronic acid/c …

02.09.2026journal-article

Hepatology

Drug-Induced Liver Injury (DILI) in clinical trials: Views and practical updates from DILI specialists at FDA

Paul H. Hayashi, Mark I. Avigan

Drug induced liver injury (DILI) continues to be a significant challenge in drug development. Just one or two cases of severe hepatotoxicity in a clinical trial can be enough to raise drug approvability concerns. Though great strides were made in DILI risk assessment and mitigation in clinical trials during the early 2000s, drugs continue to fail in development due to DILI, while severe cases still occur in late phase clinical trials and post-market. Also, changes in drug development will challenge the US Food and …

02.09.2026journal-article

European Journal of Clinical Nutrition

From mother’s plate to newborn’s health: dietary patterns and pregnancy outcomes—a cohort study

Tahnee Zacher, Rebecca Opel, Carolin Sobek, Peggy Ober, Wieland Kiess, Mandy Vogel

Abstract Background Maternal nutrition during pregnancy significantly influences both maternal and neonatal health outcomes, yet distinct dietary patterns and their impacts remain underexplored. The objective of this study was to identify dietary patterns during pregnancy and to investigate associations between these patterns and pregnancy outcomes. Methods We analyzed data from 1404 pregnant women in the LIFE Child cohort (Germany, 2011–2025) who completed a Food Frequency Questionnaire. To identify food groups an …

02.09.2026journal-article

Human Resources for Health

Physician workforce imbalances in Japan: how structural incentives shape hospital-based acute-care capacity

George Kujo

Abstract Japan's physician workforce problem in hospital-based high-intensity care is better understood as an interaction between distribution and retention than as a simple question of national physician headcount. This Comment examines three pathways that can reduce hospital service capacity: working conditions that impede entry and career continuity in high-intensity specialties; early movement from initial residency into cosmetic medicine, known as choku-bi; and later movement from hospital employment to clinic …