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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

BMC Urology

Clinical application of systematic prostate biopsy combined with contrast-enhanced ultrasound guided targeted biopsy in patients with PSA gray zone

Yan-Xia Cheng, Sha Hu, Qing-xin He, Xuan Hu, Li-Lan He, Yue Song, Zhi-Kai Lei

Abstract Objective To investigate the clinical value of combining systematic prostate biopsy with contrast-enhanced ultrasound (CEUS)-guided targeted biopsy in patients with serum prostate-specific antigen (PSA) levels in the gray zone. Methods A total of 167 patients in the PSA gray zone treated at Zhejiang Provincial Hospital of Traditional Chinese Medicine from January 2022 to October 2024 were retrospectively analyzed and divided into a systematic biopsy group and a combined biopsy group. Both groups underwent …

03.09.2026journal-article

npj Primary Care Respiratory Medicine

Barriers and facilitators to RSV vaccine acceptance among pregnant women and older adults in Hong Kong: a qualitative study guided by the Theoretical Domains Framework

Claire Chenwen Zhong, Man Kin Yim, Zehuan Yang, Vera MW Keung, Chung Yi Lo, Xiaoshu Zhang, Mingtao Chen, Junjie Huang, Martin CS Wong

Abstract Respiratory syncytial virus (RSV) poses a significant health risk to pregnant women, infants, and older adults, yet vaccine uptake remains suboptimal globally. This study aimed to explore the barriers and facilitators influencing RSV vaccine acceptance among pregnant women and older adults in Hong Kong. A qualitative design was employed, involving semi-structured interviews with pregnant women and older adults in Hong Kong. The interview guide was informed by the Theoretical Domains Framework (TDF) to capt …

03.09.2026journal-article

Acta Orthopaedica

Association of treatment method with mortality and functional outcome in patients with displaced femoral neck fracture: a cohort study of 60–69-year-old patients from the Swedish Hip Fracture Register

Pierre Campenfeldt, Margareta Hedström, Olle Olofsson, Karin Modig, Amer Al-Ani

Background and purpose: Optimal treatment for displaced femoral neck fractures (FNF) in patients aged 60–69 years remains controversial. We aimed to compare mortality and short-term clinical outcomes after total hip arthroplasty (THA), hemiarthroplasty (HA), or internal fixation (IF) after displaced FNF.Methods: We included 3,325 patients aged 60–69 years with displaced FNF recorded in the Swedish Hip Fracture Register. 1-year mortality and 4-month functional outcomes (maintenance of independent living and outdoor …

03.09.2026journal-article

Review of Clinical Pharmacology and Pharmacokinetics

Therapeutic landscape for diabetic macular edema: durable strategies with a focus on aflibercept 8 mg

Martín Roberto Basile-Alvarez, Erick André Escalante-Buendía, Karen A. Palacios-Aguirre, Alejandro Ortega Desio, Omar Yaxmehen Bello-Chavolla

To evaluate current therapies for diabetic macular edema (DME), with emphasis on durability, safety, access, and the evidence supporting aflibercept 8 mg. An expert-selected narrative synthesis of primary clinical trials, pharmacologic studies, regulatory documents, and selected real-world evidence published from January 1, 2000, through August 8, 2026, was performed. Anti-vascular endothelial growth factor therapy remains first-line treatment for most center-involved DME with visual impairment, but observation or …

03.09.2026journal-article

Journal of Clinical Immunology & Microbiology

KinModRe: A Repository of Whole Cell Kinetic Models

Nursakinah Mohamed-Khalid, Nicholas Wei Jun Liew, Felice Jia Ying Ng, Ting Yi Lim, Farhana Abdul-Samathu, Maurice HT Ling

Whole-cell kinetic models represent cellular processes as mechanistic reaction networks governed by kinetic rate laws, enabling simulation of metabolic dynamics and system-level cellular behaviour. Despite their scientific value, executable implementations of such models remain relatively scarce and many published models are distributed only as static descriptions within manuscripts. To address this limitation, we present KinModRe (https://github.com/mauriceling/kinmodre), a repository of executable whole-cell kine …

03.09.2026journal-article

Clinical Pharmacology & Therapeutics

Advances in New Approach Methodologies at FDA 's Division of Applied Regulatory Science

Ksenia Blinova, Kimberly Chiu, Anik Chaturbedi, Jahan Cooper, Tromondae K. Feaster, Paula L. Hyland, Lidiya Stavitskaya, Wendy W. Wu, Jeffry Florian, Rodney Rouse

New Approach Methodologies (NAMs) represent a paradigm shift in drug development and regulatory science, offering human‐relevant alternatives to traditional preclinical models. This mini‐review highlights recent advances in NAM development, validation, and regulatory application from FDA's Division of Applied Regulatory Science (DARS). We describe in silico NAMs including quantitative systems pharmacology (QSP) modeling for opioid overdose scenarios, (quantitative) structure–activity relationship ((Q)SAR) modeling …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Hybrid cardiac rehabilitation in patients with durable left ventricular assist devices: the REHAB-ASSIST study

Ramón Garrido-González, Elisa Velasco Valdazo, Mónica Barbero Campos, Paloma Remior Pérez, Alba Martín Centellas, Cristina Daniela Mitroi, Francisco José Hernández-Pérez, Manuel Gómez Bueno, Clemencia de Rueda Panadero, Marta Jiménez-Blanco Bravo, Susana del Prado Díaz, Susana Villar García, Javier Segovia Cubero, José Luis Zamorano Gómez, Jesús Álvarez-García, Carmen De Pablo Zarzosa, Mercedes Rivas-Lasarte

Purpose Patients with durable left ventricular assist devices (LVADs) frequently remain functionally limited despite technological advances. Cardiac rehabilitation may improve functional status, yet access is limited, and hybrid models have not been evaluated. The REHAB-ASSIST study assessed the clinical outcomes, safety, and feasibility of a hybrid cardiac rehabilitation program in this population. Methods In this prospective multicenter proof-of-concept study, LVAD recipients underwent a 12-week hybrid cardiac re …

03.09.2026journal-article

Frontiers in Immunology

Analytical validation of a multiplexed peptide microarray for multi-antigen Epstein–Barr virus serological profiling across diverse clinical specimens

Milene Peterson, Joe G. L. Hunter, Zoran Gatalica, Inga Rose, Phillip Stafford, Chris W. Diehnelt

Background Epstein–Barr virus (EBV) infects more than 95% of adults and is associated with outcomes ranging from asymptomatic latency to infectious mononucleosis (IM), malignancies, and multiple sclerosis (MS). Conventional ELISA-based EBV serology is often restricted to a small number of soluble, whole-protein antigens and does not preserve information regarding the specific linear regions of antigen recognition that contribute to the overall antibody response. Multiplexed peptide microarrays address this limitati …

03.09.2026journal-article

Ege Tıp Dergisi

Co-existence of pancytopenia, autoimmune hemolytic anemia and hepatic dysfunction in intensive care unit patient: Graves’ disease

Mustafa Murat Midik, Şükriye Miray Kılınçer Bozgül, Banu Sarer Yürekli, Devrim Bozkurt

Graves' disease (GD) may rarely present with hematologic findings and hepatic dysfunction. Diagnosis may be difficult, but early diagnosis is important to avoid delays in treatment. According to a recent literature review, the association of pancytopenia, autoimmune hemolytic anemia (AIHA) and hepatic dysfunction in GD has not been reported before. We report the case of a 57-year-old woman admitted to the intensive care unit with symptoms of heart failure and diagnosed as GD with pancytopenia, AIHA and impaired liv …

03.09.2026journal-article

Annals of Surgery

Cancer Surgery Outcomes After Implementation of a Global Budget Model in Rural Hospitals

Jacob Whitman, Eric T. Roberts, Jonathan G. Yabes, Donald Bourne, Zhaojun Sun, Manisha Bhattacharya, Jeremy M. Kahn, Bruce L. Jacobs, Lindsay M. Sabik

Objective: To evaluate the association between the implementation of the Pennsylvania Rural Health Model (PARHM), a global budget program for rural hospitals, and short-term outcomes for rural residents undergoing cancer surgery. Background: Rural hospitals play a critical role in delivering surgical care but face ongoing financial instability. Global budget models aim to stabilize hospitals and preserve access to care. While designed to stabilize finances and improve population health, its impact on quality of car …

03.09.2026journal-article

Frontiers in Medicine

Mixed pain: has pain medicine overlooked Its most common phenotype for over 20 years? A perspective on mechanistic interaction, the nociplastic paradox, and the future of pain classification

Rainer Freynhagen, Antonio Alcántara Montero

Pain medicine has progressively evolved from a binary classification of nociceptive and neuropathic pain toward a broader mechanistic framework that now includes nociplastic pain. While this evolution has substantially improved our understanding of chronic pain, it has not resolved a persistent clinical reality: most patients do not present with mechanistically pure pain states. Instead, nociceptive, neuropathic, and nociplastic mechanisms frequently coexist within the same individual and interact in ways that chal …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Case Report: Left ventricular pseudoaneurysm presenting with ventricular tachycardia

Esra Polat, Mahmut Arslan, Yusuf Çorbacıoğlu, Ahmet Khalousi, Rauf Önder, Candan Güngör

Left ventricular pseudoaneurysm is a rare and life-threatening disorder that can present with a wide range of clinical manifestations, from an asymptomatic disease to sudden cardiac death. This case report presents a 38-year-old patient with no history of cardiovascular disease who presented with ventricular tachycardia and was diagnosed with left ventricular pseudoaneurysm following multiple cardiac imaging investigations. Given the high risk of rupture, early diagnosis of this rare condition is of critical import …

03.09.2026journal-article

Frontiers in Medicine

Neoadjuvant pembrolizumab-based therapy versus dual HER2 blockade in early breast cancer: comparable surgical complication rates in a real-world cohort

Kerstin Wimmer, Katharina Kantner, Ruth Exner, Rupert Bartsch, Zsuzsanna Bago-Horvath, Stefan Konrad, Florian Fitzal, Maximilian Marhold

Background Neoadjuvant systemic therapy (NST) has become a cornerstone in the management of aggressive early breast cancer (BC) subtypes, including triple-negative (eTNBC) and HER2-positive disease. Immune checkpoint inhibition with pembrolizumab represents an active immunotherapeutic approach, whereas dual HER2 blockade with trastuzumab and pertuzumab constitutes passive immunotherapy in early HER2-positive BC. Although both strategies demonstrate substantial antitumor efficacy, real-world data directly comparing …

03.09.2026journal-article

Frontiers in Medicine

Metachronous bilateral diabetic mastopathy mimicking breast cancer in a woman with long-standing type 2 diabetes: a case report

Zhixiang Kuang, Wei Ding, Li Li

Background Diabetic mastopathy is an uncommon benign fibroinflammatory disorder of the breast that often resembles malignancy on clinical examination and imaging. Most reports involve younger women with long-standing type 1 diabetes. Metachronous bilateral disease in an older woman with type 2 diabetes is less often described. Case presentation A 69-year-old woman with a 38-year history of type 2 diabetes treated with self-administered insulin had previously undergone partial excision of a suspicious right-breast m …

03.09.2026journal-article

Frontiers in Oncology

Molecular classification of endometrial cancer in fertility-sparing-treatment: toward a personalized clinical approach

Filippo Alberto Ferrari, Giorgio Bogani, Matteo Pavone, Elena Olearo, Andrea Puppo, Marcello Ceccaroni

Molecular classification has emerged as a promising tool to improve patient selection and prognostic stratification in fertility sparing treatment (FST) for endometrial cancer (EC). Although FST is currently considered a valid option for carefully selected patients with early stage, low grade endometrioid EC, recurrence rates remain substantial and conventional clinicopathologic criteria inadequately capture tumor biological heterogeneity. Current evidence suggests that NSMP tumors represent the most favorable subg …

03.09.2026journal-article

European Journal of Dental Education

Learning Clinical Procedures Through Social Media: A Multi‐Institutional Study of Preclinical and Clinical Dental Students in Turkey

Abdul Kerim Atlı, Emel Karaman

ABSTRACT Introduction Social media platforms are increasingly used by dental students to support learning and preparation for clinical procedures. Although previous studies have described general patterns of social media use in dental education, evidence directly comparing preclinical and clinical students remains limited. This study aimed to evaluate how dental students in Turkey use social media for learning clinical procedures and to examine differences associated with clinical experience. Methods This cross‐sec …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Development and validation of a clinical-pharmacogenomic prediction model for clopidogrel-related high on-treatment platelet reactivity in patients with coronary artery disease

Ruihua Sun, Yu Du

Objective This study aimed to develop and validate a prediction model combining clinical indicators and pharmacogenomic markers for predicting clopidogrel-related high on-treatment platelet reactivity (HPR) after approximately 7 days of dual antiplatelet therapy in patients with coronary artery disease (CAD), and to identify its influencing factors to support individualized antiplatelet therapy. The model is intended for use before platelet function testing results are available, to identify patients at high risk o …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

PVN-centered multi-omics and single-cell analyses suggest shared inflammatory and immune features in acute myocardial infarction-associated ventricular arrhythmia and atrial fibrillation

Wenlong Wang, Wenbo Zhao, Yuran Chen, Xin Wang, Chunrui Ji, Jingmei Sun, Yu Bai, Yuhang Yang, Xiufen Qu

Objective Acute myocardial infarction (AMI) increases the risk of arrhythmias, particularly ventricular arrhythmias (VA), and atrial fibrillation (AF) is also common after AMI. The paraventricular nucleus (PVN) is a key regulator of sympathetic outflow. This study used a PVN-centered strategy to investigate molecular changes after AMI, prioritize candidate molecules associated with VA, and assess whether related inflammatory and immune features are also present in AF cohorts. Methods An AMI model was established in …

03.09.2026journal-article

Trials

Optimizing patient recruitment in community pharmacies using implementation science principles: a Study Within A Trial (SWAT)

Kirstin Messner, Alexa Rosenthaler, Manuel Leuenberger, Meret Berger, Lena Walz, Isabelle Arnet, Samuel Allemann

Abstract Background Decentralized trial approaches involving community pharmacies have gained increasing attention. However, recruitment in community pharmacies faces complex conditions and tailored strategies are necessary. Applying implementation science principles is a promising but underrepresented approach to facilitate recruitment processes. On the example of adherence-enhancing services, we aimed to investigate influencing factors to trial recruitment in the community pharmacy setting and to identify impleme …

03.09.2026journal-article

Frontiers in Medicine

Direct visualization-guided endoscopic management of complex colonic diverticular disease: a proof-of-concept case series

Tianjie Han, Junshan Li

Background Complex colonic diverticular disease, including diverticular bleeding, inflammatory diverticular disease, presents substantial therapeutic challenges for conventional colonoscopy because of limited intradiverticular visualization, difficult access, and restricted maneuverability. Failure to precisely localize the culprit lesion or inflammatory nidus may lead to recurrent symptoms, delayed treatment, or surgical intervention. The EyeMax direct visualization system, originally designed for pancreatobiliary …

03.09.2026journal-article

Frontiers in Medicine

Case Report: Extremely elevated ascitic fluid amylase as a diagnostic clue for peritoneal mucormycosis caused by Rhizopus microsporus following exertional heatstroke

Guanghui Chen, Haibo Lei, Guyi Wang, Yanyan Zhou

Background Mucormycosis is a rapidly progressive, life-threatening fungal infection that typically affects immunocompromised hosts. Disseminated peritoneal mucormycosis is extremely rare and often diagnosed late. Heatstroke is an under-recognized predisposing condition. Case presentation A 54-year-old male brickworker developed peritoneal mucormycosis caused by Rhizopus microsporus following exertional heatstroke. On day 11 after heatstroke, he developed massive ascites. Ascitic fluid amylase was markedly elevated …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Evolution of electrocardiographic manifestations mimicking acute coronary syndrome secondary to hypoparathyroidism: a case report

Gerile Zhang, Riletu Ge, Jing Gao, Yuzhen Zhou

Objective To promptly identify electrocardiographic (ECG) manifestations, including deep T-wave inversions and QT-interval prolongation, secondary to hypoparathyroidism and to improve its diagnostic accuracy and therapeutic management. Methods We conducted a comprehensive analysis of the integrated treatment for a patient presenting with chest pain and evolving ECG changes secondary to hypoparathyroidism, supplemented by a review of the relevant literature. Results In this case, a patient diagnosed with hypoparathy …

03.09.2026journal-article

International Journal of STD & AIDS

Anti–IL-17 therapy in people living with HIV who have cutaneous psoriasis: A four-patient case series

Melike Merve Güçlü, Fatma Aslı Hapa, Fatma Elif Yıldırım

Aim To describe the clinical, immunological, virological and safety outcomes observed during anti–IL-17 therapy in patients living with HIV who had cutaneous psoriasis. Method Four patients living with HIV who had cutaneous psoriasis and were treated with anti–IL-17 agents were included in this case series. Psoriasis Area Severity Index (PASI) scores, CD4 cell counts, HIV RNA levels, treatment duration and adverse events were obtained from medical records. Results Three patients received secukinumab and one receive …

03.09.2026journal-article

American Journal of Surgical Pathology

Differential Expression of RORγt and T-bet in ALK-Negative Anaplastic Large Cell Lymphoma

Aya Muramatsu, Daisuke Yamashita, Yuta Tsuyuki, Akira Satou, Naoko Asano, Waki Hosoda, Kennosuke Karube, Shigeo Nakamura, Seiichi Kato

ALK-negative anaplastic large cell lymphoma (ALK-negative ALCL) frequently expresses cytotoxic molecules, which may complicate its distinction from peripheral T-cell lymphoma NOS (PTCL-NOS), particularly in cytotoxic molecule-positive cases. Among these, nodal EBV-negative cytotoxic T-cell lymphoma (CTL) represents an important diagnostic consideration. We evaluated the clinicopathological features of ALK-negative ALCL in comparison with nodal EBV-negative CTL and ALK-positive ALCL, with a focus on the immunohistoc …