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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
29.08.2026journal-article

International Journal of Medical Science and Pharmaceutical Research

Benefits of Using Hydroxychloroquine/Chloroquine in the Treatment of Immunomediated Rheumatic Diseases

Jozelio Freire de Carvalho, Mariana Fernandes Carneiro

Antimalarial drugs, particularly hydroxychloroquine (HCQ) and chloroquine (CQ), have been used for decades as cornerstone therapies in the management of immune‑mediated rheumatic diseases (IMRDs). Beyond their classical role in disease activity control, these agents exert pleiotropic effects encompassing immunomodulation, anti‑inflammatory signaling, antithrombotic activity, and metabolic and cardiovascular protection. Robust clinical evidence supports their ability to reduce disease flares, limit cumulative organ …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Outcome of sepsis due to multidrug-resistant bacterial sepsis in a paediatric oncology unit in India: An eight-year retrospective analysis

C Bindu, Jyothi M, Supriya Gachinmath, Somdipa Pal, Sidharth Totadri, Vandana Bharadwaj, Anand Prakash

Abstract Background Multidrug-resistant organisms (MDRO) cause significant morbidity and mortality in hospitalised patients. This is particularly true in paediatric oncology units, especially in low- and middle-income countries with high prevalence of MDRO, like India. We present outcomes of children on cancer chemotherapy diagnosed with MDRO sepsis in our centre. Methods Retrospective chart review of all children with blood culture-proven MDRO sepsis diagnosed between October 2017 and August 2025 was performed. Be …

29.08.2026journal-article

BMC Cancer

Insurance expansion shortened time to BRCA testing and facilitated preventive strategies: a single-center cohort study in Japan

Mami Kaneko, Atsushi Nohara, Masayoshi Munemoto, Yuka Nishimura, Takayoshi Kawabata, Shigenori Wakita, Hiroshi Yoshino

Abstract Purpose Timely identification of hereditary breast and ovarian cancer (HBOC) is essential for preventive strategies such as risk-reducing surgery. In Japan, national insurance coverage for BRCA genetic testing was expanded in April 2020. This study primarily aimed to determine whether this policy change shortened the interval from breast cancer diagnosis to BRCA genetic testing among patients with pathogenic BRCA1/2 variants. As supportive analyses, we also examined the timing of second primary cancers rel …

29.08.2026journal-article

International Journal of Research in Medical Sciences

Methylene blue dye as a single tracer for sentinel lymph node biopsy in early breast cancer

Vishwanath Patil, Garima Agarwal, Shalu Gupta, Raksha R. Thobbi, Sandesh Shettigar, Ayushi Agarwal, Anushka Goyal

Background: Sentinel lymph node biopsy (SLNB) can reduce the morbidity of axillary lymph node dissection (ALND) in clinically node-negative breast cancer, but dual-tracer SLNB requires nuclear medicine infrastructure that is unavailable in many Indian hospitals. We evaluated 1% methylene blue dye (MBD) as a single tracer for SLNB in a resource-constrained setting. Methods: In this prospective observational study, 30 women with clinically node-negative, early-stage breast cancer (T1-T2, N0, M0) underwent periareolar …

29.08.2026journal-article

BMC Cancer

Adjuvant T-DM1 versus trastuzumab plus pertuzumab for residual disease after neoadjuvant dual HER2 blockade in HER2-positive early breast cancer: a multicenter real-world study

Yueran Jia, Shihao Liang, Wei Wu, Yuhang Han, Zexi Peng, Danyang Ji, Die Sang, Man Yang, Jidong Gao, Bo Yu, Jiayu Wang, Yang Luo, Bo Lan, Shanshan Chen, Pin Zhang, Fei Ma, Binghe Xu, Ying Fan

Abstract Background Despite the established benefit of adjuvant trastuzumab emtansine (T-DM1) over trastuzumab in HER2-positive early breast cancer (eBC) with residual disease after neoadjuvant chemotherapy plus HER2-targeted therapy, comparison of efficacy between T-DM1 and dual HER2 blockade (trastuzumab plus pertuzumab, HP) remains undetermined. This study evaluates survival outcomes with adjuvant T-DM1 versus HP in a multicenter real-world cohort. Methods Breast cancer patients with residual disease after neoad …

29.08.2026journal-article

Familial Cancer

The evolution of hereditary cancer genetic counselling: mainstreaming, service redesign and patient experience in Lynch syndrome

Kelly Kohut, Sarah Cable, Alekhya Ashokan, Stefania Vicari, Hannah Ditchfield, Julie Young, Ben Bux, Fiona Lalloo

Abstract Genetic counselling for hereditary cancer predisposition has evolved substantially over more than three decades, driven by advances in genomic technologies and the growing use of tumour and germline testing. These developments have expanded access to hereditary cancer testing, treatment and prevention, while also introducing new clinical, psychosocial and system-level challenges. This review examines the transition from traditional specialist-led genetic counselling to mainstreamed testing pathways. Using …

29.08.2026journal-article

Advanced Science

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

Poshan Yugal Bhattarai, Arathy Vasukutty, Yujin Na, Sung‐Chul Lim, Hong Seok Choi

ABSTRACT Nutrient deprivation in the tumor microenvironment drives metastatic progression. However, its role in breast cancer metastasis and underlying epigenetic mechanisms remain unclear. We identify an enhancer‐driven transcriptional program that promotes breast cancer metastasis under nutrient deprivation. Transient glucose–glutamine deprivation in MCF7 and MDA‐MB‐231 cells induces the expression of genes involved in migration, invasion, and metastasis. Chromatin immunoprecipitation sequencing shows distinct en …

29.08.2026journal-article

International Journal of Research in Medical Sciences

Bilateral undescended testes with intraabdominal non seminomatous germ cell tumor – a rare clinical challenge

Kalyani D. Aher, Minakshi Gadahire

Cryptorchidism is the most common congenital anomaly of the male genitalia, with nearly 72-77% of undescended testes located in the inguinal canal. Among malignancies arising in undescended testes, seminoma is the most frequent type, accounting for approximately 50-60% of cases. Tumors arising from intra-abdominal testes may grow to considerable sizes before detection, and delayed diagnosis often results in advanced-stage disease at presentation. We report a case of bilateral cryptorchidism in a young male who pres …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Optimizing Empirical Antibiotic Therapy in Febrile Pediatric Oncology Patients through a Clinical Decision Pathway

Yamileth Arellano, Martha Avilés Robles, Fernando Ríosvelasco

Abstract Background Timely management of a child with cancer and fever (CCF) requires accurate evaluation and appropriate antibiotic selection to prevent infectious complications. Clinical decision tools, such as Clinical Decision Pathways (CDPs), are increasingly adopted in healthcare systems for their ability to standardize and optimize clinical practice. The aim of this study was to assess the effectiveness and utility of an adapted CDP for initial antibiotic selection in children with cancer and fever. Methods …

29.08.2026journal-article

Medical Decision Making

Best–Worst Scaling as a Values Clarification Method within a Decision Aid for Kidney Treatment Decision Making

Semra Ozdemir, Juan Marcos Gonzalez, Eric Andrew Finkelstein

Background: Best–worst scaling (BWS) has been increasingly used as a values clarification method to help patients make value-concordant decisions. However, evidence on its use remains limited. Objective: To examine 1) the association between BWS-derived treatment preference scores and patients’ stated and real-world treatment choices and 2) whether BWS-identified best-match treatments were concordant with treatment choices among older adults with end-stage kidney disease (ESKD). Methods: We conducted a prospective …

29.08.2026journal-article

Discover Artificial Intelligence

NeuroAttnFuseNet dual branch attention fusion for brain tumor MRI classification

Md Sanowar Hossain Sabuj, Farzana Sultana, Md Hasan Or Rashid, Rahul Mudhiraj Mullela, Mohammed Yusuf

Abstract Brain tumor MRI classification remains challenging because tumor appearance varies across cases, class boundaries can be visually subtle, and public 2D MRI datasets may contain redundancy or source-specific biases that inflate reported performance. This study proposes NeuroAttnFuseNet, a dual-path attention-guided fusion network for four-class MRI image classification into glioma, meningioma, pituitary, and no tumor. The model combines a Swin-T branch for hierarchical local morphological representation wit …

29.08.2026journal-article

International Journal of Peptide Research and Therapeutics

Treatment with Alamandine Reduces Established Pulmonary Fibrosis: Preliminary Histological, Functional, and Biochemical Insights

Isabel Amaral Martins, Andresa Thomé Silveira, Juliane Flor, Aline Blanco, Giuliano Rizzotto Guimarães, Adriana Fernanda K. Vizuete, Katya Rigatto

Abstract Introduction Pulmonary fibrosis (PF) is a challenging interstitial lung disease with limited therapeutic options. This study explores the therapeutic effects of alamandine (ALA), a renin-angiotensin system peptide, in reversing established fibrotic progression in an experimental model. Methods Male Wistar rats were divided into four groups ( n = 5–6/group): control (CO), ALA-treated (ALA), bleomycin-induced fibrosis (BLM), and bleomycin plus ALA treatment (BA). Fibrosis was induced by intratracheal bleomyc …

29.08.2026journal-article

European Journal of Preventive Cardiology

Venous thromboembolism in 5-year cancer survivors: a nationwide cohort study

Adelina Yafasova, Guoli Sun, Martin Hutchings, Seiko N Doi, Morten Schou, Maja V Maraldo, Amna Alhakak, Nina Nouhravesh, John J V McMurray, Mark C Petrie, Ninian N Lang, Lars Køber, Emil L Fosbøl, Jawad H Butt

Abstract Aims Cancer is associated with a significant short-term risk of venous thromboembolism (VTE). With substantial improvements in cancer survival, concern has been raised about an increased risk of VTE in long-term cancer survivors. We aimed to investigate the long-term risk of VTE in 5-year cancer survivors according to cancer subtype, age, and sex compared with a matched background population. Methods and results Using Danish nationwide registries, we matched 5-year survivors of 21 cancers (≥18 years; diagn …

29.08.2026journal-article

African Journal of Pharmacy and Alternative Medicine

Knowledge and Attitudes Toward Cervical Cancer and Human Papilloma Virus Vaccination in Rafiki Area, Rongai Sub-County, Nakuru County, Kenya: A Cross-sectional Study

Mercy M. MICHIRA, Dinah L. SANGURA, Mercy K. JEPCHIRCHIR, Nahashon G. AKUNGA, Wairimu KARAIHIRA, James O. MEROKA, Jim AMISI

The human papillomavirus (HPV) has been proven to be a primary driver in the development of cervical cancer. Despite increasing awareness efforts, Human Papillomavirus (HPV) vaccine uptake remains low in many low-resource settings. This study assessed knowledge and attitudes towards cervical cancer and human papillomavirus vaccination, and predictors of HPV vaccine uptake among individuals aged 15-49 years in Rafiki area, Rongai sub-county, Nakuru County, Kenya. A cross-sectional survey was conducted with 328 parti …

29.08.2026journal-article

Journal of Robotic Surgery

Impact of robotic platform transition on short term outcomes in colorectal cancer surgeries

Rebeca Hara Nahime, Paulo Roberto Stevanato Filho, Tiago Santoro Bezerra, Tomás Mansur Duarte Miranda Marques, Renata Mayumi Takahashi, Bruna Elisa Catin Kupper, Wilson Toshihiko Nakagawa, Ademar Lopes, Samuel Aguiar

Abstract Robotic colorectal surgery is increasingly complex, expanding from pelvic to multiquadrant procedures. Reports on the impact of institutional robotic platform transition remain limited. This study evaluated the challenges and effects of transitioning from the da Vinci Si (dV Si) to the da Vinci X/Xi (dV X/Xi) platform. A prospective observational cohort with historical comparison describing an institutional experience that included consecutive elective robotic colorectal cancer resections performed in 2023 …

29.08.2026journal-article

Lung India

Prognostic factors after pulmonary metastasectomy for colorectal cancer lung metastasis

Elgun Valiyev, Muhammet Sayan, İsmail Tombul, Ali Çelik, Olgun Kadir Arıbas, Abdullah İrfan Tastepe, İsmail Cüneyt Kurul

Objective: Surgical resection of lung metastases in patients with colorectal cancer (CRC) can provide long-term survival in selected cases. This study aimed to evaluate the prognostic factors affecting survival after pulmonary metastasectomy (PM) performed for lung metastases due to CRC. Methods: Data from 70 patients who underwent PM for CRC-related lung metastases at our center between 2007 and 2021 were retrospectively analyzed. Demographic data, primary tumor characteristics, number, size, and localization of m …

29.08.2026journal-article

Journal of the American Chemical Society

An Inhalable Hybrid Nitric Oxide Nanogenerator for Lung Adenocarcinoma Treatment via Bioorthogonal-Activated Gas-Immunotherapy

Jinglin Zou, Yuheng Leng, Chen Zhang, Chi Zhang, Lei Shi, Pengcheng Chen, Cong Jiang, Yanjiao Liu, Dapeng Zhang, Zhangjian Huang, Yongsheng Li

Abstract Nitric oxide (NO) holds promise for circumventing resistance to platinum-based chemotherapy by reprogramming the tumor microenvironment (TME) in lung adenocarcinoma (LUAD). However, their further application is greatly hindered by uncontrolled release kinetics and off-target toxicity. Herein, an inhalable NO nanogenerator (10m@FOMs-Cu) that reprograms the TME via specific NO release is developed by encapsulating a biorthogonal-activated NO-cisplatin prodrug into TME-responsive hybrid micelles, allowing for …

29.08.2026journal-article

Analytical Chemistry

Serum Metabolomics Reveals Time-Dynamic Metabolic Changes and Candidate Markers Associated with Treatment Response in Acute Myeloid Leukemia

Rong Hu, Siwen Deng, Haishan Yi, Qiu Lin, Zhengwei Duan, Anran Shi, Yingping Cao, Yue Duan, Jingxi Zhang, Yaqin Zhang, Mengyao Wang, Jianghua Feng, Jingling Zhang, Yang Chen

Abstract Acute myeloid leukemia (AML) is a complex disease in which genetic and molecular alterations do not always reflect functional cellular states, leading to an incomplete view of disease progression. Metabolomic analysis provides a more direct measure of these states, yet most studies remain cross-sectional and lack dynamic insight. In this study, a longitudinal serum metabolomics analysis based on proton nuclear magnetic resonance was conducted in AML patients throughout chemotherapy and in healthy controls. …

29.08.2026journal-article

Current Oncology

Assessing the Opportunity for an Accelerated Access Pathway for Health Canada Priority Review Drugs: A Comparative Analysis with Ontario’s FAST Pilot Program

Catherine Y. Lau, Arif Mitha, Allison Wills

Background: Timely public reimbursement of innovative medicines remains a challenge in Canada despite expedited regulatory review pathways. This study evaluated whether an accelerated reimbursement pathway, similar to Ontario’s Funding Accelerated for Specific Treatments (FAST) for oncology drugs approved through Project Orbis could improve access for therapies approved through Health Canada’s Priority Review (PR) pathway, extending to indications beyond oncology. Methods: Health Canada drug submissions completed b …

29.08.2026journal-article

Journal of Clinical Nursing

Cultural Complexities in Conducting Research With Patients With Cancer: A Qualitative Study From the Perspective of Nurse Researchers

Ruishuang Zheng, Hanfei Cui, Yanhui Wang, Qiaohong Guo, Jun Wang, Jieqiong Xia, Ping Zhu, Melissa J. Bloomer

ABSTRACT Aim To explore the cultural challenges and complexities faced by researchers conducting studies with cancer patients in the Chinese cultural context. Design A descriptive qualitative study. Methods Semi‐structured interviews were conducted with 22 nurse researchers from tertiary hospitals, medical universities, and secondary nursing colleges from all six regions in China between April 2023 and December 2024. Data were analysed using inductive thematic analysis as described by Braun and Clarke. Results From …

29.08.2026journal-article

International Journal of Research Publication and Reviews

A Review of Pain and Sleep Problems After Breast Cancer Surgery for Designing Post-Surgery Supportive Pillows

NilanjanaBairagi, Sramana Chakraborty

30-50% of women have lasting pain and poor sleep after breast cancer surgery, as reported in different medical studies. Pain can affect the chest wall, armpit, side of the body, and upper arm of women and can be intense in many cases. When women experience persistent chest wall and chronic pain after breast cancer surgery, this is often referred to as post-mastectomy pain syndrome (PMPS). This review covers 82 papers found through different online search engines -Google Scholar and PubMed and grouped into pain afte …

29.08.2026journal-article

BMC Medicine

Bladder cancer precision-cut tumor slices (PCTS) preserve functional immune microenvironment enabling ex vivo drug evaluation

Sarah Richtmann, Maja Radak, Viktor Sincic, Jenny Hugoson, Nadja Werner, Valeriia Skoryk, Darcy Wagner, Fredrik Liedberg, Kristina Lundberg

Abstract Background The development of effective cancer immunotherapies is hindered by the lack of preclinical models that faithfully preserve tumor-immune interactions. Current approaches provide limited representation of immune components, creating a critical translational gap between laboratory findings and clinical outcomes. Precision Cut Tumor Slices (PCTS) offer a promising solution by maintaining complete tumor architecture including native immune cell populations and spatial organization. Methods We establi …

29.08.2026journal-article

Polymers

Effects of Heat Treatment on the Mechanical Properties and Thermal Stability of Bamboo

Zilu Liang, Haiyun Jiang, Yimin Tan

Bamboo contains abundant hydrophilic components such as hemicellulose which result in poor interfacial compatibility with epoxy resin and, consequently, limit its application in bamboo–epoxy composite packaging materials. In this study, we subjected bamboo (aged 3–4 years) to vacuum heat treatment to investigate the effects of treatment temperature (140, 160, and 180 °C) and holding time (4 and 6 h) and systematically evaluated the resulting changes in density, surface color, microstructure, mechanical behavior, an …

29.08.2026journal-article

BMC Cancer

Association between gallstones or cholecystectomy and upper gastrointestinal cancer risk: a systematic review and meta-analysis

Fangqing Li, Gwen A. Murphy, Gemma Mortell, Amanda J. Cross, Rhea Harewood

Abstract Background Gallstones and cholecystectomy may be associated with upper gastrointestinal cancer risk but findings from individual studies are inconsistent. We undertook a systematic review and meta-analysis of available evidence. Methods PubMed/MEDLINE and Embase were searched through April 2026 to identify case-control and cohort studies investigating gallstones or cholecystectomy and oesophageal or gastric cancer risk. Random effects models estimated pooled relative risks (RRs) and 95% confidence interval …