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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
24.08.2026journal-article

Frontiers in Surgery

Nutritional supplementation is associated with improved wound reduction during negative pressure wound therapy in complex wounds: a retrospective cohort study

Can Yahya Boztug, Ilgiz Tuzken, Attila Ulkucu, Pinar Ari, Omer Arda Cetinkaya

Background Negative pressure wound therapy (NPWT) is central to the management of complex wounds, but wound contraction and granulation require adequate metabolic substrate. We evaluated the association between nutritional supplementation and wound healing outcomes in patients treated with NPWT. Methods This retrospective cohort study included 48 adults who underwent negative pressure wound therapy for complex wounds. Patients were grouped according to receipt of nutritional supplementation. The primary outcome was …

24.08.2026journal-article

Journal of Acute Care Physical Therapy

Translating Confidence From the Simulation Laboratory to Student Doctor of Physical Therapy Inpatient Practice

Amy J. Rich, Rebecca D. Downey, Melissa C. Hofmann

ABSTRACT Introduction: Patient care in inpatient settings is challenging for health care students and requires adaptive behavioral, cognitive, and technical skills that can be enhanced with simulation-based education (SBE). This study investigates how repeated SBE experiences created in line with the Academy of Acute Care Physical Therapy Core Competencies for Entry-Level Practice in Acute Care Physical Therapy (AACPT-CCACPT) during Doctor of Physical Therapy (DPT) coursework affect self-confidence with patient man …

24.08.2026journal-article

Revista de Geopolítica

O MODELO DE PERÍCIA PSICOLÓGICA EM SAÚDE MENTAL RELACIONADA AO TRABALHO: NOVOS PARÂMETROS PARA MENSURAR DANO PSÍQUICO OCUPACIONAL

Maria Fernanda Mendes Costa, Melquizedec Arcos Rodrigues, Wesley Soares Ramos, Paulo Magnum Sousa Herculano De Lima, Matheus Pessanha Vieira, Marco Sousa Herculano De Lima, Flavio Rui Bezerra De Souza Junior, Danilo Victor do Cazal Quinta

O crescimento dos litígios e das demandas previdenciárias envolvendo o adoecimento mental relacionado ao trabalho tornou a perícia psicológica peça central do sistema de justiça e de proteção social, exigindo um modelo tecnicamente estruturado para mensurar o dano psíquico ocupacional. Este artigo analisa esse modelo, articulando suas etapas, seus instrumentos e os parâmetros de mensuração do dano. Adotou-se revisão integrativa da literatura, de natureza qualitativa, reunindo o referencial da perícia psicológica fo …

24.08.2026journal-article

Nursing in Critical Care

Gamified Cardiopulmonary Rehabilitation in a Child Undergoing LVAD Bridging Therapy to Heart Transplantation: A Case Report

Xiaomin Shan, Jiajia Zhu, Jiajia Li, Xiaomin Tang, Weihong Jiang

ABSTRACT This report details the comprehensive, gamified cardiopulmonary rehabilitation of a 6‐year‐old girl undergoing a complex clinical journey from left ventricular assist device (LVAD) bridge therapy to successful heart transplantation. Given the paucity of standardised protocols for this high‐risk population, a structured, multidisciplinary team (MDT)‐guided pathway was implemented, adapting interventions to the distinct phases of LVAD support and post‐transplant recovery. Key nursing and rehabilitation strat …

24.08.2026journal-article

International Journal of Nusantara Islam

Gap Analysis of Occupational Safety and Health Regulation and Implementation for Non-Healthcare Workers in Healthcare Facilities

Endra Yeni, Happy Yulia Anggraeni

This study analyzes the gap between regulation and implementation regarding occupational health and safety (OHS) protections for non-medical workers (e.g., cleaning staff, security personnel, and administrative staff) in healthcare facilities, grounded in universal labor protection principles. Employing a normative-juridical approach and a systematic literature review, the study examines the legal framework, empirical studies, and academic discourse concerning OHS in the healthcare sector. The findings indicate tha …

24.08.2026journal-article

Current Oncology

Combining Radiation Therapy and Tumor-Infiltrating Lymphocyte Therapy: Biological Rationale, Clinical Synergies, and Future Directions

Sean Maroongroge, Heather M. McGee, Kelly Mahuron, Savita Dandapani, Terence M. Williams, Yan Xing, Myo Htut, Colton J. Ladbury, Yufei Liu, Arya Amini

Tumor-infiltrating lymphocyte (TIL) therapy is the first adoptive cellular therapy approved to treat solid tumors and has demonstrated durable responses in advanced melanoma. However, its clinical implementation is limited by the need for tumor harvesting, manufacturing delays, and lymphodepleting conditioning. These logistic challenges are also opportunities for physicians and scientists to consider combining TIL therapy with radiation therapy (RT), a modality with well-established roles in cancer care. RT exerts …

24.08.2026journal-article

Frontiers in Immunology

Immunosuppressive cells as barriers to cancer therapy: mechanisms and emerging solutions

Mengmeng Liu, Yichen Zhu, Hemiao Liang, Yu Li, Huaimin Liu, Jia Li

Tumor microenvironment-resident immunosuppressive cells-comprising myeloid-derived suppressor cells, regulatory T cells, and tumor-associated macrophages-constitute primary obstacles to effective cancer immunotherapy. Advances in single-cell and spatial multi-omics have uncovered their substantial functional heterogeneity, tissue-adaptive reprogramming, and organ-specific architectures distinguishing primary tumors from metastatic lesions. Beyond canonical immune checkpoint pathways, non-canonical regulatory layers …

24.08.2026journal-article

INTERNATIONAL JOURNAL OF APPLIED SCIENCE AND MATHEMATICAL THEORY

Mathematical Modelling of Terrorism Dynamics and the Impact of Jail and Rehabilitation Interventions

Imrana Jega Aliyu

Terrorism remains a critical global security challenge, causing significant loss of life, economic disruption, and social instability. While previous mathematical models have explored terrorism propagation, few have explicitly incorporated correctional and rehabilitation compartments as explicit control mechanisms. This study develops a deterministic compartmental model extending existing frameworks by integrating jailed and rehabilitated populations. The model stratifies the population into six compartments: Susce …

24.08.2026journal-article

Dermatology Reports

New-onset alopecia areata during calcitonin gene-related peptide inhibitor therapy: first reported case

Luca Valtellini, Mauro Barbareschi, Silvia Mariel Ferrucci, Angelo Valerio Marzano, Andrea Sechi

Dear Editor, Calcitonin gene-related peptide (CGRP) is a neuropeptide with potent vasodilatory effects and a key role in trigeminovascular signaling, underlying the pathogenesis of migraine. Consequently, the inhibition of CGRP activity has been demonstrated to reduce the incidence of acute migraine attacks. Based on this evidence, monoclonal antibodies against CGRP or its receptor have been approved by the European Medicines Agency for prevention of both episodic and chronic migraine. Among CGRP inhibitors, galcan …

24.08.2026journal-article

Frontiers in Public Health

Digital health interventions for reducing occupational burnout in nurses: a systematic review and meta-analysis

Yange Yang, Jinpeng Wen, Hejia Wan, Qiaoju Yang, Jiayi Guan, Lijun Min, Songbo Jia, Zhenzhen Wang, Joston Gary

Objective To systematically evaluate and meta-analyze the effectiveness of digital health interventions (DHIs) in reducing occupational burnout among nurses and nursing staff compared with usual care, waitlist control, or non-digital interventions. Methods Following PRISMA 2020 guidelines, six electronic databases (PubMed/MEDLINE, CINAHL, Embase, Web of Science, PsycINFO, and Scopus) were searched from January 2015 to March 2025 for randomized controlled trials and quasi-experimental studies. Risk of bias was asses …

24.08.2026journal-article

Physiotherapy Research International

Physiotherapy in Mental Health: A Mixed Methods Systematic Review of Practitioner and Student Knowledge, Attitudes, and Perceptions

Farahdina Bachtiar, Chiara Mastrogiovanni, Grace McKeon, Davy Vancampfort, Holly Seale, Dicky C. Pelupessy, Afsana Anwar, Hilmi Zadah Faidullah, Brendon Stubbs, Simon Rosenbaum

ABSTRACT Background and Purpose Mental health physiotherapy is increasingly recognised as a specialised area of practice. Adequate knowledge and positive attitudes are essential for ensuring safe evidence‐based care and for directly influencing the quality of services delivered. Despite this, research on mental health literacy and attitudes within physiotherapy remains fragmented. This study aims to synthesise evidence on the knowledge, attitudes and perceptions of physiotherapists and physiotherapy students regard …

31.08.2026journal-article

International Journal “Speech Genres”

Genre dissipativity of online entertaining literature as a result of direct author – reader communication

Ulyana S. Alekseeva

The networking of literature has led to the growth of the electronic book market and the emergence of many samizdat platforms. Digital technologies have created a zone of close contact between the writer and the reader and the ability to satisfy the needs of even very small audiences. In these conditions, the role of the expert literary community began to blur, the author becomes the publisher of his own books, and the reader – the dictator of narrow thematic preferences. The purpose of the article is to show that …

24.08.2026journal-article

INTERNATIONAL JOURNAL OF APPLIED SCIENCE AND MATHEMATICAL THEORY

The Completeness of Exponential Stability and Patient Recovery Dynamics in Mathematical Rehabilitation

Ogbonna Nnamuchi

This paper investigates the completeness of exponential stability analysis within a nonlinear mathematical rehabilitation framework, emphasizing its implications for patient recovery dynamics. Extending earlier studies that relied primarily on first-order linearization, we develop a fully articulated Taylor series expansion around the recovery equilibrium ( r* ), incorporating higher-order derivatives to capture subtle nonlinear effects. By presenting both operator-level and index-notation expansions, the study enh …

24.08.2026journal-article

European Heart Journal - Quality of Care and Clinical Outcomes

Cardiac rehabilitation programme accreditation and certification: Comparing international practices, mapping standards, benchmarks, and future directions – A scoping review

Lamees Abdullah Mohammed Ali, Asmaa El-Heneidy, Jenna Taylor, Julie Redfern, Robyn Gallagher, Dion Candelaria, Emma E Thomas

Abstract Aims Programme accreditation and certification are key mechanisms for standardising, assuring, and continuously improving the quality of cardiac rehabilitation. Comparative evidence on existing accreditation and certification schemes remains limited. This review compared these schemes to identify key characteristics, standards, convergences, divergences, implementation, and gaps to inform future quality improvement directions. Methods A scoping review following PRISMA-ScR guidelines was conducted searching …

24.08.2026journal-article

Frontiers in Neurology

Group mindfulness-based cognitive therapy associated with reduced professional caregiver burden and improved quality of care in dementia: a multi-method study

Longyun Chen, Bencheng Wang, Ting Li, Nan Li, Xuanxuan Chen, Fei Liu, Tao Lv

Purpose To evaluate the association between an 8-week group Mindfulness-Based Cognitive Therapy (MBCT) program and changes in professional dementia caregiver burden, perceived stress, and patient neuropsychiatric symptoms. Methods This retrospective multi-method study included 94 professional dementia caregivers at a psychiatric hospital in China (intervention: n = 48; control: n = 46). The intervention group participated in an 8-week group MBCT program, while the control group received routine education. Caregiver …

24.08.2026journal-article

Frontiers in Cell and Developmental Biology

Crosstalk of regulated cell death pathways in sepsis-associated acute kidney injury: implications for therapy

Xi-Long Liu, Lei Ma

Sepsis-associated acute kidney injury (SA-AKI) is a common and severe complication in critically ill patients, independently associated with significantly increased mortality and a high risk of progression to chronic kidney disease. The pathogenesis of SA-AKI is complex and involves not only traditional concepts such as renal hypoperfusion, microcirculatory dysfunction, and direct tubular injury, but also, more importantly, the disordered activation of the host immune response. In recent years, regulated cell death …

24.08.2026journal-article

mBio

HMGB1-targeted anti-inflammatory rBox A gene therapy for viral airway infections and systemic inflammatory disease models

Kari Ann Shirey, Daniel Prantner, Lynda Coughlan, Chanhee Park, Lin Zou, Wei Chao, John Joseph, Jorge C. G. Blanco, Stefanie N. Vogel

ABSTRACT High mobility group box 1 (HMGB1) is a host-derived proinflammatory molecule released during cell injury. Elevated extracellular HMGB1 levels have been associated with disease severity. HMGB1 contributes to host influenza responses by stimulating TLR4/MD-2 signaling, amplifying lung inflammation, and tissue damage via cytokine production and leukocyte infiltration. HMGB1 also plays a central role in other inflammatory diseases, including sepsis and liver toxicity, making it both a biomarker of disease seve …

24.08.2026journal-article

Metabolites

The Statin Paradox: Drivers and Consequences of Therapy Discontinuation

Adrianna Dylik, Mikołaj Musiał, Michał Radke, Dominika Tuzimek, Dominika Rogoża, Bartosz Czekała, Anna Wawrzyniak, Nadzeya Zhuk, Katarzyna Skrypnik, Damian Skrypnik

Background: Statins are among the most frequently prescribed medications worldwide, with proven benefits in reducing all-cause and cardiovascular mortality, preventing major adverse cardiovascular events (MACEs), and lowering healthcare costs. Despite their well-established safety and effectiveness, discontinuation of statin therapy remains a common problem in both primary and secondary prevention. Methods: A systematic literature review was conducted in accordance with PRISMA guidelines and registered in the PROSP …

24.08.2026journal-article

Surabaya Physical Medicine and Rehabilitation Journal

From Frozen Shoulder to Nerve Injury: Recognizing Suprascapular Neuropathy in Adhesive Capsulitis

Steven Nanda, Stephanie Theodora Yulinda, Vonny Fibrianty Goenawan

Introduction: Adhesive capsulitis (AC), or frozen shoulder, is a chronic condition characterized by progressive pain and restricted movement due to capsular fibrosis. While its impact is primarily articular, long-standing biomechanical alterations can predispose to secondary complications. Suprascapular neuropathy is an uncommon complication, presenting with weakness and atrophy of supraspinatus and infraspinatus muscles. Case: A 48-year-old man with a 3-month history of left-sided AC presented to the neurology cli …

24.08.2026journal-article

Mini-Reviews in Medicinal Chemistry

Schiff Bases as Multifunctional Agents in Parkinson's Disease Therapy: A Comprehensive Review

Avinash Jha, Deepika Paliwal, Ankush Chauhan, Niranjan Kaushik

Abstract: Parkinson's disease (PD) is an irreversible neurodegenerative disorder leading to movement disorders including trembling, rigidity, and bradykinesia. The majority of these symptoms result from the death of dopaminergic neurons in the substantia nigra. Despite various pharmaceutical and surgical methods like levodopa treatment and neuromodulation being applied, none of them prevent the progression of PD. Various factors, both genetic and environmental (pesticides, head trauma, mitochondrial dysfunction), c …

24.08.2026journal-article

Current Signal Transduction Therapy

From Curiosity to Clinical Relevance: The Expanding Landscape of DTC Genomics

Srusti B.R., Rashmi G.B., Prashant Tiwari, Sunil Kumar Kadiri

Introduction: The direct-to-consumer (DTC) genetic testing industry has grown substantially, enabling consumers to obtain information regarding ancestry, disease predisposition, pharmacogenomics, and various traits without the necessity of healthcare provider intervention. Marketed as tools aimed for democratizing personal health insights, direct-to-consumer genetic tests may improve genetic knowledge, promote preventative healthcare, and encourage proactive health management. Methods: The study utilized medical da …

24.08.2026journal-article

Frontiers in Microbiology

Comparative efficacy and safety of vonoprazan-based dual therapy vs. bismuth-based quadruple therapy for Helicobacter pylori eradication: a GRADE-assessed systematic review and meta-analysis with trial sequential analysis

Alejandro Chen Liang, Yeison Cruz Castillo, Lorena M. Murrieta Bruciaga, Barbara Abreu Lopez, Salma Beltrán Covarrubias, Hector Jonan Flores Uribe, Vanessa Pamela Salolin-Vargas, Gabriela Flores Monar, José García-Corella, Ishaan Kalha, Ernesto Calderon Martinez

Background Helicobacter pylori infects approximately 4. 4 billion individuals worldwide, causing chronic gastritis, peptic ulcer disease, and gastric adenocarcinoma. The 2024 ACG guideline recommends bismuth-based quadruple therapy (BQT) as first-line treatment when susceptibility is unknown, while vonoprazan–amoxicillin (VA) dual therapy is conditionally endorsed as an alternative. Prior meta-analyses included vonoprazan-containing BQT control arms, introducing heterogeneity that may influence comparative efficacy …

24.08.2026journal-article

Frontiers in Pediatrics

Association between the timing of chewable complementary food introduction and functional speech disorders in children: a case-control study

Houbin Li, Guilian Huang, Qiang Qi

Objective To investigate the association between the timing of chewable complementary food introduction and functional speech disorders (FSD) in children, and to identify independent risk and protective factors with a primary focus on quantifying the effect of delayed chewable food introduction. Methods A case-control study was conducted including 90 children diagnosed with FSD and 90 healthy controls aged 2–8 years. Data were collected on demographic characteristics, electronic screen exposure, parent-child intera …