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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
30.08.2026journal-article

European Heart Journal – Cardio-Oncology

Coronary Plaque Burden and Plaque Composition in Long-Term Cancer Survivors: A Comparative CCTA Study

Cheng Hwee Soh, James Hua Wang, Shaun Khanna, Mark Nolan, Sean Tan, Joel Smith, Joshua Wong, Nitesh Nerlekar, Thomas H Marwick

Abstract Background The increased risk of atherosclerotic cardiovascular disease in cancer survivors is not fully elucidated. Understanding the coronary plaque burden and composition in survivors could address this gap. Objectives To determine whether cancer survivorship is associated with greater coronary plaque burden and more adverse plaque than non-cancer controls. Methods This analysis included asymptomatic cancer survivors ≥5 years after therapy and non-cancer controls from prospectively enrolled CT coronary …

30.08.2026journal-article

IPS Journal of Basic and Clinical Medicine

Navigating the Gap: A Review of Time to Treatment Intervals and Cervical Cancer Survival in Sub-Saharan Africa

Bright Odinaka Okorocha, Chigaemezu Remmy-Martin Akubuo, Abdulhafeez Opeyemi Busari, Lovelyn Chiamaka Nnanyereugo, John Perpetual Chimazuru, Confidence Chinaza Ogbomade, Victory Mmerichukwu Ogbatuo

Background: While cervical cancer is highly preventable through the HPV vaccine, early detection, and treatment, it continues to be a significant contributor to the morbidity and mortality of women in Sub-Saharan Africa (SSA). Poorer survival outcomes in SSA compared to high-income countries can, to a large extent, be attributed to patients being unable or unwilling to present to the health system to obtain curative treatment in a timely manner. Time-to-treatment interval (TTI) has gained traction as a key measure …

30.08.2026journal-article

JAMA Internal Medicine

Specialist Referral for Cardiovascular Risk in Patients With Prostate Cancer

Darryl P. Leong, Celestia Higano, Cristina Cano Garcia, Vincent Fradet, D. Robert Siemens, Tamim Niazi, Bobby Shayegan, Avirup Guha, Filipe Cirne, Joseph B. Selvanayagam, Philippe D. Violette, Felipe H. Valle, Luke T. Lavallée, Emmanuelle Duceppe, Patrick Anderson, Denis Xavier, Jose Patricio Lopez-Lopez, Nicolas Villareal Trujillo, Ariel Galapo Kann, Rafaela K. Piccoli, Marina Mourtzakis, David Sarid, Srivatsa Narasimha, Patrick P.W. Luke, Ludhmila A. Hajjar, Himu Lukka, Laurence Klotz, Kumar Balasubramanian, Rajibul Mian, Steven Agapay, Sumathy Rangarajan, Sarah Karampatos, Kelvin K. H. Ng, Alvaro Avezum, P. J. Devereaux, Jehonathan H. Pinthus, RADICAL PC Investigators, Alanna Hall, Meghan Cagnin, Maheen Farooqi

Importance Patients with prostate cancer have a high burden of cardiovascular risk factors, often suboptimally controlled, and adverse cardiovascular outcomes. Objective To determine whether the routine referral of patients with prostate cancer to a cardiovascular specialist to implement a systematic risk factor strategy is more likely to reduce adverse cardiovascular outcomes and improve risk factor control than usual care. Design, Settings, and Participants This randomized clinical trial included patients with pr …

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30.08.2026journal-article

Wilderness & Environmental Medicine

Epinephrine Autoinjectors as an Improvised Treatment for Severe Asthma in Austere Settings

Kenneth V. Iserson

Severe asthma exacerbations may rapidly become fatal when bronchodilator therapy is unavailable. In wilderness and disaster environments, inhaled β 2 -agonists—the standard treatment—may be lost, depleted, or otherwise inaccessible. Epinephrine has been used for more than a century as a bronchodilator and was historically administered subcutaneously or intramuscularly for acute asthma before selective β 2 -agonists became widely available. In emergency medicine, parenteral epinephrine remains an accepted rescue the …

30.08.2026journal-article

Journal of Surgical Oncology

When Explant Surprises: Management and Outcomes of Hepatocellular Carcinoma Beyond Milan Criteria Discovered Post‐Transplant‐ A Narrative Review of Literature

Serkan Sucu, Brian Longbottom, Hassan Aziz

ABSTRACT Liver transplantation (LT) is the definitive treatment for early hepatocellular carcinoma (HCC), based on established criteria. Pre‐transplant imaging occasionally underestimates the tumor burden or biological aggressiveness, leading to explant pathology that exceeds the projection criteria, such as Milan. This paper aims to review the incidence, prognostic implications, post‐transplant management, and outcomes of explant pathology in patients with HCC beyond Milan. We conducted a narrative review of the l …

30.08.2026journal-article

Arthroscopy

Editorial Commentary : Use of Glenoid Labral Augmentation as an Effective Treatment for Subcritical Glenoid Bone Loss

Anthony Zacharias

Abstract Restoration of joint function and mechanics is the goal of every shoulder stabilization surgery. Achieving this goal in the setting of altered anatomy and bone loss is easier said than done. In restoring a joint, it is important to understand what native tissue can be repaired, what can be augmented, or what needs to be reconstructed. For this, we rely on biomechanical research, patient outcomes, and long‐term follow‐up of patients. Bone augmentation procedures have provided a crucial role in shoulder inst …

30.08.2026journal-article

European Heart Journal – Cardio-Oncology

The use of natriuretic peptide to screen for stage B heart failure based on echocardiogram among cancer survivors

Cheng Hwee Soh, Joshua Wong, Guangli Zhu, Atro Azad, Kristyn Whitmore, Thomas H Marwick

Abstract Background and Aims Heart failure is a progressive disorder that can be identified at earlier stage, also known as stage B heart failure (SBHF). While N-terminal pro-B-type natriuretic peptide (NT-proBNP) was shown to be a key biomarker, its screening performance among cancer survivors remains uncertain. This study aimed to identify the performance of NT-proBNP in identifying SBHF, encompassing both structural and functional abnormalities, in survivors. Methods Survivors ≥5 years post cancer therapy and wi …

30.08.2026journal-article

Journal of Clinical Medicine

Comparison of the Effects of Sorafenib and Stem Cell Secretome on HepG2 Cancer Cells with Respect to the Ras/Raf/MEK/ERK Pathway

Aleksandra Gładyś, Aleksandra Skubis-Sikora, Bartosz Sikora, Kinga Pogoda-Mieszczak, Patrycja Wieczorek, Edyta Bogunia, Piotr Czekaj

Background/Objective: Liver cancer is a global health challenge due to its resistance to most systemic therapies. Human mesenchymal and epithelial stem cells exhibit anti-proliferative and pro-apoptotic effects on some cancer cell lines, which can be used to support standard therapy. The aim of this study was to investigate the effects of conditioned media (CM) derived from mesenchymal adipose tissue-derived stem cells (hADSCs) and amniotic membrane-derived cells expressing both mesenchymal and epithelial markers ( …

30.08.2026journal-article

Clinical Medicine (Russian Journal)

Causes of pulmonary bleeding in cancer patients

Roman S. Kiselev, Evgeniy A. Tarabrin, Z. G. Berikkhanov, S. Yu. Muravev, M. Yu. Ivanova

Objective. To analyze the causes of pulmonary hemorrhage (PH) in cancer patients. Material and methods. During the period 2010–2022, pulmonary hemorrhage was treated in cancer patients. The causes of PH were analyzed based on the nosology of cancer diseases. The involvement of the great circle of circulation (GCC) was determined based on the presence of direct or indirect radiological signs of bronchial angiography, the clinical outcome of endovascular treatment for PH, and the results of autopsy. CT of the chest w …

30.08.2026journal-article

Non-Coding RNA

Circulating Cell-Free miR-25-3p Is Upregulated in Brazilian Patients with Prostate Cancer and Contributes to Tumor Aggressiveness

Monyse Nobrega, Hellen Kuasne, Marilesia Ferreira de Souza, Mariana Bisarro dos Reis, Larissa Cristina Bastos de Oliveira, Paulo Emilio Fuganti, Morag Park, Ilce Mara de Syllos Cólus

Background/Objectives: Prostate cancer (PCa) has a high incidence worldwide, yet reliable prognostic biomarkers to distinguish indolent from aggressive forms are lacking. MicroRNAs (miRNAs), a class of small non-coding RNAs, are stable molecules that play an important role in cancer development and can be detected in circulation by non-invasive methods. This study aimed to examine the influence of the cell-free (cf) miRNAs levels on PCa risk and aggressiveness using plasma samples and cell models. Methods: Four ove …

30.08.2026journal-article

Journal of the American Heart Association

Sex Differences in Treatment Effect of Adjunctive Intra‐Arterial Urokinase After Successful Thrombectomy: A Post Hoc Secondary Analysis of the POST‐UK Randomized Clinical Trial

Xuanyu Chen, Linyu Li, Gaoming Li, Lingyu Zhang, Haoxuan Zhu, Xu Xu, Jinfu Ma, Lilan Wang, Zhixi Wang, Jiayu Li, Qiuyi Yang, Yian Chen, Mingyang Chen, Yihui Yang, Yuhan Fan, Kaiyuan Feng, Chunye Chen, Jiaxing Song, Wenjie Zi, Kunxin Lin

Background Whether adjunct intra‐arterial urokinase has differential effectiveness and safety by sex among patients with acute ischemic stroke who achieve near‐complete to complete reperfusion after endovascular thrombectomy (EVT) remains unknown. Methods This post hoc analysis of the POST‐UK (Adjunctive Intra‐Arterial Urokinase After Successful Endovascular Thrombectomy in Patients With Large‐Vessel Occlusion Stroke) multicenter randomized clinical trial included 534 patients with proximal intracranial large‐vesse …

30.08.2026journal-article

AI in Precision Oncology

Governing What We Cannot yet Verify: The Verification Paradox and Responsible AI Implementation in Precision Oncology

Yan Leyfman, Arturo Loaiza-Bonilla

Artificial intelligence (AI) is increasingly embedded in precision oncology, shaping molecular classification, biomarker interpretation, treatment selection, toxicity prediction, trial matching, and disease monitoring—yet institutional governance has not kept pace with clinical adoption. An original cross-sectional survey of U.S. oncology clinicians ( N = 52) reveals a structural governance gap: 83% use AI independently on personal platforms, 71% report no institutional governance policy, and 77% operate without in …

30.08.2026journal-article

Libyan Journal of Medical Research

Study on Ginger as a Treatment for Stress and Anxiety Comparing With Diazepam

Ashraf Alzalitini, Naima El-Kakalli, Wafa Issadiq

Background: The psychological anxiety is considered one of the most significant animals of the modern era. The most common causes natural indictors that lead to tension, severe stress and un-desirable mental problems or disease are stress Anxiety problems or disease that considered as most frequently appearing as disorders. Anxiety disease is diagnosing as condition that showed or indicate to serious and severe or pathological case as the essential disturbance emotional tone. Aim: In this study, ginger was tested i …

30.08.2026journal-article

Molecular Carcinogenesis

Multi‐Omic Analysis of Putative Cellular Senescence‐Associated Genes on the Risk of Pan‐Cancer

Bin Liu, Weidong Wu, Chang Liu, Pengya Feng, Simeng Liu, Shanshan Gong, Yingying Li, Ya Li, Jun Mi, Pengyuan Zheng, Hongtao Wen, Xia Xue, Yang Mi

ABSTRACT Cellular senescence plays a critical role in physiological and pathological processes. This study aims to elucidate the contribution of cellular senescence‐related genes to disease etiology. We investigated a cohort study of 439,501 individuals, which included 22 cancers and 9 non‐cancer diseases. We found that HLA‐E and HLA‐G ‐associated senescence in epithelial and immune cells were specific oncogenic factors for prostate and lung cancers. MAP2K4 was implicated as a risk factor for breast cancer, while Z …

30.08.2026journal-article

Advanced Science

GSTM4 Suppresses Prostate Cancer Progression by Targeting TRIM27‐mediated ACLY Ubiquitination and Lipid Metabolism

Kang‐Ping Xiong, Fei Liu, Wang Wang, Gang Wang, Kai‐Yu Qian, Sheng Tu, Si‐Ming Chen, Hui‐Min Xu, Shan‐Shan Zhang, Yong Li, Xing‐Huan Wang, Hong Weng

ABSTRACT Prostate cancer (PCa) is a prevalent malignancy in men, and lipid metabolic reprogramming contributes to its progression and therapeutic resistance. However, the drivers of lipid metabolic dysregulation in PCa remain incompletely defined. Through transcriptomic sequencing of PCa patient tissues, we identified glutathione S‐transferase mu 4 (GSTM4) as a novel regulator of lipid metabolism. GSTM4 was significantly downregulated in PCa tissues and negatively correlated with triglyceride content. Functionally, …

30.08.2026journal-article

Small

Poly (Lipoic Acid) Nanoparticles With High Blood‐Brain Barrier Permeability and Enhanced Anti‐Ferroptotic Activity for Ischemic Stroke Treatment

Qing‐Zhang Tuo, Juan Tan, Hong‐Fa Yan, Xueying Zhou, Peng Lei, Shiyong Zhang

ABSTRACT Lipoic acid (LA) scavenges free radicals and was clinically tested for ischemic stroke. However, the short half‐life and weak efficacy in penetrating the blood‐brain barrier (BBB) limit its use in the brain. Here, we developed poly (lipoic acid) nanoparticles (pLANs) with a half‐life of more than 15 h and a high efficiency to penetrate the BBB for ischemic stroke treatment. With intraperitoneal injection, imaging studies using fluorescently labelled pLANs of different sizes revealed that 30 nm pLANs entere …

30.08.2026journal-article

Health Science Reports

Temporal Trends in Colorectal Cancer Associated With Type 2 Diabetes Mellitus in U.S. Adults, 1999–2023: A CDC Wonder Database Analysis—A Population‐Based Cross‐Sectional Study

Waleed Tariq, Neha Waseem, Mehreen Maka, Bushra Ubaid, Sheetal Verma, Yusra Ejaz, Maryam Owais, Awais Tariq, Soha Waseem, Iftikhar Khan, Ehsanullah Alokozay, Muhammad Hassan Tariq, Shahzaib Ahmed, Shoaib Ahmad

ABSTRACT Background and Aims Colorectal cancer (CRC) and type 2 diabetes mellitus (T2DM) are significant contributors to global morbidity and mortality, with growing evidence suggesting a synergistic impact on disease outcomes. This research focused on analyzing trends in CRC‐related deaths among individuals with coexisting T2DM in the United States from 1999 to 2023, as well as exploring disparities among different demographic and geographic groups. Methods Data were obtained from the CDC WONDER database for death …

30.08.2026journal-article

International Journal of Molecular Sciences

Metformin Suppresses Metastatic Potential and Sensitizes Ovarian Cancer Cells to Chemotherapeutics

Megha J. Pandya, Ayokunnumi Ogunsanya, Adedoyin Ajibade, Achuth Padmanabhan

The failure of current therapeutics to elicit a durable response in metastatic ovarian cancer patients highlights the urgent need to develop more effective treatment strategies. In this study, we demonstrate that the anti-diabetic drug metformin exerts cytotoxic effects across a broad panel of ovarian cancer cell lines. Transcriptomic analyses revealed that, in addition to reducing cell viability and proliferation, metformin modulates pathways associated with metastatic progression, including cell migration, extrac …

30.08.2026journal-article

MedComm

Migraine: Epidemiology, Risk Factors, Pathophysiology, and Treatment

Weiwei Lu, Yuan Zhang, Chen Shi, Yu Tao, Shaoxin Li, Yufang Sun, Fuhai Ji, Dongsheng Jiang, Terrance P. Snutch, Jin Tao

ABSTRACT Migraine is a common, disabling brain disorder that affects about 1 billion people worldwide and disproportionately burdens women and working‐age adults. Once viewed mainly as a vascular headache, migraine is now understood as a heterogeneous neurobiological syndrome arising from interactions among genetic susceptibility, hormonal influences, environmental exposures, and cortical, brainstem, trigeminovascular, and neuroinflammatory networks. Although calcitonin gene‐related peptide (CGRP)‐pathway therapies …

30.08.2026journal-article

Cancer Medicine

Target‐Specific Dermatological Adverse Event Reporting With T‐Cell–Engaging Bispecific Antibodies: A Pharmacovigilance Analysis of FAERS and Canada Vigilance, 2016–2026

Saikat Mandal, Manideepa Maji, Arkadeep Dhali

ABSTRACT Background T‐cell–engaging bispecific antibodies are increasingly utilised in haematological malignancies and are beginning to be adopted in solid‐tumour treatment protocols. Cytokine release syndrome and neurotoxicity are well recognised, but target‐specific dermatological adverse event reporting patterns remain poorly defined. Methods We analysed 12,333,305 deduplicated FAERS reports from 2016Q1 to 2026Q1, including 23,386 reports exposed to ten T‐cell–engaging bispecific antibodies grouped by target: CD …

30.08.2026journal-article

Cancer Medicine

The Molecular and Immunological Landscape in Nasopharyngeal Carcinoma ( NPC ) Differs by Somatostatin Receptor 2 ( SSTR2 ) Expression

Dara Bracken‐Clarke, Elisabetta Xue, Harris Krause, Tolulope Adeyelu, Mark G. Evans, Dilara Akbulut, Martha Quezado, Nishant Gandhi, Alex Farrell, Heloisa P. Soares, Emil Lou, Minh Phan, Rusha Patel, Ari M. Vanderwalde, Andrew Elliott, Conor E. Steuer, Nabil F. Saba, Daniel J. Lubin, Nyall R. London, James L. Gulley, Charalampos S. Floudas

ABSTRACT Somatostatin receptor 2 is expressed in nasopharyngeal carcinoma (NPC). We report genomic and transcriptomic analysis results of 163 NPC cases, demonstrating that somatostatin receptor 2 ( SSTR2 ) gene expression in EBV‐positive and in EBV‐negative NPC correlated with genomic alterations and an inflamed microenvironment. Median SSTR2 expression was 6.52 transcripts per million (TPM), ranging from 0.59 TPM (Quartile 1 [Q1], 18.2% EBV‐positive) to 35.79 TPM (Q4, 82.9% EBV‐positive). PIK3CA (20.51%) and CYLD …

30.08.2026journal-article

Journal of Artificial Intelligence and Information

Research Progress of Xuefu Zhuyu Decoction and Its Single Herbs in the Treatment of Coronary Heart Disease

Huan Zhang, Junru Zhang, Yiman Zhang, Danlei Mao

Coronary atherosclerotic heart disease, abbreviated as coronary heart disease (CHD), is a chronic cardiovascular disease and one of the major diseases threatening the life and health of populations worldwide. Its morbidity and mortality rates are on the rise. In recent years, CHD has also shown a trend of affecting younger individuals, making long-term treatment and management critically important. In traditional Chinese medicine (TCM), CHD falls under the category of “chest stuffiness and heart pain” (xiongbi xint …

30.08.2026journal-article

Mini-Reviews in Medicinal Chemistry

Regulation of PI3K Signaling by lncRNAs in Breast Cancer: A Mini-Review

Azita Asadi, Mehran Molavand, Bahman Yousefi

Despite remarkable advancements, the treatment of breast cancer remains a serious challenge. In recent decades, extensive studies have been conducted to identify new therapeutic targets for the treatment of breast cancer. Among these therapeutic targets that have gained attention in recent years are lncRNAs. These molecules appear to affect proliferation, metastasis, and drug resistance in cancer cells by regulating multiple signaling pathways. Among the signaling pathways implicated in breast cancer, the PI3K/AKT/ …

30.08.2026journal-article

Precision Radiation Oncology

Precise delineation of radiation targets for thoracic tumors in the immunotherapy era: from immune mechanisms to clinical practice

Xiaoying Chen, Minxiao Yi, Yu Deng, Qian Shen

Abstract As a core modality for local control of thoracic tumors, including lung and esophageal cancers, radiotherapy (RT) shows synergistic effects with immunotherapy, fundamentally reshaping the landscape of cancer treatment. Given the rapid advancements in immunotherapy, this review explores the critical role of precise delineation of radiotherapy targets in achieving synergistic effects between RT and immunotherapy. It elucidates the dual‐edged nature of RT, which can both activate antitumor immune responses an …