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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
30.08.2026journal-article

Journal of Clinical Medicine

Association of PI-RADS Score with Clinically Significant Prostate Cancer and Histopathological Upgrading in Patients Undergoing Radical Prostatectomy: A Retrospective Single-Centre Study

Hubert Andrzej Krzepkowski, Tomasz Ząbkowski, Andrzej Wieczorek, Maciej Walędziak, Tomasz Waldemar Kamiński, Hubert Dąbrowski, Tomasz Syryło

Background and Objectives: Multiparametric magnetic resonance imaging (mpMRI) is widely used in prostate cancer diagnosis, but biopsy findings may still underestimate tumor aggressiveness. This study evaluated the association of Prostate Imaging Reporting and Data System (PI-RADS) assessment with clinically significant prostate cancer (csPCa) and histopathological upgrading after radical prostatectomy. Methods: The retrospective analysis comprised 564 patients who underwent mpMRI–transrectal ultrasound fusion-guide …

30.08.2026journal-article

International Journal of Stroke

Clinical Outcomes among Patients with Active Cancer and Acute Ischemic Stroke Treated with Antiplatelet versus Anticoagulant Therapy.

Gianluca Costamagna, Andreas Hottinger, Francoise Livio, Babak Benjamin Navi, Davide Strambo, Patrik Michel

Background: Patients with acute ischemic stroke (AIS) and active cancer (AC) face high risks of recurrent stroke and death. Evidence guiding antithrombotic selection remains limited. Aims: To investigate post-AIS prescribing patterns of antiplatelet versus anticoagulant therapy in AIS patients with AC and their associated clinical characteristics and outcomes. Methods: We retrospectively analyzed 2003–2024 data from the Acute-Stroke-Registry-and-Analysis-of-Lausanne (ASTRAL). We included patients with AC discharged …

30.08.2026journal-article

Open Access Indonesian Journal of Medical Reviews

Preoperative Sarcopenia and Major Postoperative Complications After Gastrectomy for Gastric Cancer: Does Adding Muscle Function to Muscle Mass Improve Risk Prediction? A Systematic Review and Meta-Analysis

I Putu Oktayana, Gregorius Iwan Budiman Bomba, Nugroho Sofian Aji

Background: Consensus bodies define sarcopenia by low muscle mass plus impaired function, yet most gastrectomy studies use computed-tomography muscle mass alone. Whether adding function improves prediction of major postoperative complications remains uncertain. Objective: To quantify the association between preoperative sarcopenia and major complications after gastrectomy for gastric cancer and compare function-inclusive with imaging-mass-only definitions. Case presentation: This systematic review and meta-analysis …

30.08.2026journal-article

Advanced Science

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu

ABSTRACT Recurrence and progression remain major clinical challenges in bladder cancer (BC), yet the mechanisms linking glycolysis to persistent malignant states remain incompletely defined. Here, we identify alanyl tRNA synthetase 1 (AARS1) as a clinically relevant driver of aggressive and recurrent BC. AARS1 is upregulated in BC tissues, enriched in muscle invasive and recurrent tumors, and associated with unfavorable survival. Functionally, AARS1 promotes proliferation, epithelial mesenchymal transition, invasio …

30.08.2026journal-article

Advanced Science

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

Peng Jun Xu, Zhou Jing Zhang, Jing Jin, Hai Yuan Xu, Ya Xin Gu, Qian Qian Yang, You Lang Zhou

ABSTRACT Chimeric antigen receptor (CAR)‐engineered cell therapies are being extended from hematological malignancies to autoimmune, inflammatory, and fibrotic diseases, although the maturity of evidence differs markedly among platforms and indications. Early clinical evidence from case reports, small case series, and early‐phase trials suggests that CD19‐ or BCMA‐directed CAR‐T cells can induce deep B‐cell or plasma‐cell depletion and sustained remission in selected patients with refractory autoimmune diseases; ho …

30.08.2026journal-article

Сибирский научный медицинский журнал

CRISPR/Cas9 technology in oncology: mechanisms, applications, and future perspectives

M. A. Omarov, E. I. Karacheva, M. M. Arapieva, K. S. Ulyumdzhiev, V. A. Deiko, I. M. Batyrshin

The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology is a cutting-edge genome editing tool based on the adaptive immune mechanism of prokaryotes. This system, which operates through three key stages‒adaptation, expression, and interference‒offers high precision and efficiency in genetic modification. This article explores the mechanisms of CRISPR/Cas action and its applications in hematologic malignancies, breast cancer, colorectal cancer, gastric cancer, and lung cancer. Genome editing …

30.08.2026journal-article

Genes

The Inhibition of Histone Lysine Demethylases Affects Head and Neck Cancer Cell Growth and Response to Cisplatin

Dawid Dorna, Robert Kleszcz, Violetta Krajka-Kuźniak, Jarosław Paluszczak

Background/Objectives: Head and neck squamous cell carcinomas (HNSCC) are a heterogenous group of tumors, which are usually treated with surgery and radiotherapy, while chemotherapy (e.g., cisplatin), anti-EGFR, or immune checkpoint inhibitors are used to treat locoregionally advanced and recurrent cases. However, survival outcomes are still unsatisfactory, and novel augmenting treatments are required. Recently, histone lysine demethylases (KDMs) emerged as promising anti-cancer targets. In order to further charact …

30.08.2026journal-article

International Journal of Computer Information Systems and Industrial Management Applications

ADVANCED DEEP LEARNING TECHNIQUES FOR BRAIN TUMOR SEGMENTATION AND CLASSIFICATION

Akash Dudhe, Prakash G. Burade

Problems with uncontrolled cell growth in the human body are a major cause of cancer, like brain cancer, which occurs in the brain or the nervous system. Tumours are categorised as benign or malignant and are defined by cellular activity and structure. Cancerous tumours are invasive and might require surgical removal, so early and accurate diagnosis is crucial. A radiologist-based diagnosis manually is time-consuming and error-prone, especially in denseness regions. This work aims to solve this problem through the …

30.08.2026journal-article

Health Science Reports

Sexual Silence in Breast Cancer Survivorship: A Secondary Qualitative Study of Healthcare Practices and Sexual Concerns

Mina Esmkhani, Charrlotte Seib, Armin Ariana

ABSTRACT Background and Aims In routine breast cancer follow‐up care, sexual concerns are rarely discussed, shaping how women understand and respond to post‐treatment changes. This study examined how survivorship care practices influence the expression and recognition of sexual concerns among women after breast cancer treatment. Methods This study employed a qualitative secondary analysis of semi‐structured interview data from 31 women aged 32–72 years who had completed primary treatment for breast cancer in Austra …

30.08.2026journal-article

Dermatitis®

Reasons for Upadacitinib Discontinuation and Risk of Recurrence in the Treatment of Atopic Dermatitis

Yuxin Luo, Ziyi Zhang, Shu Ding, Li Lei, Jing Chen

Background: Treatment discontinuation is common with Janus kinase inhibitors, such as upadacitinib, in moderate-to-severe atopic dermatitis (AD), and this often results in disease relapse and an increased patient burden. Objective: To explore reasons for discontinuation, risk factors, and willingness to reuse upadacitinib. Methods: This retrospective study enrolled 104 patients with AD (50 in the discontinuation, 54 in the non-discontinuation) from Xiangya Third Hospital (Feb–Mar 2026). Data on DLQI, pruritus NRS, …

30.08.2026journal-article

Molecular Carcinogenesis

Spatial Genetic Mapping of Normal Human Prostate Tissue Identifies Epithelial Compartments Enriched for Prostate Cancer Association

Shuai Liu, Owen T. M. Chan, Hua Zhong, Ali Shahabi, Lang Wu, Jingjing Zhu

ABSTRACT Previous genome‐wide association studies have identified more than 400 prostate cancer (PCa) susceptibility loci. However, the tissue and spatial epithelial contexts through which inherited PCa risk may operate in the normal prostate remain incompletely understood. We analyzed normal human prostate spatial transcriptomic data using a gsMap‐based framework to localize PCa association signals across spatially resolved prostate compartments. Spatial spots were clustered using SpaGCN and then manually curated …

30.08.2026journal-article

VIEW

Biopolymer‐Based Polyelectrolyte Nanoplatforms for Targeted Photodynamic Therapy of Breast Cancer

Athira Narayanan, Benedetta di Chiara Stanca, Daniela Pinheiro, Laura Giannotti, Fabrizio Damiano, André Ferreira Moreira, Sónia Miguel, Leonardo Lamanna, Eleonora Stanca, Maria Grazia Raucci, Gianpiero Colangelo, Luisa Siculella, Alessandro Sannino, Paula Coutinho, Christian Demitri

Abstract Nanomedicine has reshaped healthcare, especially in targeted drug delivery systems (DDSs) and diagnostics, addressing the limitations of traditional cancer therapies. Integration of photodynamic therapy (PDT) with nanoparticle‐based DDSs has significantly improved the targeted accumulation and pharmacokinetic properties of photosensitizers within tumor cells, enabling selective tumor cell death while sparing healthy tissues. This study developed chitosan‐sericin polyelectrolyte nanoparticles (CSSN NPs) via …

30.08.2026journal-article

Iraqi Journal of Science

Classifying High-Dimensional Lung Cancer Data Using an Improved Deep Learning Model

Sarab M. Hameed, Dhuha Abdulhadi Abduljabbar

Anomalous cell growth, known as cancer, can cause tumors, weaken the immune system, and cause fatal complications. Early detection of cancer makes treatment easier and contributes to lower mortality rates. Gene expression data contributes crucially to the classification of cancer in its early stages. Accurately classifying cancer is a complex problem because gene expression data is high-dimensional compared to the limited number of samples. This research proposes an improved Deep Learning model that integrates both …

30.08.2026journal-article

Jurnal Kejuruteraan

Effect of Hot Water Treatment on Physical and Mechanical Properties of Oil Palm Empty Fruit Bunch Fibre Cement Boards

Nurul Huda Azmi, Mohammad Soffi Md Noh, Nik Mohd Zaini Nik Soh

The growing demand for sustainable construction materials has increased interest in fibre–cement composites reinforced with natural fibres. Oil palm empty fruit bunch (OPEFB) is an abundant agricultural by-product with strong potential for fibre cement boards. However, its hydrophilic nature and weak fibre–matrix adhesion limit dimensional stability and mechanical performance. While hot water treatment has been shown to improve fibre compatibility, most studies have focused only on untreated, 60°C, and 100°C condit …

30.08.2026journal-article

Cancers

A Logistic Regression Model Integrating Flow Cytometry−Derived Immune Cell Profiles and Hematological Parameters for Preoperative Prediction of Peritoneal Metastasis in Gastric Cancer

Ruihu Zhao, Yuming Ju, Zhichao Yu, Yingwei Xue, Hongjiang Song

Background: Peritoneal metastasis (PM) is a lethal and often occult event in advanced gastric cancer (GC), and its preoperative detection remains difficult. The role of peripheral NK and NKT−like cells in predicting PM has not been well defined. Methods: We retrospectively analyzed 433 patients who underwent surgery for GC from 2016 to 2020. Patients were stratified by PM status and randomly assigned to training and held−out internal validation cohorts. Flow cytometry−derived lymphocyte subset percentages were trea …

30.08.2026journal-article

Aggregate

Dual‐Acceptor Engineered Multimodal Phototheranostic NIR‐II AIEgens for Orthotopic Breast Cancer Treatment

Miaomiao Kang, Yu Pei, Zengming Yang, Yinzhen Pan, Zhijun Zhang, Xue Li, Dong Wang, Ben Zhong Tang

ABSTRACT “One‑for‑all” phototheranostics has emerged as a promising alternative to conventional cancer therapies. Aggregation‑induced emission luminogens (AIEgens) are exemplary templates for constructing such versatile systems. However, developing robust NIR‑II (1000–1700 nm)‐emitting “one‑for‑all” phototheranostic AIEgens remains challenging, due to the drastically lowered reactive oxygen species (ROS) generation capability and strong intermolecular π‐π stacking in the NIR‑II range. To address this, an ingenious …

30.08.2026journal-article

Jurnal Kejuruteraan

Influence of Bitumen Chemistry and Crumb Rubber Pre-Treatment on the Storage Stability and Rheological Performance of Modified Binders

Naeem Aziz Memon, Nur Izzi Md. Yusoff, Ahmed Suliman B. Ali, Warid Wazien, Aawag Mohsen Alawag, Zubair Ahmed Memon, Shabir Hussain Khahro

The incorporation of crumb rubber (CR) into bitumen offers significant performance and sustainability advantages, yet its widespread adoption is impeded by poor storage stability caused by thermodynamic incompatibility. To address this fundamental challenge, this study investigates the role of bitumen chemistry, specifically the balance of fractions determined via SARA analysis, and the efficacy of crumb rubber pre-treatment in creating a stable binder system. Two base bitumen with distinct chemical compositions (P …

30.08.2026journal-article

Journal of Artificial Intelligence and Information

Research Progress on the Use of Yue ju Pill in the Treatment of Functional Dyspepsia

Jianing Ma, Hui Ding

Yueju Pill are derived from *Danxi Xinfa*; the formula comprises Atractylodes lancea, Cyperus rotundus, Ligusticum chuanxiong, Shenqu and Gardenia jasminoides, and is primarily indicated for relieving various forms of stagnation. Later generations of medical practitioners have also extended its use to treat disorders of the digestive and nervous systems, amongst others. This article provides a systematic review of the progress made in clinical and basic research on Yueju pill in the treatment of functional dyspepsi …

30.08.2026journal-article

Cancer Science

Adding Intratumoral Antibody‐Photoabsorber Conjugate Improves Efficacy of Near‐Infrared Photoimmunotherapy ( NIR ‐ PIT )

Miyu Kano, Aki Furusawa, Seiichiro Takao, Makoto Kano, Motofumi Suzuki, Hiroshi Yamamoto, Shuhei Okuyama, Ko Kitamura, Peter L. Choyke, Hisataka Kobayashi

ABSTRACT Near‐infrared photoimmunotherapy (NIR‐PIT) is a new type of cancer treatment that specifically kills target cells while sparing normal tissue. This treatment induces cancer cell death by activating a photoreactive dye with near‐infrared light in an antibody‐photoabsorber conjugate (APC) bound to the cognate target antigen on the tumor cell surface. NIR‐PIT has already been clinically applied in Japan to head and neck cancer patients using an anti‐EGFR antibody‐IR700 dye conjugate, with very promising resul …

30.08.2026journal-article

Bipolar Disorders

Optimizing Ketamine Infusion Therapy for Treatment‐Resistant Bipolar Depression: Commentary on Zhou et al. (2023)

Chih‐Cheng Lin, Lien‐Chung Wei

ABSTRACT Objectives To contextualize the real‐world findings of repeated intravenous ketamine infusions for treatment‐resistant bipolar depression (TRBPD) and identify priorities for safer, more durable clinical implementation. Methods We provide a focused commentary on Zhou et al. (2023) and integrate selected evidence concerning inflammatory and metabolic correlates, neurocognitive outcomes, and continuation‐phase ketamine treatment. Results Repeated subanesthetic ketamine infusions may rapidly improve depressive …

30.08.2026journal-article

The Laryngoscope

Beyond TNM : Tumor Volume as a Prognostic Marker in Laryngeal Cancer

Daniel Uralov, Chiara Iovine, Luciana Di Cristina, Alberto Paderno, Caterina Giannitto, Luca Canali, Federica Gullà, Elena Tosi, Marco Dassie, Marcello Rodari, Maria Ausilia Teriaca, Fabio Ferreli, Paolo Bossi, Ciro Franzese, Giuseppe Spriano, Francesca Gaino, Giuseppe Mercante

ABSTRACT Objectives The objective of this study is to determine whether radiologic tumor volume adds prognostic value for overall survival (OS) and disease‐free survival (DFS) in laryngeal squamous cell carcinoma (LSCC) and to evaluate associations with T stage, nodal status, histologic grade, subsite, and treatment modality. Methods Patients with cT2–T4 LSCC treated with curative intent between 2018 and 2024 were included. Tumor volumes derived from CT, MRI, or radiotherapy planning contours were analyzed as conti …

30.08.2026journal-article

International Journal of Human and Health Sciences (IJHHS)

The Submandibular Tumor: Unmasking a Rare Hypoglossal Schwannoma

Mohd Naqiuddin Mohd Najib, Norsyamira Aida Mohamad Umbaik, Nur Asyilla Che Jalil, Norhafiza Mat Lazim

Hypoglossal schwannoma(HS) is a rare benign tumor of the twelfth cranial nerve, and its extracranial presentation can closely resemble a submandibular gland mass. We report a patient with a painless, gradually enlarging left submandibular swelling initially thought to arise from the submandibular gland. Imaging revealed an enlarged left submandibular gland containing a well-defined, heterogeneous lesion and fine-needle aspiration(FNAC) suggested pleomorphic adenoma(PA). Surgical excision via a transcervical approac …

30.08.2026journal-article

Ukrainian Heart Journal

Оцінка ефективності й безпечності використання аксилярної канюляції при хірургічному лікуванні патології грудної аорти

O. V. Zelenchuk

The aim – to evaluate the efficacy and safety of direct axillary artery cannulation during reconstructive surgery for thoracic aortic disease by comparing intraoperative parameters, early clinical outcomes, and the incidence of neurological and local complications with those of femoral artery cannulation.Materials and methods. The study included 110 patients who underwent reconstructive surgery for thoracic aortic disease between 2016 and 2025 using peripheral arterial cannulation. Femoral artery cannulation was pe …

30.08.2026journal-article

International Journal of Computer Information Systems and Industrial Management Applications

A Novel 3D Hybrid Transformer-Dense Segmentation Network with Adaptive Capsule-LSTM Classification for Early-Stage Lung Cancer Detection on Kaggle CT Images

Shafiulla Shariff, Avinash K G

Background: Early lung cancer detection from CT scans is critical yet challenged by volumetric complexity and multi-site acquisition heterogeneity in benchmarks such as Kaggle Data Science Bowl 2017 (DSB 2017).Methods: We present HybridSeg-Net comprising: (1) 3D-HTDSeg with novel Attention-Modulated Dense Skip (AMDS) connections applying axial self-attention transformer blocks directly onto skip tensors; (2) ACaps-LSTM combining adaptive dynamic routing capsule encoding with bidirectional LSTM; (3) IQHO — Intensity …