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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
30.08.2026journal-article

Ukrainian Heart Journal

Ізольована дисекція верхньої брижової артерії: ендоваскулярне лікування. Клінічний випадок

S. M. Furkalo, Yu. H. Vahis, A. O. Danylets

The aim – to describe a case of elective endovascular treatment of asymptomatic spontaneous isolated dissection of the superior mesenteric artery with a self-expanding covered stent via right transbrachial access and to justify the indication for intervention based on morphological risk criteria.Materials and methods. The follow-up of a 67-year-old man with coronary artery disease, compensated type 2 diabetes mellitus, arterial hypertension, dyslipidaemia and previous left total hip arthroplasty is presented. The d …

30.08.2026journal-article

Eskisehir Medical Journal, Eskisehir City Hospital

TREATMENT STRATEGY AND INTERVENTION TIMING IN ELDERLY PATIENTS WITH ACUTE MESENTERIC ISCHEMIA: A MULTICENTER RETROSPECTIVE COHORT STUDY

Mehmet Emin Gonullu, Ahmet Tugrul Zeytin, Gurkan Guneri, Kadir Corbaci, Mucahit Unal, Fatih Gursoy, Erman Yekenkurul

Introduction: This study aimed to evaluate the association between treatment modality, intervention timing, and clinical outcomes in patients aged 65 years or older with acute mesenteric ischemia (AMI). Methods: This multicenter retrospective cohort study included 126 patients aged 65 years or older who were diagnosed with AMI between January 2015 and December 2025. Patients were classified according to treatment modality as endovascular treatment, open surgery, or conservative management. The primary outcome was 3 …

30.08.2026journal-article

Anatolian Journal of Health Research

The relationship between infertility stress, coping, and quality of life among women undergoing infertility treatment

Büşra Çark, Seyhan Çankaya, Ümmügülsüm Esenkaya

Aim: This study aimed to examine the relationships between infertility-related stress, coping strategies, and quality of life among women undergoing infertility treatment. Methods: This descriptive, cross-sectional study was conducted between April-November 2025 with 200 women attending an infertility outpatient clinic at a city hospital in Central Anatolia, Türkiye. Data were collected using a Personal Information Form, the COMPI Fertility Problem Stress Scales, the COMPI Coping Strategy Scales, and the Fertility …

30.08.2026journal-article

European Heart Journal

Safety of withdrawal of pharmacological treatment after recovery from HER2 therapy-related cardiac dysfunction: the HER-SAFE trial

B Dowsing, H-M Dehbi, M S Andres, R Chung, A Oashou, J M Wilson, I Hussein, B Meredith, I Pierce, S Ahmed, J Pedra, O Worn, M Howe, S Assadullah, P Schmid, R Roylance, T Crake, M Westwood, A K Ghosh, D Auger, C M Plymen, J Baksi, M S Nazir, J C Moon, D Chen, A R Lyon, J M Walker, C H Manisty

Abstract Background Heart failure therapy (HFT) is routinely continued in breast cancer survivors after recovery from anti-HER2 cancer therapy-related cardiac dysfunction (CTRCD), despite limited evidence. HER-SAFE is the first randomised trial to assess HFT withdrawal in this population. Methods In this open-label, multicentre, randomised controlled trial, breast cancer survivors with recovered anti-HER2 CTRCD (asymptomatic, left ventricular ejection fraction [LVEF] ≥50%, normalised biomarkers) were randomised to …

30.08.2026journal-article

MedComm

Artificial Intelligence Integration With Nanotechnology for Cancer Therapy

Shengbin Liu, Zhi Liu, Haixing Shi, Chengyi Wei, Ruijie Zhang, Xiangrong Song

ABSTRACT Cancer nanomedicine offers a versatile platform for improving therapeutic index, but its clinical translation remains limited by unpredictable in vivo behavior, heterogeneous biological contexts, and inefficient design paradigms. Artificial intelligence (AI) is emerging as an integrative framework that links data‐driven modeling with nanomedicine design, biological transport, and clinical decision‐making. In this review, we discuss AI‐guided strategies for material design, targeting, payload optimization, …

30.08.2026journal-article

Phlebology: The Journal of Venous Disease

Clinical treatment strategies and perioperative management of restenosis or secondary deep venous thrombosis after iliac vein balloon angioplasty

Zi-shuo Yang, Shuang-jie Tang

Objective To explore the surgical selection of iliac vein balloon angioplasty, as well as the treatment and management of postoperative complications including restenosis and secondary deep venous thrombosis. Methods All 55 enrolled patients received routine telephone follow-up, and imaging reexamination and statistical analysis were only performed on 10 patients complicated with restenosis or secondary thrombosis after balloon angioplasty. Conclusion This study provides reference basis for the selection of clinica …

30.08.2026journal-article

Medicina

Radiotherapy Modality and Primary Tumor Type as Determinants of Outcomes in Brain Metastases: A Retrospective Study of 734 Patients

Lucie Hnidakova, Andrea Pagacova, Sarka Kristkova, Jan Svancara, Ludmila Hynkova, Petr Pospisil, Renata Belanova, Jana Maistryszinova, Radek Lakomy, Tomas Prochazka, Miroslav Vrzal, Jiri Sana, Radim Jancalek, Martin Smrcka, Ivana Kolouskova, Lukas Moran, Katerina Prochazkova, Vera Andraskova, Jan Garcic, Pavel Slampa, Pavel Fadrus, Tomas Kazda

Background and Objectives: Radiotherapy (RT) is a standard component of palliative treatment for brain metastases. The aim of this retrospective analysis of consecutive patients treated between 2017 and 2023 is to analyze overall survival after brain radiotherapy depending on the type of radiotherapy delivered and to monitor the shift from whole-brain radiotherapy (WBRT) to stereotactic radiotherapy (SRS/FSRT) in real-world practice before the era of routinely used modern brain-penetrant targeted therapy. Materials …

30.08.2026journal-article

Cancer Medicine

Chronic Kidney Disease in Children Within Five Years After Ifosfamide Chemotherapy for Childhood Cancer: A Dutch Pediatric Oncology Cohort Study

Lotte Pitlo, Francis S. P. L. Wens, Paulien A. M. A. Raymakers‐Janssen, Lianne M. Haveman, Johannes H. M. Merks, Martine van Grotel, Geert O. Janssens, Marta Fiocco, Marry M. van den Heuvel‐Eibrink, Gerrit van den Berg

ABSTRACT Introduction Children treated with ifosfamide seem to have an increased risk for developing chronic kidney disease (CKD) already within the first years following chemotherapy. However, studies investigating CKD prevalence in this specific phase are scarce. This study aimed to determine the prevalence, course, and determinants of CKD in ifosfamide‐treated children within the first five years after chemotherapy. Methods This cohort study included children treated with ifosfamide at the Princess Máxima Center …

30.08.2026journal-article

Cellular Oncology

The role of hSSB1 and hSSB2 in the DNA damage response: mechanisms and implications

Armin Sharifi, Amila Suraweera, Kenneth J. O’Byrne, Derek J. Richard

Abstract The DNA damage response preserves genome integrity by detecting DNA lesions, activating checkpoint signalling, and coordinating repair with cell-cycle control. Defective or incomplete repair can promote mutation accumulation, chromosomal instability, cancer development, and ageing-associated diseases. In this review, we discuss the human single-stranded DNA-binding proteins hSSB1 and hSSB2, with an emphasis on their roles in ssDNA-rich repair intermediates generated during double-strand break repair, repli …

30.08.2026journal-article

Frontiers on Healthcare Research

What Explains the Survival Gap? Decomposing Cross-National Inequality in Breast Cancer Mortality-to-Incidence Ratios Using Open Global Data Repositories

Graduate Institute of Translational Medicine and New Drug Development, College of Medicine, China Medical University, Taichung, Taiwan, Siti Mardhiah El-Khairah Siti Mardhiah, Department of Epidemiology, Faculty of Public Health, Universitas Andalas, Padang, Indonesia, Melsi Pita Sari Melsi Pita

Background: Women diagnosed with breast cancer in low-resource countries are several times more likely to die from the disease than those in high-income countries, despite lower incidence. The mortality-to-incidence ratio (MIR) captures this survival gap, but previous studies have mainly described its association with national wealth rather than quantified the contribution of specific health-system factors. We aimed to measure inequality in breast cancer MIR across the human development gradient and identify key de …

30.08.2026journal-article

Advanced Science

Hyper‐Intense Tumor Peripheral Accumulation of Antibody‐Conjugated Iron Oxide Nanoparticles can Enable Breast Cancer Detection by Magnetic Particle Imaging

Preethi Korangath, Hayden Carlton, Theresa Wong, Sean Healy, Toby Sanders, Mason Song, Patrick W. Goodwill, Cordula Grüttner, Kathleen Gabrielson, Robert Ivkov

ABSTRACT Targeting nanoparticles to cancer cells in vivo remains a challenge for cancer imaging. We assessed nanoparticle distribution after injecting iron oxide nanoparticles conjugated with either a monoclonal anti‐HER2 (human epidermal growth factor 2), or a non‐specific IgG antibody into a human HER2 overexpressing murine breast cancer model. We used Magnetic Particle Imaging (MPI) and histopathology to assess particle localization at 72 h after injection. MPI detects magnetic moments produced by magnetic parti …

30.08.2026journal-article

Biomedicines

Basic Periodontal Treatment Improves Periodontal Inflamed Surface Area Without Adverse Events in Patients Receiving Direct Oral Anticoagulants: A Retrospective Clinical Study with an Animal Model

Ryousuke Fujimori, Yuri Taniguchi, Kazuhisa Ouhara, Shunsuke Miyauchi, Shinji Matsuda, Naoya Kuwahara, Shoya Ueda, Yitong Hou, Masaru Shimizu, Misako Tari, Shoko Kono, Tomoyuki Iwata, Tomoaki Shintani, Mikihito Kajiya, Mutsumi Miyauchi, Yukiko Nakano, Noriyoshi Mizuno

Background/Objectives: The optimal management of periodontal treatment in patients receiving direct oral anticoagulants (DOACs) remains poorly established, and bleeding concerns may lead clinicians to delay or limit treatment. We evaluated the clinical efficacy and safety of nonsurgical periodontal treatment in patients receiving DOAC therapy. Methods: This retrospective study included 67 patients receiving continuous DOAC therapy (edoxaban, apixaban, dabigatran, or rivaroxaban) who underwent nonsurgical periodonta …

30.08.2026journal-article

Journal of Clinical Nursing

Nursing‐Led Models of Tracheostomy Management for Patients With Head and Neck Cancer: A Mixed‐Methods Study

Sarah Davies, Carsten Palme, Faruque Riffat, Emma Charters

ABSTRACT Background The incidence of head and neck cancer (HNC) is rising globally, with patients undergoing extensive surgical resection for advanced disease frequently requiring prophylactic tracheostomy to secure the airway in the early postoperative period. Specialised HNC nurses undertake extended scope tracheostomy procedures, including tube changes and decannulations, yet practice varies widely between institutions and no standardised training framework exists. Aims and Objectives To benchmark the roles and …

30.08.2026journal-article

Journal of Research and Investigation in Education

Development of a Web-Based Expert System for Cancer and GERD Diagnosis

Aprilia Adelina Roring, Gilbert Josua Mangkay, Jean Stella Saragih, Ricat Abetnego Sundari, Jhosua Allesandro Tingon, Paul Aleksander Mundung, Yulisa Aprianti

Cancer and Gastroesophageal Reflux Disease (GERD) are serious health problems whose early detection is often hampered by limited access and awareness. This research aims to develop a website-based expert system as a solution to help the public perform an initial diagnosis of cancer and GERD independently. The system development methodology includes a requirements analysis phase, data flow design using DFD and ERD, and implementation using Visual Studio Code with programming languages ​​such as Python and JavaScript …

30.08.2026journal-article

International Journal of Molecular Sciences

Systemic Immune-Inflammatory Biomarkers in Epithelial Ovarian Cancer: Subgroup-Dependent Prognostic Performance and Integrated Risk Stratification

E Sun Paik, Young Eun Chung, Seoyoung Youn, Seongyun Lim, Jun-Hyeong Seo, Chel Hun Choi, Tae-Joong Kim, Jeong-Won Lee, Yoo-Young Lee

Systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) are surrogate markers of the systemic immune-inflammatory response proposed as perioperative prognostic biomarkers in epithelial ovarian cancer (EOC), yet their performance across subgroups remains unexamined. In 373 EOC patients undergoing primary cytoreductive surgery, postoperative day-1 changes (ΔSII, ΔNLR, ΔPLR) were compared for overall survival (OS) and progression-free survival (PFS) across …

30.08.2026journal-article

Brain Pathology

Complement receptor C3aR marks heterogeneous tumor‐associated macrophage states associated with improved survival in IDH ‐wildtype glioblastoma

Marion Imara, Yosra Bedoui, Théotime Pignolet, Sebastien Freppel, Camille Brochard, Auguste Delattre, David Cappellen, Luc Bauchet, Mohamed Khettab, Franck Ah‐Pine

Abstract Glioblastomas (GBM), IDH‐wildtype, are highly aggressive brain tumors with poor prognosis and inter‐individual variability despite established prognostic factors such as age, performance status, and MGMT promoter (MGMTp) methylation. Increasing evidence highlights the role of the tumor microenvironment (TME) in GBM progression. The complement system, a key component of innate immunity, can influence tumor growth and immune regulation through the generation of the anaphylatoxin C3a and the activation of its …

30.08.2026journal-article

npj Breast Cancer

Genomic characterization of ER-positive primary tumors and corresponding relapses identifies potentially targetable alterations

Caroline Schagerholm Stanev, Stephanie Robertson, Hosein Toosi, Emmanouil G. Sifakis, Jens Lagergren, Johan Hartman

Abstract The majority of breast cancer patients have tumors expressing estrogen receptor α (ER) and receive endocrine therapy. However, around one-third relapse in their disease, predominantly with retained ER expression. Molecular alterations are proposed to be contributors to the resistance mechanisms. Patients with ER-positive, human epidermal growth factor receptor 2 (HER2)-negative primary breast cancer with an ER-positive relapse

30.08.2026journal-article

Catalysts

Machine Learning-Enabled Photocatalytic Wastewater Treatment: Recent Advances in Catalyst Design, Performance Prediction, and Process Optimization

Mai M. A. Hassan Shanab, Taoheed Abiodun Yusuf, Abdullah M. Aldawsari, Amani M. Alansi, Musaad Aleid, Idris K. Popoola, Alya M. Alotaibi, Talal F. Qahtan

Photocatalytic wastewater treatment is a promising technology for degrading persistent organic pollutants; however, its optimization remains challenging because photocatalytic performance depends on complex interactions among catalyst properties, operating conditions, and wastewater composition. Machine learning (ML) has emerged as a powerful tool for accelerating catalyst development, predicting photocatalytic performance, and optimizing process parameters. This review critically analyzes recent studies on ML-assi …

30.08.2026journal-article

Brain and Behavior

Could Subjective Cognitive Complaints Give the Facts of Objective Cognitive Impairments in Non‐Central Nervous System Cancer? A Systematic Review

Chieh‐Ning Li, Nai‐Wen Guo, Bei‐Yi Su

ABSTRACT Introduction Non‐central nervous system (non‐CNS) cancer patients experienced cognitive impairment, both subjectively and objectively. However, they are only weakly correlated. Previous studies indicated that subjective cognitive complaints (SCCs) could be a distinct neural phenotype from objective neuropsychological function. To explore what underlies SCCs, we examined the relationship between SCCs and objective neuropsychological assessment in this systematic review. Methods Following the PRISMA guidelin …

30.08.2026journal-article

ChemistrySelect

Molecular Optimization of Benzimidazole Scaffolds for Targeted Protein Kinase Inhibition in Oncology

Heba T. Abdel‐Mohsen

ABSTRACT Benzimidazole is one of the most prestigious heterocyclic motifs, with a variety of biological applications. Over the years, diverse benzimidazole hybrids have proved single or multi‐protein kinase inhibitory activity. Some examples were approved by the Food and Drug Administration (FDA) for use in the treatment regimens of certain types of cancers, other benzimidazole‐based protein kinase inhibitors are still in clinical trials. Additionally, different research groups have employed different approaches fo …

30.08.2026journal-article

SJ Pediatrics and Child Health Africa

Depression, Associated Factors, and Coping Mechanisms among Caregivers of Children with Cancer at Mobile Hospice Mbarara, Uganda: A Cross-Sectional Study

Ninyikiriza Jackline, Tweheyo Otwiine, Jordan Amanyire

Background: Caregivers of children with cancer experience substantial psychological, emotional, and socioeconomic challenges that increase their risk of depression. Despite the growing burden of pediatric cancer in Uganda, evidence on the prevalence of depression, its associated factors, and coping mechanisms among caregivers in palliative care settings remains limited. This study assessed the prevalence of depression, factors associated with depression, and coping mechanisms among caregivers of children with cance …

30.08.2026journal-article

Clinical and Experimental Dental Research

Machine Learning Prediction of Anterior Open‐Bite Development After Stabilization Splint Treatment in Temporomandibular Disorder

Jae Joon Hwang, Hye‐Mi Jeon, Hye‐Min Ju, Sung‐Hee Jeong, Yong‐Woo Ahn, Soo‐Min Ok

ABSTRACT Objectives To develop interpretable machine learning (ML) models for risk stratification of clinically meaningful anterior overbite decrease after stabilization splint therapy in temporomandibular disorder (TMD) patients, and to compare ML performance with conventional logistic regression. Materials and Methods This retrospective cohort included 87 TMD patients treated with stabilization splints, physical therapy, and pharmacologic therapy. Thirty‐five pre‐treatment cephalometric and demographic features w …

30.08.2026journal-article

Archiv Euromedica

THE ROLE OF DIET AND LIFESTYLE IN THE TREATMENT OF ATTENTION DEFICIT HYPERACTIVITY DISORDER: A NARRATIVE REVIEW

Aleksandra Katarzyna Kłosowicz, Aleksandra Olga Pakulska, Natalia Rządzińska, Aleksandra Maria Błoch, Maria Anna Miller, Kornelia Julia Fimiarz, Aleksandra Jolanta Kamińska

Background Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder characterized by impaired concentration, impulsivity, and excessive motor activity. Although conventional therapy is effective in many patients, it may be associated with high costs, adverse effects, and incomplete symptom control. Therefore, complementary methods, such as dietary modifications and lifestyle factors, are gaining increasing importance in the management of ADHD. Aims The aim of this narrative review was to cri …

30.08.2026journal-article

Advanced Science

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu

ABSTRACT Recurrence and progression remain major clinical challenges in bladder cancer (BC), yet the mechanisms linking glycolysis to persistent malignant states remain incompletely defined. Here, we identify alanyl tRNA synthetase 1 (AARS1) as a clinically relevant driver of aggressive and recurrent BC. AARS1 is upregulated in BC tissues, enriched in muscle invasive and recurrent tumors, and associated with unfavorable survival. Functionally, AARS1 promotes proliferation, epithelial mesenchymal transition, invasio …