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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
17.08.2026journal-article

Autism in Adulthood

A Diagnosis Buried in the Closet: How Autistic People Learn of Their Autism Diagnoses

Dakyeom Lee, Insuk Ryu, Joonheon Kwon, wn-ho Yoon, Hee Jeong Yoo, So Yoon Kim

Background: Learning that one is autistic can be a pivotal turning point in self-understanding, but autistic people learn of this information under highly variable conditions. How these disclosure conditions shape autistic people’s experiences of learning and making sense of the diagnosis remains underexamined, particularly for those who received an autism diagnosis in childhood but learned about it later, and in non-Western contexts. Methods: We conducted semi-structured qualitative interviews with 22 formally dia …

17.08.2026journal-article

FPOP Bulletin: Psychology of Older People

The Confidence in Dementia (CODE) Scale: A review of its development and application

Ruth Elvish, John Keady

This review article outlines the development and properties of the Confidence in Dementia (CODE) scale, which was first published in 2014 in a study led by the first author of this review article. The validity and reliability of the CODE scale have been subjected to rigorous independent testing since its first publication, translated into several different languages, and used in dementia care settings and contexts outside of its original development in the general hospital setting. The CODE scale may be particularl …

17.08.2026journal-article

Journal of Indigenous Knowledge and Practice

Roots, Rituals, and Resistance: The Indigenous Knowledge Systems of the Tharu People in Nepal

Uddhav Sigdel, Man B. Sunuwar, Laxmi Adhikari, Tara B. Thapa

Indigenous knowledge systems (IKS) are epistemological traditions that have supported human communities over time which are dynamic, ecologically embedded, and socially reproduced. Although growing scientific and policy attention is being directed towards indigenous knowledge systems. In general, Tharu people continue to be underrepresented in mainstream scientific and development discourses, and in particular, ethnically and geographically marginal communities within South Asia have their traditional knowledge sys …

17.08.2026journal-article

Geriatrics

Beyond Chronological Age: Frailty, Vulnerability, and Invasive Decision-Making in Older Adults with Acute Coronary Syndromes

Lourdes Vicent, Rafael Salguero-Bodes, Pablo R. Alonso, Helena Alarcos, Elena Puerto García-Martín, Carlos Diaz-Arocutipa, Fernando Arribas Ynsaurriaga, Roberto Martín-Asenjo

Older adults represent a growing proportion of patients presenting with acute coronary syndromes (ACS), yet they remain a highly heterogeneous population in terms of biological reserve, comorbidity burden, functional status, cognitive performance, and recovery potential. Chronological age alone is an insufficient basis for invasive decision-making, as it may lead to both therapeutic nihilism and disproportionate treatment escalation. Frailty has emerged as a clinically meaningful construct that captures vulnerabili …

17.08.2026journal-article

Physiotherapy Research International

Acute Foot Warming Enhances Plantar Tactile Sensitivity With Limited Postural Control Effects in Obese Older Adults

Mathias Sosa Machado, Lissandra dos Santos Gonçalves, Amanda Carolina Paim Camponogara, Marieli Miranda Paz, Álvaro Sosa Machado, Felipe P. Carpes

ABSTRACT Background and Purpose Interventions to enhance tactile sensitivity, such as warming the feet, positively affect skin sensitivity with varying influence on postural control. Here, we hypothesize that foot warming may benefit tactile sensitivity and postural control in older adults, particularly those with obesity. Methods Fifty participants divided into 16 middle‐aged adults (14 women, mean ± standard deviation: age 40.29 ± 3.73 years, body mass index, BMI, 24.51 ± 1.70 kg/m 2 ), 17 non‐obese older adults …

17.08.2026journal-article

Chinese Medical Journal

Age-specific anti-Müllerian hormone reference values using an ultrasensitive assay: Associations with ovarian aging and menopausal transition symptoms

Keyan Xu, Yehuan Yang, Peihao Liu, Shuxin Ma, Chunmei Zhang, Xin Liang, Xiaowei Wu, Xinyi Wu, Zifeng Cao, Yilin Yang, Fangyuan Chen, Zhongliang Li, Jiao Liu, Zhanbing Hu, Dongshan Zhu, Ruimin Zheng, Yingying Qin, Ting Guo, Zijiang Chen

Abstract Background: Accurately assessing ovarian aging remains a critical challenge in women’s health, particularly during the late reproductive stage and menopausal transition. Anti-Müllerian hormone (AMH) is widely used to reflect ovarian reserve, but its application in midlife women is limited by the lack of standardized age-specific reference values and poor sensitivity of conventional assays at low AMH levels. This study aimed to establish age-specific AMH reference percentiles in midlife Chinese women using …

17.08.2026journal-article

Genes

Epigenetic Skeletal Muscle Memory: The Impact of Physical Activity on Aging and Post-Injury Regeneration

Antoni Godlewski, Marcin Wróblewski, Julia Kuk, Magdalena Moritz, Filip Dobrak, Renata Kołodziejska, Alina Woźniak

Skeletal muscle retains adaptive information from previous mechanical loading, enabling faster responses to subsequent training and regenerative challenges. This review synthesizes current evidence on the cellular and epigenetic mechanisms underlying skeletal muscle memory and examines how these mechanisms are modified by aging and post-injury regeneration. Muscle memory emerges from complementary structural and molecular components, including myonuclear retention, persistent DNA methylation changes, chromatin remo …

17.08.2026journal-article

UNIFUNEC CIÊNCIAS DA SAÚDE E BIOLÓGICAS

A IMPORTÂNCIA DO ENVOLVIMENTO DA FAMÍLIA NOS CUIDADOS DOS PACIENTES COM ALZHEIMER

Adriele Ferreira dos SANTOS, Polyana Trindade Pereira de OLIVEIRA, Monique Araujo de PAULA, Camila Maria Buso Weiller VIOTTO, Adriana Luiz Sartoreto MAFRA

O envelhecimento da população traz desafios significativos para a saúde pública, especialmente no que diz respeito ao aumento das doenças crônicas, como as demências. A Doença de Alzheimer, a forma mais comum de demência, tende a se tornar mais prevalente com o envelhecimento, resultando em um maior número de internações e a necessidade de cuidados institucionais. Neste contexto, o envolvimento da família nos cuidados com os pacientes é essencial, pois ela oferece apoio emocional, físico e prático, contribuindo par …

17.08.2026journal-article

Frontiers in Aging Neuroscience

Role of STX1A in Parkinson’s disease: evidence, mechanistic hypotheses, and translational perspectives

Rui Xu, Rui Li, Hongmei Li, Qingyun Li, Yanping Li, Gang Wu, Xiaolin Dong

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by degeneration of substantia nigra dopaminergic neurons, α-synuclein pathology, and widespread synaptic dysfunction. Syntaxin-1A (STX1A), a presynaptic Qa-SNARE protein, is essential for synaptic vesicle fusion and also interacts with proteins involved in ion-channel regulation and neuronal excitability. Several animal, extracellular-vesicle, and peripheral-blood studies have reported reduced STX1A abundance in PD. However, the avai …

17.08.2026journal-article

FPOP Bulletin: Psychology of Older People

Understanding behaviour in dementia: Translating psychological approaches into everyday care

Frances Duffy

Changes in behaviour, mood and communication are highly prevalent in dementia and are a major driver of caregiver burden, psychotropic medication use, breakdown in care arrangements, service escalation and avoidable hospital admissions. Psychological approaches emphasise understanding these changes as meaningful and rooted in unmet need. Despite a strong evidence base supporting psychosocial interventions, implementation across health and social care systems remains inconsistent. This paper explores how psychologic …

17.08.2026journal-article

FPOP Bulletin: Psychology of Older People

Staff training as a mechanism to improve the use of non-pharmacological interventions for Behaviours that Challenge in dementia

Annie Melaugh McAteer, Lily Starr, Clare Howie

For individuals living with dementia, behaviours that challenge are frequently conceptualised as expressions of distress and unmet need. In line with best practice guidelines, non-pharmacological interventions are recommended in their management. Effective implementation of such interventions requires staff to have a comprehensive understanding of dementia, the nature of unmet needs, and the key factors contributing to distress. This article describes the evaluation of a successful staff training initiative using C …

17.08.2026journal-article

Frontiers in Public Health

Internet use and physical activity among older adults in China: a multi-dimensional analysis with endogeneity mitigation

Xiaolu Li, Benle Zhan

Background As population aging accelerates globally, promoting physical activity among older adults has emerged as a central public health challenge. Although internet use has been widely promoted as a potential enabler of healthy aging, its net effects on exercise behavior and the underlying mechanisms remain theoretically ambiguous and empirically underexplored, particularly in large developing economies. Methods Using nationally representative microdata from the 2022 China Family Panel Studies (CFPS) covering 6, …

17.08.2026journal-article

Biology

Human Skin Aging: Physiology and Pathophysiology

Vu Thi Phuong Thao, Nguyen Thi Phan Thuy

Skin is the outermost layer which covers all organs of the body. Skin can be divided into three layers, including epidermis, dermis and hypodermis. Similarly to many organs of the body, skin also experiences biological process that could not resist aging. There are the following two types of human skin aging: endogenous and exogenous. Endogenous aging involves a series of physiological changes that gradually occur over time and are influenced by genes and hormones. In contrast, extrinsic aging (or exogenous aging), …

17.08.2026journal-article

Frontiers in Public Health

Association between pain and sarcopenia in middle-aged and older adults: a systematic review and meta-analysis

Xiang Li, Yujian Chen, Yannan Zhao, Yao Jiang, Zexing Wen, Wei Xie

Background Sarcopenia contributes substantially to functional decline in middle-aged and older adults. Pain is common in this population and may be associated with impaired muscle health; however, the magnitude and clinical characteristics of this association remain uncertain. This systematic review and meta-analysis aimed to quantify the association between pain and sarcopenia-related outcomes in middle-aged and older adults. Methods PubMed, Embase, Web of Science, and the Cochrane Library were searched from datab …

17.08.2026journal-article

FPOP Bulletin: Psychology of Older People

Reflections on introducing Positive Behaviour Support on a Mental Health Ward for Older People and Positive Approach to Care® on a Dementia Ward for Older People

Abigail Robinson, Stephanie Page

The first part of this article introduces the Positive Behaviour Support (PBS) model and describes the processes regarding its selection and implementation on a mental health ward for older people including the findings and reflections regarding this pilot. The second part of this article reflects on the process engaged in to introduce Positive Approach to Care (PAC®) on a dementia ward for older people with the hope of equipping the team with knowledge and skills to support behaviours that challenge (BtC). Finally …

17.08.2026journal-article

Psychogeriatrics

Toward Precision Neuropsychiatry of Dementia: Neuropsychiatric Symptoms as Multidimensional Clinical Phenotypes

Shunichiro Shinagawa, Tomoyuki Nagata

ABSTRACT Neuropsychiatric symptoms (NPS) are the most clinically consequential manifestations of dementia, yet they are frequently underestimated as secondary behavioural complications. This review introduces a precision neuropsychiatry framework that conceptualises NPS—including apathy, agitation, psychosis, depression, and sleep disturbances—as multidimensional clinical phenotypes. These phenotypes bridge neurodegeneration, biological aging, brain network disruption, psychosocial context, functional decline, and …

17.08.2026journal-article

ARPHA Conference Abstracts

From Pathways to People: Stakeholder Engagement as a Foundation for Marine Biosecurity Uptake

Lucinda Lintott, Hannah Tidbury, Paul Stebbing

The introduction and spread of Non‑Native Species (NNS) are driven by human activities. In the marine environment, pathways such as recreational boating, commercial shipping, water sport and aquaculture facilitate the movement of organisms across biogeographical boundaries. Biosecurity constitutes the initial and most effective stage of NNS management, targeting human‑mediated pathways to reduce the risk of NNS introduction and spread. Recognising and addressing the human dimension of NNS introduction and spread is …

17.08.2026journal-article

Journal of Qualitative Research in Education

Longitudinal Insights on the Perception and Negotiation of Challenges in Media Use among Young People

Katrin Kreutz, Saskia Draheim

Current debates increasingly portray children’s and adolescents’ media use as problematic or even addictive, often leading to a pathologization of their media practices. However, prevalence studies predominantly show that only a minority of young people meet clinical criteria for media-related disorders, while many more experience challenges. The present study investigates how adolescents and their parents perceive problematic media use, how these perceptions develop over time, and how they are negotiated within fa …

17.08.2026journal-article

International Journal of Molecular Sciences

Cerebral Intramural Cells: A Missing Cellular Link Between Vascular Aging and Alzheimer’s Disease

Eliza-Mihaela Arbănași, Emil-Marian Arbănași, Tudor-Gabriel Boghițoiu, Stephanie Ada Cărare, Bogdan Andrei Cordoș, Kawthar Braysh, Nicoleta Suciu, Laura Chinezu, Doina Ramona Manu, Axel Montagne, Jennifer Dewing, Eliza Russu, Claudia-Violeta Bănescu, Septimiu-Toader Voidăzan, Roxana-Octavia Cărare

The pathological deposition of amyloid-β (Aβ) in the walls of cerebral blood vessels as cerebral amyloid angiopathy (CAA) is a key feature of Alzheimer’s disease (AD) and is linked to impaired clearance of Aβ via intramural periarterial drainage (IPAD). The spontaneous contractions of cerebral smooth muscle cells (SMCs) are thought to drive IPAD, but the relationship between vascular aging and Aβ accumulation remains unclear. We propose a unified framework centered on cerebral intramural cells (CICs), including art …

17.08.2026journal-article

FPOP Bulletin: Psychology of Older People

Introducing Communication and Interaction Training (CAIT) in North Cumbria care homes: A service evaluation of staff confidence and preferred training format

Lewis Fawcett, Aliya Siddique, Morag Ritchie

This paper is an evaluation which explores the acceptability and impact of Communication and Interaction Training (CAIT) introduced to care homes in North Cumbria. The study evaluates the impact of CAIT on staff confidence in dementia care and compares two different delivery formats: modular workshops and a two-day workshop. Sixty-six care homes were invited to nominate staff for CAIT training, with 261 staff attending from 53 different care homes. Twelve modular sessions (N=104) and 17 two-day sessions (N=157) wer …

17.08.2026journal-article

FPOP Bulletin: Psychology of Older People

Enhancing the consistency and range of non-pharmacological interventions recommended for people living with dementia in care homes exhibiting Behaviours that Challenge: A service evaluation

Chloe Shaw, Bethan Denver, Julia Cook

‘Behaviours that Challenge’ (BtC) describes how people communicate distress when unable to meet their needs independently. NICE (2018) guidelines for working with people with dementia recommend non-pharmacological interventions as first-line approaches. A 2021 service evaluation within an older adult mental health (OAMH) service found that most care home referrals for BtC resulted in documented recommendations for pharmacological interventions. In response, a BtC information pack was developed to support OAMH staff …

17.08.2026journal-article

Frontiers in Public Health

Unravelling the obesity epidemic among young people in Qatar: a literature review

Mohammed Ali Abdulla, Jassim Khalid Al-Hail, Christine Gaskell

Background The prevalence of childhood and adolescent obesity has risen dramatically over recent decades, particularly in rapidly developing countries undergoing significant dietary transition. Qatar now has one of the highest rates of childhood overweight and obesity globally, coinciding with increased availability and consumption of processed and ultra-processed foods (UPFs). Although associations between UPF consumption and obesity are well established, the biological and behavioural mechanisms underpinning this …

17.08.2026journal-article

Frontiers in Medicine

SAM3-AgeSeg: an adaptive segmentation model for bone tumors in the aging population

Fang Zhang, Xiaoling Yuan, Hongxia Song, Yueying Chen, Tianting Bai

Background Accurate segmentation of bone tumors from X-ray images is crucial for clinical diagnosis and treatment planning. However, elderly patients pose a significant challenge to general-purpose segmentation models. Methods To address this aging-related medical challenge, we propose SAM3-AgeSeg, an adaptive segmentation model specifically designed for the aging population. Built on the powerful foundation model SAM3, our approach uses a lightweight fine-tuning technique, Low-Rank Adaptation (LoRA), to efficientl …