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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
24.08.2026journal-article

Journal of Clinical Medicine

Factors Associated with Adherence to Cardiac Rehabilitation: A Retrospective Cohort Study

Jessica Campo-Álvarez, Mónica Rincón-Roncancio, Eduardo Tuta-Quintero, Yuli Fuentes, Claudia Mondragón-Rinta, Liliana García-Gutiérrez

Introduction: Cardiac rehabilitation (CR) is an evidence-based secondary prevention strategy that improves functional capacity, quality of life, and cardiovascular outcomes. However, adherence to CR programs remains suboptimal, limiting their effectiveness. Methods: A retrospective multicenter cohort study was conducted among patients enrolled in outpatient CR programs at two specialized cardiovascular centers. Adherence was defined as attendance at ≥70% of the prescribed sessions (≥25 of 36 sessions). Bivariate an …

24.08.2026journal-article

Journal for Person-Oriented Research

Treatment of anxiety in athletes using cognitive behavioral therapy: A single-case experimental design with multiple baselines.

Rebecka Ekelund, Stefan Holmström, Andreas Stenling

Anxiety is one of the most prevalent mental health problems in athletes, yet the inclusion of athletes with clinical mental health problems in intervention studies remains limited. Furthermore, no studies to date have investigated the mechanisms of cognitive behavioral therapy (CBT) on anxiety and positive affect in athletes. Hence, the aim of the current study was to examine the effect of CBT on moderate to severe symptoms of anxiety and positive affect in athletes, as well as to investigate the mediated effects o …

24.08.2026journal-article

Healthcare

Four-Year Management of Severe COPD–OSA Overlap Syndrome with Phased, Closed-Loop Respiratory Rehabilitation: A Case Report

Qiufeng Peng, Dajun Liu, Hongbo Xue, Haoyang Hei, Hua Guo, Jingchun He, Kui Ye

Background: Severe COPD–OSA overlap syndrome remains challenging to manage, and existing approaches rarely combine guideline-directed OSA therapy with sustained pulmonary rehabilitation, leaving patients vulnerable to recurrent acute exacerbations. Case Presentation: A 71-year-old male with severe overlap syndrome had been hospitalized three times for hypercapnic encephalopathy requiring invasive ventilation. Following admission in 2021, we implemented a four-year, three-stage closed-loop rehabilitation program com …

24.08.2026journal-article

International Journal of Basic & Clinical Pharmacology

A retrospective evaluation of anti-retroviral therapy regimen modifications due to adverse drug reactions in a tertiary care hospital

Deepika K. K., Syed Mohsin Ahmed, Basavanna P. L.

Background: Antiretroviral therapy (ART) has transformed HIV infection into a chronic manageable disease and substantially improved survival among people living with HIV. Despite these advances, adverse drug reactions (ADRs) remain a major cause of treatment modification, potentially affecting adherence, treatment continuity, and long-term outcomes. Real-world pharmacovigilance data describing ADR-driven ART regimen changes in Indian settings remain limited. Aim was to evaluate the frequency and pattern of ART regi …

24.08.2026journal-article

International Journal of Basic & Clinical Pharmacology

CRISPR gene therapy: a review

Sanjeyan N., Gobika G., Harshini Reethu S., Renuka A.

The adaptive immune system of prokaryotes is the source of CRISPR-Cas9, a ground-breaking genome editing technique that uses RNA-guided nucleases to precisely alter DNA sequences. An summary of CRISPR/Cas9's discovery, structural elements, mode of action, therapeutic uses, and present limitations is given in this article. The Cas9 nuclease and guide RNA work together to identify particular DNA targets and cause double-strand breaks in the system. Cellular processes like homology-directed repair or non-homologous en …

24.08.2026journal-article

International Journal of Molecular Sciences

Coumarin and Curcumin-Metal Complexes as Next-Generation Photosensitizers in Cancer Photodynamic Therapy

Siu Kan Law, Albert Wing Nang Leung, Chuanshan Xu

To explore the emerging role of natural ligands, specifically coumarin and curcumin, and their coordination with the transition metals ruthenium (Ru) and iridium (Ir) as photosensitizers (PSs) in photodynamic therapy (PDT) for cancer. This highlights the integration of natural compounds and transition metals to overcome limitations in photophysical properties, hypoxia tolerance, and clinical translation. Regarding PDT oncology, this examines an immunological effect on Ru/Ir complexes and natural ligand-metal hybrid …

24.08.2026journal-article

Veterinary Evidence

Efficacy of vincristine-ivermectin combination therapy in the treatment of canine transmissible venereal tumour (CTVT)

Athulya Prakash

PICO Question In dogs diagnosed with canine transmissible venereal tumour (CTVT), does treatment with vincristine combined with ivermectin, compared to treatment with vincristine alone, lead to improved clinical outcomes? Clinical bottom line Category of research Treatment. Number and type of study designs reviewed Two randomised controlled trials. Strength of evidence Weak. Outcomes reported The studies collectively indicate that the combination of vincristine and ivermectin may be an effective and well-tolerated …

24.08.2026journal-article

Advanced Science

A Cascaded DNA Nanocircuit for Multi‐Signal‐Responsive Precision siRNA Delivery in Cancer Therapy

Yan Zhao, Yufei Lan, Min‐Goo Lee, Jinjun He, Yueran Pan, Eunji Kim, Xin Fu, Sungwook Jung, Wanxia Lu, Jinyue Fan, Haoxiang Chen, Yuanbo Zhao, Yuling Xu, Jong Seung Kim, Chao Zhang

ABSTRACT Precision control over nucleic acid delivery remains a critical challenge in cancer therapy, particularly for siRNA‐based gene silencing, where off‐target effects limit clinical translation. Herein, we report a programmably engineered DNA nanocircuit with cascaded dual‐AND logic gates, which enables the development of a spatiotemporally controlled siRNA delivery strategy for precision cancer therapy. The DNA nanocircuit is engineered to respond to three tumor‐specific signals in a sequential manner: extrac …

24.08.2026journal-article

Surabaya Physical Medicine and Rehabilitation Journal

Effects of a Community-Based Multicomponent Exercise Program on Frailty, Mobility, Strength, and Balance Among Older Adults in East Lombok

Lalu Suprawesta, Indri Susilawati, Ni Ketut Dewita Putri, Siti Ainun Ma'rufa

Background: Frailty is a common geriatric syndrome that increases vulnerability to falls, disability, hospitalization, and loss of independence, particularly among older adults living in rural and low-resource settings. Preventive strategies that are feasible, community-oriented, and clinically relevant are essential to support healthy aging. Aim(s) (including purpose setting): This study aimed to evaluate the effects of a community-based multicomponent therapeutic exercise model on frailty status and functional pe …

24.08.2026journal-article

Electronics

Global Perspectives on AI-Based Digital Twins in Smart Rehabilitation and Physiotherapy: Convergence of IoMT, Multiphysics Modeling, and Wireless Bio-Integrated Sensing

Emilia Mikołajewska, Jolanta Masiak, Ewelina Panas, Urszula Rogalla-Ładniak, Dariusz Mikołajewski

Artificial intelligence (AI)-based digital twins (DTs) are emerging as a groundbreaking paradigm in rehabilitation and physiotherapy, enabling the creation of dynamic virtual representations of patients for continuous monitoring, prognostic assessment and personalised therapeutic interventions. This article presents a global, interdisciplinary review of AI-based DT technologies in rehabilitation settings utilising the Internet of Medical Things (IoMT), with particular emphasis on the integration of wearable and imp …

24.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Phonological Awareness and Reading Impairments in Cantonese Speakers With Congenital Amusia: Comorbid Dyslexia Traits Matter

Yuhong Zhu, William Choi, Jiwei Ma, Caicai Zhang

Purpose: This study investigated the nature and underlying mechanisms of phonological awareness and literacy impairments in Cantonese-speaking adults with congenital amusia (amusia hereafter) while accounting for the potential role of dyslexia traits. Method: Twenty-one Cantonese speakers with amusia and 21 matched controls were assessed using segmental (onset phoneme deletion and spoonerism) and suprasegmental (tone oddity) phonological awareness tasks, literacy tasks (word reading, 1-min word reading, and dictati …

24.08.2026journal-article

International Journal of Biology and Life Sciences

The Metabolic Reprogramming of Immune Cells in the Tumor Microenvironment and the Mechanism of Immune Therapy Resistance

Ganyu Yi

The efficacy of immune checkpoint inhibitors (ICIs) is often limited by primary and acquired resistance induced by the tumor microenvironment (TME), with the metabolic reprogramming of immune cells being the core mechanism. This review systematically analyzes the three key metabolic stresses in the TME: glucose deprivation, lactate accumulation, and adenosine accumulation. How these metabolic stresses, by reshaping the metabolic states and functions of T cells, macrophages, and dendritic cells, jointly construct an …

24.08.2026journal-article

Current Opinion in Obstetrics & Gynecology

Management of menopausal hormone therapy

Julia Switzer, Lindsey Vignali, Jonathan Vignali, Rebecca Jackson

Purpose of review The purpose of this review is to provide practical guidance on managing menopausal hormone therapy (MHT) and to provide updated guidance on the risks and benefits of MHT. Recent findings Reanalysis of the Women’s Health Initiative and recent studies have demonstrated the protective role of estrogen in cardiovascular disease (CVD) and bone health, particularly when initiated before the age of 60. There is an increased risk of venous thromboembolism (VTE) with oral formulations, but formulations usi …

24.08.2026journal-article

Jurnal Kebidanan

Factors Associated with Hyperemesis Gravidarum among First-trimester Pregnant Women in the Midwifery Ward of RSDKH Balangan

Sintia Wulandari, Darmayanti Wulandatika, Siti Fatimah, Kristina Yuniarti

Background:Hyperemesis gravidarum (HG) is a severe form of nausea and vomiting in pregnancy that may cause dehydration, weight loss, electrolyte disturbances, and impaired quality of life. Early identification of women who require closer assessment may support timely antenatal care.Objective:This study aimed to examine the associations of maternal age, education level, economic status, and parity with HG among first-trimester pregnant women treated in the Midwifery Ward of RSDKHBalangan.Methods:A retrospective anal …

24.08.2026journal-article

English Language Teaching and Linguistics Studies

An Analysis of Request Speech Acts in Jane Eyre: A Corpus-Based Local Grammar Approach

Keyi Zhang

Request speech acts are key elements in literary text construction, and Jane Eyre offers an ideal exemplar for their examination, with ample scope for interpretation. This study attempts to analyse the local grammatical patterns of request speech acts in Jane Eyre using a custom-built corpus. It aims to identify the types and frequencies of these patterns, to explore how different characters deploy requests, and to examine how such differences reflect the characters’ social status, personality traits, and psycholog …

24.08.2026journal-article

JMIR Rehabilitation and Assistive Technologies

Effects of Using a Lumbar-Type Hybrid Assistive Limb by Older Adults With Frailty on Exercise Self-Efficacy: Retrospective Analysis Based on the Kanagawa Prospective ME-BYO Cohort Study

Makoto Nagasawa, Sho Nakamura, Yoshinobu Saito, Yuko Oguma, Takashi Kasukawa, Kaname Watanabe, Hiroto Narimatsu

Abstract Background Improving exercise self-efficacy (ESE) is a key strategy for promoting sustained physical activity among older adults with frailty. The lumbar-type Hybrid Assistive Limb (HAL), a wearable device that supports voluntary movement through bioelectric signals, may facilitate mastery experiences in individuals with low baseline self-efficacy via adjustable assistance. However, its effects on ESE remain unclear. Objective This study evaluated the effects of lumbar-type HAL exercise on ESE in older adu …

24.08.2026journal-article

South African Journal of Arts Therapies

A Field in Formation

Sinethemba Makanya

This paper examines the development of Art Therapy in South Africa through a synthesis of practitioner reflections from four arts therapists working across the field. Rather than presenting a unified account, the paper engages thepartial, divergent, and at times contradictory perspectives that emerge from these reflections. Drawing on thematic analysis, the paper explores how Art Therapy in South Africa has been shaped through ongoing negotiations around origin, professionalisation, epistemological authority, acces …

24.08.2026journal-article

Orthopedic Reviews

Mapping the Competitive Swimming Sports Medicine Literature: A Bibliometric Analysis of Injuries, Biomechanics, Rehabilitation, and Performance

Hitomi Nakamura, Pranay Gadikota, Omar Viswanath, Latha Ganti

Introduction Competitive swimming sports medicine is an interdisciplinary field encompassing musculoskeletal injury prevention, exercise physiology, biomechanics, rehabilitation, and performance optimization. This study aimed to characterize the growth, contributors, collaboration networks, and thematic evolution of research involving competitive swimmers. Methods A two-layer search strategy was applied to the Web of Science Core Collection using sport-specific topic terms and selected Web of Science categories, in …

24.08.2026journal-article

South African Journal of Arts Therapies

Looking back to move forward

Linda Mdena-Thibedi

This article reviews the history and development of the Drama Therapy programme at the University of the Witwatersrand in South Africa, reflecting on its past to prepare for and address future challenges and growth. Both personal reflections from the author and interviews with the programme’s founders, Tamara Gordon-Roberts and Warren Nebe, inform the article. A key consideration is the Drama Therapy programme’s position within Drama for Life, the postgraduate department dedicated to using the arts as a medium for …

24.08.2026journal-article

LUTS: Lower Urinary Tract Symptoms

Safety and Efficacy of Rezūm Water Vapor Energy Therapy for Benign Prostatic Hyperplasia With Continued Antithrombotic Therapy: A Comparative Study

Naoki Fujisawa, Satoshi Washino, Yuka Yasuda, Shigetoshi Maiya, Tetsuo Shinozaki

ABSTRACT Objectives Evidence regarding the safety of water vapor energy (WAVE) therapy in patients continuing antithrombotic (AT) agents remains limited. This study compared the safety and efficacy of WAVE therapy between patients receiving AT therapy and those not receiving such therapy. Methods This retrospective comparative study included 103 consecutive patients who underwent WAVE therapy at a single institution between February 2023 and October 2024. Patients were divided into an AT group ( n = 36) and a non‐A …

24.08.2026journal-article

International Journal of Biology and Life Sciences

Core Bottlenecks and Optimization Strategies of Delivery Systems for Cancer Gene Therapy: Intracellular Delivery Barriers, Deficient Targeting, and Insufficient Stability

Jialin Shi

Cancer gene therapy can intervene in cancer progression at the genetic level, which is an important innovative direction for tumor treatment. Its clinical application is limited by the safety and efficiency of nucleic acid delivery in the body. With the continuous optimization of related technologies and vectors, the academic circle has made key progress in overcoming in vivo delivery barriers and improving material systems. Nevertheless, existing delivery systems still face key challenges such as the difficulty in …

24.08.2026journal-article

Russian Journal of Anesthesiology and Reanimatology

Predicting the need for mechanical ventilation and vasopressor therapy in patients with traumatic brain injury

L.B. Berikashvili, D.L. Kolesov, P.A. Polyakov, M.Ya. Yadgarov, A.N. Kuzovlev, A.A. Yakovlev, V.V. Likhvantsev

Patients with traumatic brain injury (TBI) represent potentially difficult subgroup, as they are prone to chronic critical illness characterized by persistent organ dysfunction. Maintaining vital functions in these patients often requires vasopressor therapy and mechanical ventilation that is associated with adverse outcomes. Identifying the predictors of these interventions is essential for risk stratification and intensive care planning. Objective. To assess the risk factors and develop a model for predicting the …

24.08.2026journal-article

Frontiers in Immunology

Case Report: Diagnostic pitfall and biomarker-guided therapy in CD20-negative Epstein–Barr virus-positive diffuse large B-cell lymphoma

Jingjing Wen, Chenxing Zhao, Shaozhen Chen, Xiurong Chen, Qinghu Lv, Wei Liu, Jiesong Wang, Daoguang Chen

De novo CD20-negative Epstein–Barr virus-positive diffuse large B-cell lymphoma, not otherwise specified (EBV+ DLBCL, NOS), is a rare subtype of DLBCL. CD20 loss complicates both diagnosis and treatment by limiting anti-CD20 antibody use and broadening differential diagnosis. We report a case where comprehensive immunophenotypic and molecular analyses enabled accurate diagnosis. A biomarker-driven strategy combining CD30-targeted therapy and PD-1 blockade achieved a complete metabolic response. This case underscore …

24.08.2026journal-article

Frontiers in Dental Medicine

Assessing the environmental impact of clear aligner therapy: a scoping review

Sapthami Pai, Dhruv Ahuja, Ashith MV, Haneesh Kiran PT, Amoli Singh

Objective To evaluate the environmental impact and sustainability-related practices of clear aligner therapy (CAT), focusing on environmental impact, economic implications, waste management, recycling practices, manufacturing processes, and aligner materials. It further explores the alignment of clear aligner practices with Sustainable Development Goals (SDG's) 3,9,12 and 13. Methodology A scoping review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Sco …