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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
24.08.2026journal-article

International Journal of Innovative Technologies in Social Science

ROLE OF ANTIFIBRINOLYTIC THERAPY IN GYNECOLOGIC SURGERY: TRANEXAMIC ACID FOR REDUCING PERIOPERATIVE BLOOD LOSS

Michał Batory, Jakub Jakubowski, Karol Kraska, Nadzieja Krasucka, Aleksandra Zynkowska, Aleksandra Magdalena Skrzyniarz, Maria Kiełbus, Julia Oziębło, Magdalena Kijowska, Karolina Klusek

Perioperative hemorrhage remains an important clinical concern in gynecologic surgery, including hysterectomy, myomectomy, cesarean delivery, and oncologic procedures, as excessive blood loss may contribute to postoperative anemia, transfusion requirements, reoperation, prolonged hospitalization, and increased perioperative morbidity. Tranexamic acid (TXA) is a synthetic antifibrinolytic agent that reversibly binds to plasminogen and inhibits its conversion to plasmin, thereby reducing fibrin degradation and stabil …

24.08.2026journal-article

BMC Psychiatry

Predicting response to electroconvulsive therapy combined with antipsychotics in patients with schizophrenia using insula-related functional connectivity: an interoceptive theory-driven analysis

Yapeng Cui, Ruoxi Yun, Xue Li, Rui Zhao, Lixue Liang, Zixin Yin, Mengkai Zhang, Jinyang Li, Shuhao Mei, Xiao Zeng, Xuejuan Yang, Qiguang Li, Changjiang He, Yibin Xi, Hong Yin, Peng Liu, Jinbo Sun

Abstract Background Variability in electroconvulsive therapy (ECT) response among patients with schizophrenia and the risks of ineffective treatment limit its clinical use. Identifying reliable predictors to accurately forecast patient response to ECT continues to be a major challenge. This study aimed to investigate whether insula-related functional connectivity features (FCs), grounded in interoceptive dysfunction theory, can accurately predict ECT-antipsychotics (APs) combination outcomes in schizophrenia and id …

24.08.2026journal-article

Journal of Endovascular Therapy

Clinical Outcomes with Therapeutic Cerebrospinal Fluid Drainage for Spinal Cord Ischemia in Complex Endovascular Aortic Repair Using Fenestrated and Branched Stent-Grafts

Min-Yuan Liu, Nai-Hsin Chi, Hsi-Yu Yu, Yih-Sharng Chen, Shu-Chien Huang, I-Hui Wu

Purpose: Spinal cord ischemia (SCI) remains a major concern following thoracoabdominal aortic aneurysm (TAAA) repair, even with advances in endovascular techniques. The clinical efficacy of selective therapeutic cerebrospinal fluid drainage (CSFD) over routine prophylactic strategies for managing postprocedural SCI remains to be fully elucidated. This study evaluated outcomes of fenestrated and branched endovascular aortic repair (F/B-EVAR) using the Zenith t-Branch device and assessed the neurological outcomes of …

24.08.2026journal-article

International Journal of Biology and Life Sciences

Engineering Probiotics for Serotonin Production as a Potential Adjunctive Therapy for Depression

Qinhan Liu

Depression remains the main cause affecting global mental health, but current drug treatments are often limited by slow onset and significant side effects. As a potential alternative, we explored the possibility of programming bacterial hosts to directly synthesize serotonin (5-HT) in the gut. To this end, we constructed a synthetic operon containing tryptophan hydroxylase (TPH) and tryptophan decarboxylase (TDC) genes, which were fused by overlapping PCR and inserted under the control of the trc promoter in the pT …

24.08.2026journal-article

Thyroid®

A Novel Protocol for Pre-Treatment Diagnostic 131 I Scan Within 24 Hours Post-Second rhTSH Administration to Guide Radioiodine Therapy in Differentiated Thyroid Cancer

Rongfang Shen, Huiting Yang, Xiaoting Ye, Ziqing Li, Xuequn Zhu, Rongqin Zhang, Zhanwen Zhang

Background: In the current conventional recombinant human thyrotropin (rhTSH) protocol, radioiodine therapy (RAIT) is given at 24 h post-second injection and diagnostic 131 I whole-body scan (Dx-WBS) at 72 h; hence, Dx-WBS cannot precede RAIT within the same two-injection cycle. This study aimed to evaluate whether Dx-WBS could be performed within 24 hours after the second injection of a novel rhTSH, thereby enabling timely pre-RAIT evaluation without altering the established rhTSH-based RAIT schedule. Methods: Thi …

24.08.2026journal-article

Diseases

Comparative Dosimetry of Single and Hybrid 177Lu, 161Tb, and 90Y in PSMA-Targeted Therapy

Olatunde Michael Oni, Tim A. D. Smith

Background: Patient-specific targeted radionuclide therapy (TRT) requires consideration not only of administered activity but also of the spatial distribution of radiopharmaceutical uptake and radionuclide-specific energy deposition. This study developed a voxel-based computational workplan to compare 177Lu, 161Tb and 90Y, together with hybrid radionuclide models, using patient-specific PSMA PET-derived tumour activity distributions. Methods: PSMA PET/CT data from 20 patients with prostate cancer, comprising 10 18F …

24.08.2026journal-article

Small

A Biomimetic Breast Tumor‐On‐Chip Platform Reveals Mesenchymal Marker Upregulation Following Gold Nanorod Photothermal Therapy

Camila A. Salvego, Hasti Honari, Anastasiia Dubrova, Stéphanie Descroix, Martha S. Ribeiro, Aurore V. Walle, Claire Wilhelm

ABSTRACT Photothermal therapy (PTT) using plasmonic nanoparticles has emerged as a promising strategy for localized cancer treatment, yet physiologically relevant models for assessing cell‐line model‐dependent responses remain limited. Here, we engineered a breast tumor‐on‐chip platform to investigate gold nanorod (AuNR)‐mediated PTT in a 3D type I collagen microenvironment using luminal‐like MCF7 and triple‐negative breast cancer MDA‐MB‐231 spheroids. A custom microfluidic architecture incorporating sliding‐wall t …

24.08.2026journal-article

Journal of Medical Microbiology

Biofilm sensitization to break Staphylococcus aureus tolerance to cold atmospheric plasma therapy

Abdullah Baz, Jontana Allkja, Muhanna Alshehri, Yao He, Zainab Bilal, Eve Hughes, Olivia Sealy, Craig Williams, Karen Faulds, Gordon Ramage, Jason L. Brown

Introduction. Biofilm-associated infections present a major therapeutic challenge due to their intrinsic tolerance to conventional antimicrobials. Cold atmospheric plasma (CAP) has shown promise as a non-antibiotic antimicrobial modality; however, some bacteria including Staphylococcus aureus can exhibit tolerance to plasma exposure. Gap Statement. Strategies that sensitize CAP-tolerant biofilms to plasma treatment may improve CAP efficacy, but suitable adjunctive compounds and mechanisms remain poorly defined. Aim …

24.08.2026journal-article

British Educational Research Journal

Occupational recognition and teachers’ retention intentions: A latent profile analysis informed by recognition theory

Mengting Qian, Yufei Fang, Chunshun Yan, Yangxi Liu

Abstract Teacher retention is often explained through workload, job satisfaction and burnout, but these accounts have examined less systematically whether teachers experience their profession as socially and institutionally recognised. Drawing on recognition theory, this study examines how occupational recognition is configured across material and employment conditions, proximal relationships and societal‐policy status, and how these configurations are associated with retention‐related intentions. Using IBM SPSS St …

24.08.2026journal-article

INTERNATIONAL JOURNAL OF EDUCATION AND EVALUATION

Efficacy of Rational Emotive Behavior Therapy (Rebt) and Cognitive Behavioral Therapy (CBT) on Drug Users in the NDLEA Rehabilitation Centre, Federal Capital Territory, Abuja, Nigeria

Fatima Abiola Popoola

This study examined the efficacy of Rational Emotive Behaviour Therapy (REBT) and Cognitive Behavioural Therapy (CBT) on drug users in the NDLEA Rehabilitation Centre, Federal Capital Territory, Abuja, Nigeria. Drug abuse remains a major public health challenge globally and in Nigeria, with significant psychological, social, and behavioural consequences. The study was guided by three research questions and three corresponding hypotheses. A quasi experimental research design involving a pre-test and post-test approa …

24.08.2026journal-article

Revista Sustinere

Qualidade de vida de adolescentes com fissura labiopalatina em reabilitação em serviços públicos especializados no sul do Brasil

Cristina Junges Hartmann, Ana Maria Pujol Vieira dos Santos

A fissura labiopalatina (FLP) é a mais comum entre as malformações craniofaciais e causa problemas estéticos, funcionais e psicossociais, afetando a qualidade de vida relacionada à saúde. Este estudo investigou a qualidade de vida dos pacientes com FLP em reabilitação nos centros especializados públicos do sul do Brasil. Aplicou-se o questionário CLEFT-Q em 12 pacientes entre 14 e 16 anos com FLP isolada que estão em reabilitação com equipe de Cirurgia Pediátrica nos centros participantes. As médias dos escores for …

24.08.2026journal-article

Theoretical and Natural Science

Physical Therapy for Plantar Fasciitis in Athletic Population: A Review of Research Progress

Ziyi Feng

In recent years, the use of various physical therapy interventions for treating heel pain and plantar fasciitis has attracted increasing attention. However, current reviews related to physical therapy for plantar fasciitis have mainly focused on the general population. These reviews are without consideration of the return-to-sport needs of athletic populations, and there remains a lack of systematic review and comprehensive discussion for addressing plantar fasciitis in athletic populations. This review searched da …

24.08.2026journal-article

Frontiers in Medicine

Comparative efficacy of digital health interventions and traditional mind-body exercises for pulmonary rehabilitation in chronic obstructive pulmonary disease: a systematic review and network meta-analysis

Kunning Wei, Xiaoyan Liu, Bowen Luo, Haiyan Wang, Haoyu Su, Chunli Mei

Background Digital health interventions (DHIs) and traditional mind-body exercises (TMBEs) have shown potential benefits for pulmonary rehabilitation in stable COPD, but their comparative efficacy remains unclear. Objective To compare DHIs (Synchronous telerehabilitation, Composite digital interventions) and TMBEs (Tai Chi, Baduanjin, Yoga) for stable COPD using network meta-analysis. Methods PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wanfang, and VIP were searched from inception to April 2026. RCTs co …

31.08.2026journal-article

International Journal “Speech Genres”

On the integral description of speech genres (discussing the new research by V. V. Dementyev)

Vladimir A. Salimovsky

The paper discusses the theory of integral description of speech genres being developed by V. V. Dementyev. It argues that the key principles of this concept organically align with the study of complex self-developing systems (V. S. Stepin), which have become the focus of cutting-edge sciences in recent decades (biology, geology, cosmology, artificial intelligence, some social and humanitarian disciplines). It is stated that M. M. Bakhtin’s linguistic methodology involves the study of one of such systems: its upper …

24.08.2026journal-article

Aposta: Revista de Ciencias Sociales

Efficacy of hyperbaric oxygen therapy versus conventional therapy in the management of diabetic foot ulcers: a randomized controlled trial

Hafsa Farhat, Zaki Hussain Salamat, Junaid Anwar, Mohammad Rashid Husnain, Roha Khan, Natasha Atiq

Background: Diabetic foot ulcers (DFUs) are major complications of diabetes mellitus and a leading cause of morbidity, infection, and limb amputation worldwide. Hyperbaric oxygen therapy (HBOT) has been proposed as an effective adjunct to conventional wound care, but evidence regarding its comparative efficacy remains inconsistent. Objective: To compare the efficacy of hyperbaric oxygen therapy and conventional therapy in the management of diabetic foot ulcers. Study Design and Setting: Randomized controlled trial …

24.08.2026journal-article

Muscles, Ligaments and Tendons Journal

Gua Sha therapy reduces thoracolumbar fascia thickness and improves lumbar flexibility: A pilot randomized controlled trial

Beibei Wang, Yang Hu, Yuan Xie, Wichai Eungpinichpong

Background: Chronic low back pain (LBP) is associated with changes in the thoracolumbar fascia (TLF) structure. Gua Sha is a traditional manual therapy that can relieve LBP, but there is a lack of clinical evidence on whether it can affect fascial properties. Objectives: To investigate the immediate effects of Gua Sha on TLF thickness and functional parameters in healthy adults. Methods: In this pilot randomized controlled trial, 24 healthy participants were randomly assigned to a Gua Sha group (n = 12) or a contro …

24.08.2026journal-article

American Journal of Speech-Language Pathology

Engaging Children in Brain–Computer Interface (BCI) Development: Utilizing an Interactive iPad Tool to Capture Picture-Based P300-Based BCI Augmentative and Alternative Communication Design Preferences

Kevin M. Pitt, Amber Thiessen, Grace Fowler, Elena Butler

Introduction: P300-based brain–computer interface augmentative and alternative communication (P300-BCI-AAC) systems show promise for supporting communication for children with severe speech and physical impairments. However, little is known about how children prefer these displays to be designed. This study examined children's design choices and the rationales guiding those choices to inform the development of user-centered, pediatric BCI-AAC displays. Method: Thirty-eight typically developing children (8–12 years …

24.08.2026journal-article

International Journal of Basic & Clinical Pharmacology

Melasma-like facial hyperpigmentation associated with long-term dasatinib therapy in Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia: a rare cutaneous adverse event

Kavya Ronanki, Reshma Benson, Arjun Kacchwaha, Uttam Kumar Nath

Tyrosine kinase inhibitors (TKIs) have significantly improved survival in Philadelphia chromosome-positive leukemias, including chronic myeloid leukemia (CML) and Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL). Dasatinib, a second-generation TKI, is frequently used in Ph+ ALL due to its potent BCR-ABL inhibition and ability to cross the blood-brain barrier. While common adverse effects of dasatinib include cytopenias and fluid retention, cutaneous side effects are rare, particularly pigmentary changes …

24.08.2026journal-article

Frontiers in Pediatrics

Microbiological spectrum and antimicrobial resistance patterns in pediatric acute appendicitis: implications for evidence-based empirical therapy

Jia Zhang, Huaiwei Zhang, Yan Peng, Yubin Li

Background Acute appendicitis is one of the most common surgical emergencies in children, and timely empirical antimicrobial therapy is particularly important in complicated cases. However, antibiotic selection is increasingly challenged by regional variability in pathogen distribution and antimicrobial resistance. This study aimed to characterize the microbiological spectrum and antimicrobial susceptibility profiles of purulent specimens from pediatric patients with acute appendicitis and to provide evidence for o …

24.08.2026journal-article

Applied Sciences

C-MCSS-Mamba: Counterfactual Mechanism-Contrastive Selective Scan Within Mamba for Block-Causal Speech Deepfake Detection

Gaopeng Zhang, Shidong Liu, Dengtao Zhang, Liang Tang

Speech deepfake detection (SDD) is commonly formulated as offline utterance-level binary classification, which limits early decisions in streaming communication and provides little mechanism-level evidence for a spoofing prediction. We propose C-MCSS-Mamba, a block-causal SDD framework that processes fixed-duration audio blocks with a partially fine-tuned XLS-R frontend and carries detection states across blocks through Mamba. Its selective scan is replaced by the proposed Counterfactual Mechanism-Contrastive Selec …

24.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Auditory–Somatosensory Influences on Vocal Motor Control in Primary Muscle Tension Dysphonia

Adrianna C. Shembel, Elizabeth D. Young, Julianna Smeltzer, Roozbeh Behroozmand

Purpose: Auditory and somatosensory systems jointly support vocal motor control, yet their relative contributions in primary muscle tension dysphonia (pMTD) remain poorly understood. This study examined how auditory and somatosensory feedback influence vocal motor control and adaptation in individuals with and without pMTD. Method: Fifty-eight participants (pMTD: n = 17; controls: n = 41) completed a 200-trial altered auditory feedback paradigm involving sustained vowel productions with fundamental frequency downwa …

24.08.2026journal-article

Frontiers in Stroke

Access to stroke rehabilitation services for patients discharged from the Mulago National Referral Hospital Neurology unit, Kampala—Uganda: a mixed-methods study

Ronald Bwambale, Ronald Ssenyonga, Mark Kaddumukasa, Martha Sajatovic, Aggrey David Mukose

Introduction Rehabilitation is the primary form of therapy for stroke survivors. However, there is a dearth of information regarding access to stroke rehabilitation services following discharge from hospitalization. This study, therefore, examined the level of access and experiences of accessing stroke rehabilitation services following discharge from the Mulago National Referral Hospital (MNRH) Neurology unit, Kampala, Uganda. Methodology This was a concurrent mixed-methods study. Quantitative data were collected u …

24.08.2026journal-article

Journal of Clinical Medicine

Factors Associated with Adherence to Cardiac Rehabilitation: A Retrospective Cohort Study

Jessica Campo-Álvarez, Mónica Rincón-Roncancio, Eduardo Tuta-Quintero, Yuli Fuentes, Claudia Mondragón-Rinta, Liliana García-Gutiérrez

Introduction: Cardiac rehabilitation (CR) is an evidence-based secondary prevention strategy that improves functional capacity, quality of life, and cardiovascular outcomes. However, adherence to CR programs remains suboptimal, limiting their effectiveness. Methods: A retrospective multicenter cohort study was conducted among patients enrolled in outpatient CR programs at two specialized cardiovascular centers. Adherence was defined as attendance at ≥70% of the prescribed sessions (≥25 of 36 sessions). Bivariate an …

24.08.2026journal-article

International Journal of Basic & Clinical Pharmacology

A retrospective evaluation of anti-retroviral therapy regimen modifications due to adverse drug reactions in a tertiary care hospital

Deepika K. K., Syed Mohsin Ahmed, Basavanna P. L.

Background: Antiretroviral therapy (ART) has transformed HIV infection into a chronic manageable disease and substantially improved survival among people living with HIV. Despite these advances, adverse drug reactions (ADRs) remain a major cause of treatment modification, potentially affecting adherence, treatment continuity, and long-term outcomes. Real-world pharmacovigilance data describing ADR-driven ART regimen changes in Indian settings remain limited. Aim was to evaluate the frequency and pattern of ART regi …