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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
25.08.2026journal-article

Journal of Midwifery & Women's Health

Experiences of Preceptors in Underserved Areas: A National Qualitative Study

Cara Busenhart, Jenna A. LoGiudice, Hannah Cole McGrew, Christy Evers, Katherine Ferrell Fouquier, Angélica Avellaneda‐Leiva, Shannon Pirrie, Denise C. Smith, Rebecca Fabian, Lisa Kane Low, Sharon Ruyak, Pam Reis, Julia Phillippi

Introduction Clinical education of midwifery students depends on preceptors to guide students’ transition from theoretical knowledge to safe beginning practice. However, there is limited information on the experiences for clinical preceptors working in sites serving rural and medically underserved communities. The purpose of this qualitative study was to understand the experiences of midwives working in lower‐resource areas who also act as clinical preceptors for students enrolled in midwifery education programs ac …

25.08.2026journal-article

Probiotics and Antimicrobial Proteins

Computational Discovery of Novel CYP51 Inhibitors for Antifungal Therapy Against Aspergillus fumigatus

Shah Faisal Mohammad, Taqdees Fatima Shahid, Sana Noor, Iqra Ahmad, Mahnoor Zia, Hanbing Song, Sayyar Ali Shah, Venugopal Thiruvengadam, Umar Nishan, Khaled Fahmi Fawy, Mohibullah Shah

Abstract Lanosterol 14-alpha demethylase (CYP51), encoded by the Erg11 gene, is a crucial enzyme in pathogenic fungi. It catalyzes the demethylation of lanosterol to ergosterol, a vital component of fungal cell membranes. Inhibition of CYP51 disrupts ergosterol biosynthesis, compromises membrane integrity, and inhibits fungal growth, making it a key target for antifungal therapy. In this study, we employed a comprehensive computational approach comprising molecular docking, drug-likeness analysis, dynamics simulati …

25.08.2026journal-article

Journal of Surgical Oncology

Multimodal Neoadjuvant Therapy for Pancreatic Ductal Adenocarcinoma (PDAC) With Vascular Involvement: What Is the Impact of Radiation on Perioperative Outcomes, Local Control, and Survival?

Dhruv J. Patel, Lauren M. Janczewski, Joseph H. Cotler, George Molina, Brett L. Ecker, David Bentrem, Shishir K. Maithel, Mohamed E. Abazeed, John P. Hayes, Bryan Palis, Amanda B. Francescatti, Ronald J. Weigel, Judy Boughey, Lesly Dossett, Akhil Chawla

ABSTRACT Objectives Neoadjuvant chemoradiation for PDAC with vascular invasion remains understudied. The aim of this study is to compare neoadjuvant chemotherapy with chemoradiation (NAC + CRT) versus neoadjuvant chemotherapy (NAC) for PDAC with vascular involvement. Methods The National Cancer Database was reviewed between 2018 and 2023, including patients with T4 PDAC initiating NAC or NAC + CRT. The primary outcome of overall survival (OS) was examined among unresected and resected cohorts. Secondary outcomes in …

25.08.2026journal-article

Frontiers in Medicine

Optimizing aerosol therapy in mechanically ventilated acute respiratory distress syndrome: a delivery-fidelity framework

Zhao-kun Fan, Zhi-rong Zhang, Ying-ying Shen, Wei Chen, Cheng-en Li

Aerosol therapy is frequently used in adults with acute respiratory distress syndrome (ARDS) receiving invasive mechanical ventilation, yet its clinical effects remain difficult to interpret because prescribed dose is not equivalent to lung exposure. This Mini Review examines aerosol therapy as a drug-device-circuit-patient intervention by integrating ARDS guideline context, delivery evidence, drug-class literature, and implementation data. Exposure is shaped by generator and formulation, fill and residual volume, …

25.08.2026journal-article

Research Announcements "Heritage BG"

Music Therapy as a Holistic Intervention for Enhancing Wellnesslifestyle and Oxygen Saturation

Bistra Dimitrova

Целта на настоящото изследване е да се анализира въздействието на музикалната терапия като допълваща Уелнес интервенция чрез оценка на нейния ефект върху обективни физиологични показатели и субективните възприятия за здраве и благополучие. Специален акцент е поставен върху влиянието на различни звукови честоти върху артериалното налягане, кислородната сатурация (SpO₂), пулсовата честота, интензитета на пулса и самооценката на участниците относно техния уелнес опит (Selfness). Изследването съчетава физиологични изме …

25.08.2026journal-article

Ear & Hearing

The Intelligibility-Based Repeat-Recall Test: I. Bayesian-Guided Estimation of Multiple Speech Reception Thresholds

Christopher Slugocki, Francis Kuk, Petri Korhonen, Heidi Peeters

Objectives: The intelligibility-based Repeat-Recall Test (i-RRT) seeks to compare secondary speech-in-noise (SiN) test outcomes, such as listening effort, against normative references measured at equal levels of SiN intelligibility. The present study evaluates the reliability, sensitivity, and accuracy of the easy speech reception threshold (“ezSRT”) test, the first part of the i-RRT, a Bayesian-guided adaptive SiN test for quickly estimating a listeners’ complete performance-intensity functions and deriving estima …

25.08.2026journal-article

Global Journal of Computing and Artificial Intelligence

Legal Responses to Online Hate Speech and Misinformation in Democratic Societies

Research Author

The rapid expansion of digital communication technologies, social media platforms, artificial intelligence, and online news ecosystems has transformed the way information is created, shared, and consumed in democratic societies. While digital platforms have strengthened freedom of expression, political participation, public discourse, and access to information, they have simultaneously facilitated the rapid spread of online hate speech, misinformation, disinformation, extremist content, and digitally manipulated me …

25.08.2026journal-article

Frontiers in Immunology

Protein palmitoylation in hematological malignancies: mechanistic links to lipid metabolic reprogramming and therapy resistance

Qian Zhao, Jiangang Mei, Siqi Qian, Jingjing Pu, Feng Li

Protein palmitoylation has emerged as a central post-translational mechanism governing protein localization, stability, and signal transduction. In hematological malignancies, this dynamic modification lies at the intersection of lipid metabolic reprogramming, tumor–immune interactions, and therapeutic resistance. Here, we review how dysregulated palmitoyltransferases and depalmitoylases modify metabolic enzymes, lipid transporters, lipid-droplet proteins, oncogenic signaling components, and immune-regulatory molec …

25.08.2026journal-article

International Journal of Psychosexual Therapy

205: Black Women and Sexual Liberation: Breaking the ‘Strong Black Woman’ Narrative. An American Perspective

LaTanya Jones

For centuries, the intersections of race, gender, and sexuality have shaped how Black women’s erotic lives are perceived, regulated, and expressed. This presentation examines how American historical stereotypes and contemporary expectations, most notably the Strong Black Woman (SBW) narrative (Abrams et al., 2019), have influenced Black women’s sexual agency, pleasure, and liberation (West, 1995; Collins, 2000). From the hypersexualized Jezebel to the nurturing yet desexualized Mammy, and through the moral constrai …

25.08.2026journal-article

International Journal of Psychosexual Therapy

203: Uncertainty, Autonomy, and the Regulation of Chemsex: A Cultural Psycholegal Perspective Uncertainty, Autonomy, and the Regulation of Chemsex: A Cultural Psycholegal Perspective

Bryson Kelpe

Chemsex coined by David Stuart is not merely a clinical phenomenon—this intentional use of psychoactive substances to enhance or prolong sexual experience is quite often positioned in psycholegal discourse as a problem sexual behaviour in need of societal control, particularly through restrictive treatments and legal prohibitions and abstinence-based treatment protocols. This paper examines chemsex through a psycholegal cultural lens, drawing on Juan J. García Blesa’s analysis of legal culture, the author’s clinica …

25.08.2026journal-article

International Journal of Psychosexual Therapy

207: Impact of Labiaplasty in Young Adults: Sexual Function, Body Image and Psychosocial Effects, case study

Wafaa Eltantawy

Labiaplasty, one of the most frequently performed genital cosmetic procedures, has seen a marked rise among young adults over the past decade. While commonly presented as a means of improving comfort or genital aesthetics, the psychological, sexual, and social implications of this procedure remain complex and multifactorial. Understanding its broader impact on sexual function and well-being is essential for ethical and patient-centred practice. To explore the current evidence on the outcomes of labiaplasty in young …

25.08.2026journal-article

Advanced Healthcare Materials

Human Hair–Derived Carbon Dot–Functionalized Scaffolds for Metabolism‐Targeted Antibacterial Therapy and Regeneration of Infected Bone Defects

Xiaofeng Shi, Zhaofan Wu, Yujun Wang, Xiaopeng Chen, Yongchen Wang, Xinlin Jia, Liang Ma, Huanming Xiong, Yuanqing Mao

ABSTRACT Infected bone defects (IBDs) represent a major clinical challenge in which persistent infection, microenvironmental dysregulation, and impaired regeneration reinforce a vicious cycle that is difficult to resolve. Here, we report carbon dot–functionalized Haversian‐mimetic scaffolds designed to combine antibacterial activity with regenerative support in IBDs. A 3D‐printed scaffold fabricated by digital light processing is constructed by integrating human hair–derived carbon dots (CrCi‐CDs) into a silk fibro …

25.08.2026journal-article

Journal of Chittagong Medical College Teachers' Association

Hemoadsorption Therapy for Expanded Dengue Syndrome Patients : A Case Series Study

Mohammad Shaiful Azam, Mohamed Rezaul Karim, Rocky Das Gupta

Background: Dengue is a tropical infection transmitted by mosquitoes. It manifests expanded spectrum of diseases from mild to severe form. Pathogenesis of denguecauses thrombocytopenia by immune destructionwhich may cause bleeding manifestationand also a high viral load causes activation of T cell that make "storm" of inflammatory cytokines, leading to huge plasma leakage as a result patient develop haemoconcentration and shock. Expanded dengue syndrome is a rare category of dengue infection that involves multiple …

25.08.2026journal-article

AIDS

Viral suppression in models of care for improving engagement of antiretroviral therapy in postpartum women living with HIV

Mustafa Shuaib, Jasantha Odayar, Tamsin K. Phillips, Thokozile R. Malaba, Elaine J. Abrams, Landon Myer

Objective: To compare viral suppression between two models of care [adherence club and integrated maternal and child healthcare (MCH)] for improving engagement of postpartum women with HIV (WWH) to antiretroviral therapy (ART). Design: Individual participant data network meta-analysis (IPD-NMA) of two randomized controlled trials in Cape Town, South Africa [Postpartum Adherence Clubs for Antiretroviral Therapy (PACART) comparing adherence clubs to standard of care (primary healthcare ART clinics, SOC), and MCH-ART …

25.08.2026journal-article

Neurorehabilitation and Neural Repair

White Matter Diffusion Anisotropy and the Effects of Inpatient Multidisciplinary Rehabilitation in Parkinson’s Disease: A Diffusion Tensor Imaging Analysis

Kohei Marumoto, Tetsuo Koyama, Ryuichi Takahashi, Shinji Yamamoto, Yuki Kawami, So Matsugashita, Ayumi Nakatani, Hiroshi Yamamoto, Michiko Inoue, Eiji Mizuta, Norihiko Kodama, Yuki Uchiyama

Background: In Parkinson’s disease (PD), compensatory increases in corticospinal tract (CST) fractional anisotropy (FA) occur early; whether pretreatment white matter integrity predicts rehabilitation responsiveness is unknown. Objective: To determine whether pretreatment CST FA predicts inpatient rehabilitation response in PD. Methods: Ninety-four PD patients and 13 age-matched healthy controls underwent DTI before an 8-week inpatient multidisciplinary rehabilitation program. Patients were classified as responders …

25.08.2026journal-article

European Heart Journal Open

Effect of low-flow oxygen therapy on 6 minute walk test in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: a randomized non-inferiority crossover trial

Carmen Wick, Mona Lichtblau, Anna Titz, Julian Müller, Alessandro Vella, Zoe Bousraou, Michael Furian, Stéphanie Saxer, Esther I Schwarz, Silvia Ulrich

Abstract Aims Patients with pulmonary arterial and distal chronic thromboembolic pulmonary hypertension (PAH/CTEPH) frequently experience exertional dyspnoea with desaturation. Although ambulatory low-flow supplemental oxygen therapy (SOT) is commonly prescribed, its effect via portable concentrators in daily life has not been studied. We investigated the effect of ambulatory SOT on six-minute walk distance (6MWD). Methods and results This was a randomized non-inferiority crossover study in patients with PAH or CTE …

25.08.2026journal-article

Physiotherapy Research International

Associations Between Health‐Related Physical Fitness and Accelerometry‐Based Energy Expenditure in Physiotherapy Workers

Marina Horvat Tišlar, Gordana Grozdek Čovčić, Mihaela Grubišić, Lukrecija Jakuš

ABSTRACT Background and Purpose Although it has been assumed that higher physical activity (PA) levels will contribute to better physical fitness (PF) performance, the interplay between these two has yet to be investigated. Moreover, the majority of studies have been presented in children and adolescents, and older adults, while little is known about the correlation in the adult working population of physiotherapists. Therefore, the main purpose of the study was to examine associations between objectively measured …

25.08.2026journal-article

Clinical Infectious Diseases

When Choosing Antiretroviral Therapy Meets Immigration Policy: An Ethical Analysis

Ava Diarra, Nicolas Vignier, Claire Tantet, Bettina Petit, Heloïse Delagrèverie, Ornella Milleliri, Olivier Bouchaud, Jeanne Goupil de Bouillé

Abstract Migration policies increasingly shape the conditions of care for migrants living with HIV. In France, access to residence permits on medical grounds intersects with clinical practice, raising important ethical challenges. We describe a 29-year-old woman from Guinea living in France with HIV and severe obesity, with an irregular migration status. Although virologically stable on oral antiretroviral therapy, she requests a switch to a long-acting injectable regimen, motivated by both anticipated administrati …

25.08.2026journal-article

Artefactum - revista de estudos interdisciplinares

THE IMPACTS OF CLOWN THERAPY ON THE HOSPITAL ENVIRONMENT AT THE HOSPITAL OF TROPICAL DISEASES IN ARAGUAÍNA – TOCANTINS

João Gabriel Jacinto, Raphael Mariano Gomes Calzada, Anna Carollinna Garcia Marchado, Carolina Galgane Lage Miranda

This study aimed to analyze the perception of different groups regarding the impacts of clown therapy on the hospital environment at the Hospital de Doenças Tropicais of the Federal University of Northern Tocantins, located in Araguaína, Tocantins, Brazil. This was a descriptive, observational, cross-sectional study with a qualitative and quantitative approach, conducted after clown therapy interventions in hospital wards and common areas of the institution. Data were collected through a structured questionnaire co …

25.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

Understanding healthcare professionals’ perceptions of artificial intelligence: A bibliometric and thematic analysis using VOSviewer

Esra Yurt, Gülseren Keskin

Background Artificial intelligence (AI) is transforming healthcare by influencing clinical decision-making, service delivery, and professional roles. Healthcare professionals’ perceptions of AI are critical to its successful implementation and integration into clinical practice. Understanding research trends in this field can support future scientific and policy developments. Objective This study aimed to examine the scientific structure, research trends, and thematic development of the literature on healthcare pro …

25.08.2026journal-article

Frontiers in Cell and Developmental Biology

RAS signaling and remodeling of the immune microenvironment in pancreatic ductal adenocarcinoma: implications of emerging RAS-targeted therapy

Di Meng, Cheng Zhang

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies. Its poor prognosis is closely related to early invasion, extensive stromal deposition, and a strongly immunosuppressive tumor microenvironment. Mutant KRAS is a major driver of PDAC initiation and progression, but its effects are not limited to cancer-cell proliferation. Increasing evidence indicates that oncogenic RAS signaling also alters the surrounding microenvironment by affecting fibroblast activation, extracellular matrix pr …

25.08.2026journal-article

Frontiers in Neurology

Tuina combined with pulsed dry cupping for constipation and gastrointestinal recovery in severe traumatic brain injury: a multidimensional rehabilitation study

Wenjuan Huang, Hongyi Sun, Yuexiang Zhao, Yuxia Pan

Objective To evaluate the efficacy of Tuina combined with pulsed dry cupping for constipation management and gastrointestinal (GI) function recovery in severe traumatic brain injury (sTBI), and its associations with nutritional status, neurological function, and patient satisfaction. Methods This study was a prospective real-world observational cohort study. A total of 120 patients with severe traumatic brain injury (sTBI) were consecutively enrolled between March 2023 and March 2024. Patients were classified into …

25.08.2026journal-article

Anuradhapura Medical Journal

Plasmapheresis as rescue therapy in fulminant seronegative autoimmune hepatitis

Nissanka Sanduni de Silva, Krishantha Jayasekara, Ranjith P. Jayasinghe

Autoimmune hepatitis (AIH) is an immune-mediated inflammatory liver disease that may present a broad clinical spectrum, including acute liver failure. We report a 71-year-old Sri Lankan female presenting with jaundice, hepatocellular liver injury and acute liver failure secondary to AIH. The diagnosis was confirmed by liver biopsy despite negative serological markers. She was initially treated with corticosteroids and due to progression to liver failure, ultimately with plasma exchange. This case highlights diagnos …

24.08.2026journal-article

International Journal of Innovative Technologies in Social Science

ROLE OF ANTIFIBRINOLYTIC THERAPY IN GYNECOLOGIC SURGERY: TRANEXAMIC ACID FOR REDUCING PERIOPERATIVE BLOOD LOSS

Michał Batory, Jakub Jakubowski, Karol Kraska, Nadzieja Krasucka, Aleksandra Zynkowska, Aleksandra Magdalena Skrzyniarz, Maria Kiełbus, Julia Oziębło, Magdalena Kijowska, Karolina Klusek

Perioperative hemorrhage remains an important clinical concern in gynecologic surgery, including hysterectomy, myomectomy, cesarean delivery, and oncologic procedures, as excessive blood loss may contribute to postoperative anemia, transfusion requirements, reoperation, prolonged hospitalization, and increased perioperative morbidity. Tranexamic acid (TXA) is a synthetic antifibrinolytic agent that reversibly binds to plasminogen and inhibits its conversion to plasmin, thereby reducing fibrin degradation and stabil …