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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

American Journal of Medical Genetics Part A

The Evaluation of Molecular Genetics and Clinical Manifestations in Patients With LZTR1 ‐Associated Noonan Syndrome: A Retrospective Chart Review and Review of Literature

Hager Jaouadi, Şakir Hicazi, Carolyn R. Raski, Lindsey Aschbacher‐Smith, Ghada Hijazi, Amy E. Roberts, Carlos E. Prada, K. Nicole Weaver

ABSTRACT Pathogenic variants in LZTR1 are an established cause of Noonan syndrome (NS) and uniquely exhibit both autosomal dominant (AD) and autosomal recessive (AR) inheritance. However, the phenotypic spectrum and genotype–phenotype correlations remain incompletely defined. We conducted a multi‐center retrospective chart review of patients diagnosed with LZTR1 ‐NS evaluated at three tertiary care centers. Clinical, molecular, and imaging data were systematically collected. A comprehensive literature review (2015– …

02.09.2026journal-article

Current Oncology

Tumour GDF-15 Expression and Clinical Outcomes in Intermediate-Risk Metastatic Clear-Cell Renal Cell Carcinoma Treated with Second-Line Nivolumab

Orhun Akdogan, Betul Ogut, Osman Sutcuoglu, Melike Urganci, Burcu Ulas Kahya, Ipek Isik Gonul, Hatice Azra Begum Salimoglu, Tuba Ugur Tuzcu, Ozan Yazici, Ahmet Ozet, Nuriye Ozdemir

Background: Immune checkpoint inhibitors have improved outcomes in metastatic clear-cell renal cell carcinoma (mRCC), yet clinically applicable tissue biomarkers remain limited. Growth differentiation factor-15 (GDF-15) promotes tumour immune evasion and has emerged as a potential therapeutic target in immuno-oncology. We evaluated the prognostic significance of tumour GDF-15 expression in patients with intermediate-risk clear-cell mRCC treated with second-line nivolumab. Methods: Forty-six patients with intermedia …

02.09.2026journal-article

Ophthalmic Plastic & Reconstructive Surgery

Prospective Analysis of Blink Dynamics and Ocular Surface Changes After Levator Aponeurosis Advancement

Anil Ağaçkesen, Derya Çepni Çakir, Murat Oklar

Purpose: To prospectively evaluate changes in blink dynamics following unilateral ptosis surgery and to assess their relationship with ocular surface parameters. Methods: Sixteen patients (10 female, 6 male; mean age 56.0 ± 13.2 years) undergoing unilateral levator aponeurosis advancement were enrolled. Incomplete blink percentage and blink rate were assessed using slow-motion smartphone videography. Noninvasive tear break-up time, meibomian gland area loss, palpebral fissure height, and margin reflex distance 1 we …

02.09.2026journal-article

Journal of Clinical Medicine

Clinicopathological Significance of SCD Expression in Colon Adenocarcinoma: Association with Histological Grade and Exploratory Assessment in Relation to PCNA

Jerzy Z. Piecuch, Adam Piecuch, Marek Michalski, Magdalena Rynkiewicz, Natalia Matysiak, Magdalena Onyszczuk, Marlena Brzozowa-Zasada

Background/Objectives: Colon adenocarcinoma is a heterogeneous disease, and tumours of similar pathological stage may differ in their metabolic and proliferative characteristics. Stearoyl-CoA desaturase (SCD) is involved in lipid metabolic reprogramming and may reflect aspects of tumour biology. The main goal of this study was to analyse SCD expression and its associations with clinicopathological factors, particularly focusing on histological grade. The relationship between SCD and proliferating cell nuclear antig …

02.09.2026journal-article

Asian Journal of Neurosurgery

Polyvinyl Alcohol Nasal Pack as a Rare Cause of Brain Abscess Following Endoscopic Sinus Surgery

Suraj Ethiraj, Ananth P. Abraham, Ranjith K. Moorthy

Abstract Brain abscesses are rare but severe infections that often require surgical intervention and prolonged antibiotic therapy. Development of a brain abscess following endoscopic sinus surgery (ESS) for nasal polyposis is extremely rare. We report the case of a 52-year-old female with a history of multiple endoscopic surgeries for nasal polyposis. She presented with symptoms of headache and fever for 20 days, following revision ESS performed a month earlier. Imaging revealed a right frontal lobe abscess with an …

02.09.2026journal-article

Multidisciplinary Respiratory Medicine

Pilot study comparing the quality of airway seal in an endotracheal tube with a viscoelastic cuff compared to standard endotracheal tubes

Pedro Alejandro Bravo Fernández, Daniel A Cuevas Nieves, Nieves Leon-Gomez, Juan Jose Artazkoz del Toro, Ricardo Martinez-Ruiz

Background: Inadequate endotracheal tube (ETT) cuff sealing permits microaspiration of subglottic secretions, driving ventilator-associated pneumonia and perioperative respiratory complications. Standard cylindrical and tapered cuffs remain susceptible to microchannel formation and leakage. This pilot study evaluated a novel ETT with a 90-mm self-expanding viscoelastic cuff (V-Cuff®) operating at ambient pressure compared to standard and specialty ETTs in vitro. Methods: Five ETTs of each type—standard cylindrical …

02.09.2026journal-article

ASCE MAGAZINE

Barreras y factores asociados al tamizaje y diagnóstico temprano del cáncer cervicouterino en mujeres de zonas rurales: una revisión sistemática

Jessica Andrea Encalada Falconí, Luis Alberto Erosa-De Haro, Jesús Javier Ñaccha Urbano, Milena Mishelle Paredes Sandoval, Nathaly Elvia Sánchez Navarrete

El cáncer cervicouterino, constituye un importante problema de salud pública, aunque dispone de medidas eficaces de prevención, y detección temprana; sin embargo, las mujeres que residen en zonas rurales, enfrentan dificultades que limitan su acceso a los programas de tamizaje, lo que incrementa el riesgo de diagnósticos tardíos, y reduce las posibilidades de tratamiento oportuno. Por ello, el objetivo fue; identificar, analizar y sintetizar, la evidencia disponible sobre las barreras, y los factores asociados al a …

02.09.2026journal-article

Journal of Travel Medicine

SEVMALrisk: An Externally Validated Clinical Risk Score for Early Risk Stratification of Severe Imported Malaria

Perry J J van Genderen, Michele Fumarola, Robert-Jan Hassing, Foekje Stelma, Jaap J van Hellemond

Abstract Background Early recognition of severe imported malaria is essential because treatment decisions frequently need to be made before reliable parasite density measurements become available. Objective tools to support early risk stratification during this interval are lacking. This study developed and externally validated SEVMALrisk, an explainable clinical risk score derived from a machine-learning prediction model using routinely available admission laboratory parameters. Methods Adult patients with confirm …

02.09.2026journal-article

Applied Biosciences

Pure Mycelium Sheets from Edible Mushrooms for Sustainable Packaging: A Comparative Assessment of Glycerol and ZnONPs Treatment

Sasikan Channgam, Gad Elsayed Mohamed Salem, Thatsanee Luangharn, Supachai Pisuchpen, Thomas Karbowiak, Pornchai Rachtanapun, Wirongrong Tongdeesoontorn

Increasingly, mycelium-based biomaterials are being investigated as sustainable alternatives to conventional packaging materials, but their inherent brittleness limits their practical application. The present study investigated the properties of pure mycelium sheets sourced from Ganoderma sp., Lentinus sp., and Pleurotus sp., employing glycerol plasticization and zinc oxide nanoparticles (ZnONPs). The findings revealed that growth and structural attributes varied according to the species, with Ganoderma and Lentinu …

02.09.2026journal-article

The American Journal of Sports Medicine

Quadriceps Tendon Autograft Harvest Technique Affects Both Graft Strength and Cross-sectional Area

Andrew S. Bi, Edouard J. Augustin, Cade C. Smelley, Morgan L. Angotti, Kofi K. Acheampong, Divesh Sachdev, Elizabeth Shewman, Adam B. Yanke

Background: Bone–patellar tendon–bone (BTB) autografts have been considered the gold standard for anterior cruciate ligament reconstruction, although the popularity of quadriceps tendon (QT) autografts is increasing. Hypothesis/Purpose: The purpose of this study was to compare the ultrasound-derived cross-sectional area (CSA) and biomechanical strength of BTB and QT grafts harvested with different techniques. The authors hypothesized that ultrasound CSA measurements would be reliable and that QT grafts would be lar …

02.09.2026journal-article

Measurement Science and Technology

CARENet: a novel interpretable channel attention residual enhanced network for gearbox fault diagnosis under strong noise conditions

Kejia Zhai, Yi Zhang, Yanqiang Yang, Zhiheng Zhang, Yehui Zhao, Qingjiang Li, Guangming Wang

Abstract Gearbox fault diagnosis is crucial for ensuring production safety and improving operational efficiency. However, gearbox fault diagnosis still faces challenges due to strong noise environments. To address these challenges, we propose a novel interpretable channel attention residual enhancement network (CARENet) for robust fault diagnosis under noisy conditions. Vibration signals are first transformed into time-frequency representations using continuous wavelet transform, enhancing the characterization of t …

02.09.2026journal-article

Frontiers in Cardiovascular Medicine

Circulating lipid profiles and atrial fibrillation: from incident risk to post-ablation recurrence

Mi Yan, Jingfeng Zou, Wen Peng

Circulating lipids are widely used in cardiovascular risk assessment, but their relationship with atrial fibrillation (AF) differs from the conventional atherosclerotic framework. Higher triglyceride levels have often been associated with increased AF risk, whereas lower total cholesterol, low-density lipoprotein cholesterol, or remnant cholesterol have paradoxically been linked to greater risk in some populations. These inconsistent findings suggest that lipid measures may reflect stage-specific metabolic and clin …

02.09.2026journal-article

Journal of Clinical Technology and Theory

Research progress and challenges of stem cell therapy for Parkinson's disease

Liancheng Zhi

Parkinson's Disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, leading to striatal dopamine depletion and resulting motor (e.g., tremor, bradykinesia) and non-motor symptoms (e.g., cognitive decline and sleep abnormalities). Current treatment strategies mainly focus on dopamine replacement therapy and deep brain stimulation. Although these methods can temporarily relieve symptoms, they cannot reverse nerve damage, and long-term use is …

02.09.2026journal-article

Frontiers in Pharmacology

The Tibetan Medicinal Formula Ruyi Zhenbao: Research progress on pharmacological actions, clinical evidence and compatibility

Cairang Xiadao, Pengcuo Danzhi, Tsedien Nhamdriel, Dongzhi Yangchang, Chenlei Ganghuan, Yongzhong Zeweng, Zhang Wang, Ma Mi

Objective To comprehensively review the research progress on the compatibility principles, pharmacological mechanisms, and clinical evidence of the Tibetan medicinal formula Ruyi Zhenbao. Methods Guided by fundamental Tibetan medical theory, a critical review of domestic and international literature was conducted, systematically integrating Tibetan medicinal compatibility theory, preclinical pharmacological evidence, and clinical research data. Results Based on the multi-level medicinal property compatibility struc …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Clinical and Laboratory Features of Scrub Typhus among Adult Patients with Acute Febrile Illness in Tak and Nakhon Phanom Provinces, Thailand, 2017–2020

Adelaide F. Green, Betsy Cadwell, Emily Bloss, Nuttagarn Chuenchom, Supphachoke Khemla, Sumonmal Uttayamakul, Pongpun Sawatwong, Ornuma Sangwichian, Duangkamon Siludjai, Phanthaneeya Teepruksa, Beth Skaggs, Cecilia Y. Kato, Christopher J. Gregory, John R. MacArthur, James D. Heffelfinger, Stephanie J. Salyer, Saithip Bhengsri

ABSTRACT. Scrub typhus (ST), caused by Orientia tsutsugamushi , is an underdiagnosed cause of acute febrile illness in Southeast Asia. Acute febrile illness surveillance data from febrile patients presenting to health facilities in two Thailand border provinces (Tak [north] and Nakhon Phanom [northeast]) were analyzed to estimate ST prevalence and describe clinical and epidemiological characteristics and risk factors. Scrub typhus cases were classified as confirmed (polymerase chain reaction-positive), probable (ac …

02.09.2026journal-article

Annals of African Medicine

Evaluation of von Willebrand Factor Antigen as a Prognostic Marker of Major Adverse Cardiac Events in Acute Coronary Syndrome: A Prospective Observational Study

Preethi Yazhini Ravichandran, Krishnaswamy Madhavan

Abstract Background: Acute coronary syndrome (ACS) is a major global cause of morbidity and mortality. Early identification of high-risk patients is crucial for guiding treatment. Von Willebrand factor (VWF) antigen, a marker of endothelial activation and platelet adhesion, plays a role in ACS-related thrombosis. This study evaluated the ability of VWF antigen to predict major adverse cardiovascular events (MACE) and mortality in patients with ACS. Materials and Methods: In this prospective study conducted at a ter …

02.09.2026journal-article

Neuro-Oncology Practice

Dutch Linguistic Intraoperative Protocol Extended: new standardized items and tasks for language monitoring in awake glioma surgery for mild to severe aphasia

Marike Donders-Kamphuis, Arnaud Vincent, Saskia Mooijman, Ellen Collée, Clemens Dirven, Rob Nabuurs, Bram Bulté, Dorien Vandenborre, Evy Visch-Brink, Elke De Witte, Djaina Satoer

Abstract Background Awake surgery is the standard treatment for low-grade glioma patients in eloquent areas, but also seems to result in better surgical outcomes in glioblastoma patients. The Dutch Linguistic Intraoperative Protocol (DuLIP) is a validated tool for intraoperative language monitoring. However, in clinical practice, there is a need for additional items and tasks. Therefore, we aimed to develop and standardize an extended version of DuLIP (DuLIP-Extended). Methods We developed 1) Extra items for word r …

02.09.2026journal-article

Physics in Medicine & Biology

Sinogram-based regularization parameter learning for 2D penalized maximum-likelihood PET image reconstruction

Younes Moussaoui, Saïd Moussaoui, Diana Mateus, Thomas Carlier, Simon Stute

Abstract Positron Emission Tomography (PET) is a molecular imaging technique that creates an image of radiopharmaceutical distribution using acquired sinogram data. Accurate PET reconstruction requires a balance between data fidelity and regularization. The choice of penalty type and the adjustment of the regularization parameters have a critical effect on image quality, including noise suppression, edge preservation, and contrast recovery. However, manually determining optimal regularization strength is challengin …

02.09.2026journal-article

Ibnosina Journal of Medicine and Biomedical Sciences

Mechanistic Insights into IL-17 Pathway Modulation in Breast Cancer by Pteridaceae Bioactive Compounds: A Network Pharmacology and Molecular Docking Approach

Purodhika Gupta, Pankaj Sharma, Ashish K. Yadav, Priya Bansal, Abhishek Kumar

Abstract This study assessed the pharmacological prospects of Pteridaceae phytoconstituents using an integrated network pharmacology (NP) and computational molecular docking (MD) strategy. Various peer-reviewed literature databases, including ScienceDirect, PubMed, Scopus, and Google Scholar, were used to gather bioactive constituents reported from this family. Absorption, Distribution, Metabolism, Excretion and Toxicology (ADMET) parameters, drug-likeness rules, and bioavailability scores were evaluated using Swis …

02.09.2026journal-article

JMIR Formative Research

Health Care Professionals’ Perceptions of AI in Clinical Practice: Productivity, Enjoyment, and Pay

Michael L Chen, Jiyeong Kim, Mariana Ramirez Posada, David Entwistle, Isabella de Vere Hunt, Yifan Li, Xue Li, Nathanael J Fast, Fatima Rodriquez, Albert Chiou, Euan Ashley, Eleni Linos

Abstract Despite widespread discussion of opportunities and risks about AI in medicine, few health care professionals routinely used AI during this study period. Physicians and men were more likely to report frequent AI use, and frequent AI users more often reported positive sentiments about AI’s future impacts on pay, enjoyment, and productivity at work. The youngest professionals (≤29 years) were less engaged and more skeptical about AI’s future benefits. These findings highlight a gap between AI’s promise and me …

02.09.2026journal-article

PLOS One

Factors associated with academic-medicine faculty attrition before promotion to senior rank: A national-cohort study

Maria Pérez, William E. Freeman, Yaheng Lu, Donna B. Jeffe

Background Women and certain groups remain underrepresented among academic-medicine faculty at senior ranks (associate professor or professor). Variables associated with attrition before promotion to senior rank remain understudied. Methods The Association of American Medical Colleges provided data for a national cohort of 129,860 U.S. MD-granting medical-school matriculants in academic years 1993–1994 through 2000–2001; the authors included graduates from 1997 through 2012, first appointed to full-time instructor …

02.09.2026journal-article

European Journal of Heart Failure

Contemporary decongestion strategies in acute heart failure: an individual patient data analysis of three randomized controlled trials

Lara E E C Zonneveld, Pieter Martens, Juan C Trullàs, Kevin Damman, Frederik H Verbrugge, Jeroen Dauw, Iris E Beldhuis, Jesús Casado, Jose Luís Morales-Rull, Wilfried Mullens, Jozine M ter Maaten

Abstract Aims Recent randomized controlled trials (RCTs) showed improved decongestive response with intensified treatment during hospitalization for acute decompensated heart failure (ADHF). Nevertheless, none demonstrated long-term benefit, possibly due to lack of statistical power. We therefore pooled individual data from three recent RCTs to assess the clinical impact of intensified decongestive therapy. Methods Individual patient data from three RCTs evaluating decongestive strategies in ADHF—acetazolamide (ADV …

02.09.2026journal-article

Journal of Clinical Medicine

Differentiating Nontuberculous Mycobacterial Lung Disease from Pulmonary Tuberculosis: A Retrospective Study on Clinical Features and a Diagnostic Model

Yuanjie Li, Shuang Zhao, Jinyan Li, Jing Ren, Yuan Wang, Yaoxi Chen, Chuanqi Wei, Xiaofeng Xiong, Zhixin Qiu

Background: Nontuberculous mycobacterial pulmonary disease (NTM-PD) and pulmonary tuberculosis (PTB) present with similar clinical and radiological features, frequently leading to misdiagnosis. This study aimed to compare NTM-PD with extrapulmonary NTM disease (ENTM) and PTB and to develop a predictive model for early differentiation. Methods: We retrospectively analyzed 473 NTM patients (340 NTM-PD, 112 ENTM, 21 disseminated) and 218 PTB patients treated between January 2008 and December 2024. A diagnostic model w …

02.09.2026journal-article

Phytotaxa

Fungal diversity in landfill soil from a waste treatment plant in Hebei, China with the description of Scytalidium asiaticum sp. nov. (Helotiales, Ascomycota)

YU-HONG LU, PENG-WEI SU, JI-HANG JIANG, YUAN YAO, LI-WEI ZHOU

Soil is one of the most favored habitats for fungi, but fungal diversity from plastic-contaminated soil has rarely been explored. This study focused on landfill soil at a waste treatment plant in Hebei, China, resulting in the isolation of 62 strains. These strains were identified to 25 species, belonging to the genera Alternaria, Aspergillus, Beauveria, Cephalotrichum, Cladosporium, Fusarium, Gliomastix, Marquandomyces, Metarhizium, Mortierella, Mucor, Paraphaeosphaeria, Penicillium, Pseudogymnoascus, Scytalidium, …