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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
25.08.2026journal-article

Statistics in Medicine

Dynamic Predictions and Predictimands for Salvage Therapy in Recurrent Prostate Cancer Using Joint Models

Lukas Owens, Dimitris Rizopoulos, Jonathan Fainberg, Sigrid Carlsson, Nicole Liso, Sean McBride, Vincent Laudone, Ruth Etzioni, Jeremy M. G. Taylor

ABSTRACT Prostate cancer patients with biochemical recurrence (BCR) face a decision of whether to start salvage therapy (ST), which may reduce the probability of metastatic progression at the cost of side effects. To inform the decision to start ST at or after BCR, models that make counterfactual predictions incorporating treatment are highly desirable. However, estimation of such models using observational data requires care due to time‐varying confounding by the longitudinal biomarker prostate‐specific antigen (P …

25.08.2026journal-article

Frontiers in Public Health

Occupational stress and psychological wellbeing among critical care nurses in private hospitals in Somalia: a national cross-sectional study

Abdullahi Hassan Elmi, Rasha Kadri Ibrahim, Rayaan Abdirahman Hassan, Fahma Hussein Ibrahim

Background Critical care nurses operate in some of the most demanding environments within the health system, and their psychological wellbeing is closely tied to patient outcomes and workforce sustainability. Somalia's fragile healthcare system, marked by persistent resource shortages and limited regulation, presents additional pressures that may elevate stress among ICU nurses. However, evidence from the Somali context has been lacking. This study examined the relationship between occupational stress and psycholog …

25.08.2026journal-article

Frontiers in Human Neuroscience

Advanced imaging–integrated rTMS therapy for frontal network recovery after traumatic brain injury

Nan Hu, Zhiling Chen, Jiante Li, Yang Zheng

Background Traumatic brain injury is frequently followed by persistent executive dysfunction linked to disruption of frontal and frontoparietal networks. High-frequency repetitive transcranial magnetic stimulation (rTMS) targeting the dorsolateral prefrontal cortex (DLPFC) has been proposed as a potential adjunctive intervention to support frontal-network recovery. Still, evidence remains heterogeneous and biomarker-guided interpretation is limited. Methods This retrospective multicenter observational cohort study …

25.08.2026journal-article

Phytochemical Analysis

Can Herbal Supplement Be a Suitable Alternative of Ferrous Iron Oral Therapy to Bypass Gastrointestinal Side Effects

Anuradha Sharma, Kiran Gill, Mary Chatterjee

ABSTRACT Introduction Iron deficiency anemia (IDA) is one of the most common nutritional problems. Although it works, traditional oral ferrous iron therapy frequently causes gastrointestinal (GI) side effects such as diarrhea, nausea, constipation, and abdominal discomfort, which makes patients less likely to comply. Objectives This review aims to evaluate whether herbal supplements can serve as suitable alternatives to conventional oral ferrous iron therapy for reducing GI side effects. This review addresses the p …

25.08.2026journal-article

Life

Adjunctive Synbiotic Therapy for Helicobacter pylori Eradication: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials

Chonticha Romyasamit, Thitinat Duangchan, Yosita Leepromma, Morteza Saki, Phoomjai Sornsenee

Background: Synbiotics may improve the effectiveness of antibiotic-based Helicobacter pylori eradication therapy; however, the available evidence remains limited. This systematic review and meta-analysis updated the evidence on the efficacy and safety of adjunctive synbiotics for H. pylori eradication and treatment-related adverse events. Methods: This systematic review and meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) guidelines and was registered in PR …

25.08.2026journal-article

Bulletin of Rehabilitation Medicine

Clinical and physiological rationale and methodology for the use of medical xenon in the complex treatment of pain syndrome in osteoarthritis: a review

Elena A. Shomina, Vladimir V. Guriev, Nikolay V. Yarygin

INTRODUCTION. This review presents an in-depth analysis of the use of medical xenon as a universal agent in modern anesthesiology and therapeutic practice. Particular attention is paid to the use of xenon for the management of chronic pain syndrome in osteoarthritis, where adverse effects and insufficient analgesic efficacy often limit traditional pharmacotherapy. A high safety profile, the absence of systemic toxicity, and the ability to modulate central sensitization make this inert gas a promising component of m …

25.08.2026journal-article

JMIR Research Protocols

Efficacy of Corticosteroid Therapy on Neurological Outcomes in Near-Hanging Patients With Altered Sensorium: Protocol for a Multicenter, Double-Blinded, Placebo-Controlled, Randomized Trial (CHANGING Trial)

Ramadoss Ramu, Dineshbabu Sekar, Aswin K, Ashish Behera, Manu Ayyan, Harichandra Kumar KT, Kavitha B, Mohan Kumar Hanumanthappa, Sree Naga Sowndary Rajendran

Abstract Background In India, hanging is the leading method of suicide, and survivors of near-hanging often present with altered sensorium due to cerebral edema from cervical vascular compression and hypoxia. Management typically involves supportive care and antiedema measures, such as mannitol, hypertonic saline, and dexamethasone. Dexamethasone, a corticosteroid that crosses the blood-brain barrier, is commonly used for presumed cerebral edema. However, evidence supporting its efficacy is limited, and there are n …

25.08.2026journal-article

Nursing Reports

How the Camel’s Back Breaks: A Scoping Review of Cumulative Occupational Distress and the Conceptual Absence of Micro-Trauma in Nursing

Megan Dale, Maude Chapman, Caryn West

Background/Objectives: Nursing involves repeated exposure to emotionally, morally, and psychologically distressing experiences, yet the mechanisms through which low-intensity occupational stressors accumulate and contribute to psychological harm remain conceptually unclear. This scoping review examined how the nursing literature conceptualises the cumulative effects of repeated occupationally distressing experiences and identified the conceptual gap created by the absence of a unifying term such as micro-trauma. Me …

25.08.2026journal-article

International Journal of Psychosexual Therapy

Editor’s Introduction

Caleb Jacobson

It is with great pleasure that we present the first supplemental edition of the International Journal of Psychosexual Therapy, dedicated to the abstracts presented at the 3rd Annual International Symposium on Sex Therapy. This special issue reflects both the continued growth of the symposium and the expanding international dialogue surrounding psychosexual therapy as a distinct and evolving clinical discipline. The International Symposium on Sex Therapy serves as the annual scientific meeting of the International A …

25.08.2026journal-article

International Journal of Psychosexual Therapy

Intellectual Pluralism and Editorial Authority: A Response to the Journal of Sexual and Relationship Therapy’s Statement on ‘Sex Addiction’

Caleb Jacobson

Upon reading the recent “Statement on behalf of the editorial board…” by Twist et al. (2025), I briefly revisited the masthead to confirm that I was indeed engaging with a scholarly journal rather than a manifesto framed within academic typography. The concern extends beyond tone. The article adopts a posture that appears to foreclose dialogue rather than invite it, positioning addiction oriented models of sexual behavior as implicitly religiously motivated and therefore professionally suspect. It collapses diverse …

25.08.2026journal-article

Physiotherapy Quarterly

A randomized controlled trial assessing the impact of Pilates exercise on the static and dynamic balance ability and balance confidence of geriatric individuals aged 60–69 years: preliminary study

Li Jiang, Archrawadee Srijaroon, Yada Thadanatthaphak

Introduction This study aims to investigate the effect of Pilates exercise on static and dynamic balance abilities, as well as balance confidence, in elderly individuals aged 60 to 69 years following a 12-week Pilates exercise intervention. Methods The 43 participants were recruited from the Chongqing Hongshan Community Elderly Care Service Center, China. They were randomly assigned to the control group (22 persons) and the experimental group (21 persons). The experimental group spent 12 weeks performing specially …

25.08.2026journal-article

BMC Endocrine Disorders

From local control to systemic management: radiotherapy and sequential methotrexate therapy in an adult BRAF-negative hypothalamic-pituitary Langerhans cell histiocytosis – a case report with 15-month follow-up

Chi Feng, Zhiming Chen, Liang Chen, Jun Qin, Desheng Wei, Lei Mou

Abstract Background Langerhans cell histiocytosis (LCH) is a rare clonal neoplastic disorder characterized by the proliferation of CD1a+/Langerin+ dendritic cells. Hypothalamic-pituitary region (HPR) involvement in adults—particularly when followed by multisystem progression after local therapy—remains poorly characterized. We report a 35-year-old female with HPR-LCH who achieved durable local metabolic remission after radiotherapy but later developed systemic progression, which was successfully managed with system …

25.08.2026journal-article

Frontiers in Molecular Medicine

Spinal muscular atrophy in the disease-modifying therapy era: successes, limitations and future directions

Madison M. Sexton, Emma W. Crow, Congyue Annie Peng

Spinal Muscular Atrophy (SMA) is a rare and debilitating neurodegenerative disease characterized by the progressive loss of motor neurons in the spinal cord, leading to muscle weakness, respiratory failure, and premature mortality. The pathogenesis of SMA is highly complex and the investigation of downstream pathways and specific cellular mechanisms is still ongoing. In recent years, three FDA-approved disease-modifying therapies, nusinersen, risdiplam, and onasemnogene abeparvovec, have improved the quality of lif …

25.08.2026journal-article

Brain Sciences

Online Comprehensive Care Therapy Complementary Program Improves Quality of Life in People with Parkinson’s Disease

Diego Santos García, Pablo Campo Prieto, Carmen M. Breijo García, Lucía Dafonte Gil, Juan Pereiro Nogueira, Jessica Blanco López, Francisco Doblas

Objectives: Non-pharmacological therapies are a cornerstone of Parkinson’s disease (PD) treatment, but there is not enough evidence of their benefit when delivered altogether online. Our objective was to analyze the efficacy and safety of an online comprehensive care therapy program (OL-CCTP) in people with PD (PwP). Material and methods: This was a proof-of-concept experimental, prospective, 6-month interventional study comparing a PD treatment group (PwP-T) with a control group (PwP-C). The OL-CCTP included group …

25.08.2026journal-article

Nano Letters

Membrane-Fusogenic Nanoparticles for Gene and Cell Therapy

Huimin Kong, Ke Yi, Yuxin Huang, Chunxiong Zheng, Yu Tao, Mingqiang Li

Abstract Inspired by natural membrane-fusion processes, membrane-fusogenic nanoparticles have emerged as a versatile platform for precise and efficient therapeutic delivery. By fusing directly with target cells, these systems efficiently transfer encapsulated bioactive cargo into the cytoplasm while bypassing endosomal entrapment. Simultaneously, the fusion process enables direct membrane engineering by integrating functional agents into the cell surface through lipid mixing. Leveraging this dual capability, membra …

25.08.2026journal-article

Bulletin of Rehabilitation Medicine

Health resort services for patients with nervous system disorders in military health resorts: a non-randomized study

Aleksey F. Sukhoterin, Anna A. Kirsanova, Sergey V. Dolgikh, Svetlana A. Bay, Anastasia V. Skorikova, Oleg A. Skachkov, Andrey V. Sobolev, Denis V. Kovlen

INTRODUCTION. Disorders affecting the nervous system rank among the top causes of illness and disability within the population. Military health resort facilities possess a unique potential for rehabilitating patients with central and peripheral nervous system disorders. Some prospects have been mapped out for developing the potential of military health resorts in the field of neurological rehabilitation. AIM. To evaluate the capacity of military health resorts to provide treatment for patients with disorders of the …

25.08.2026journal-article

Sensors

Recent Advances in Sensor-Based Upper-Limb and Hand Exoskeletons for Post-Stroke Rehabilitation: A Technical and Biomedical Review

Alberto Borboni, Matteo Verzeletti, Alireza Rastegarpanah, Jorge Hugo Villafañe

Background: Recent advancements in enabling technologies, including artificial intelligence and telemedicine, alongside robust clinical study outcomes, have led to significant progress in upper limb and hand exoskeletons utilised for post-stroke rehabilitation. Objectives: This review aims to synthesize the recent scientific literature (2010–2025) on post-stroke upper-limb and hand exoskeletons, with particular attention to the sensing architectures—sensing modalities, signal processing, sensor fusion, and sensor-d …

25.08.2026journal-article

Frontiers in Digital Health

The representational bottleneck in rehabilitation AI: from human-cognitive proxies to pathway-based clinical representations

Eun Joo Yang, Seung Hyun Chung

Artificial intelligence (AI) in healthcare is often framed as a problem of model performance. This view overlooks a prior representational problem: many clinical data are human-cognitive proxies built for communication, documentation, classification, or administration rather than high-fidelity computational access to clinical phenomena. In rehabilitation medicine, movement quality, compensatory strategy, sensorimotor integration, fatigue-related deterioration, and postural instability are frequently compressed into …

25.08.2026journal-article

Frontiers in Medicine

Spontaneous conception and successful live birth during hormone replacement therapy in a patient with iatrogenic premature ovarian insufficiency: a case report

Jung Min Lee, Ju Seok Yang, Ji Eun Park, Jong Chul Baek, Jae Yoon Jo, Hyen Chul Jo

Background Premature ovarian insufficiency (POI) is defined as loss of ovarian function before the age of 40 years. It has a profound impact on patients’ quality of life, particularly due to infertility and menopausal symptoms related to estrogen deficiency. Although most patients diagnosed with POI require assisted reproductive technologies (ART) or oocyte donation to achieve pregnancy, a small subset experiences a spontaneous resumption of ovarian function, leading to natural conception in approximately 5 to 10% …

25.08.2026journal-article

OTJR: Occupational Therapy Journal of Research

Evidence-Informed Occupational Therapy Decision Support Using Graph Retrieval-Augmented Generation

Ichiro Kutsuna, Naoki Tomiyama, Akira Masuo, Kyosuke Yorozuya, Shinya Onda, Aiko Hoshino

Occupational therapy clinical decision-making requires support that is both evidence-informed and traceable. To develop and evaluate a clinical decision-support system (CDSS) for occupational therapy using the Japanese Association of Occupational Therapists (JAOT) Case Report Corpus. A total of 3,023 cases were included, with 90% used as a reference case set and 10% as a test case set. A knowledge graph linking assessment findings, goals, and intervention plans was constructed from the reference case set. Using GPT …

25.08.2026journal-article

Frontiers in Oncology

The double-edged sword of SASP in breast cancer: from tumor suppression to progression and therapy resistance

Xianneng Gao, Yunlong Zhang, Yue Sun, Tiefeng Xu

The senescence-associated secretory phenotype (SASP) represents a complex and dynamic collection of bioactive factors secreted by senescent cells, which exerts dual regulatory effects on breast cancer (BC) progression. When SASP is transiently expressed, it promotes tumor suppression by recruiting immune cells to enhance immunosurveillance against senescent cells, and by transmitting paracrine signals that inhibit cancer cell proliferation. In contrast, when senescent cells cannot be cleared in a timely manner and …

25.08.2026journal-article

International Journal of Psychosexual Therapy

201: Nine Types of Desire: Clinical and Empirical Perspectives on Use of the Enneagram in Psychosexual Therapy

Sam Greenberg, Lyndsey Fraser

Psychosexual therapy, while effective with many clients, can be unresponsive to the diverse ways clients experience and express desire. Emerging research suggests that nine distinct patterns of sexual desire and expression exist, consistent across demographic categories and associated with each of the nine Enneagram personality types. The Enneagram of personality, a map of motivations and personality structures, can provide a framework for sex therapists to create individualized therapeutic approaches for clients. …

25.08.2026journal-article

Kidney and Blood Pressure Research

Impact of Renal Replacement Therapy on Severe Lactic Acidosis in ICU Patients: A MIMIC-IV retrospective replication analysis

Alexander Jerman, Luka Petravić, Vanja Peršič

Introduction. Severe lactic acidosis (SLA), defined as lactate ≥5 mmol/L, is a critical condition in intensive care unit (ICU) patients and is associated with high mortality. Despite the broad use of renal replacement therapy (RRT) to manage metabolic derangements, its impact on outcomes in SLA remains uncertain. Implementing a replication analysis, we aimed to validate the previous findings by Van de Ginste et al. regarding the association between RRT initiation and patient outcomes for patients with SLA in ICU. M …

25.08.2026journal-article

Drug Metabolism and Personalized Therapy

Withania somnifera ameliorates endoplasmic reticulum stress in human hepatocellular carcinoma HepG2 cells

Eshita Sharma, Dilip Mehta, Anand Bhaskar, Aswathi Biju, Juhi Srivastava, Sujit Nair

Abstract Objectives Endoplasmic reticular (ER) stress plays an important role in gene modulation and the consequent release of several inflammatory mediators i.e., cytokines and proteases, key players associated with systemic-induced inflammation in various liver diseases. Natural products containing bioactive compounds have emerged as better therapeutic agents, attributed to their affordability as well as inherent biological properties. Withania somnifera (WS, Ashwagandha) is recognized for its immunomodulatory ac …