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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
31.08.2026journal-article

CADERNOS DE EDUCAÇÃO, SAÚDE E FISIOTERAPIA

INTERVENÇÕES FISIOTERAPÊUTICAS NA REABILITAÇÃO FUNCIONAL DE MULHERES COM CÂNCER DE MAMA: REVISÃO INTEGRATIVA

Patrícia Aparecida Tavares, Daniela Aparecida de Faria, Flávia de Oliveira, Kelly Aline Rodrigues Costa

O câncer de mama configura-se como uma das neoplasias de maior incidência entre mulheres no Brasil e no mundo, estando frequentemente associado a limitações físicas e funcionais decorrentes do tratamento cirúrgico e adjuvante. A fisioterapia desempenha papel fundamental na recuperação dessas pacientes, contribuindo para a reabilitação funcional, analgesia e melhoria da qualidade de vida. Este estudo teve como objetivo identificar as principais intervenções fisioterapêuticas utilizadas na recuperação funcional e no …

31.08.2026journal-article

Gazi Üniversitesi Fen Bilimleri Dergisi Part C: Tasarım ve Teknoloji

Comparative Analysis of the Effects of Microstructures Formed After Hardening Heat Treatment on the Mechanical Properties of AISI 4140 and AISI 4340 Grade Steels

Murat Ok, Bahadır Aydaş

This study presents an experimental investigation into the mechanical and microstructural properties of AISI 4140 and AISI 4340 grade steels, which are widely used in the automotive industry, following hardening heat treatment. These medium-carbon alloy steels are critical for components that require high strength and wear resistance. The materials were subjected to austenitizing at 870 °C followed by water quenching and tempering at 550 °C. Mechanical performance was evaluated using tensile tests and Vickers hardn …

31.08.2026journal-article

International Journal for Research in Applied Science and Engineering Technology

NeuroCAM-X: An Explainable Hybrid AI Framework for Brain Tumor Classification Using MRI and Clinical Reports with Advanced Tumor Analytics

Priyanka Kalyanrao Tawale, Amol Wakhare, Vaibhav Tawale

Brain tumor classification from Magnetic Resonance Imaging (MRI) is a critical task in medical diagnostics that demands both high accuracy and clinical interpretability. This research presents NeuroCAM-X, a novel explainable hybrid artificial intelligence framework that integrates deep learning-based MRI image analysis with Optical Character Recognition (OCR)-enabled clinical report interpretation for comprehensive brain tumor diagnosis. The system employs an EfficientNet-B0 architecture achieving 97.0% classificat …

31.08.2026journal-article

Journal of the Chinese Medical Association

Surgical treatment of pulsatile tinnitus arising from sigmoid sinus wall anomalies

Dong Woo Nam, Jung Kyu Lee, Jae-Jin Song

Pulsatile tinnitus (PT) caused by sigmoid sinus (SS) wall anomalies, most commonly diverticulum and dehiscence, represents a prevalent and potentially reversible venous etiology. This narrative review summarizes contemporary concepts in diagnosis and treatment and proposes a practical framework for clinical decision-making. The characteristic features of venous-type PT are first outlined, with emphasis on strict clinicoradiologic correlation using high-resolution temporal bone computed tomography and magnetic reson …

31.08.2026journal-article

Health Expectations

Adapting a Cancer Cost and Health Insurance Tool for Implementation: Rapid Qualitative Analysis

Ashley J. Housten, Rachelle Roy, Krista Cooksey, Hannah Rice, Viktoria Vonder Haar, Sophia Larson, Su‐Hsin Chang, Jennifer Irvin, Mary C. Politi

ABSTRACT Background Cancer‐related financial hardships are common and negatively impact cancer‐related outcomes. Supporting patient‐clinician cost discussions, financial navigation, and insurance literacy may help mitigate this distress. This qualitative study informed the adaptation of the “Improving Cancer Patients’ Insurance Choices” (I Can PIC) tool into the “Cancer Affordability REsources” (CARE) Tool by updating content, design, and implementation processes. Methods Patients ≥ 18 years, diagnosed with lung, p …

31.08.2026journal-article

Theoretical and Applied Ergonomics

Multi-Phase, Multi-Method Usability Evaluation of an Enhanced Dosimetry Quality Assurance Checklist in Radiation Oncology: From Think-Aloud Testing to Near-Live Clinical Implementation

Karthik Adapa, Shiva K. Das, Prithima R. Mosaly, Fei Yu, Carlton Moore, Lukasz Mazur

The treatment planning stage accounts for most reported patient safety events in radiation therapy, and automated quality assurance (QA) checklists are a common countermeasure; few of these tools, however, undergo formal human factors evaluation before they are released into clinical use. Building on our prior work demonstrating suboptimal usability of an institutional dosimetry QA checklist (DQC) and its participatory, theory-driven redesign, this study evaluated an enhanced DQC using Borycki and Kushniruk’s multi …

31.08.2026journal-article

Clinical Trials

How to be SMART in oncology: A practical framework to assess the contribution of phase using sequential multiple adaptive randomized treatment designs

Kristine R. Broglio, Elizabeth F. Krakow, Erica E. M. Moodie

Background: Sequential multiple adaptive randomized treatment designs can generate registrational-quality evidence for the contribution of phase in perioperative oncology by preserving randomized comparisons and intent-to-treat estimation while improving efficiency relative to traditional three-arm trials, and yet they remain underappreciated. We present a sequential multiple adaptive randomized treatment design framework for perioperative regimens with neoadjuvant and adjuvant phases, motivated by perioperative im …

31.08.2026journal-article

Nuclear Medicine Communications

Treatment response evaluation in extraspinal musculoskeletal tuberculosis using molecular imaging (18F-fluorodeoxyglucose PET/computed tomography): a prospective observational study

Roshan Banjara, Dilip Kumar Sankhwar, Ashish Dutt Upadhyay, Jaiben George, Rakesh Kumar, Vivek Shankar, Venkatesan Sampath Kumar, Shah Alam Khan

Objective The aim of the study was to evaluate the role of 18 F-fluorodeoxyglucose (FDG) PET/computed tomography (CT) in monitoring treatment response and determining treatment end points in patients with extraspinal musculoskeletal tuberculosis (MSK-TB) receiving anti-tubercular therapy (ATT). Methods In this prospective observational study, 62 patients with extraspinal MSK-TB underwent baseline 18 F-FDG PET/CT before ATT, with follow-up scans at 6, 12, and 18 months. Total lesion glycolysis (TLG), maximum standar …

31.08.2026journal-article

Frontiers in Surgery

Development of a predictive model for adverse outcomes after unilateral biportal endoscopic spine surgery in the treatment of lumbar disc herniation using six interpretable machine learning models

Yuelong Tan, Yu Xi, Naiyan Hu, Lin Liu, Luo Xu

Objective This study aimed to develop and validate an interpretable machine learning model incorporating clinical and radiological features to predict the risk of adverse outcomes in patients with lumbar disc herniation (LDH) following unilateral biportal endoscopic (UBE) surgery. The model was designed to facilitate preoperative risk stratification and assist individualized clinical decision-making. Methods A retrospective cohort study was conducted involving 418 patients with LDH who underwent UBE surgery at our …

31.08.2026journal-article

Journal of Fundamental Nursing Science

Factors Influencing Quality of Life in Pancreatic Cancer Patients Undergoing Home-Based Chemotherapy via Disposable Infusion Pumps

hyesun Kim, Inju Hwang, Miyeong Kim, Eunha Bae, Nayeon Lee, Minji Jung, minkyeong Jo

Purpose: This study aimed to identify the level of quality of life (QoL) and the factors influencing it among patients with pancreatic cancer receiving home-based FOLFIRINOX chemotherapy via disposable infusion pumps.Methods: A descriptive cross-sectional study was conducted with 111 adults receiving FOLFIRINOX at a tertiary hospital who continued 46-hour 5-fluorouracil infusions at home. Data were collected using self-report questionnaires and electronic medical records. The measures included the EORTC QLQ-C30, th …

31.08.2026journal-article

Medical Journal of Western Black Sea

Real-world effectiveness of trastuzumab deruxtecan in heavily pretreated her2-positive metastatic breast cancer: A single-center experience

Orçun Can, Osman Gökhan Demir

Aim: Trastuzumab deruxtecan (T-DXd) has shown substantial activity in trials of HER2-positive metastatic breast cancer (mBC), but real-world data in heavily pretreated patients, in those with CNS metastases, and in patients started at reduced doses remain limited. To evaluate real-world efficacy and safety of T-DXd in HER2-positive mBC, focusing on late-line use, CNS disease, and reduced-dose initiation.Material and Methods: This retrospective single-center cohort included 42 consecutive HER2-positive mBC patients …

31.08.2026journal-article

Advances in Anatomic Pathology

Postchemotherapy Germ Cell Tumor Phenotypes

Alexander Fichtner, Pailin Pongratanakul, Daniel Nettersheim, Felix Bremmer

Germ cell tumors of the testis are the most common malignant tumor in young adults. The introduction of the use of cisplatin-based chemotherapy for testicular germ cell tumors from certain tumor stages in the 1970s has significantly improved the prognosis for these tumors. The resection of tumors that have undergone prior chemotherapy, usually in the area of retroperitoneal lymph node metastases or other sites of tumor metastasis, is an important part of the treatment for these patients. But prior treatment with ch …

31.08.2026journal-article

Frontiers in Psychology

Effects of stressful life events on ART treatment outcomes: a prospective study on the role of individual and personality characteristics and psychological health conditions

Maria Clelia Zurlo, Federica Vallone, Maria Francesca Cattaneo Della Volta

Background Infertility research highlighted that early exposure to stressful life events (SLEs) and childhood adversities are significantly associated not only with women’s psychological health, but also with outcomes of assisted reproductive technologies. Nevertheless, there is a lack of studies adopting a multidimensional and transactional approach exploring how early life and family-related stressors potentially influence treatment outcomes through multiple interacting variables. Objective The present study aime …

31.08.2026journal-article

Frontiers in Immunology

Case Report: Single-cell transcriptomic profiling of a pediatric ALK-negative gastric inflammatory myofibroblastic tumor

Jusen Nong, Weikun Li, Bo Shi

Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal neoplasm, approximately 50% of which harbor ALK rearrangements. ALK-negative gastric IMT (G-IMT) in pediatric patients is exceptionally rare and poorly characterized. We report a 6-year-old male with fever, melena, and severe anemia (Hb 30 g/L). Imaging revealed a gastric fundus mass, and subtotal gastrectomy confirmed IMT with dense plasma-cell infiltrate and negative ALK immunostaining. We performed single-cell RNA sequencing on tumor and paired adjac …

31.08.2026journal-article

International Journal of Innovative Science and Research Technology

Conceptual Design of a 60 kL/d Effluent Treatment and Water-Reuse System for an Integrated Edible-Oil and Home-Care Manufacturing Facility

Ashok Agarwal

This design case presents a conceptual effluent treatment plant (ETP) for a facility that combines edible-oil refining, soap and detergent manufacture, margarine or shortening production, and personal-care formulation. A nominal wastewater flow of 60 kL/d is used as the project basis. The proposed configuration is source segregation; screening and oil separation; equalization and pH control; coagulation-flocculation and dissolved-air flotation (DAF); biological treatment; clarification and filtration; and, where a …

31.08.2026journal-article

Restorative Dentistry & Endodontics

Impact of bacteriological testing using an anaerobic culture system on the success of nonsurgical endodontic treatment: a retrospective study

Jun Nakanishi, Noriko Saito-Nakayama, Shizu Hirata-Tsuchiya, Daisuke Furutama, Ayaka Miyata-Arita, Tomoki Kawayanagi, Takuya Arita, Saki Nishihama, Tomoya Naruse, Wang Chutian, Song Bingxin, Naoki Sadaoka, Tomoki Kumagai, Kazuma Yoshida, Katsuhiro Takeda, Hideki Shiba

Objectives: Residual bacteria at the time of root canal obturation significantly influence endodontic treatment outcomes in teeth with apical periodontitis, and confirmation of bacterial elimination from the root canal prior to obturation may improve long-term prognosis. However, the contribution of root canal bacterial culture to treatment outcomes in teeth with infected root canals is debated. This study aimed to retrospectively evaluate treatment outcomes in cases in which root canal obturation was performed aft …

31.08.2026journal-article

Cell Death & Disease

NRF2-WNT5A promotes stem cell persistence and radioresistance in esophageal squamous cancer

Lei Feng, Kaikai Zhao, Xiaoyang Yin, Junpeng Zhang, Zhe Li, Chunyan Zheng, Conghe Liu, Shuqian Zhang, Minghao Li, Baosheng Li

Abstract The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) drives radioresistance in esophageal squamous cell carcinoma (ESCC), thereby compromising therapeutic efficacy; however, the underlying mechanisms remain elusive. Cancer stem cells (CSCs) are recognized to harbor intrinsic radioresistance regulated by complex oncogenic signaling networks. Here, integrating 3D cancer spheroid models with RNA-seq analysis, we investigated NRF2 hyperactivation in CSCs and its role as a core mediator o …

31.08.2026journal-article

Current Oncology

Cellular and Immunotherapy for Pediatric Brain Tumors: A Primer

Irem Yenidogan, Nirav Thacker, Anirban Das, Magimairajan Issai Vanan

Brain tumors are the most common solid malignancies in children and the leading cause of cancer-related mortality in this age group. Cancer immunotherapy has shown a lot of promise in the treatment of both adult and pediatric cancers. In this review, we summarize the use of immunotherapies in the treatment of pediatric brain tumors with special emphasis on CAR T cells, Immune checkpoint inhibitors and oncolytic viral therapy.

31.08.2026journal-article

Cancer Medicine

EfficientNet ‐ B0 –Based Screening of WBC ‐Diff Scattergram Images for Hematological Abnormalities

Mingzhu Long, Xuan Luo, Lixia Zhang, Te Chen, Haixia Wang

ABSTRACT White blood cell differential (WBC‐Diff) scattergrams are used to screen for hematological abnormalities in potential hematopoietic malignancies and abnormal conditions. However, these potential indications can be easily missed. We applied deep learning models to develop a new and rapid workflow by learning the characteristics of WBC‐Diff scattergram images for early hematological abnormality screening. A total of 4297 WBC‐Diff scattergram images, including healthy controls, were included and divided into …

31.08.2026journal-article

Ophthalmologica Indonesiana

Preseptal Cellulitis: A Multidisciplinary Perspective on Diagnosis and Treatment

Carennia Paramita, Erica Widodo, Made Susiyanti

Introduction: Preseptal cellulitis is a common pediatric infection involving the eyelid and anterior orbital tissues, characterized by eyelid erythema and edema. Although most cases respond well to oral antibiotics, delayed diagnosis or inadequate treatment may lead to complications requiring more intensive management. Case Presentation: A febrile 7 year-old boy presented with progressive swelling, erythema, and purulent discharge of the right upper eyelid for two weeks despite prior oral antibiotic therapy. Examin …

31.08.2026journal-article

International Journal of Integrated Science and Technology

Small Cell Lung Cancer Mimicking Pulmonary Tuberculosis in a 22-Year-Old Man: A Diagnostic Challenge in a Tuberculosis-Endemic Setting

Doby Indrawan, Muhammad Ramadhani Aurino Disastranegara

Small cell lung cancer (SCLC) is an aggressive neuroendocrine malignancy characterized by rapid progression and early metastasis. Its clinical and radiological manifestations may overlap with pulmonary tuberculosis, creating a diagnostic challenge in tuberculosis-endemic settings. This overlap may be particularly misleading in young adults, in whom primary lung malignancy is rarely suspected. Case Presentation: A 22-year-old man presented with a persistent cough, intermittent fever, and an unintentional weight loss …

31.08.2026journal-article

Cancer Medicine

Study of Adaptive Radiotherapy for High‐Grade Glioma Based on Interfraction MRI

Shuangshuang He, Hang Yu, Yuan Yang, Qing Mao, Xiang Wang, Yunhui Zeng, Feng Wang, Mengyuan Liu, Yuantai Li, Kun Gao, Xingchen Peng, Yanhui Liu, Ping Ai

ABSTRACT Background Currently, there is no clear guidance on the appropriate population or timing for adaptive radiotherapy (ART) in high‐grade glioma (HGG) patients. This study aims to provide individualized ART for HGG patients. Methods Participants received standard “radiotherapy combined with temozolomide” and underwent MRI before radiotherapy (FX0), after fraction 10 (FX10), and after fraction 20 (FX20). The primary endpoint was anatomical and dosimetric changes in targets and organs at risk (OARs). Results Am …

31.08.2026journal-article

International Journal Of Community Medicine And Public Health

Oral cancer awareness among male adolescent population in Kanpur, Uttar Pradesh: a systematic review

Sourav Goswami, Jagruti Bhattacharjee

Oral cancer is one of the most common cancers in India and constitutes a major public health challenge. Tobacco use, areca nut consumption, smoking, alcohol use, and poor awareness regarding oral cancer contribute significantly to disease burden. Adolescents are particularly vulnerable because many risk-related behaviours begin during this period of life. Understanding the level of oral cancer awareness among male adolescents is essential for designing effective preventive interventions. Objectives were to systemat …