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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Clinical and Translational Oncology

Prognostic modeling of overall survival in metastatic pancreatic cancer: an inflammation-based tool validated in PANTHEIA-SEOM cohort

Vilma Pacheco-Barcia, Axel Mariño-Mendez, María Ángeles Vicente Conesa, María de Toro Carmena, Paula Cerdà Serdà, Carmen Guillen-Ponce, Mónica Benavente Lucas, Raquel Hernández San Gil, Ángela Lamarca, Javier Gallego, Maria Luisa Soriano Tabares de Nava, Jorge Hernando, Elena Brozos-Vazquez, Ana López-Alfonso, Jorge Adeva, Ismael Ghanem, Sandra Soriano, Javier Soto-Alsar, Andrés Muñoz, Paula Jimenez-Fonseca, Alberto Carmona-Bayonas

Abstract Purpose To develop and internally validate the PANTHEIA-SIRI prognostic model, which integrates log-transformed systemic inflammation response index (SIRI) with clinical predictors, to estimate overall survival (OS) in metastatic pancreatic ductal adenocarcinoma (mPDAC) treated with first-line chemotherapy. Methods We used data from the multicenter PANTHEIA-SEOM registry. OS was defined from chemotherapy start. The model was fitted as a Weibull accelerated failure time model in the survival-analysis popula …

03.09.2026journal-article

Frontiers in Oncology

Type I collagen promotes triple-negative breast cancer progression through a UBE2V1–ACSL5 regulatory axis

Lu Liu, Yida Wang, Haiyue You, Cenzhu Wang, Xinfeng Yang, Feng Zhang, Danping Wu, Xin Ning, Zhiwen Qian, Ying Jiang, Yan Zhang, Xiaoqian Zhao, Tingting Han

Introduction Triple-negative breast cancer (TNBC) is characterized by aggressive behavior and extensive extracellular-matrix remodeling. Type I collagen (COL I), a major stromal component, promotes tumor progression, but the downstream tumor-cell mechanisms remain incompletely defined. We investigated whether COL I regulates acyl-CoA synthetase long-chain family member 5 (ACSL5) through ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1) and whether this relationship contributes to malignant behavior. Methods We int …

03.09.2026journal-article

BMC Cancer

Study protocol of a multicenter prospective [¹⁸F]F-FAPI PET-CT imaging study in patients with cancer of unknown primary

Esther Droogers, Mathijs P. Hendriks, Warnyta Minnaard, Walter Kool, Leo J. Schouten, Caroline Loef, Frederik. A. Verburg, Debbie G.J. Robbrecht, Sophie E.M. Veldhuijzen van Zanten

Abstract Background Cancer of unknown primary (CUP) is defined by the presence of metastatic disease without an identified primary tumor despite comprehensive diagnostics. The absence of a known primary tumor creates substantial diagnostic uncertainty for patients and caregivers, and precludes site-specific, evidence-based treatments. Fibroblast activation protein inhibitor (FAPI) PET tracers have recently gained attention as promising alternatives to [ 18 F]fluoro-2-deoxy-d-glucose ([ 18 F]FDG), as they selectivel …

03.09.2026journal-article

Turkish Journal of Gastroenterology

Lumen-Apposing Metal Stent in the Treatment of Persistent Dysphagia due to Cervical Radiation Therapy

Eren Yilmaz, Mucahit Ergul, Oguz Ozturk, Kadir Can Acun, Emir Tuğrul Keskin, Orhan Coskun, Ilhami Yuksel

Cite this article as: Yilmaz E, Ergul M, Ozturk O, et al. Lumen-apposing metal stent in the treatment of persistent dysphagia due to cervical radiation therapy. Turk J Gastroenterol. Published online September 3, 2026. doi: 10.5152/tjg.2026.26290.

03.09.2026journal-article

Frontiers in Oncology

Changes in life expectancy due to trends in cancer mortality rates, Spain 1980 – 2024

Javier Llorca, Inés Gómez-Acebo, Jessica Alonso-Molero, Sara Valero-Domínguez, Trinidad Dierssen-Sotos

Background Cancer is a leading cause of death worldwide. Although cancer mortality has declined in recent decades, its contribution to gains in life expectancy and to female-male life expectancy gap has not been fully quantified in Spain. This study assessed trends in age-adjusted cancer mortality in Spain from 1980 to 2024 and quantified their contribution to overall life expectancy and by cancer type (lung, colorectal, stomach, breast, and prostate). Methods Mortality data and life tables for the Spanish populati …

03.09.2026journal-article

Frontiers in Oncology

Bibliometric and clinical trial landscape of hepatoblastoma (2000–2024): a multi-database analysis of global research

Xu Li, Junyi Lou, Xiaoyu Li, Shibo Tang, Shuang Li, Zining Luo, Jiebin Xie

Background Hepatoblastoma (HB) is the most common childhood liver malignancy, yet its research trajectory and trial landscape remain uncharacterized. Methods We analyzed 219 trials from 16 international registries and 2,635 PubMed publications (2005–2024) using joinpoint regression, Gini coefficient, and diversity indices. Results Trial activity peaked in 2013 and 2016, driven by risk-stratified protocols and the emergence of targeted therapies. Phase III/IV trials were scarce. Cisplatin dominated drug utilization, …

03.09.2026journal-article

Frontiers in Oncology

Construction and validation of a nomogram model for predicting 60-day mortality in patients with acute myeloid leukaemia

Man Yang, Youmei Zi, Xuyang Dai, Yongqiang Liu, Luyao Zhu, Lihua Wang, Yuan Zhang, Guoqing Lv, Sun Wu, Weihong Lu, Yan Huang

Objective To construct and internally validate a nomogram for predicting 60-day all-cause mortality in adult patients with de novo acute myeloid leukaemia (AML) and to compare its performance with European Leukaemia Network (ELN) 2022 risk stratification. Methods Clinical data from 140 patients with newly diagnosed de novo AML treated at The First Affiliated Hospital of Henan Medical University between 2020 and 2025 were retrospectively analysed. Patients were allocated by stratified random split into a training co …

03.09.2026journal-article

Visual Computing for Industry, Biomedicine, and Art

Lightweight Transformer-based knowledge distillation framework for high-dimensional spatiotemporal radiomics in breast cancer risk prediction

Haofan Huang, Han Zhou, Kaibin Huang, Jie Yang, Peixi Ying, Puxiang Lai, Yan Lin, Yi Gao

Abstract Breast cancer exhibits significant spatiotemporal heterogeneity. Traditional radiomics approaches usually rely on low-temporal-resolution imaging and discrete image phases, failing to capture the rapid and continuous kinetic evolution within the tumor microenvironment. Although ultrafast dynamic contrast-enhanced magnetic resonance imaging captures precise contrast agent permeation, current methodologies lack systematic, dedicated computational frameworks to extract these high-dimensional dynamic features. …

03.09.2026journal-article

Frontiers in Immunology

Long-term comorbidities and mortality associations with treatment in generalized pustular psoriasis: a multi-institutional cohort study

Teng-Li Lin, Yi-Hsuan Fan, Kuo-Sheng Fan, Chao-Kuei Juan, Yi-Ju Chen, Chun-Ying Wu

Background Generalized pustular psoriasis (GPP) is a rare, severe inflammatory disease with limited evidence on long-term prognosis and treatment–mortality associations. Objective To compare mortality and major comorbidities in GPP, psoriasis vulgaris (PV), and non-psoriatic individuals, and treatment–mortality associations in GPP. Methods Adults with GPP, psoriasis vulgaris (PV) without pustular psoriasis, and non-psoriatic controls were identified. GPP patients were 1:1 propensity score–matched to PV and non-psor …

03.09.2026journal-article

Frontiers in Immunology

Spatial architecture of tumor-infiltrating lymphocytes adds predictive value beyond stromal TIL density for neoadjuvant response in triple-negative breast cancer

Ke Yang, Hua Huang, Wei Shen, Yang Liu, Daxin Gao, Tian Hao, Haiyu Zhou, Yonghong Huang

Background Stromal tumor-infiltrating lymphocytes (TILs) are established biomarkers in triple-negative breast cancer (TNBC), but conventional density-based assessment does not capture their spatial relationship to tumor nests. We evaluated whether an H&E-derived spatial architecture index (SAI) provides predictive information beyond stromal TIL density for pathologic complete response (pCR) after neoadjuvant therapy. Methods This single-center retrospective cohort included 236 patients with TNBC who had evaluab …

03.09.2026journal-article

Frontiers in Imaging

Artificial intelligence in breast cancer imaging: a systematic review of detection, segmentation, explainability, and clinical translation

Iqra Iqbal Khan, Syed Adil Hussain Shah, Alexandra Tsipourakis, Marta Malavolta, Aleesha Aleesha, Syed Baqir Hussain Shah, Mozhdeh Hajiani, Andrea Buccoliero, Konstantinos Panagiotopoulos, Syed Taimoor Hussain Shah, Marco Agostino Deriu

Introduction Breast cancer remains the most commonly diagnosed malignancy in women worldwide, with approximately 2.3 million new cases and 670,000 deaths in 2022. Artificial intelligence (AI) is increasingly being applied across breast imaging for detection, characterization, segmentation, risk stratification, explainability, and clinical translation. Methods This systematic review synthesized 284 eligible peer-reviewed publications published between 2015 and 2025, identified through a PRISMA 2020-compliant search …

03.09.2026journal-article

Frontiers in Immunology

Differentiating poor prognosis from treatment-related fluctuations in Guillain-Barré syndrome for repeating immunoglobulin treatment: an illustrative case report

Alessio D’Elia, Luciana Mascia, Luca Gregorio Giaccari, Angela Comanducci, Barbara Maistrello, Emilio Lozupone, Monica Santo Sabato, Mariangela Bianco, Guglielmo Lucchese

Background Guillain-Barré syndrome (GBS) is an acute immune-mediated polyradiculoneuropathy that may follow infectious triggers and can progress to severe weakness, cranial nerve involvement, autonomic dysfunction, and respiratory failure. Cytomegalovirus (CMV)-associated GBS is often linked to a more severe clinical course. Although intravenous immunoglobulin (IVIG) and plasma exchange are established first-line treatments, management becomes challenging when patients deteriorate after initial therapy, particularl …

03.09.2026journal-article

Cancers

Tumor Topography Remodels TME Signalling via Compartment-Specific Host–Microbiome–Tumor Crosstalk in Hepatoblastoma

Beate Obermüller, Sabine Obermüller, Karin Wagner, Maximilian Nepel, Holger Till, Georg Singer, Bettina Leber

Background & Aims: Signaling within the tumor microenvironment (TME) emerges from dynamic crosstalk among cancer cells, host tissues, and the microbiome. Orthotopic and ectopic xenograft models are widely used in preclinical liver cancer research, yet it remains unclear to what extent tumor location shapes systemic host responses and gut–liver communication. We therefore investigated how anatomical context influences host transcriptomes and spatially resolved intestinal microbial ecosystems in hepatoblastoma (HB). …

03.09.2026journal-article

Cancer Discovery

A Foundation Model of Cancer Genotype Enables Precise Predictions of Therapeutic Response

JungHo Kong, Ingoo Lee, Dean Boecher, Akshat Singhal, Marcus R. Kelly, Jimin Moon, Chang Ho Ahn, Chan-Young Ock, Dexter Pratt, Tannavee Kumar, Timothy J. Sears, David Laub, Sarah Wright, Patrick Wall, Hannah Carter, Zhen Wang, Trey Ideker

Abstract Although genetic sequencing is routine in cancer care, translating a tumor’s complex mutation profile into actionable treatment decisions remains a central challenge. MutationProjector is pretrained on a large corpus of genomic alterations across more than 30,000 tumors, integrated with extensive molecular knowledge. The resulting projection reveals a tumor’s altered molecular pathways, facilitating model interpretation, and it accurately reconstructs held-out mutations, demonstrating model generalization. …

03.09.2026journal-article

Frontiers in Oncology

Risk of malignancy and surveillance of premalignant gastrointestinal lesions in adult celiac disease

Jan Bures, Katerina Kamaradova, Vladimira Rezacova, Michaela Zapletalova, Michaela Cvanova, Stepan Suchanek, Pavel Drastich, Nadija Brodyuk, Jiri Dolezal, Tomas Tuma, Jozef Malik, Tomas Grega, Doris Vokurkova, Radek Pohnan, Petr Urbanek, Miroslav Zavoral, Darina Kohoutova

Celiac disease is a systemic autoimmune affliction triggered by dietary gluten in genetically predisposed subjects. Current estimation of the prevalence of celiac disease is approximately 1% for the global population. These data are consistent with current figures from the Czech Republic (prevalence of 1.06% in 2023). Celiac disease can be associated with several complications including malignancy. Exact epidemiology data on T-cell lymphoma and small intestinal adenocarcinoma in the Czech Republic over the period 2 …

03.09.2026journal-article

Frontiers in Oncology

Efficacy and safety of endoscopic submucosal dissection for rectal tumors with or without dentate line involvement: a propensity score matching analysis

Yan Hu, Qiang Zhang, Limei Gu, Jun Xiao, Qide Zhang, Huimin Guo, Min Chen, Juanjuan Huang, Ying Zhou, Tingsheng Ling

Objective To evaluate the technical feasibility, safety, and therapeutic outcomes of endoscopic submucosal dissection (ESD) for rectal tumors extending to the dentate line (RTDLs) compared with non-RTDLs using propensity score matching (PSM). Methods We retrospectively reviewed 127 patients with rectal tumors treated with ESD at two tertiary centers from November 2012 to December 2023 (51 RTDLs, 76 non-RTDLs). A 1:1 PSM based on age, sex, and lesion diameter yielded 51 matched pairs (102 patients in total). Procedu …

03.09.2026journal-article

Cancers

Understanding the Rising Incidence of Early-Onset Colorectal Cancer: Life-Course Determinants and Opportunities for Primary Prevention

Antoni Alegre-Martinez, Luis Cabañas-Alite, Ines E. Fernández-Benet, Manuel Sánchez-Casalongue, Jose M. Martin-Moreno

Background/Objectives: Early-onset colorectal cancer (EOCRC), diagnosed before age 50 years, is increasing in many countries, but its causes remain uncertain. Evidence on potentially modifiable determinants is heterogeneous and vulnerable to retrospective assessment and residual confounding. We synthesized metabolic, behavioral, dietary, medication-related, clinical, and socioeconomic factors, emphasizing consistency and life-course relevance. Methods: Two core PubMed searches covering publications from 1 January 2 …

03.09.2026journal-article

Cell Communication and Signaling

The paracrine Ephrin A4/BMP4 feed-forward loop sustains a tumor–CAF vicious cycle in osteosarcoma

Giorgia Giordano, Cristina Tucciarello, Erika Gucciardo, Jørgen Wesche, Leonardo A. Meza-Zepeda, Ola Myklebost, Elisa Tirtei, Alessandra Merlini, Simona Comparato, Santina Cutrupi, Lorenzo D’Ambrosio, Franca Fagioli, Dario Sangiolo, Claudio Isella, Anna Sapino, Caterina Marchiò, Giovanni Grignani, Ymera Pignochino

Abstract Background Advanced osteosarcoma (OS) remains a clinical challenge due to its aggressive behavior and poor prognosis. Cancer-associated fibroblasts (CAFs) have been shown to contribute to tumor progression, but the tumor–CAF crosstalk in OS is still poorly defined. Elucidating these interactions could reveal novel therapeutic targets. Methods Human OS surgical samples and cell lines were implanted into immunocompromised mice to generate 10 patient-derived (PDXs) and 10 cell line-derived xenografts (CDXs), …

03.09.2026journal-article

Frontiers in Immunology

Immune remodeling during cervical cancer chemoradiotherapy: temporal biomarkers and the timing of checkpoint blockade

Chenguang Yang, Xuan Song, Hongmei Sun, Min Chen, Xialing Zhu

Concurrent chemoradiotherapy (CRT) is the backbone of curative treatment for locally advanced cervical cancer, and PD-(L)1 blockade has entered first-line practice. Yet the pivotal trials diverge: pembrolizumab added to CRT improved survival in KEYNOTE-A18, whereas durvalumab did not in CALLA. Most prior syntheses organize the cervical tumor immune microenvironment by cell type and rely on cross-sectional, pre-treatment sampling, and several predate KEYNOTE-A18 and recent longitudinal multi-omic data. Here we refra …

03.09.2026journal-article

Frontiers in Oncology

Adjuvant therapy in chromophobe renal cell carcinoma: current evidence and unmet needs

Niovi Bejjani, Joseph Kattan

Objectives Chromophobe renal cell carcinoma (chRCC) is a rare subtype of kidney cancer with biological and clinical features that differ significantly from clear cell renal cell carcinoma (ccRCC). While adjuvant treatments have evolved for ccRCC, chRCC has been excluded or understudied in clinical trials, which has led to insufficient histology-specific data to guide postoperative treatment. This research aimed to summarize and critically appraise the current evidence regarding adjuvant therapies for chRCC, highlig …

03.09.2026journal-article

International Journal of Science, Strategic Management and Technology

White Spot Lesions Following Orthodontic Treatment: Contemporary Management

Y.Muni Akash

White spot lesions (WSLs) often develop after fixed orthodontic treatment. They appear as milky white spots on teeth due to enamel demineralization. These lesions are a common aesthetic concern, affecting 45.8% to 97% of orthodontic patients [1]. Today, dentistry focuses on non-invasive remineralization therapies to treat WSLs and prevent their progression.

03.09.2026journal-article

Frontiers in Oncology

Deep learning model using contrast-enhanced CT imaging features and clinical variables to predict surgical risk after hepatic resection for hepatocellular carcinoma

Kimika Kato, Yasuhito Mitsuyama, Hiroji Shinkawa, Takuma Okada, Atsushi Sugimoto, Ryota Tanaka, Sadaaki Nishimura, Jun Tauchi, Masahiko Kinoshita, Genki Watanabe, Kohei Nishio, Takeaki Ishizawa

Background Accurate preoperative risk assessment is crucial for patients undergoing hepatic resection for hepatocellular carcinoma (HCC). Conventional prediction methods are limited by the inability to capture complex relationships among multiple factors, and existing deep learning (DL) approaches focus on individual surgical outcomes. In this study, we developed and evaluated a DL model that integrates preoperative contrast-enhanced computed tomography (CT) imaging features and clinical variables to predict intrao …

03.09.2026journal-article

Frontiers in Medicine

Facial discoid lupus erythematosus complicated by a Candida tropicalis fungal granuloma in a patient with rhupus syndrome: a case report of successful treatment with oral itraconazole

Lingling Dong, Ting Zhang, Tong Hua, Yan Wang, Zhenhua Nie, Qingkang Lyu, Zuotao Zhao

Discoid lupus erythematosus (DLE) is a chronic cutaneous subtype of lupus erythematosus characterized by inflammatory lesions that are highly susceptible to secondary infection, particularly in immunocompromised individuals. Cutaneous fungal granulomas caused by Candida tropicalis and superimposed on pre-existing DLE lesions are exceedingly rare and pose substantial diagnostic challenges. We report the case of a 48-year-old female patient with a 2-year history of rheumatoid arthritis (RA), who presented with facial …