Frontiers in Psychiatry
Baseline amyloid burden and global cognitive change during a home-based tDCS protocol in late-life depression: an exploratory single-arm study
Background Late-life depression often co-occurs with cognitive difficulty, but whether amyloid burden is associated with mood and cognitive change during transcranial direct current stimulation (tDCS) in older adults is unknown. Methods In this single-arm pre–post study, 41 older adults were enrolled; 3 withdrew before receiving the device, and 38 received home-based tDCS and completed baseline (V1), post-stimulation (V2), and follow-up (V3) assessments. Depression, insomnia, subjective cognition, MoCA, and a detai …